ROS1
11 drugsROS Proto-Oncogene 1
Predictive biomarker for patient selection in 12 indications
Understanding ROS1
What it means: ROS1 rearrangements create fusion proteins similar to ALK. Found in ~1-2% of non-small cell lung cancers.
Why it matters: ROS1+ cancers respond to crizotinib (FDA-approved) and other ALK/ROS1 inhibitors like entrectinib.
Testing: Tested via FISH (break-apart probe), IHC (screening), or NGS for fusion identification.
11
Approved Drugs
12
Indications
10
Companies
ROS1 is a precision-medicine biomarker linked to 11 FDA-approved targeted drugs from 10 companies, spanning 12 indications including ROS1-positive metastatic non-small cell lung cancer (NSCLC) in adults, NTRK gene fusion-positive solid tumors in adult and pediatric patients older than 1 month, Medullary Thyroid Cancer. Explore the targeted therapies, indications, testing methods, and companies developing ROS1 drugs below.
Search ROS1 Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting ROS1
| Drug | Company | Therapeutic Area |
|---|---|---|
| ALUNBRIG | Takeda | Oncology |
| AUGTYRO | Bristol-Myers Squibb | Oncology |
| CABOMETYX | EXELIXIS | Oncology |
| COMETRIQ | EXELIXIS | Oncology |
| ENSACOVE | XCOVERY | Oncology |
| IBTROZI | NUVATION | Oncology |
| LORBRENA | Pfizer | Oncology |
| RESNIBEN | AZURITY | Oncology |
| ROZLYTREK | Roche | Oncology |
| XALKORI | PF PRISM CV | Oncology |
| ZYKADIA | Novartis | Oncology |
ROS1 Indications
ROS1-positive metastatic non-small cell lung cancer (NSCLC) in adults NTRK gene fusion-positive solid tumors in adult and pediatric patients older than 1 month Medullary Thyroid Cancer Advanced renal cell carcinoma Hepatocellular carcinoma previously treated with sorafenib Locally advanced or metastatic differentiated thyroid cancer Well-differentiated pancreatic neuroendocrine tumors Well-differentiated extra-pancreatic neuroendocrine tumors Non-Small Cell Lung Cancer Solid Tumors Anaplastic Large Cell Lymphoma Inflammatory Myofibroblastic Tumor