IDH1
3 drugsIsocitrate Dehydrogenase 1
Predictive biomarker for patient selection in 5 indications
Understanding IDH1
What it means: IDH1 mutations produce 2-hydroxyglutarate, an oncometabolite that blocks cell differentiation. Found in AML and gliomas.
Why it matters: IDH1 inhibitors (ivosidenib) induce differentiation and show responses in IDH1-mutant AML and cholangiocarcinoma.
Testing: Tested via NGS or PCR. R132 mutations are most common. Also detectable via immunohistochemistry.
3
Approved Drugs
5
Indications
2
Companies
Search IDH1 Clinical Trials
Search recruiting trials on ClinicalTrials.gov