Landscape → Cardiovascular

Arrhythmia Clinical Trial Landscape

Data updated: May 20, 2026

83 clinical trials tracked since 2008

Arrhythmia is being studied across 83 clinical trials registered since 2008, with 25 programs currently active. The competitive pipeline includes 7 active Phase 3 trials, 10 active Phase 2 trials, and 5 active Phase 1 trials. Top industry sponsors include Cardurion Pharmaceuticals, Inc., Solid Biosciences Inc., Agiana Pharmaceuticals.

25 active

83 total (since 2008)

Phase 1 Active

11 total

Phase 2 Active

25 total

Phase 3 Active

28 total

Phase 4 Active

29 total

Top Industry Sponsors

Sorted by active Active Done Failed

Cardurion Pharmaceuticals, Inc. 1 0 1

Solid Biosciences Inc. 1 0 0

Agiana Pharmaceuticals 1 0 0

AskBio Inc 1 0 0

Biosense Webster, Inc. 0 2 2

Featured Phase 3 Trials

NCT07174986 RECRUITING

Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest

Gabriel Riva n=916

NCT06281977 RECRUITING

Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

Ottawa Heart Institute Research Corporation n=192

NCT05047198 RECRUITING

Catheter Ablation Versus Radio-Ablation for Ventricular Tachycardia: a Randomized Controlled Trial

Ottawa Heart Institute Research Corporation n=244

NCT06965998 RECRUITING

A Pilot Trial Comparing Full Dose Rivaroxaban to Prophylactic Dose Rivaroxaban in Patients With Superficial Vein Thrombosis in the Leg

Ottawa Hospital Research Institute n=50

NCT05890664 RECRUITING

Colchicine After Electrocardioversion for Atrial Fibrillation

University Hospital, Basel, Switzerland n=416

+ 23 more Phase 3 trials — see full database below

Arrhythmia — Trials Started by Year (last 10 years)

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Cardurion Pharmaceuticals, Inc.

Solid Biosciences Inc.

Agiana Pharmaceuticals

AskBio Inc

Biosense Webster, Inc.

Haisco-USA Pharmaceuticals, Inc.

Medtronic Cardiac Ablation Solutions

Corxel Pharmaceuticals

RyCarma Therapeutics, Inc.

Gilead

Active Trials by Phase

Phase 1

Phase 2

Phase 3

Phase 4

Enrollment Size Distribution

1-50

51-200

201-500

501-1k

1k+

All Industry Sponsors

Sorted by active Active Done Failed

Cardurion Pharmaceuticals, Inc. 1 0 1

Solid Biosciences Inc. 1 0 0

Agiana Pharmaceuticals 1 0 0

AskBio Inc 1 0 0

Biosense Webster, Inc. 0 2 2

NCT07174986 RECRUITING

Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest

Gabriel Riva n=916

NCT06281977 RECRUITING

Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

Ottawa Heart Institute Research Corporation n=192

NCT05047198 RECRUITING

Catheter Ablation Versus Radio-Ablation for Ventricular Tachycardia: a Randomized Controlled Trial

Ottawa Heart Institute Research Corporation n=244

NCT06965998 RECRUITING

A Pilot Trial Comparing Full Dose Rivaroxaban to Prophylactic Dose Rivaroxaban in Patients With Superficial Vein Thrombosis in the Leg

Ottawa Hospital Research Institute n=50

NCT05890664 RECRUITING

Colchicine After Electrocardioversion for Atrial Fibrillation

University Hospital, Basel, Switzerland n=416

NCT06717685 RECRUITING

Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients

Rashid Latif Medical College n=210

NCT05213104 ACTIVE NOT RECRUITING

Assessment of Flecainide to Lower the Patent Foramen Ovale Closure Risk of Atrial Arrhythmia or Tachycardia

Assistance Publique - Hôpitaux de Paris n=186

NCT04952610 COMPLETED

Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia

Milestone Pharmaceuticals Inc. n=130

NCT04134845 COMPLETED

A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.

Vanderbilt University Medical Center n=68

NCT01898221 COMPLETED

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation

The Methodist Hospital Research Institute n=343

NCT01426425 COMPLETED

Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia

Medtronic Cardiac Ablation Solutions n=572

NCT01385202 COMPLETED

THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation

Biosense Webster, Inc. n=172

NCT00721149 TERMINATED

NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation- Treatment Use Study

Biosense Webster, Inc. n=10

NCT05410860 COMPLETED

Efficacy and Safety Study of Etripamil Nasal Spray Self-Administration for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia

Corxel Pharmaceuticals n=500

NCT03635996 TERMINATED

Safety Study of Intranasal Etripamil for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia (PSVT). NODE-302

Milestone Pharmaceuticals Inc. n=169

NCT03464019 TERMINATED

Efficacy and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT).

Milestone Pharmaceuticals Inc. n=1,097

NCT04072835 COMPLETED

Safety Study of Etripamil Nasal Spray for Patients With Paroxysmal Supraventricular Tachycardia. NODE-303

Milestone Pharmaceuticals Inc. n=1,116

NCT02624765 COMPLETED

Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)

Edgar Jaeggi n=105

NCT04392362 COMPLETED

A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT)

University of Pretoria n=30

NCT00789165 WITHDRAWN

Empiric Quinidine for Asymptomatic Brugada Syndrome

International Registry of Asymptomatic Brugada Syndrome

NCT03021343 COMPLETED

Effect of Colchicine on the Incidence of Atrial Fibrillation in Open Heart Surgery Patients

Jordan Collaborating Cardiology Group n=360

NCT01439386 COMPLETED

Impact Of Different Ablation Approaches on Outcome In Coexistent Atrial Fibrillation and Flutter

Texas Cardiac Arrhythmia Research Foundation n=86

NCT01038960 COMPLETED

Exercise Training in ICD Recipients; Effect on Therapy Delivered, Depression and Anxiety

Helse Stavanger HF n=40

NCT02652338 COMPLETED

Dietary Supplement on Symptom Awareness and Heart Rhythm in Patients With Cardiac Arrhythmia

Trommsdorff GmbH & Co. KG n=74

NCT01798277 WITHDRAWN

Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia

Newmarket Electrophysiology Research Group Inc

NCT00624520 TERMINATED

Mental Stress Reduction in Defibrillator Patients

US Department of Veterans Affairs n=129

NCT01045668 COMPLETED

Ablation of Clinical Ventricular Tachycardia Versus Addition of Substrate Ablation on the Long Term Success Rate of VT Ablation

Texas Cardiac Arrhythmia Research Foundation n=120

NCT00749307 COMPLETED

Effects of Docosahexaenoic Acid (DHA) on Heart Rate Variability in Elderly Patients

Campus Bio-Medico University n=50

NCT05511246 RECRUITING

Venous Ethanol for Ventricular Tachycardia

The Methodist Hospital Research Institute

NCT06658899 RECRUITING

A Phase 2 Study of CRD-4730 in CPVT

Cardurion Pharmaceuticals, Inc.

NCT07359872 NOT YET RECRUITING

Relaxin Therapy for Atrial Fibrillation

Deeptankar DeMazumder

NCT05439031 RECRUITING

StereoTactic Arrhythmia Radiotherapy in the NetherLands no. 2

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT07263139 RECRUITING

Safety, Tolerability, and Exploratory Efficacy of AGP100 in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Agiana Pharmaceuticals

NCT05763953 RECRUITING

The NODE-202 Study (Study of Etripamil Nasal Spray in Pediatric Patients)

Milestone Pharmaceuticals Inc.

NCT05258422 ENROLLING BY INVITATION

Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia (StAR-VT)

McGill University Health Centre/Research Institute of the McGill University Health Centre

NCT04984265 ACTIVE NOT RECRUITING

SBRT in Chagas Disease Ventricular Tachycardia

University of Sao Paulo General Hospital

NCT04154982 COMPLETED

N-Acetylcysteine Protection Against Radiation Induced Cellular Damage

Centro Cardiologico Monzino

NCT06005428 TERMINATED

Effectiveness of CRD-4730 in Participants With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Cardurion Pharmaceuticals, Inc.

NCT05122975 TERMINATED

Treatment of an Inherited Ventricular Arrhythmia

RyCarma Therapeutics, Inc.

NCT02919618 COMPLETED

Phase I/II Study of EP-guided Noninvasive Cardiac Radioablation for Treatment of Ventricular Tachycardia

Washington University School of Medicine

NCT05084391 WITHDRAWN

Phase I/II Randomized Study of Stereotactic Ablative Radiotherapy (SABR) Versus Standard of Care for Refractory Structural Cardiac Arrhythmias (SABR-HEART)

M.D. Anderson Cancer Center

NCT02296190 COMPLETED

Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm

Milestone Pharmaceuticals Inc.

NCT02104583 COMPLETED

Evaluating Ventricular Arrhythmia in Subjects With Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy-Defibrillator

Gilead Sciences

NCT03153072 WITHDRAWN

Evaluation of the Pharmacokinetic Profile, Pharmacodynamic Effects, Acceptability and Tolerability of an Oral Amiodarone Solution of 15 mg / mL in Children With Supra Ventricular Tachycardia

Centre Hospitalier Universitaire, Amiens

NCT00993382 COMPLETED

Dose Ranging Study of Celivarone With Amiodarone as Calibrator for the Prevention of Implantable Cardioverter Defibrillator (ICD) Interventions or Death

Sanofi

NCT01032317 COMPLETED

Study of a New Catheter Using Force Sensing Capabilities for the Treatment of Atrial Fibrillation and Ventricular Tachycardia

Biosense Webster, Inc.

NCT02232204 COMPLETED

Sleep and Ventricular Arrhythmias Study

University of Florida

NCT01396226 COMPLETED

A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in Patients

AstraZeneca

NCT07405229 RECRUITING

MEdical Treatment in Idiopathic Ventricular Fibrillation Patients

Bo Gregers Winkel

NCT03826524 RECRUITING

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

Unity Health Toronto

NCT07205757 RECRUITING

Adding Lidocaine to Custodiol Mixture

Fayoum University Hospital

NCT07211347 RECRUITING

Percutaneous Blockade of the Stellate Ganglion in Electrical Storm

University of Sao Paulo General Hospital

NCT06964464 RECRUITING

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

University of Rochester

NCT06993038 RECRUITING

Adenosine vs Diltiazem for Treatment of SVT in the ED

Anne E. Zepeski

NCT03833089 ACTIVE NOT RECRUITING

Targeted Potassium Levels for Prevention of ICD Therapy

Rigshospitalet, Denmark

NCT02114528 TERMINATED

Anti-arrhythmic Therapy vs Catheter Ablation as First Line Treatment for AICD Shock Prevention

Ottawa Heart Institute Research Corporation

NCT07554170 COMPLETED

Comparison of Single-syringe vs. Double-syringe Techniques for Adenosine Administration in PSVT

Hormozgan University of Medical Sciences

NCT07456423 COMPLETED

Adenosine vs. Diltiazem

Haseki Training and Research Hospital

NCT04694079 COMPLETED

Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance

Azienda Ospedaliero, Universitaria Pisana

NCT06574555 COMPLETED

Norepinephrine ED90 Bolus After Spinal Anesthesia in Cesarean Section

Pontificia Universidad Catolica de Chile

NCT01841242 COMPLETED

Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation

Centre Hospitalier Universitaire de Saint Etienne

NCT02830360 COMPLETED

Antiarrhythmics or Ablation for Ventricular Tachycardia 2

John Sapp

NCT05486377 COMPLETED

Remimazolam vs Desflurane for General Anesthesia for Ablation of Arrhythmia

Seoul National University Bundang Hospital

NCT03035227 TERMINATED

Catheter Ablation of Arrhythmias to Improve CRT Response

Kansas City Heart Rhythm Institute

NCT02666742 COMPLETED

DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation

Kansas City Heart Rhythm Institute

NCT03029169 COMPLETED

Propafenone Versus Amiodarone in Septic Shock

Charles University, Czech Republic

NCT01628666 COMPLETED

Prevention of Arrhythmia Device Infection Trial (PADIT)

Population Health Research Institute

NCT03273634 COMPLETED

The Effect of Proton Pump Inhibition on Palpitations

Jordan Collaborating Cardiology Group

NCT02203630 TERMINATED

Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients

Vanderbilt University Medical Center

NCT01557842 TERMINATED

Early Ablation Therapy for the Treatment of Ischemic Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillators

Biosense Webster, Inc.

NCT02988219 COMPLETED

Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method

Medical University of Warsaw

NCT02083016 COMPLETED

Ultra-high Density Mapping With Multielectrode Catheter vs Conventional Point by Point Mapping for Ventricular Tachycardia Substrate Ablation

Hospital Clinic of Barcelona

NCT00905853 COMPLETED

Ventricular Tachycardia (VT) Ablation or Escalated Drug Therapy

John Sapp

NCT00851279 COMPLETED

Stereotaxis Study To Obliterate Persistent Ventricular Tachycardia

Stereotaxis

NCT01613092 COMPLETED

Prevention of Arrhythmia Device Infection Trial (PADIT)

Population Health Research Institute

NCT00787800 COMPLETED

The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock

Mayo Clinic

NCT01655316 COMPLETED

Oral Verapamil in Acute Paroxysmal Supra Ventricular Tachycardia(PSVT) Recurrence Control

Tehran University of Medical Sciences

Full Arrhythmia Pipeline

Every sponsor, every trial across Phase 1–4. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only