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Landscape → CNS

Alcohol Use Disorder Clinical Trial Landscape

Data updated: May 20, 2026

443 clinical trials tracked since 2008

Alcohol Use Disorder is being studied across 443 clinical trials registered since 2008, with 112 programs currently active. The competitive pipeline includes 16 active Phase 3 trials, 83 active Phase 2 trials, and 25 active Phase 1 trials. Top industry sponsors include Eli Lilly, Pop Test Oncology LLC, Newleos Therapeutics, Inc..

112 active
/
443 total (since 2008)
25
Phase 1 Active
105 total
83
Phase 2 Active
280 total
16
Phase 3 Active
71 total
4
Phase 4 Active
46 total

Top Industry Sponsors

Sorted by active Active Done Failed
Eli Lilly 3 3 0
Pop Test Oncology LLC 1 2 0
Newleos Therapeutics, Inc. 1 0 0
Clearmind Medicine Inc. 1 0 0
Shenzhen Sciencare Medical Industries Co., Ltd. 1 0 0

+ 8 more sponsors — see full table below

Featured Phase 3 Trials

NCT07219953 RECRUITING
A Study of Brenipatide in Participants With Alcohol Use Disorder
Eli Lilly and Company n=1,100
NCT07219966 RECRUITING
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
Eli Lilly and Company n=1,100
NCT07118839 RECRUITING
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder
VA Office of Research and Development n=80
NCT04616781 RECRUITING
Ketone Ester Intervention in Alcohol Use Disorder
University of Pennsylvania n=20
NCT06559995 RECRUITING
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
University of Pennsylvania n=30

+ 66 more Phase 3 trials — see full database below

Alcohol Use Disorder — Trials Started by Year (last 10 years)

2016
28
2017
20
2018
20
2019
26
2020
14
2021
26
2022
20
2023
25
2024
27
2025
32
2026
25

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Eli Lilly
6
Pop Test Oncology LLC
3
Newleos Therapeutics, Inc.
1
Clearmind Medicine Inc.
1
Shenzhen Sciencare Medical Industries Co., Ltd.
1
Altimmune, Inc.
1
Inventage Lab., Inc.
1
Afasci Inc
1
Evon Medics LLC
1
H. Lundbeck A/S
6

Active Trials by Phase

Phase 1
25
Phase 2
83
Phase 3
16
Phase 4
4

Enrollment Size Distribution

1-50
189
51-200
164
201-500
48
501-1k
11
1k+
5

All Industry Sponsors

Sorted by active Active Done Failed
Eli Lilly 3 3 0
Pop Test Oncology LLC 1 2 0
Newleos Therapeutics, Inc. 1 0 0
Clearmind Medicine Inc. 1 0 0
Shenzhen Sciencare Medical Industries Co., Ltd. 1 0 0
Altimmune, Inc. 1 0 0
Inventage Lab., Inc. 1 0 0
Afasci Inc 1 0 0
Evon Medics LLC 1 0 0
H. Lundbeck A/S 0 5 1
Alkermes, Inc. 0 4 0
GSK 0 3 1
Otsuka Pharmaceutical Co., Ltd. 0 3 0
NCT06807918 NOT YET RECRUITING
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
University of Pennsylvania n=60
NCT07148843 NOT YET RECRUITING
Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving
Johns Hopkins University n=105
NCT07219953 RECRUITING
A Study of Brenipatide in Participants With Alcohol Use Disorder
Eli Lilly and Company n=1,100
NCT07219966 RECRUITING
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
Eli Lilly and Company n=1,100
NCT07218354 NOT YET RECRUITING
Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial to Evaluate the Efficacy and Safety of a GLP-1 Receptor Agonist Semaglutide in U.S. Veterans With Alcohol Use Disorder
VA Office of Research and Development n=622
NCT07118839 RECRUITING
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder
VA Office of Research and Development n=80
NCT06173973 ENROLLING BY INVITATION
Effects of Ketone Supplementation on Acute Alcohol Withdrawal
University of Pennsylvania n=50
NCT05015881 ENROLLING BY INVITATION
Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder
University of Pennsylvania n=20
NCT07433413 NOT YET RECRUITING
Evaluate the Efficacy and Safety of Naltrexone Hydrochloride Implant in Patients With Alcohol Use Disorder
Shenzhen Sciencare Medical Industries Co., Ltd. n=240
NCT04616781 RECRUITING
Ketone Ester Intervention in Alcohol Use Disorder
University of Pennsylvania n=20
NCT06790342 NOT YET RECRUITING
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya
University of Chicago n=300
NCT06559995 RECRUITING
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
University of Pennsylvania n=30
NCT06702007 RECRUITING
Electronic Harm Reduction Treatment for Alcohol
University of Washington n=160
NCT05827159 RECRUITING
Emergency Department-Initiated Medications for Alcohol Use Disorder
Yale University n=240
NCT04971577 RECRUITING
Efficacy of Simvastatin in Alcoholic Liver Fibrosis
Anna Cruceta n=90
NCT05613608 RECRUITING
Alcohol Use Disorder and Cannabidiol
University of Colorado, Denver n=180
NCT05458609 COMPLETED
Lemborexant Augmentation of Naltrexone for Alcohol Craving and Sleep
Baylor College of Medicine n=8
NCT06143059 SUSPENDED
The Effects of Sex Hormones and Alcohol on Sleep
Lauren Whitehurst n=130
NCT05748639 COMPLETED
Integrated Digital Intervention for Alcohol Use Disorder
Quit Genius n=242
NCT01182766 COMPLETED
New Treatment for Alcohol and Nicotine Dependence
University of Virginia n=236
NCT01604330 COMPLETED
Baclofen for the Treatment of Alcohol Drinkers
Assistance Publique - Hôpitaux de Paris n=323
NCT04098302 COMPLETED
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
UConn Health n=180
NCT02918370 COMPLETED
Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
University of Texas Southwestern Medical Center n=75
NCT03634917 COMPLETED
Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence
Technische Universität Dresden n=82
NCT04101227 COMPLETED
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms
Adial Pharmaceuticals n=302
NCT05093296 COMPLETED
Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
Central Institute of Mental Health, Mannheim n=62
NCT02884908 COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
University of Maryland, Baltimore n=57
NCT04603781 SUSPENDED
CBD Oil for Reducing Emotional Impact of COVID-19
University of Texas at Austin n=200
NCT03176953 COMPLETED
Topiramate and Prolonged Exposure
VA Office of Research and Development n=100
NCT02824354 WITHDRAWN
Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence.
Centre Hospitalier Universitaire, Amiens
NCT02901041 COMPLETED
Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism
Boston University Charles River Campus n=81
NCT02187224 COMPLETED
Progesterone Effect on Individuals Diagnoses With AD and PTSD.
Yale University n=13
NCT01591291 WITHDRAWN
Pharmacogenetic Treatments for Alcoholism
University of Virginia
NCT03539887 COMPLETED
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
The University of Texas Health Science Center, Houston n=33
NCT02016378 COMPLETED
EEG/Event-related Brain Potential Risk Markers as Predictors and Outcomes of SUD Treatment in Adolescents
University of Michigan n=25
NCT02900352 COMPLETED
Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action
Virginia Commonwealth University n=156
NCT02368431 TERMINATED
Effectiveness of Zonisamide in Alcohol Dependent Veterans
VA Office of Research and Development n=92
NCT00571246 WITHDRAWN
The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder
Yale University
NCT02382276 COMPLETED
A Long-term Extension Study for the Phase 3 Study of Nalmefene (339-14-001) in Patients With Alcohol Dependence
Otsuka Pharmaceutical Co., Ltd. n=405
NCT00622921 WITHDRAWN
Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence
Yale University
NCT04318639 COMPLETED
The Combination of Donepezil and Cognitive Training for Treating Alcohol Use Disorder
VA Connecticut Healthcare System n=15
NCT00744055 COMPLETED
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Yale University n=96
NCT03339024 COMPLETED
Intranasal Oxytocin Effects in Alcohol Withdrawal and Dependence; Follow-up Study
Norwegian University of Science and Technology n=38
NCT02358226 COMPLETED
HIV & Drug Abuse Prevention for South African Men
University of California, Los Angeles n=1,211
NCT02539511 COMPLETED
Glutamatergic Modulation of Disordered Alcohol Use
New York State Psychiatric Institute n=50
NCT02723383 COMPLETED
Baclofen to Prevent Agitation in Alcohol Addicted Patients in ICU
Nantes University Hospital n=314
NCT02364947 COMPLETED
A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial)
Otsuka Pharmaceutical Co., Ltd. n=678
NCT03663374 COMPLETED
Efficacy and Safety Evaluating Study of Odelepran for the Use in Patient With Alcohol Dependence
R-Pharm n=644
NCT01141049 COMPLETED
Gabapentin for Abstinence Initiation in Alcohol Dependence
New York State Psychiatric Institute n=40
NCT01169610 TERMINATED
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
Mayo Clinic n=1
NCT01908062 COMPLETED
Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study
Oregon Health and Science University n=51
NCT01856712 COMPLETED
Oral vs. Injectable Naltrexone for Hospitalized Veterans With Alcohol Dependence
University of Wisconsin, Madison n=54
NCT02903251 COMPLETED
Oxytocin and Alcohol Withdrawal and Dependence
Norwegian University of Science and Technology n=40
NCT01347112 COMPLETED
Varenicline Treatment for Active Alcoholic Smokers
Mayo Clinic n=33
NCT02652585 COMPLETED
Validation of a Test System for Development of Medications for Alcoholism
Technische Universität Dresden n=46
NCT01711125 COMPLETED
Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease
South West Sydney Local Health District n=104
NCT01292057 COMPLETED
Aripiprazole Effects on Alcohol Drinking and Craving
Medical University of South Carolina n=99
NCT01342549 COMPLETED
Treatment Strategy for Alcohol Use Disorders in Veterans With TBI
VA Office of Research and Development n=62
NCT00639288 COMPLETED
Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence
Yale University n=9
NCT02557815 COMPLETED
Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) n=80
NCT01266655 COMPLETED
Baclofen for the Treatment of Alcohol Dependence
Charite University, Berlin, Germany n=56
NCT01738282 COMPLETED
Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients
Ethypharm n=316
NCT01348113 TERMINATED
Efficacy of a Brief Alcohol Intervention for Non Dependant Alcohol-misusing Patients Undergoing a Scheduled Surgery
Rennes University Hospital n=3
NCT00811941 COMPLETED
Safety and Efficacy of Nalmefene in Patients With Alcohol Dependence
H. Lundbeck A/S n=665
NCT00812461 COMPLETED
Efficacy of Nalmefene in Patients With Alcohol Dependence
H. Lundbeck A/S n=678
NCT00811720 COMPLETED
Efficacy of Nalmefene in Patients With Alcohol Dependence
H. Lundbeck A/S n=598
NCT00768508 COMPLETED
Combined Pharmacotherapies for Alcoholism
Bankole Johnson n=300
NCT01145677 COMPLETED
Efficacy of Topiramate for Hospitalized Patients With Alcoholism
Chiang Mai University n=90
NCT00751985 COMPLETED
Web-based Ultra-brief Intervention for Heavy Drinkers Trial
University of Southern Denmark n=1,380
NCT00728767 COMPLETED
Brief Intervention for Heavy Drinkers
University of Southern Denmark n=772
NCT00732095 COMPLETED
Promoting Self-Change From Alcohol Problems: Mechanisms of Change in a Community-Based Intervention
Nova Southeastern University n=283

Full Alcohol Use Disorder Pipeline

Every sponsor, every trial across Phase 1–4. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only