Anxiety Clinical Trial Landscape
Data updated: May 20, 2026
457 clinical trials tracked since 2008
Anxiety is being studied across 457 clinical trials registered since 2008, with 94 programs currently active. The competitive pipeline includes 21 active Phase 3 trials, 49 active Phase 2 trials, and 10 active Phase 1 trials. Top industry sponsors include VistaGen Therapeutics, Inc., Beijing Union Pharmaceutical Factory Ltd, Definium Therapeutics US, Inc..
94 active
/
457 total (since 2008)
10
Phase 1 Active
84 total
49
Phase 2 Active
213 total
21
Phase 3 Active
104 total
19
Phase 4 Active
107 total
Top Industry Sponsors
Sorted by active Active Done Failed
VistaGen Therapeutics, Inc. 3 1 2
Beijing Union Pharmaceutical Factory Ltd 3 0 0
Definium Therapeutics US, Inc. 2 1 0
Intra-Cellular Therapies, Inc. 2 0 0
AbbVie 1 3 1
+ 10 more sponsors — see full table below
Featured Phase 3 Trials
NCT06741228 ACTIVE NOT RECRUITING
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage)
Definium Therapeutics US, Inc. n=214
NCT06809595 ACTIVE NOT RECRUITING
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
Definium Therapeutics US, Inc. n=250
NCT06615557 RECRUITING
Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-4)
VistaGen Therapeutics, Inc. n=236
NCT06752759 RECRUITING
Nebulized Ketamine for the Treatment of Major Depressive Disorder
Theresa Jacob, PhD, MPH n=40
NCT07221578 RECRUITING
Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder
Vanda Pharmaceuticals n=500
+ 99 more Phase 3 trials — see full database below
Anxiety — Trials Started by Year (last 10 years)
2016 16
2017 18
2018 16
2019 16
2020 12
2021 25
2022 26
2023 24
2024 31
2025 40
2026 16
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
VistaGen Therapeutics, Inc. 6
Beijing Union Pharmaceutical Factory Ltd 3
Definium Therapeutics US, Inc. 3
Intra-Cellular Therapies, Inc. 2
AbbVie 5
Vanda Pharmaceuticals 2
Valenta Pharm JSC 2
RDC Clinical Pty Ltd 1
Psicofarma, S.A. De C.V. 1
Reunion Neuroscience Inc 1
Active Trials by Phase
Phase 1 10
Phase 2 49
Phase 3 21
Phase 4 19
Enrollment Size Distribution
1-50 163
51-200 178
201-500 67
501-1k 17
1k+ 4
All Industry Sponsors
Sorted by active Active Done Failed
VistaGen Therapeutics, Inc. 3 1 2
Beijing Union Pharmaceutical Factory Ltd 3 0 0
Definium Therapeutics US, Inc. 2 1 0
Intra-Cellular Therapies, Inc. 2 0 0
AbbVie 1 3 1
Vanda Pharmaceuticals 1 1 0
Valenta Pharm JSC 1 1 0
RDC Clinical Pty Ltd 1 0 0
Psicofarma, S.A. De C.V. 1 0 0
Reunion Neuroscience Inc 1 0 0
Synendos Therapeutics AG 1 0 0
Ono Pharmaceutical Co., Ltd. 1 0 0
Newleos Therapeutics, Inc. 1 0 0
Cybin IRL Limited 1 0 0
Nyree Penn 1 0 0
NCT06741228 ACTIVE NOT RECRUITING
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage)
Definium Therapeutics US, Inc. n=214
NCT06809595 ACTIVE NOT RECRUITING
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
Definium Therapeutics US, Inc. n=250
NCT06615557 RECRUITING
Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-4)
VistaGen Therapeutics, Inc. n=236
NCT06752759 RECRUITING
Nebulized Ketamine for the Treatment of Major Depressive Disorder
Theresa Jacob, PhD, MPH n=40
NCT07221578 RECRUITING
Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder
Vanda Pharmaceuticals n=500
NCT05552053 ACTIVE NOT RECRUITING
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Cedars-Sinai Medical Center n=150
NCT07477990 RECRUITING
Clinical Trial to Evaluate the Efficacy and Safety of the Aurora® Digital Medical Device in Adult Patients With Moderate to Severe Generalized Anxiety Disorder
Psicofarma, S.A. De C.V. n=162
NCT07123467 RECRUITING
Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder
Wayne State University n=90
NCT07336095 NOT YET RECRUITING
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Ain Shams University n=195
NCT06358651 ACTIVE NOT RECRUITING
Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-3)
VistaGen Therapeutics, Inc. n=238
NCT05474846 RECRUITING
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
M.D. Anderson Cancer Center n=188
NCT05625360 RECRUITING
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Wake Forest University Health Sciences n=160
NCT06273527 RECRUITING
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego n=128
NCT07138391 NOT YET RECRUITING
Chamomile Gummies and Pediatric Dental Anxiety
Ain Shams University n=78
NCT04760275 ACTIVE NOT RECRUITING
Fluoxetine vs CBT in Childhood Anxiety Disorders
Children's Hospital Los Angeles n=316
NCT04598230 ACTIVE NOT RECRUITING
Partners in Caring for Anxious Youth
Ann & Robert H Lurie Children's Hospital of Chicago n=468
NCT05772104 RECRUITING
Clinical Trial of Shugan Jieyu Capsule in Generalized Anxiety Disorder
Sichuan Jishengtang Pharmaceutical Co., Ltd. n=495
NCT06243640 RECRUITING
Phase 3 Clinical Trial of Buagafuran Capsules in the Treatment of GAD
Beijing Union Pharmaceutical Factory Ltd n=504
NCT06243614 RECRUITING
Phase Ⅲ Clinical Trial of Buagafuran Capsules in the Treatment of GAD
Beijing Union Pharmaceutical Factory Ltd n=410
NCT05510752 NOT YET RECRUITING
Cognitive Behavioural Therapy Versus Psychoeducation for Perinatal Anxiety
St. Joseph's Healthcare Hamilton n=216
NCT02568878 RECRUITING
Creatine for Depressed Male and Female Methamphetamine Users
Montana State University n=29
NCT06973577 COMPLETED
P3b Short-term Study of CTN in Patients With ADHD and Comorbid Anxiety
Otsuka Pharmaceutical Development & Commercialization, Inc. n=315
NCT05011396 TERMINATED
PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge - 2
VistaGen Therapeutics, Inc. n=228
NCT06510504 COMPLETED
Efficacy of BNC210 in Acute, As-needed Treatment of Anxiety in Social Anxiety Disorder - 1
Bionomics Limited n=370
NCT05030350 TERMINATED
Open-label Safety Trial of PH94B in Social Anxiety Disorder (SAD)
VistaGen Therapeutics, Inc. n=481
NCT05729373 COMPLETED
A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc. n=434
NCT04754802 COMPLETED
PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge
VistaGen Therapeutics, Inc. n=224
NCT06854601 COMPLETED
Safety and Efficacy of Mexidol® for ADHD in Children Aged 6-12
Pharmasoft n=333
NCT07092189 COMPLETED
Colposcopy Anxiety and the Role of Pre-procedure Nursing Intervention
Université de Sherbrooke n=140
NCT02349412 COMPLETED
Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers
Alliance for Clinical Trials in Oncology n=405
NCT06103188 COMPLETED
Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively
University of Jordan n=87
NCT05126459 COMPLETED
A Comparison of Oral Sedation-related Events of Three Multiagent Oral Sedation Regimens in Pediatric Dental Patients
Loma Linda University n=60
NCT02415309 COMPLETED
Premedication With Melatonin in Lumbar Medial Branch Block Procedure
United States Naval Medical Center, San Diego n=25
NCT03829241 COMPLETED
Randomized Trial of Adult Participants With Generalized Anxiety Disorder
Biohaven Pharmaceuticals, Inc. n=881
NCT03810456 COMPLETED
Transdiagnostic Cognitive Behavioral Treatment for Anxiety
VA Office of Research and Development n=359
NCT05586789 COMPLETED
A Study of the Efficacy and Safety of Ranquilon Tablets in Patients With Anxiety in Neurasthenia and Adjustment Disorders
Valenta Pharm JSC n=220
NCT03485274 COMPLETED
Substance Misuse To Psychiatric Disorders for Cannabis
The University of Hong Kong n=37
NCT03227562 TERMINATED
Is Initial Response to Low Dose Risperidone Predictive for Outcome in Anxiety?
Marion Trousselard n=120
NCT03017508 COMPLETED
Acute Anxiolytic Effects of Riluzole on Subjects With Social Anxiety Disorder
Yale University n=22
NCT04569760 WITHDRAWN
Cannabinoids for the Treatment of Anxiety Disorders: An 8-Week Pilot Study
McMaster University
NCT04091139 COMPLETED
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
Chinese University of Hong Kong n=27
NCT04237532 COMPLETED
Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment
Nourhan M.Aly n=42
NCT04393818 COMPLETED
Mobile Phone Based Intervention to Protect Mental Health in Healthcare Workers at Frontline Against COVID19
Fundació d'investigació Sanitària de les Illes Balears n=560
NCT02686333 COMPLETED
Meditation for Depression and Anxiety Symptoms in Dialysis Patients
Lady Davis Institute n=50
NCT01482806 COMPLETED
Online Treatments for Mood and Anxiety Disorders in Primary Care
University of Pittsburgh n=700
NCT02268357 COMPLETED
The Effects of Propranolol on Fear of Tooth or Molar Extraction
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) n=36
NCT01281969 COMPLETED
Intravenous Immunoglobulin for PANDAS
National Institute of Mental Health (NIMH) n=48
NCT01629966 COMPLETED
Safety, Efficacy and Tolerability of Vilazodone in Generalized Anxiety Disorder
Forest Laboratories n=680
NCT01844115 COMPLETED
Safety, Efficacy and Tolerability of Vilazodone in (GAD) Generalized Anxiety Disorder
Forest Laboratories n=415
NCT01766401 COMPLETED
Safety, Efficacy and Tolerability of Vilazodone in Patients With Generalized Anxiety Disorder
Forest Laboratories n=402
NCT03069677 COMPLETED
Music vs Midazolam During Preop Nerve Block Placement
University of Pennsylvania n=160
NCT00836069 TERMINATED
Fixed Dose Study of PD 0332334 and Paroxetine for the Treatment of Generalized Anxiety Disorder
Cedars-Sinai Medical Center n=5
NCT01416805 COMPLETED
Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers
University of South Florida n=100
NCT02096900 COMPLETED
A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
Loma Linda University n=86
NCT02305797 COMPLETED
EDG004 Treatment of Adult Patients With Generalized Anxiety Disorder (GAD)
Edgemont Pharmaceuticals, LLC n=495
NCT02374567 TERMINATED
Pharmacovigilance in Gerontopsychiatric Patients
Hannover Medical School n=407
NCT00671853 COMPLETED
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
University Hospitals Cleveland Medical Center n=120
NCT00868374 TERMINATED
Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder
Keming Gao n=23
NCT02065843 COMPLETED
Three Anxiolytic Drugs Used in Third Molar Surgery
Universidade Federal de Sergipe n=30
NCT01667822 COMPLETED
Cognitive Behavioral Therapy, Guided Self Help Versus Individual Therapy
Karolinska Institutet n=396
NCT02013531 COMPLETED
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms
Otsuka Pharmaceutical Development & Commercialization, Inc. n=37
NCT01667809 COMPLETED
CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care
Karolinska Institutet n=5
NCT01636791 COMPLETED
CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care
Karolinska Institutet n=211
NCT01594606 COMPLETED
Randomized Control Trial of an Animal-Assisted Intervention With Adjudicated Youth
Wayne State University n=150
NCT02622958 COMPLETED
Feasibility Study of PH94B Nasal Spray for Acute Treatment of Social Anxiety Disorder (SAD)
Pherin Pharmaceuticals, Inc. n=23
NCT00902330 COMPLETED
Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
Virginia Commonwealth University n=161
NCT02565316 COMPLETED
Efficacy of Nepeta Menthoides Extract on Anxiety of Patients With Depression: a Double-blind Randomized Controlled Clinical Trial
Shiraz University of Medical Sciences n=70
NCT00788034 COMPLETED
Relapse-prevention Study With Lu AA21004 (Vortioxetine) in Patients With Generalized Anxiety Disorder
H. Lundbeck A/S n=459
NCT01901003 COMPLETED
Sedative Premedication: Efficacy On Patient Experience
Assistance Publique Hopitaux De Marseille n=1,200
NCT01545414 COMPLETED
Internet-CBT (Cognitive Behavioral Therapy) for Depression and Anxiety in Parkinsons Disease
Karolinska Institutet n=150
NCT00887679 COMPLETED
Treatment Effects of Escitalopram (Lexapro®) on Generalized Anxiety Disorder in Patients With HIV and AIDS
Duke University n=30
NCT00794456 COMPLETED
Association of Passiflora Incarnata L; Crataegus Oxyacantha L and Salix Alba L. on Mild and Moderate Anxiety
Marjan Industria e Comercio ltda n=150
NCT01226511 COMPLETED
A Study in Pediatric Participants With Generalized Anxiety Disorder
Eli Lilly and Company n=281
NCT00744627 COMPLETED
Efficacy and Safety of Vortioxetine (Lu AA21004) for Treatment of Generalized Anxiety Disorder in Adults.
Takeda n=301
NCT00773162 COMPLETED
Flushing in Social Anxiety Disorder on Seroquel
START Clinic for Mood and Anxiety Disorders n=21
NCT00734071 COMPLETED
An Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Treating Generalized Anxiety Disorder
Takeda n=304
NCT00731120 COMPLETED
Study of Efficacy and Safety of Vortioxetine (Lu AA21004) in Treating Generalized Anxiety Disorder
Takeda n=457
NCT00730691 COMPLETED
Efficacy of Vortioxetine (Lu AA21004) in Treating Generalized Anxiety Disorder
Takeda n=781
NCT00958880 COMPLETED
Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety
Southern Methodist University n=40
NCT00978185 COMPLETED
Acupressure Wristbands or Standard Care in Controlling Nausea Caused by Chemotherapy
University of Manchester n=699
NCT01178385 COMPLETED
Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
University of South Florida n=45
NCT01228890 WITHDRAWN
Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)
University of Chicago
NCT00738738 WITHDRAWN
6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD)
Pfizer
NCT00735267 TERMINATED
A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder (GAD)
Pfizer n=468
NCT00658372 TERMINATED
A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)
Pfizer n=360
NCT00658008 TERMINATED
A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1)
Pfizer n=501
NCT00658762 TERMINATED
A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3)
Pfizer n=286
NCT01687933 COMPLETED
The Effect of Virtual Reality Glasses on Labor Pain
Mashhad University of Medical Sciences n=30
NCT01659359 COMPLETED
The Effect of Virtual Reality Glasses on Pain and Anxiety
Mashhad University of Medical Sciences n=30
NCT01654510 COMPLETED
A Systems Level Intervention for Unemployed Persons With Social Anxiety Disorder
University of Michigan n=165
NCT01622374 COMPLETED
Effects of "Music for the Mind" on Pre-operative Anxiety in Dentistry
Azad University of Medical Sciences n=120
NCT01035294 COMPLETED
A Mindfulness-based Intervention for Treatment of Anxiety in ICD (Implantable Cardioverter Defibrillator) Patients
University of Massachusetts, Worcester n=46
NCT01006187 COMPLETED
Comparison of Different Methods for Reducing Pain From Influenza Vaccine Injections
The Hospital for Sick Children n=352
NCT01285115 COMPLETED
The Comparative Clinical Study of Gamisoyosan on Anxiety of Generalized Anxiety Disorder According to Dosage Form
Korea Health Industry Development Institute n=147
NCT00803361 COMPLETED
Duloxetine for the Treatment of Generalized Anxiety Disorder
Eli Lilly and Company n=210
NCT00914329 COMPLETED
Gelsemium Sempervirens in Anticipatory Anxiety
University Hospital, Grenoble n=180
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only