Acute Kidney Injury Clinical Trial Landscape

Data updated: May 20, 2026

215 clinical trials tracked since 2008

Acute Kidney Injury is being studied across 215 clinical trials registered since 2008, with 69 programs currently active. The competitive pipeline includes 17 active Phase 3 trials, 37 active Phase 2 trials, and 8 active Phase 1 trials. Top industry sponsors include Ebima Clifford Okundaye, Novartis, Arch Biopartners Inc..

69 active

215 total (since 2008)

Phase 1 Active

27 total

Phase 2 Active

94 total

Phase 3 Active

56 total

Phase 4 Active

61 total

Top Industry Sponsors

Sorted by active Active Done Failed

Ebima Clifford Okundaye 2 0 0

Novartis 1 1 1

Arch Biopartners Inc. 1 1 0

Vantive Health LLC 1 0 1

M2RLAB SL 1 0 0

+ 10 more sponsors — see full table below

Featured Phase 3 Trials

NCT06337838 RECRUITING

Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial

Hamilton Health Sciences Corporation n=100

NCT05399537 RECRUITING

Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

Vantive Health LLC n=40

NCT06531642 RECRUITING

Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients

The University of Texas Health Science Center, Houston n=100

NCT06344442 RECRUITING

Low-dose Arginine-vasopressin Supplementation on Post-transplant Acute Kidney Injury After Liver Transplantation (AVENIR Trial)

Assistance Publique - Hôpitaux de Paris n=304

NCT05084196 RECRUITING

Melatonin for Prevention of Kidney Injury

Rutgers, The State University of New Jersey n=300

+ 51 more Phase 3 trials — see full database below

Acute Kidney Injury — Trials Started by Year (last 10 years)

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Ebima Clifford Okundaye

Novartis

Arch Biopartners Inc.

Vantive Health LLC

M2RLAB SL

CalciMedica, Inc.

AstraZeneca

Noorik Biopharmaceuticals AG

Hope Biosciences LLC

Bilix Co.,Ltd.

Active Trials by Phase

Phase 1

Phase 2

Phase 3

Phase 4

Enrollment Size Distribution

1-50

51-200

201-500

501-1k

1k+

All Industry Sponsors

Sorted by active Active Done Failed

Ebima Clifford Okundaye 2 0 0

Novartis 1 1 1

Arch Biopartners Inc. 1 1 0

Vantive Health LLC 1 0 1

M2RLAB SL 1 0 0

CalciMedica, Inc. 1 0 0

AstraZeneca 1 0 0

Noorik Biopharmaceuticals AG 1 0 0

Hope Biosciences LLC 1 0 0

Bilix Co.,Ltd. 1 0 0

Fresenius Medical Care North America 1 0 0

EnnovaBio 1 0 0

Kelifarma 1 0 0

Complexa, Inc. 0 4 0

MediBeacon 0 3 0

NCT06337838 RECRUITING

Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial

Hamilton Health Sciences Corporation n=100

NCT07550894 NOT YET RECRUITING

Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT

Sun Yat-sen University n=220

NCT05399537 RECRUITING

Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

Vantive Health LLC n=40

NCT06531642 RECRUITING

Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients

The University of Texas Health Science Center, Houston n=100

NCT07161843 NOT YET RECRUITING

Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)

Ebima Clifford Okundaye n=500

NCT06344442 RECRUITING

Low-dose Arginine-vasopressin Supplementation on Post-transplant Acute Kidney Injury After Liver Transplantation (AVENIR Trial)

Assistance Publique - Hôpitaux de Paris n=304

NCT05084196 RECRUITING

Melatonin for Prevention of Kidney Injury

Rutgers, The State University of New Jersey n=300

NCT04982419 RECRUITING

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

VA Office of Research and Development n=240

NCT06196853 NOT YET RECRUITING

Prevention of Cisplatin-induced Nephrotoxicity

Mahidol University n=24

NCT05906758 RECRUITING

Ultra-Low Contrast Angiography in AKI

Tulane University n=32

NCT07156786 NOT YET RECRUITING

N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial

Fakultas Kedokteran Universitas Indonesia n=72

NCT05272878 ACTIVE NOT RECRUITING

Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.

Assistance Publique - Hôpitaux de Paris n=508

NCT06866236 NOT YET RECRUITING

Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression

Ebima Clifford Okundaye n=3,000

NCT04589546 ACTIVE NOT RECRUITING

Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?

Centre Hospitalier Universitaire, Amiens n=310

NCT04216927 RECRUITING

NO During CPB in Neonates to Reduce Risk of AKI

Children's Hospital Medical Center, Cincinnati n=40

NCT05339139 RECRUITING

SAfety of Regional Citrate Anticoagulation (SARCA Study)

Fresenius Medical Care North America n=50

NCT06014801 RECRUITING

Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients

Jikei University School of Medicine n=400

NCT05468203 TERMINATED

PREVENTion With Sglt-2 Inhibition of Acute Kidney Injury in Intensive Care

The George Institute n=51

NCT02836899 COMPLETED

Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

Massachusetts General Hospital n=250

NCT01636089 COMPLETED

Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit

University Hospital, Caen n=300

NCT01682590 TERMINATED

I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)

Centre Hospitalier Universitaire Dijon n=500

NCT01467466 COMPLETED

Prevention of Serious Adverse Events Following Angiography

VA Office of Research and Development n=5,177

NCT02664753 TERMINATED

L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury

Centre Hospitalier Universitaire de Nīmes n=254

NCT02860130 TERMINATED

Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)

Vantive Health LLC n=34

NCT07072572 COMPLETED

Lung Point of Care Ultrasound to Guide Albumin Administration in Cirrhosis

Centro Medico Issemym n=72

NCT06000748 TERMINATED

NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients

University of California, San Francisco n=6

NCT05049590 COMPLETED

Acute Normovolemic Hemodilution in Complex Cardiac Surgery

University of California, Los Angeles n=63

NCT04411472 TERMINATED

(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI

AM-Pharma n=676

NCT03630224 TERMINATED

Plasmalyte Versus Saline in Trauma Patients

Assistance Publique - Hôpitaux de Paris n=365

NCT01077895 WITHDRAWN

The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function

University Hospital, Ghent

NCT02620761 TERMINATED

Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants

Medical College of Wisconsin n=1

NCT02980003 COMPLETED

PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization

G. d'Annunzio University n=240

NCT04051073 COMPLETED

Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.

University Hospital Birmingham NHS Foundation Trust n=30

NCT05375188 COMPLETED

To Evaluate if Dexmedetomidine Infusion Provides Renal Protection in Patients Undergoing Coronary Artery Bypass Graft

National Institute of Cardiovascular Diseases, Pakistan n=60

NCT02665377 COMPLETED

Prevention of Akute Kidney Injury, Hearttransplant, ANP

Sahlgrenska University Hospital n=86

NCT03403751 TERMINATED

Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury

Atox Bio Ltd n=58

NCT04297839 SUSPENDED

Evaluation of Regional Anticoagulation With Citrate in Extended Hemodialysis

University of Sao Paulo General Hospital n=200

NCT02875873 COMPLETED

Balanced Solution Versus Saline in Intensive Care Study

Hospital do Coracao n=11,075

NCT03277677 COMPLETED

The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients

Chulalongkorn University n=116

NCT02799368 COMPLETED

Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)

Seoul National University Hospital n=493

NCT01391520 WITHDRAWN

Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent

CorMedix

NCT04019184 COMPLETED

Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine

University Hospital Muenster n=64

NCT04259684 WITHDRAWN

Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury

Children's Hospital Medical Center, Cincinnati

NCT02272725 COMPLETED

Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances

Stanford University n=91

NCT03331146 WITHDRAWN

Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass

University of Alabama at Birmingham

NCT01225094 COMPLETED

Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's n=606

NCT03070353 COMPLETED

Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury

Ramathibodi Hospital n=10

NCT00557219 TERMINATED

Fenoldopam and Ketanserin for Acute Kidney Failure Prevention After Cardiac Surgery

Medical University of Gdansk n=60

NCT00286403 WITHDRAWN

Vasodilators and Anti-Oxidant Therapy in Early ATN

Southeast Renal Research Institute

NCT01786824 TERMINATED

Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration

Centre Hospitalier Universitaire de Nīmes n=9

NCT01239966 COMPLETED

Pulmonary And Renal Support During Acute Respiratory Distress Syndrome

Hôpital Européen Marseille n=11

NCT00621790 COMPLETED

Fenoldopam and Acute Renal Failure

Università Vita-Salute San Raffaele n=667

NCT00978354 TERMINATED

Furosemide in Early Acute Kidney Injury

University of Alberta n=72

NCT01197235 TERMINATED

Effect of Darbepoetin in Contrast-induced Nephropathy

Seoul National University Bundang Hospital n=80

NCT00875069 COMPLETED

Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial

University Hospital, Clermont-Ferrand n=1,460

NCT01562925 COMPLETED

Effect of Red Wine, White Wine and Beer on Contrast-Medium Induced Acute Kidney Injury

University of Cologne n=260

NCT07052513 RECRUITING

Modified Autologous Leukocyte Cells for the Treatment of Acute Kidney Injury After Cardiac Surgery

M2RLAB SL

NCT05996835 ACTIVE NOT RECRUITING

Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)

Novartis Pharmaceuticals

NCT06374797 ACTIVE NOT RECRUITING

A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"

CalciMedica, Inc.

NCT05909150 RECRUITING

Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

Fernando Bacal

NCT05879432 RECRUITING

LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Arch Biopartners Inc.

NCT07215702 RECRUITING

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

AstraZeneca

NCT04633889 ACTIVE NOT RECRUITING

Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury

Brigham and Women's Hospital

NCT05853601 RECRUITING

Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage

Medical College of Wisconsin

NCT06256432 ACTIVE NOT RECRUITING

Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome

Noorik Biopharmaceuticals AG

NCT07212595 NOT YET RECRUITING

Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy

Stuart Goldstein, MD

NCT07273838 RECRUITING

Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

Yale University

NCT06654193 RECRUITING

Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury

Hope Biosciences LLC

NCT05758896 ACTIVE NOT RECRUITING

Study of APX-115 in Contrast Induced Acute Kidney Injury in Subjects Undergoing PCI

Aptabio Therapeutics, Inc.

NCT07438262 NOT YET RECRUITING

The AminoECMO Pilot Trial

Australian and New Zealand Intensive Care Research Centre

NCT05900284 ENROLLING BY INVITATION

Safety and Feasibility of Metformin for Sepsis Induced AKI

Hernando Gomez

NCT07236463 NOT YET RECRUITING

Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury

Centre Hospitalier Universitaire de Nīmes

NCT06528405 RECRUITING

The Efficacy and Safety of Sodium-glucose Cotransporter 2 Inhibitors in Patients With Acute Kidney Disease

National Taiwan University Hospital

NCT07293078 NOT YET RECRUITING

Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial

MetroWest Artificial Intelligence Research Workgroup

NCT06886464 RECRUITING

Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin

Matthew James

NCT07229040 RECRUITING

A Double-blind Non Inferiority Clinical Trial to Compare the Nephroprotection of Cilastatn Versus Thiosulfate in Patients Undergoing Debulking Surgery With Intraoperative Hyperthermic Intraperitoneal Chemotherapy With Cisplatin.

Hospital General Universitario Gregorio Marañon

NCT07224997 NOT YET RECRUITING

Trimethoprim-Sulfamethoxazole (TMP/SMX) Prophylaxis After Acute Kidney Injury to Prevent Post-discharge Infections

Hospital Civil de Guadalajara

NCT03329313 RECRUITING

Effects of Variation of Sodium Dialysate in ICU

University Hospital, Montpellier

NCT07164833 RECRUITING

A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)

Bilix Co.,Ltd.

NCT06954740 RECRUITING

Clinical Study to Evaluate the Efficacy and Safety of Mesenchymal Stromal Cells (Amimestrocel ) in Patients With Acute Kidney Injury

Chinese PLA General Hospital

NCT06937307 RECRUITING

Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

Giuseppe Cullaro, MD

NCT07001098 NOT YET RECRUITING

Amino Acids for Cardiac Surgery Associated AKI

Stanford University

NCT06706258 RECRUITING

Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)

The University of Texas Health Science Center, Houston

NCT04750616 RECRUITING

NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial

Kaiser Permanente

NCT06632613 RECRUITING

Efficacy and Safety of ENN0403 in Patients At High Risk for Acute Kidney Injury Following Elective Cardiac Surgery

EnnovaBio

NCT06678399 NOT YET RECRUITING

Phase 1B/2 Clinical Trial Assessing the Safety, Tolerability and Preliminary Efficacy of the Intravenous Administration of Allogeneic Placental Mesenchymal Cells for the Preemptive Treatment of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery

Kelifarma

NCT05092165 COMPLETED

Methylene Blue for the Prevention of Hypotension During Hemodialysis

Federal University of São Paulo

NCT05524051 TERMINATED

A Multi-center Study to Evaluate the Safety, Tolerability and Efficacy of TIN816 in Patients at Risk for Acute Kidney Injury Following Cardiac Surgery.

Novartis Pharmaceuticals

NCT06602453 TERMINATED

A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)

Genentech, Inc.

NCT06154226 COMPLETED

Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor

The University of Texas Health Science Center, Houston

NCT05507437 COMPLETED

Pharmacokinetics and Safety of TIN816 in Patients With Sepsis-associated Acute Kidney Injury

Novartis Pharmaceuticals

NCT02962102 COMPLETED

Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury

David Leaf

NCT04402957 COMPLETED

LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)

Arch Biopartners Inc.

NCT06871826 COMPLETED

Tissue Inhibitor of Metalloproteinases 2 Level in Patients Undergoing Cardiac Surgery

Wuhan University

NCT03941483 COMPLETED

Study to Evaluate the Efficacy of ASP1128 (MA-0217) in Subjects at Risk for Acute Kidney Injury (AKI) Following Coronary Artery Bypass Graft (CABG) and/or Valve Surgery

Astellas Pharma Inc

NCT05475717 TERMINATED

A Study to Explore the Efficacy of Alprostadil Liposomes Injection in the Prevention of CI-AKI

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

NCT05960227 COMPLETED

Effect of Intravenous Iron Repletion on Renal Function in Patients With Iron Deficiency and Acute Kidney Injury

Hospital Civil de Guadalajara

NCT02142699 COMPLETED

Heme Arginate in Cardiac Surgery Patients

University of Edinburgh

NCT05038488 COMPLETED

Phase 2a MIB-626 vs. Placebo COVID-19

Metro International Biotech, LLC

NCT05126303 TERMINATED

Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery

Guard Therapeutics AB

NCT04342975 COMPLETED

Protection From Acute Kidney Injury (AKI) With Basis™ Treatment

Mayo Clinic

NCT04564833 COMPLETED

Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing CABG and/or Cardiac Valve Surgery

Renibus Therapeutics, Inc.

NCT04103307 WITHDRAWN

Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

NCT04071171 COMPLETED

Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation

Medical University Innsbruck

NCT04818216 COMPLETED

Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection

The University of Texas Health Science Center at San Antonio

NCT05309200 COMPLETED

A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury

Ocelot Bio, Inc

NCT02772276 COMPLETED

Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

MediBeacon

NCT03627130 COMPLETED

The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy

Barts & The London NHS Trust

NCT02046135 TERMINATED

Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery

Northwell Health

NCT02554253 COMPLETED

The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

Mayo Clinic

NCT04531579 WITHDRAWN

Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients

Westat

NCT04531592 WITHDRAWN

Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients

Westat

NCT04200950 WITHDRAWN

Trial for the Early Identification of Acute Kidney Injury

Dascena

NCT03725267 TERMINATED

Melatonin for Renal Protection in Patients Receiving Polymyxin B

Hospital de Clinicas de Porto Alegre

NCT01777165 COMPLETED

A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Cardiac Surgery

AbbVie

NCT03251131 COMPLETED

REVERSE-AKI Randomized Controlled Pilot Trial

Helsinki University Central Hospital

NCT01336959 TERMINATED

Safety & Efficacy of BCT197 in Patients Undergoing Cardiac Surgery

Mereo BioPharma

NCT03665311 COMPLETED

Saline Versus Albumin Fluid for Extracorporeal Removal With Slow Low Efficiency Dialysis Feasibility Study

Ottawa Hospital Research Institute

NCT02182440 COMPLETED

A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI

AM-Pharma

NCT03527381 COMPLETED

Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery

Nikolay Kamenshchikov

NCT02610283 COMPLETED

A Study to Evaluate Efficacy and Safety of QPI-1002 for Prevention of Acute Kidney Injury Following Cardiac Surgery

Quark Pharmaceuticals

NCT03329443 COMPLETED

The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography

Alhasan Mujtaba Abdul-Wahid

NCT02869347 COMPLETED

Recombinant Human C1 Esterase Inhibitor in the Prevention of Contrast-induced Nephropathy in High-risk Subjects

University Hospital, Basel, Switzerland

NCT02668952 COMPLETED

Fluid Chloride and AKI in Cardiopulmonary Bypass

University of New Mexico

NCT01830920 COMPLETED

A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)

Thrasos Innovation, Inc.

NCT02397213 COMPLETED

Ciclosporin to Protect Renal Function In Cardiac Surgery

Region Skane

NCT00870883 COMPLETED

N-acetylcysteine Plus Deferoxamine for Patients With Hypotension

Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude

NCT02414906 COMPLETED

Goal Directed Therapy for Acute Kidney Injury in Critical Ill Patients

Barretos Cancer Hospital

NCT01557361 COMPLETED

Standard Versus Accelerated Initiation of Dialysis in Acute Kidney Injury

Unity Health Toronto

NCT01602328 TERMINATED

A Study to Evaluate the Safety and Efficacy of AC607 for the Treatment of Kidney Injury in Cardiac Surgery Subjects

AlloCure Inc.

NCT01758861 COMPLETED

Effect of Erythropoietin on the Incidence of Acute Kidney Injury Following Complex Valvular Heart Surgery

Yonsei University

NCT00878956 TERMINATED

Bicarbonate in Cardiac Surgery

Austin Health

NCT01146925 COMPLETED

Deferiprone for the Prevention of Contrast-Induced Acute Kidney Injury

CorMedix

NCT00676234 COMPLETED

Recombinant Human Erythropoietin Use in Intensive Care Unit (ICU) Patients: Does it Prevent Acute Renal Failure

University Hospital, Geneva

NCT05360615 ACTIVE NOT RECRUITING

The Effects of Empagliflozin on Renal Outcomes in Post Severe Acute Kidney Injury Survivors

Chulalongkorn University

NCT06958367 NOT YET RECRUITING

Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries

Ain Shams University

NCT06917859 RECRUITING

Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass

Ain Shams University

NCT07141693 COMPLETED

Renal Oximetry-Guided Anesthesia With Near-Infrared Spectroscopy for Improved Postoperative Outcomes

Chinese PLA General Hospital

NCT06247462 COMPLETED

Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat

University of New Mexico

NCT05295784 WITHDRAWN

PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia

University of Arkansas

NCT04829916 COMPLETED

A Study to Evaluate RMC-035 in Subjects Undergoing Cardiac Surgery

Guard Therapeutics AB

NCT03204955 COMPLETED

A Low ChloridE hyperTonic Solution for Brain Edema

Emory University

NCT03946462 WITHDRAWN

Nitric Oxide During CPB to Reduce AKI in Neonates

Fabio Savorgnan

NCT00821522 COMPLETED

The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

Robert Kramer, MD

NCT03630029 WITHDRAWN

RBT-1 Phase 1b Clinical Trial in Healthy Volunteers and Subjects With CKD

Renibus Therapeutics, Inc.

NCT02136329 COMPLETED

A Study to Determine the Pharmacokinetic Profile, Safety and Tolerability of Sildenafil (REVATIO®) in Cardiac Surgery

University of Leicester

NCT01275612 WITHDRAWN

Mesenchymal Stem Cells In Cisplatin-Induced Acute Renal Failure In Patients With Solid Organ Cancers

Mario Negri Institute for Pharmacological Research

NCT02127190 COMPLETED

Study of CXA-10 in Healthy Volunteers

Complexa, Inc.

NCT02248051 COMPLETED

Open-Label Safety, Tolerability, PK Study of IV CXA-10 Emulsion in Subjects in Chronic Kidney Injury

Complexa, Inc.

NCT02098187 COMPLETED

Pharmacokinetics of MP-3180 and Use of Noninvasive Fluorescence Detection Device in Healthy Volunteers

MediBeacon

NCT02098174 COMPLETED

Pharmacokinetics of MP-3180 in Healthy Volunteers

MediBeacon

NCT02547402 COMPLETED

A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males

Complexa, Inc.

NCT02460146 COMPLETED

PK and PD of Sequential Multiple Ascending, Repeat Doses of Oral CXA-10 in Healthy Obese Male Subjects

Complexa, Inc.

NCT00683553 TERMINATED

A Dose Escalation and Safety Study of I5NP to Prevent Acute Kidney Injury (AKI) in Patients at High Risk of AKI Undergoing Major Cardiovascular Surgery (QRK.004)

Quark Pharmaceuticals

NCT07030933 NOT YET RECRUITING

Amino Acid Infusion in Cardiac Surgery

Milton S. Hershey Medical Center

NCT07464431 NOT YET RECRUITING

Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury

Universität Münster

NCT07556107 NOT YET RECRUITING

The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)

Bassett Healthcare

NCT07518303 NOT YET RECRUITING

Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury

Jianfeng Xie

NCT06229990 RECRUITING

A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy

Chiang Mai University

NCT06802224 RECRUITING

The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

University of California, San Francisco

NCT06954129 RECRUITING

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

University of Pennsylvania

NCT06696235 RECRUITING

Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator

Samsung Medical Center

NCT07270874 NOT YET RECRUITING

Study to Evaluate the Efficacy of Intravenous Administration of Human Albumin Versus Saline Solution in Patients With descomp��nsate Cirrhosis Grade 1B or Higher Renal Failure

Fundacion Clinic per a la Recerca Biomédica

NCT06535945 RECRUITING

Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation

Rennes University Hospital

NCT07182422 RECRUITING

AST-120 (Kremezin®) for the Renal Protection and Attenuation of Decline in Acute Kidney Disease

Chang Gung Memorial Hospital

NCT04592744 ENROLLING BY INVITATION

Angiotensin 2 for AKI After OLT

University of California, Los Angeles

NCT05590143 ACTIVE NOT RECRUITING

proMoting Effective Renoprotection in Cardiac sURgery Patients by Inhibition of SGLT-2

Amsterdam UMC

NCT04705896 RECRUITING

Albumin To Enhance Recovery After Acute Kidney Injury

Ottawa Hospital Research Institute

NCT06570187 RECRUITING

The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

Cairo University

NCT06521697 NOT YET RECRUITING

Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery

National Taiwan University Hospital

NCT06418542 ACTIVE NOT RECRUITING

Contrast Nephropathy Associated FFA

Saglik Bilimleri Universitesi

NCT05429515 NOT YET RECRUITING

Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury

Peking Union Medical College Hospital

NCT04279457 RECRUITING

Single-Center Prospective Study to Investigate the Difference in the Incidence of Contrast-Induced Nephropathy in High-Risk Patients With the Use of the Dye-Vert Plus System

CAMC Health System

NCT06254183 COMPLETED

Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy(LSG)

Tanta University

NCT06622291 COMPLETED

Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients

Beijing Anzhen Hospital

NCT07286526 COMPLETED

Comparison of Bolus and Continuous Hydration Regimens for the Prevention of Contrast-Associated Acute Kidney Injury in the Emergency Department

Yunus Emre Gemici

NCT03810417 COMPLETED

Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI

University of Maryland, Baltimore

NCT06825156 COMPLETED

Metabolic and Renal Outcomes in Cardiac Surgery Patients Receiving SGLT2 Inhibitors

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT04893733 COMPLETED

Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients With AKI

Caja Nacional de Salud

NCT02933892 COMPLETED

Benefit of Transradial Approach in Chronic Kidney Disease Population Undergoing Cardiac Catheterization

Texas Tech University Health Sciences Center

NCT06646328 TERMINATED

Oxidative Stress and Circulating Nuclear DNA (cfDNA) in Acute Kidney Injury and Continuous Renal Replacement Therapies.

Fernando Sanchez

NCT04558359 COMPLETED

Renin and Renal Biomarker Response to Angiotensin II

Alexander Flannery

NCT05435235 SUSPENDED

Dapagliflozin in the Prevention of Post-Coronary Angioplasty Acute Kidney Injury

Albert Einstein Healthcare Network

NCT04523064 COMPLETED

POST-CABGDM: Empagliflozin in Perioperative CABG

University of Sao Paulo General Hospital

NCT04530448 TERMINATED

Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization

West Virginia University

NCT05094154 COMPLETED

Effect of Antibiotic Choice On ReNal Outcomes (ACORN)

Vanderbilt University Medical Center

NCT05158153 TERMINATED

Outpatient Recovery From Acute Kidney Injury Requiring Dialysis

University of California, San Francisco

NCT03846258 WITHDRAWN

High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy

Mayo Clinic

NCT03336801 COMPLETED

The Effect of Propofol or Sevoflurane on Renal Function

Uppsala University

NCT02531724 COMPLETED

Effects of Levosimendan in Acute Kidney Injury After Cardiac Surgery

Sahlgrenska University Hospital

NCT03731117 TERMINATED

FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU

Assistance Publique - Hôpitaux de Paris

NCT02669589 COMPLETED

Investigating Different Anticoagulants for Renal Replacement Therapy

University Hospital Muenster

NCT03526367 WITHDRAWN

A Randomized Trial of Rosuvastatin Loading Combined With Early hydrAtion Versus Standard-of-care Medications for the Prevention of CIAKI in Patient With AMI Undergoing Emergency PCI

Shenyang Northern Hospital

NCT02481518 COMPLETED

Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity

Mahidol University

NCT01269112 COMPLETED

Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy

University Hospital, Geneva

NCT01318811 TERMINATED

A Comparison of Dilute Versus Concentrated Heparin for CRRT Anticoagulation

Vanderbilt University

NCT02499185 TERMINATED

Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients

Universitair Ziekenhuis Brussel

NCT02718261 COMPLETED

Sup-Icu RENal (SIREN)

Insel Gruppe AG, University Hospital Bern

NCT03627884 COMPLETED

Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation

Coney Island Hospital, Brooklyn, NY

NCT01920126 COMPLETED

The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery

Yonsei University

NCT02458157 TERMINATED

Forced Fluid Removal in High Risk Acute Kidney Injury

Nordsjaellands Hospital

NCT02467075 TERMINATED

Double-Blind Placebo-Controlled CIN Trial

University of Michigan

NCT02157337 COMPLETED

The Effect of Atorvastatin on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery

Yonsei University

NCT02059460 COMPLETED

Perioperative Evaluation of Terlipressin Infusion During Living Donor Liver Transplantation on Incidence of Acute Kidney

National Liver Institute, Egypt

NCT01947335 COMPLETED

IVUS Guidance to Reduce Contrast in Coronary Angioplasty

InCor Heart Institute

NCT02084771 WITHDRAWN

Oral Salt and Water to Prevent Contrast Nephropathy

Ottawa Hospital Research Institute

NCT01560650 COMPLETED

Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury

Wei Shi

NCT02225431 COMPLETED

Personalized Versus Standard Hydration for Prevention of CI-AKI: a Randomized Trial With Bioimpedance Analysis

Ospedale Misericordia e Dolce

NCT00816790 TERMINATED

Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock

Fraser Health

NCT02478242 COMPLETED

Trial to Assess the Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy

Kyungpook National University Hospital

NCT02195726 COMPLETED

Efficacy of RIPC to Reduce AKI for Patients Undergoing PCI

A.O.U. Città della Salute e della Scienza

NCT01742130 COMPLETED

Early Hydration in Acute Myocardial Infarction

Ospedale Misericordia e Dolce

NCT01394419 COMPLETED

Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft

Yonsei University

NCT01594489 COMPLETED

Aminophylline and Contrast Induced Nephropathy in Acute Myocardial Infarction

Ospedale Misericordia e Dolce

NCT00675818 COMPLETED

The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study

Unity Health Toronto

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only