Drug Targets
Biological targets being pursued by FDA-approved drugs
857
Unique Targets
59
Major Targets (10+ drugs)
2341
Company-Target Pairs
1311
Indications Covered
Most Targeted (10+ approved drugs)
Glucocorticoid receptor
41 drugs Immunology, Respiratory
MC2, AMNEAL IRELAND LTD, CATALYST PHARMS +25 more
COX-2
32 drugs Immunology, Ophthalmology
ATNAHS PHARMA US, COASTAL PHARMS, AMNEAL PHARMS +24 more
COX-1
28 drugs Immunology, Ophthalmology
ATNAHS PHARMA US, COASTAL PHARMS, AMNEAL PHARMS +20 more
Estrogen Receptor
27 drugs Oncology, Women's Health
MSN, Eli Lilly, Viatris +20 more
Beta-2 adrenergic receptor
26 drugs Cardiovascular, Ophthalmology
Pfizer, RUBICON RESEARCH, J MOLNER +14 more
AT1 receptor
26 drugs Cardiovascular, Renal
RISING, Viatris, WATSON LABS TEVA +13 more
Mu-opioid receptor
25 drugs Pain, Gastrointestinal
Teva, STRIDES PHARMA INTL, QUAGEN +16 more
ERBB2
22 drugs Oncology
Roche, Pfizer, Boehringer Ingelheim +13 more
D2 receptor
20 drugs CNS, Gastrointestinal
IVAX SUB TEVA PHARMS, Teva, DOUGLAS PHARMS +13 more
ACE
20 drugs Cardiovascular
Teva, Sun Pharma, BAUSCH +12 more
TNF
20 drugs Oncology, Immunology
BRECKENRIDGE, Amgen, EMERGE BIOSCIENCE PTE LTD +12 more
Insulin receptor
20 drugs Metabolic
Eli Lilly, Sanofi, Novo Nordisk +4 more
beta-adrenergic receptor
19 drugs Cardiovascular, Ophthalmology
STRIDES PHARMA INTL, Teva, NEPHRON +14 more
Factor Xa
19 drugs Cardiovascular
HENGRUI PHARMA, Dr. Reddy's, Fresenius Kabi +7 more
DPP-4
18 drugs Metabolic
Boehringer Ingelheim, ZYDUS PHARMS USA, SUNSHINE +6 more
SGLT2
18 drugs Metabolic, Cardiovascular
Boehringer Ingelheim, BIOCON PHARMA, ALKEM LABS LTD +6 more
opioid receptor
17 drugs Other, Pain
Viatris, CHARTWELL RX, Fresenius Kabi +6 more
HMGCR
17 drugs Cardiovascular, Metabolic
SENORES PHARMS, Teva, OXFORD PHARMS +13 more
Beta-1 adrenergic receptor
17 drugs Cardiovascular, Ophthalmology
Pfizer, RUBICON RESEARCH, J MOLNER +9 more
EGFR
17 drugs Oncology
CHARTWELL RX, AstraZeneca, Pfizer +11 more
GABA A receptor
17 drugs Pain, CNS
QUAGEN, COSETTE, ASPIRO +11 more
GLP1R
17 drugs Metabolic
BIOCON PHARMA, Novo Nordisk, SANOFI-AVENTIS US +2 more
VEGFA
17 drugs Oncology, Metabolic
BIOCON BIOLOGICS INC, Roche, Sanofi +7 more
RANKL
17 drugs Oncology
AMNEAL PHARMS, Amgen, SHANGHAI HENLIUS BIOTECH +6 more
alpha-adrenergic receptor
16 drugs Cardiovascular, Other
Teva, NEPHRON, Pfizer +11 more
KIT
16 drugs Oncology
FOSUN WANBANG, NOVUGEN, Teva +10 more
H+/K+ ATPase
15 drugs Gastrointestinal
ANI PHARMS, Aurobindo Pharma, EPIC PHARMA LLC +9 more
FKBP-12
15 drugs Immunology, Oncology
Dr. Reddy's, ENCUBE, PF PRISM CV +8 more
CD20
15 drugs Oncology, Immunology
GENMAB US, INC., Novartis, Roche +5 more
Norepinephrine transporter
14 drugs Pain, CNS
STRIDES PHARMA INTL, Apotex, BAUSCH +10 more
Dihydrofolate reductase
14 drugs Oncology
QUAD PHARMS, Pfizer, GLAND +9 more
Antithrombin III
14 drugs Cardiovascular
HENGRUI PHARMA, Fresenius Kabi, Pfizer +3 more
RET
14 drugs Oncology
Roche, BLUEPRINT MEDICINES, FOSUN WANBANG +9 more
Calcium channel
13 drugs Cardiovascular
Sun Pharma, TORRENT, MACLEODS PHARMS +7 more
JAK2
13 drugs Oncology, Immunology
SOBI, BLUEPRINT MEDICINES, Eli Lilly +7 more
Thyroid hormone receptor
13 drugs Oncology
ACCORD HLTHCARE, IBSA, Viatris +7 more
IL-23
13 drugs Immunology
AbbVie, ACCORD BIOPHARMA INC., Eli Lilly +8 more
D2
12 drugs CNS
ZYDUS LIFESCIENCES, Johnson & Johnson, MSN +6 more
Factor IIa
12 drugs Cardiovascular
Fresenius Kabi, Pfizer, Baxter +1 more
JAK1
12 drugs Oncology, Immunology
BLUEPRINT MEDICINES, Eli Lilly, INCYTE CORP +5 more
GnRH receptor
12 drugs Oncology, Women's Health
VERITY, AbbVie, ENDO OPERATIONS +5 more
Carbonic anhydrase
11 drugs CNS, Metabolic
Sun Pharma, SUPERNUS PHARMS, VIVUS LLC +7 more
5-HT2A receptor
11 drugs CNS
IVAX SUB TEVA PHARMS, Teva, DOUGLAS PHARMS +5 more
alpha-2 adrenergic receptor
11 drugs Ophthalmology, CNS
REGCON HOLDINGS, AbbVie, CAPLIN +5 more
CD3
11 drugs Oncology, Metabolic
Amgen, PROVENTION BIO INC, IMMUNOCORE LTD +5 more
PDE5
11 drugs Urology, Cardiovascular
PHARMOBEDIENT, Teva, VIVUS LLC +6 more
RARgamma
11 drugs Dermatology, Immunology
DOW PHARM, ALMIRALL, BAUSCH +3 more
ROS1
11 drugs Oncology
Bristol-Myers Squibb, XCOVERY, NUVATION +7 more
PDCD1
11 drugs Oncology
BEIGENE, Merck, GSK +5 more
VEGFR-1
10 drugs Oncology
PF PRISM CV, NOVUGEN, Teva +6 more
VEGFR-2
10 drugs Oncology
PF PRISM CV, NOVUGEN, Teva +6 more
VEGFR-3
10 drugs Oncology
PF PRISM CV, NOVUGEN, Teva +6 more
Cyclooxygenase
10 drugs Immunology, Cardiovascular
Teva, Lupin, ANI PHARMS +4 more
FLT3
10 drugs Oncology
SOBI, BLUEPRINT MEDICINES, FOSUN WANBANG +6 more
RARalpha
10 drugs Dermatology, Immunology
DOW PHARM, ALMIRALL, BAUSCH +2 more
RARbeta
10 drugs Dermatology, Immunology
DOW PHARM, ALMIRALL, BAUSCH +2 more
Phospholipase A2
10 drugs Pain, Dermatology
AMNEAL, HARROW EYE, Merck +5 more
Calcineurin
10 drugs Immunology, Ophthalmology
ENCUBE, ASTELLAS, GLENMARK PHARMS LTD +6 more
Hyaluronan
10 drugs Oncology, CNS
Merck, Roche, Johnson & Johnson +2 more
Other Notable Targets (3-9 drugs)
beta 2-adrenergic receptor 9
Respiratory
H1 receptor 9
Respiratory
SERT 9
CNS
Muscarinic receptor 9
Urology
CD19 9
Oncology
mTOR 9
Immunology
Thymidylate Synthase 9
Oncology
GH receptor 9
Endocrine
CSF receptor 9
Oncology
alpha-1 adrenergic receptor 8
Cardiovascular
Carbonic Anhydrase II 8
Ophthalmology
Ribonucleotide reductase 8
Oncology
5-HT1A receptor 8
CNS
CYP3A 8
Infectious Disease
5-HT1B 8
CNS
5-HT1D 8
CNS
P2Y12 8
Cardiovascular
Kappa-opioid receptor 8
CNS
NTRK1 8
Oncology
TRKB 8
Oncology
VEGFR2 8
Oncology
IL-12 8
Immunology
Dopamine transporter 8
CNS
Muscarinic acetylcholine receptor 8
Respiratory
MET 8
Oncology
cholinergic receptor 7
CNS
Beta-adrenoreceptor 7
Cardiovascular
NET 7
CNS
Topoisomerase II 7
Oncology
NK1R 7
Oncology
ALK 7
Oncology
guanylate cyclase 7
Cardiovascular
Mu opioid receptor 7
CNS
LCK 7
Oncology
FGFR1 7
Oncology
c-KIT 7
Oncology
C5 7
Immunology
CFTR 7
Gastrointestinal
BRAF 7
Oncology
FLT-3 7
Oncology
Androgen Receptor 7
Oncology
GABA-A receptor 6
CNS
Cholinesterase 6
CNS
Somatostatin receptor 6
Endocrine
Serotonin transporter 6
CNS
SV2A 6
CNS
Thrombin 6
Cardiovascular
Tubulin 6
Oncology
5-HT3 receptor 6
CNS
MAO-B 6
CNS
Folylpolyglutamate Synthetase 6
Oncology
Glycinamide Ribonucleotide Formyltransferase 6
Oncology
M3 6
Respiratory
BTK 6
Oncology
PDE4 6
Respiratory
CSF1R 6
Oncology
VMAT2 6
CNS
5HT2 6
CNS
TRKC 6
Oncology
PSMA 6
Oncology
+ 166 more targets