Drug Targets
Biological targets being pursued by FDA-approved drugs
857
Unique Targets
59
Major Targets (10+ drugs)
2339
Company-Target Pairs
1311
Indications Covered
Most Targeted (10+ approved drugs)
Glucocorticoid receptor
41 drugs Respiratory, Pain
GSK, AstraZeneca, Merck +24 more
COX-2
32 drugs Immunology, Ophthalmology
ROXANE, CHARTWELL RX, ALEMBIC +23 more
COX-1
28 drugs Immunology, Ophthalmology
ROXANE, CHARTWELL RX, AFT PHARMS US +19 more
Estrogen Receptor
27 drugs Women's Health, Oncology
Teva, EUGIA PHARMA, Novo Nordisk +19 more
Beta-2 adrenergic receptor
26 drugs Cardiovascular, Ophthalmology
Hikma, CHARTWELL MOLECULAR, Baxter +13 more
AT1 receptor
26 drugs Cardiovascular, Renal
Teva, Apotex, Viatris +13 more
Mu-opioid receptor
25 drugs Pain, CNS
PADAGIS US, Dr. Reddy's, PROTEGA PHARMS +15 more
ERBB2
22 drugs Oncology
Roche, Boehringer Ingelheim, AstraZeneca +13 more
D2 receptor
20 drugs CNS, Cardiovascular
IVAX SUB TEVA PHARMS, AIPING PHARM INC, OTSUKA PHARM CO LTD +14 more
ACE
20 drugs Cardiovascular
Dr. Reddy's, Hikma, Lupin +12 more
TNF
20 drugs Immunology, Oncology
Johnson & Johnson, Teva, Viatris +12 more
Insulin receptor
20 drugs Metabolic
SANOFI-AVENTIS US, SANOFI-AVENTIS U.S. LLC, Novo Nordisk +4 more
beta-adrenergic receptor
19 drugs Ophthalmology, Immunology
Novartis, Viatris, RISING +14 more
Factor Xa
19 drugs Cardiovascular
Bristol-Myers Squibb, Fresenius Kabi, Apotex +7 more
DPP-4
18 drugs Metabolic
Viatris, SUNSHINE, MSN +6 more
SGLT2
18 drugs Metabolic, Cardiovascular
Novartis, Cipla, Boehringer Ingelheim +6 more
opioid receptor
17 drugs Other, Pain
Viatris, Fresenius Kabi, PADAGIS ISRAEL +6 more
HMGCR
17 drugs Cardiovascular, Metabolic
Sun Pharma, WATSON LABS TEVA, Apotex +13 more
Beta-1 adrenergic receptor
17 drugs Cardiovascular, Ophthalmology
Hikma, CHARTWELL MOLECULAR, Baxter +9 more
EGFR
17 drugs Oncology
Eli Lilly, AstraZeneca, NATCO PHARMA LTD +11 more
GLP1R
17 drugs Metabolic
SANOFI-AVENTIS US, Novo Nordisk, BIOCON PHARMA +2 more
GABA A receptor
17 drugs CNS, Other
IMMEDICA PHARMA, Hikma, UPJOHN +10 more
VEGFA
17 drugs Metabolic, Oncology
Novartis, AMNEAL PHARMS, Regeneron +7 more
RANKL
17 drugs Oncology
AMNEAL PHARMS, SAMSUNG BIOEPIS CO LTD, BIOCON BIOLOGICS INC +6 more
alpha-adrenergic receptor
16 drugs Immunology, Cardiovascular
Viatris, ADAMIS PHARMS CORP, AMNEAL +11 more
KIT
16 drugs Oncology
Bayer, FOSUN WANBANG, EUGIA PHARMA +10 more
H+/K+ ATPase
15 drugs Gastrointestinal
PHARMOBEDIENT, Dr. Reddy's, LANNETT CO INC +9 more
FKBP-12
15 drugs Immunology, Oncology
Teva, AMNEAL, AADI +8 more
CD20
15 drugs Oncology, Immunology
Roche, Amgen, TG THERAPEUTICS, INC +5 more
Norepinephrine transporter
14 drugs CNS, Pain
ZYDUS PHARMS USA, NALPROPION, NORTHSTAR HLTHCARE +10 more
Dihydrofolate reductase
14 drugs Oncology
QUAD PHARMS, BIOCON LTD, PRINSTON INC +9 more
Antithrombin III
14 drugs Cardiovascular
Fresenius Kabi, CORMEDIX, BRIGHTGENE +3 more
RET
14 drugs Oncology
Bayer, FOSUN WANBANG, EXELIXIS +9 more
Calcium channel
13 drugs Cardiovascular
Lupin, TORRENT, CHENGDU SHUODE +7 more
Thyroid hormone receptor
13 drugs Oncology
Dr. Reddy's, STEVENS J, Viatris +7 more
JAK2
13 drugs Dermatology, Oncology
LEO PHARMA AS, INCYTE CORP, Eli Lilly +7 more
IL-23
13 drugs Immunology
Amgen, Fresenius Kabi, BIO-THERA SOLUTIONS LTD +8 more
D2
12 drugs CNS
CHARTWELL RX, Johnson & Johnson, VANDA PHARMS INC +5 more
Factor IIa
12 drugs Cardiovascular
Fresenius Kabi, CORMEDIX, Pfizer +1 more
JAK1
12 drugs Dermatology, Oncology
LEO PHARMA AS, INCYTE CORP, Eli Lilly +5 more
GnRH receptor
12 drugs Oncology, Women's Health
TOLMAR, AbbVie, INVAGEN PHARMS +5 more
5-HT2A receptor
11 drugs CNS
IVAX SUB TEVA PHARMS, AIPING PHARM INC, OTSUKA PHARM CO LTD +5 more
Carbonic anhydrase
11 drugs CNS, Rare Disease
PHARMACO, Johnson & Johnson, RISING +7 more
alpha-2 adrenergic receptor
11 drugs Ophthalmology, CNS
Apotex, Novartis, REGCON HOLDINGS +6 more
PDE5
11 drugs Urology, Cardiovascular
Teva, MACLEODS PHARMS LTD, Eli Lilly +6 more
PDCD1
11 drugs Oncology
Bristol-Myers Squibb, INCYTE CORP, COHERUS BIOSCIENCES INC +5 more
RARgamma
11 drugs Dermatology, Rare Disease
BAUSCH, MAYNE PHARMA, DOW PHARM +3 more
ROS1
11 drugs Oncology
Roche, EXELIXIS, NUVATION +7 more
CD3
11 drugs Oncology, Metabolic
Roche, Pfizer, RENGENERON PHARMACEUTICALS, INC. +5 more
Cyclooxygenase
10 drugs Cardiovascular, Immunology
CHARTWELL MOLECULAR, Aurobindo Pharma, Takeda +5 more
Calcineurin
10 drugs Immunology, Ophthalmology
Teva, CHENGDU, ASTELLAS +6 more
Phospholipase A2
10 drugs Ophthalmology, Pain
ALIMERA SCIENCES INC, ALEMBIC, BAUSCH AND LOMB INC +4 more
RARalpha
10 drugs Dermatology, Immunology
BAUSCH, MAYNE PHARMA, DOW PHARM +2 more
RARbeta
10 drugs Dermatology, Immunology
BAUSCH, MAYNE PHARMA, DOW PHARM +2 more
VEGFR-1
10 drugs Oncology
Takeda, Bayer, AVEO PHARMS +6 more
VEGFR-2
10 drugs Oncology
Takeda, Bayer, AVEO PHARMS +6 more
VEGFR-3
10 drugs Oncology
Takeda, Bayer, AVEO PHARMS +6 more
FLT3
10 drugs Oncology
FOSUN WANBANG, Novartis, SOBI +6 more
Hyaluronan
10 drugs Immunology, Oncology
ARGENX BV, Bristol-Myers Squibb, Johnson & Johnson +2 more
Other Notable Targets (3-9 drugs)
beta 2-adrenergic receptor 9
Respiratory
5-HT1B 9
CNS
5-HT1D 9
CNS
H1 receptor 9
Respiratory
SERT 9
CNS
Muscarinic receptor 9
Urology
Thymidylate Synthase 9
Oncology
mTOR 9
Immunology
CD19 9
Immunology
CSF receptor 9
Oncology
GH receptor 9
Endocrine
Ribonucleotide reductase 8
Oncology
alpha-1 adrenergic receptor 8
Cardiovascular
5-HT1A receptor 8
CNS
Dopamine transporter 8
CNS
Carbonic Anhydrase II 8
Ophthalmology
Kappa-opioid receptor 8
CNS
Muscarinic acetylcholine receptor 8
Respiratory
P2Y12 8
Cardiovascular
NTRK1 8
Oncology
TRKB 8
Oncology
IL-12 8
Immunology
CYP3A 8
Infectious Disease
VEGFR2 8
Oncology
MET 8
Oncology
cholinergic receptor 7
CNS
Beta-adrenoreceptor 7
Cardiovascular
Mu opioid receptor 7
CNS
guanylate cyclase 7
Cardiovascular
CFTR 7
Gastrointestinal
Topoisomerase II 7
Oncology
NET 7
CNS
NK1R 7
Oncology
LCK 7
Oncology
c-KIT 7
Oncology
ALK 7
Oncology
BRAF 7
Oncology
FLT-3 7
Oncology
Androgen Receptor 7
Dermatology
FGFR1 7
Oncology
C5 7
Immunology
Somatostatin receptor 6
Endocrine
5-HT3 receptor 6
Gastrointestinal
SV2A 6
CNS
GABA-A receptor 6
CNS
Thrombin 6
Cardiovascular
5HT2 6
CNS
IL-6R 6
Immunology
Tubulin 6
Oncology
Cholinesterase 6
CNS
PDE4 6
Respiratory
Folylpolyglutamate Synthetase 6
Oncology
Glycinamide Ribonucleotide Formyltransferase 6
Oncology
VMAT2 6
CNS
M3 6
Urology
PDGFRbeta 6
Oncology
MAO-B 6
CNS
TRKC 6
Oncology
PSMA 6
Oncology
BTK 6
Oncology
+ 166 more targets