Drug Targets
Biological targets being pursued by FDA-approved drugs
723
Unique Targets
71
Major Targets (10+ drugs)
2280
Company-Target Pairs
1303
Indications Covered
Most Targeted (10+ approved drugs)
Beta-2 adrenergic receptor
42 drugs Ophthalmology, Cardiovascular
Teva, AM REGENT, THEA PHARMA +19 more
Glucocorticoid receptor
41 drugs Pain, Respiratory
BAUSCH AND LOMB INC, Teva, Sun Pharma +23 more
Mu-opioid receptor
32 drugs Pain, Respiratory
NESHER PHARMS, STRIDES PHARMA INTL, TRIS PHARMA INC +21 more
D2 receptor
32 drugs CNS, Cardiovascular
Dr. Reddy's, Teva, BIONPHARMA +19 more
COX-2
32 drugs Immunology, Ophthalmology
AIPING PHARM INC, Pfizer, RISING +22 more
Estrogen Receptor
30 drugs Oncology, Women's Health
SCIEGEN PHARMS, Novo Nordisk, MILLICENT MFG PR +20 more
COX-1
28 drugs Immunology, Ophthalmology
AIPING PHARM INC, Pfizer, RISING +19 more
AT1 receptor
26 drugs Cardiovascular, Renal
Lupin, PHARMOBEDIENT, AZURITY +14 more
GABA A receptor
23 drugs CNS, Sleep
Teva, UCB INC, ZYDUS PHARMS +17 more
KIT
23 drugs Oncology
Bayer, Teva, AVEO PHARMS +15 more
ERBB2
22 drugs Oncology
CELLTRION INC, PUMA BIOTECH, Bayer +13 more
5-HT2A receptor
21 drugs CNS
Teva, Dr. Reddy's, ACCORD HLTHCARE +12 more
Beta-1 adrenergic receptor
21 drugs Ophthalmology, Cardiovascular
Teva, AM REGENT, THEA PHARMA +10 more
Factor Xa
21 drugs Cardiovascular
SOLOPAK, Baxter, Fresenius Kabi +9 more
TNF
21 drugs Immunology, Oncology
UCB INC, IMMUNEX, HETERO LABS LTD V +12 more
Insulin receptor
21 drugs Metabolic, Oncology
Eli Lilly, Viatris, SANOFI-AVENTIS U.S. LLC +5 more
ACE
20 drugs Cardiovascular
MPP PHARMA, Aurobindo Pharma, Lupin +11 more
beta-adrenergic receptor
19 drugs Cardiovascular, Ophthalmology
NESHER PHARMS, Teva, PH HEALTH +14 more
H+/K+ ATPase
19 drugs Gastrointestinal, Immunology
Novartis, Viatris, PHARMOBEDIENT +13 more
DPP-4
19 drugs Metabolic
Dr. Reddy's, MSN, TORRENT +5 more
VEGFR-2
18 drugs Oncology, Respiratory
Bayer, AVEO PHARMS, DECIPHERA PHARMS +13 more
SGLT2
18 drugs Metabolic, Cardiovascular
Johnson & Johnson, Apotex, MSN +6 more
HMGCR
17 drugs Cardiovascular, Metabolic
Dr. Reddy's, CHARTWELL RX, MICRO LABS +13 more
SERT
17 drugs Pain, CNS
STRIDES PHARMA INTL, PRINSTON INC, AMNEAL PHARMS +12 more
VEGFA
17 drugs Ophthalmology, Metabolic
Regeneron, Amgen, Roche +7 more
alpha-2 adrenergic receptor
17 drugs CNS, Ophthalmology
Teva, ALEMBIC, SABA ILAC SANAYIVE +12 more
FLT3
17 drugs Oncology, Respiratory
Bristol-Myers Squibb, Dr. Reddy's, CPPI CV +11 more
opioid receptor
17 drugs CNS, Other
Dr. Reddy's, NOVEN, Hikma +7 more
GLP1R
17 drugs Metabolic
Novo Nordisk, Novartis, Eli Lilly +2 more
RANKL
17 drugs Oncology
Novartis, BIOCON BIOLOGICS INC, Amgen +6 more
EGFR
17 drugs Oncology
PUMA BIOTECH, MSN, Bayer +11 more
5HT2
16 drugs CNS
Dr. Reddy's, CHEPLAPHARM, MSN +9 more
H1 receptor
16 drugs Respiratory, Sleep
Dr. Reddy's, TRIS PHARMA INC, ZYDUS LIFESCIENCES +13 more
alpha-adrenergic receptor
16 drugs Cardiovascular, Immunology
Teva, PH HEALTH, LONG GROVE PHARMS +11 more
5-HT1B
16 drugs CNS
Apotex, Teva, PHARMOBEDIENT +11 more
5-HT1D
16 drugs CNS
Apotex, Teva, PHARMOBEDIENT +11 more
VEGFR-1
16 drugs Oncology, Respiratory
Bayer, AVEO PHARMS, Dr. Reddy's +11 more
VEGFR-3
16 drugs Oncology, Respiratory
Bayer, AVEO PHARMS, Dr. Reddy's +11 more
FKBP-12
15 drugs Immunology, Oncology
Viatris, Apotex, PF PRISM CV +8 more
PDGFR-beta
15 drugs Oncology
Bayer, Teva, AVEO PHARMS +10 more
CD20
15 drugs Oncology, Immunology
GENMAB US, INC., Novartis, Roche +5 more
Norepinephrine transporter
14 drugs Pain, CNS
STRIDES PHARMA INTL, Teva, TWI PHARMS +10 more
Dihydrofolate reductase
14 drugs Oncology
NORBROOK, Hikma, Apotex +10 more
Antithrombin III
14 drugs Cardiovascular
Baxter, Fresenius Kabi, BRIGHTGENE +4 more
RET
14 drugs Oncology
Bayer, Dr. Reddy's, CPPI CV +9 more
JAK2
13 drugs Oncology, Immunology
INCYTE CORP, Bristol-Myers Squibb, AbbVie +7 more
CSF1R
13 drugs Oncology, Respiratory
Bayer, Dr. Reddy's, CPPI CV +9 more
Thyroid hormone receptor
13 drugs Oncology
ASCENT PHARMS INC, CEDIPROF INC, STEVENS J +7 more
GnRH receptor
13 drugs Oncology, Women's Health
VERITY, INVAGEN PHARMS, TERSERA +6 more
Calcium channel
13 drugs Cardiovascular
CHENGDU SHUODE, NOVEL LABS INC, CHIESI +7 more
IL-23
13 drugs Immunology
AbbVie, Johnson & Johnson, CELLTRION, INC. +8 more
5-HT1A receptor
12 drugs CNS
Teva, Apotex, Takeda +5 more
Factor IIa
12 drugs Cardiovascular
Baxter, Fresenius Kabi, CORMEDIX +2 more
PDE5
12 drugs Urology, Cardiovascular
Teva, Viatris, CMP DEV LLC +6 more
NMDA receptor
12 drugs CNS, Other
AMNEAL PHARMS, Sun Pharma, ANI PHARMS +9 more
JAK1
12 drugs Oncology, Immunology
INCYTE CORP, AbbVie, Pfizer +5 more
alpha-1 adrenergic receptor
12 drugs Urology, Cardiovascular
Lupin, SAGENT PHARMS INC, NESHER PHARMS +7 more
RARgamma
12 drugs Immunology, Dermatology
CHARTWELL RX, DOW PHARM, BAUSCH +4 more
Carbonic anhydrase
11 drugs CNS, Rare Disease
Teva, TORRENT, XERIS +7 more
mTOR
11 drugs Immunology, Oncology
STRIDES PHARMA, Teva, Apotex +5 more
Cyclooxygenase
11 drugs Immunology, Pain
ZYDUS PHARMS, VALEANT PHARMS INTL, NOVITIUM PHARMA +5 more
GH receptor
11 drugs Endocrine
EMD SERONO INC, Novartis, PHARMACIA +5 more
PDCD1
11 drugs Oncology
Regeneron, GSK, Bristol-Myers Squibb +5 more
CD3
11 drugs Oncology, Metabolic
GENMAB US, INC., Amgen, PROVENTION BIO INC +5 more
ROS1
11 drugs Oncology
Roche, PF PRISM CV, Takeda +7 more
Calcineurin
10 drugs Immunology, Ophthalmology
Viatris, ASTELLAS, VELOXIS PHARMS INC +6 more
Phospholipase A2
10 drugs Pain, Immunology
Dr. Reddy's, GALDERMA LABS, BAUSCH AND LOMB INC +5 more
Kappa-opioid receptor
10 drugs CNS, Pain
ASCENT PHARMS INC, EDENBRIDGE PHARMS, BDSI +6 more
Hyaluronan
10 drugs Oncology, CNS
Johnson & Johnson, Roche, Bristol-Myers Squibb +2 more
RARalpha
10 drugs Immunology, Dermatology
CHARTWELL RX, DOW PHARM, BAUSCH +2 more
RARbeta
10 drugs Immunology, Dermatology
CHARTWELL RX, DOW PHARM, BAUSCH +2 more
Other Notable Targets (3-9 drugs)
M3 9
Urology
Muscarinic receptor 9
Urology
FGFR1 9
Oncology
PDGFR-alpha 9
Oncology
Thymidylate Synthase 9
Oncology
CSF receptor 9
Oncology
CD19 9
Oncology
Ribonucleotide reductase 8
Oncology
Carbonic Anhydrase II 8
Ophthalmology
Thrombin 8
Cardiovascular
NTRK1 8
Oncology
P2Y12 8
Cardiovascular
PDE4 8
Immunology
CYP3A 8
Infectious Disease
Muscarinic acetylcholine receptor 8
Ophthalmology
NK1R 8
Oncology
ETA 8
Cardiovascular
C5 8
Immunology
FGFR3 8
Oncology
TRKB 8
Oncology
MET 8
Oncology
Dopamine transporter 8
CNS
IL-12 8
Immunology
Somatostatin receptor 7
Endocrine
cholinergic receptor 7
Other
guanylate cyclase 7
Cardiovascular
M1 7
Urology
Vitamin D3 receptor 7
Renal
G-CSF receptor 7
Oncology
BRAF 7
Oncology
CRAF 7
Oncology
TIE2 7
Oncology
S1PR1 7
CNS
NET 7
CNS
LCK 7
Oncology
DOPA decarboxylase 7
CNS
Tubulin 7
Oncology
Topoisomerase II 7
Oncology
Beta-adrenoreceptor 7
Cardiovascular
CFTR 7
Respiratory
ALK 7
Oncology
Androgen Receptor 7
Oncology
SNAP-25 7
CNS
Cholinesterase 6
CNS
SV2A 6
CNS
5-HT3 receptor 6
Gastrointestinal
M2 6
Urology
M4 6
Urology
M5 6
Urology
IL-6R 6
Immunology
FGFR2 6
Oncology
BTK 6
Oncology
S1PR5 6
CNS
VMAT2 6
CNS
Folylpolyglutamate Synthetase 6
Oncology
Glycinamide Ribonucleotide Formyltransferase 6
Oncology
MAO-B 6
CNS
PSMA 6
Oncology
MAP2K1 6
Oncology
TYK2 6
Immunology
+ 136 more targets