EYLEA
Eylea (aflibercept) is a vascular endothelial growth factor (VEGF) inhibitor indicated for the treatment of several serious retinal conditions. It is used in adult patients to treat neovascular (wet) age-related macular degeneration, macular edema following retinal vein occlusion, diabetic macular edema, and diabetic retinopathy. The medication is also approved for the treatment of retinopathy of prematurity in pediatric patients.
How EYLEA Works
Aflibercept functions as a soluble decoy receptor that binds to vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF). By capturing these growth factors, the drug prevents them from binding to and activating VEGFR-1 and VEGFR-2 receptors on the surface of endothelial cells. This inhibition blocks the biological processes that lead to neovascularization and increased vascular permeability.
Details
- Status
- Prescription
- First Approved
- 2011-11-18
- Routes
- INJECTION
- Dosage Forms
- INJECTABLE
EYLEA Approval History
What EYLEA Treats
5 indicationsEYLEA is approved for 5 conditions since its original approval in 2011. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Neovascular (Wet) Age-Related Macular Degeneration (AMD)
- Macular Edema Following Retinal Vein Occlusion (RVO)
- Diabetic Macular Edema (DME)
- Diabetic Retinopathy (DR)
- Retinopathy of Prematurity (ROP)
EYLEA Competitors
Pro6 other drugs also target VEGF. Compare mechanisms, indications, and trial activity.
Competitors share the same molecular target (VEGF). Earlier expiry dates signal biosimilar/generic opportunities.
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Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
EYLEA FDA Label Details
ProIndications & Usage
FDA Label (PDF)EYLEA is indicated for the treatment of: EYLEA is a vascular endothelial growth factor (VEGF) inhibitor indicated for the treatment of patients with: Neovascular (Wet) Age-Related Macular Degeneration (AMD) Macular Edema Following Retinal Vein Occlusion (RVO) Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Retinopathy of Prematurity (ROP) 1.1 Neovascular (Wet) Age-Related Macular Degeneration (AMD) 1.2 Macular Edema Following Retinal Vein Occlusion (RVO) 1.3 Diabetic Macular Edema (DME) 1.4 Diabetic Retinopathy (DR) 1.5 Retinopathy of Prematurity (ROP)
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.