Drug Targets
Biological targets being pursued by FDA-approved drugs
843
Unique Targets
60
Major Targets (10+ drugs)
2352
Company-Target Pairs
1311
Indications Covered
Most Targeted (10+ approved drugs)
Glucocorticoid receptor
41 drugs Rare Disease, Pain
ZYDUS LIFESCIENCES, BAUSCH AND LOMB, PTC THERAP +24 more
COX-2
32 drugs Immunology, Pain
Cipla, PHARMOBEDIENT, Lupin +25 more
COX-1
28 drugs Immunology, Pain
Cipla, Lupin, EXELA HOLDINGS +21 more
Estrogen Receptor
27 drugs Women's Health, Oncology
BRECKENRIDGE PHARM, WATSON LABS INC, SAGENT PHARMS INC +20 more
Beta-2 adrenergic receptor
26 drugs Cardiovascular, Ophthalmology
Sun Pharma, Teva, QUANTUM PHARMICS +14 more
AT1 receptor
26 drugs Cardiovascular, Renal
CHARTWELL RX, TORRENT, Apotex +15 more
Mu-opioid receptor
25 drugs Pain, Respiratory
LANNETT, PH HEALTH, NOVEL LABS INC +17 more
ERBB2
22 drugs Oncology
Boehringer Ingelheim, Roche, DAIICHI SANKYO +13 more
ACE
20 drugs Cardiovascular
COREPHARMA, Lupin, CHARTWELL RX +12 more
D2 receptor
20 drugs CNS, Gastrointestinal
Teva, DOUGLAS PHARMS, LANNETT CO INC +13 more
TNF
20 drugs Immunology, Oncology
AbbVie, HETERO LABS LTD V, Novartis +13 more
Insulin receptor
20 drugs Metabolic
SANOFI-AVENTIS US, Novo Nordisk, SANOFI-AVENTIS U.S. LLC +4 more
Factor Xa
19 drugs Cardiovascular
Baxter, REGCON HOLDINGS, Johnson & Johnson +7 more
beta-adrenergic receptor
19 drugs Cardiovascular, Immunology
SINOTHERAPEUTICS INC, NEXUS, ARS PHARMS OPERATION +14 more
DPP-4
18 drugs Metabolic
Novartis, SUNSHINE, Sun Pharma +6 more
SGLT2
18 drugs Metabolic, Cardiovascular
Merck, MSN, Boehringer Ingelheim +6 more
Beta-1 adrenergic receptor
17 drugs Cardiovascular, Ophthalmology
Sun Pharma, Teva, Novartis +10 more
HMGCR
17 drugs Cardiovascular, Metabolic
PLIVA HRVATSKA DOO, OXFORD PHARMS, Teva +14 more
VEGFA
17 drugs Ophthalmology, Oncology
Roche, Pfizer, Sanofi +8 more
GABA A receptor
17 drugs Pain, CNS
QUAGEN, UCB INC, Viatris +12 more
EGFR
17 drugs Oncology
Takeda, Teva, Eli Lilly +11 more
opioid receptor
17 drugs CNS, Other
Hikma, EUGIA PHARMA, Dr. Reddy's +7 more
GLP1R
17 drugs Metabolic
Fresenius Kabi, Eli Lilly, SANOFI-AVENTIS US +2 more
RANKL
17 drugs Oncology
Fresenius Kabi, Amgen, Novartis +6 more
alpha-adrenergic receptor
16 drugs Cardiovascular, Immunology
NEXUS, ARS PHARMS OPERATION, IMPAX +11 more
KIT
16 drugs Oncology
Bayer, EISAI INC, YABAO PHARM +11 more
H+/K+ ATPase
15 drugs Gastrointestinal
Sun Pharma, Cipla, CHARTWELL RX +9 more
FKBP-12
15 drugs Immunology, Oncology
GLENMARK PHARMS LTD, Teva, ASTELLAS +7 more
CD20
15 drugs Oncology, CNS
Roche, CELLTRION INC, SPECTRUM PHARMS +5 more
Dihydrofolate reductase
14 drugs Oncology
ABRAXIS PHARM, Teva, ACCORD HLTHCARE +9 more
Antithrombin III
14 drugs Cardiovascular
Baxter, HENGRUI PHARMA, Fresenius Kabi +3 more
Norepinephrine transporter
14 drugs Pain, CNS
PH HEALTH, SUPERNUS PHARMS, Johnson & Johnson +10 more
RET
14 drugs Oncology
Bayer, EISAI INC, YABAO PHARM +10 more
Calcium channel
13 drugs Cardiovascular
Viatris, MANKIND PHARMA, Teva +6 more
Tubulin
13 drugs Oncology
SEATTLE GENETICS, EISAI INC, LONG GROVE PHARMS +9 more
Thyroid hormone receptor
13 drugs Oncology
WATSON LABS TEVA, STEVENS J, GENUS LIFESCIENCES +7 more
IL-23
13 drugs Immunology
BIOCON BIOLOGICS INC, Johnson & Johnson, Eli Lilly +8 more
JAK2
13 drugs Immunology, Dermatology
Pfizer, LEO PHARMA AS, INCYTE CORP +7 more
Factor IIa
12 drugs Cardiovascular
Baxter, Fresenius Kabi, Pfizer +1 more
GnRH receptor
12 drugs Women's Health, Oncology
AbbVie, VERITY, TOLMAR +5 more
D2
12 drugs CNS
Apotex, MSN, LUYE INNOMIND PHARMA +5 more
JAK1
12 drugs Immunology, Dermatology
Pfizer, LEO PHARMA AS, INCYTE CORP +5 more
Carbonic anhydrase
11 drugs CNS, Rare Disease
ACCORD HLTHCARE, UPSHER SMITH LABS, XERIS +7 more
alpha-2 adrenergic receptor
11 drugs Ophthalmology, CNS
Apotex, CAPLIN, Merck +6 more
5-HT2A receptor
11 drugs CNS
Teva, DOUGLAS PHARMS, LANNETT CO INC +6 more
PDE5
11 drugs Urology, Cardiovascular
PAR PHARM INC, NORVIUM BIOSCIENCE, HETERO LABS LTD V +7 more
ROS1
11 drugs Oncology
Takeda, XCOVERY, Bristol-Myers Squibb +8 more
PDCD1
11 drugs Oncology
COHERUS BIOSCIENCES INC, Merck, INCYTE CORP +5 more
CD3
11 drugs Oncology, Metabolic
Roche, IMMUNOCORE LTD, Johnson & Johnson +5 more
RARgamma
11 drugs Dermatology, Immunology
VALEANT BERMUDA, MAYNE PHARMA, BAUSCH +4 more
Calcineurin
10 drugs Immunology, Ophthalmology
GLENMARK PHARMS LTD, Teva, ASTELLAS +6 more
Cyclooxygenase
10 drugs Immunology, Cardiovascular
Teva, Novartis, Hikma +4 more
FLT3
10 drugs Oncology
ASTELLAS, Dr. Reddy's, RIGEL PHARMS +6 more
Hyaluronan
10 drugs Oncology, CNS
Roche, Merck, Johnson & Johnson +2 more
Phospholipase A2
10 drugs Immunology, Pain
GALDERMA LABS LP, HARROW EYE, Merck +5 more
RARalpha
10 drugs Dermatology, Immunology
VALEANT BERMUDA, MAYNE PHARMA, BAUSCH +3 more
RARbeta
10 drugs Dermatology, Immunology
VALEANT BERMUDA, MAYNE PHARMA, BAUSCH +3 more
VEGFR-1
10 drugs Oncology
YABAO PHARM, AZURITY, Teva +7 more
VEGFR-2
10 drugs Oncology
YABAO PHARM, AZURITY, Teva +7 more
VEGFR-3
10 drugs Oncology
YABAO PHARM, AZURITY, Teva +7 more
Other Notable Targets (3-9 drugs)
H1 receptor 9
Respiratory
SERT 9
CNS
beta 2-adrenergic receptor 9
Respiratory
5-HT1B 9
CNS
5-HT1D 9
CNS
Thymidylate Synthase 9
Oncology
CSF receptor 9
Oncology
Muscarinic receptor 9
Urology
mTOR 9
Oncology
GH receptor 9
Endocrine
alpha-1 adrenergic receptor 8
Cardiovascular
Ribonucleotide reductase 8
Oncology
Carbonic Anhydrase II 8
Ophthalmology
VEGFR2 8
Oncology
Muscarinic acetylcholine receptor 8
Respiratory
5-HT1A receptor 8
CNS
P2Y12 8
Cardiovascular
Kappa-opioid receptor 8
CNS
CYP3A 8
Infectious Disease
MET 8
Oncology
NTRK1 8
Ophthalmology
IL-12 8
Immunology
Dopamine transporter 8
CNS
TRKB 8
Oncology
Beta-adrenoreceptor 7
Cardiovascular
NET 7
CNS
cholinergic receptor 7
Other
Mu opioid receptor 7
CNS
CFTR 7
Gastrointestinal
Androgen Receptor 7
Oncology
NK1R 7
Oncology
ALK 7
Oncology
FLT-3 7
Oncology
Topoisomerase II 7
Oncology
guanylate cyclase 7
Cardiovascular
LCK 7
Oncology
c-KIT 7
Oncology
C5 7
Immunology
BRAF 7
Oncology
FGFR1 7
Oncology
GABA-A receptor 6
CNS
Somatostatin receptor 6
Endocrine
SV2A 6
CNS
Serotonin transporter 6
CNS
Topoisomerase I 6
Oncology
5-HT3 receptor 6
Gastrointestinal
Folylpolyglutamate Synthetase 6
Oncology
Glycinamide Ribonucleotide Formyltransferase 6
Oncology
Cholinesterase 6
CNS
M3 6
Urology
VMAT2 6
CNS
Thrombin 6
Cardiovascular
MAO-B 6
CNS
BTK 6
Oncology
PDGFRbeta 6
Oncology
5HT2 6
CNS
CSF1R 6
Oncology
FGFR2 6
Oncology
VEGFR1 6
Oncology
VEGFR3 6
Oncology
+ 165 more targets