Brain Tumor Clinical Trial Landscape
Data updated: May 20, 2026
781 clinical trials tracked since 2008
Brain tumors are abnormal growths of cells within the brain, which can be cancerous or non-cancerous, and affect both adults and children. Clinical research is crucial for developing new and improved treatments for these complex conditions. Since 2008, 777 brain tumor trials have been registered, with 310 currently active, meaning they are recruiting, enrolling, or active but not recruiting patients. The majority of active trials are in early phases of development, with 178 in Phase 1 and 144 in Phase 2. Phase 3 trials account for 34 active trials, while Phase 4 has 7. Industry sponsorship is distributed across multiple companies, with Pfizer and InSightec leading with 3 active trials each. Jazz Pharmaceuticals, Novartis, and Eli Lilly each have 2 active trials in this space. The high volume of Phase 1 and 2 trials suggests a strong focus on early-stage investigation of novel therapies for brain tumors.
314 active
/
781 total (since 2008)
181
Phase 1 Active
460 total
148
Phase 2 Active
383 total
34
Phase 3 Active
55 total
7
Phase 4 Active
20 total
Top Industry Sponsors
Sorted by active Active Done Failed
Pfizer 3 0 1
InSightec 3 0 0
Jazz Pharmaceuticals 2 0 3
Novartis 2 2 0
Eli Lilly 2 1 0
+ 10 more sponsors — see full table below
Featured Phase 3 Trials
NCT04166409 RECRUITING
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
National Cancer Institute (NCI) n=170
NCT04576117 ACTIVE NOT RECRUITING
A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma
National Cancer Institute (NCI) n=300
NCT06905587 RECRUITING
Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue
Odense University Hospital n=50
NCT05580562 RECRUITING
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Jazz Pharmaceuticals n=510
NCT05317858 RECRUITING
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
InSightec n=30
+ 50 more Phase 3 trials — see full database below
Brain Tumor — Trials Started by Year (last 10 years)
2016 53
2017 43
2018 45
2019 38
2020 50
2021 34
2022 32
2023 46
2024 53
2025 62
2026 46
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
Pfizer 4
InSightec 3
Jazz Pharmaceuticals 5
Novartis 4
Eli Lilly 3
Cellectar Biosciences, Inc. 3
Beijing Biotech 2
NaviFUS Corporation 2
Beijing Bio-Targeting Therapeutics Technology Co., Ltd 2
Rigel Pharmaceuticals 2
Active Trials by Phase
Phase 1 181
Phase 2 148
Phase 3 34
Phase 4 7
Enrollment Size Distribution
1-50 497
51-200 209
201-500 27
501-1k 5
1k+ 3
All Industry Sponsors
Sorted by active Active Done Failed
Pfizer 3 0 1
InSightec 3 0 0
Jazz Pharmaceuticals 2 0 3
Novartis 2 2 0
Eli Lilly 2 1 0
Cellectar Biosciences, Inc. 2 0 1
Beijing Biotech 2 0 0
NaviFUS Corporation 2 0 0
Beijing Bio-Targeting Therapeutics Technology Co., Ltd 2 0 0
Rigel Pharmaceuticals 2 0 0
Day One Biopharmaceuticals, Inc. 2 0 0
VPIX Medical 2 0 0
Plus Therapeutics 2 0 0
Regeneron 1 0 1
Actuate Therapeutics Inc. 1 0 1
NCT04166409 RECRUITING
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
National Cancer Institute (NCI) n=170
NCT04576117 ACTIVE NOT RECRUITING
A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma
National Cancer Institute (NCI) n=300
NCT06905587 RECRUITING
Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue
Odense University Hospital n=50
NCT05580562 RECRUITING
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Jazz Pharmaceuticals n=510
NCT05317858 RECRUITING
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
InSightec n=30
NCT03871257 ACTIVE NOT RECRUITING
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
National Cancer Institute (NCI) n=165
NCT06496971 RECRUITING
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
NaviFUS Corporation n=32
NCT06388733 RECRUITING
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Ivy Brain Tumor Center n=450
NCT06229483 RECRUITING
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
Stephen Lownie n=102
NCT05303519 RECRUITING
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
Nuvation Bio Inc. n=365
NCT05566795 ACTIVE NOT RECRUITING
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
Day One Biopharmaceuticals, Inc. n=418
NCT07440290 NOT YET RECRUITING
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
Cancer Research UK n=30
NCT06888817 RECRUITING
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
The Netherlands Cancer Institute n=408
NCT05476939 RECRUITING
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Gustave Roussy, Cancer Campus, Grand Paris n=433
NCT07376304 NOT YET RECRUITING
Intraoperative Ultrasound for Brain Tumor Surgery Enhanced by AI
Hospital del Rio Hortega n=100
NCT06780930 ACTIVE NOT RECRUITING
Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 Mutation
Servier n=57
NCT05770544 RECRUITING
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
Cancer Research UK n=30
NCT05768178 RECRUITING
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
Cancer Research UK n=30
NCT06988475 RECRUITING
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
Cancer Research UK n=30
NCT07239115 NOT YET RECRUITING
Levetiracetam for Seizure Prevention After Brain Tumor Surgery
Beijing Tiantan Hospital n=558
NCT02864888 NOT YET RECRUITING
Effect of Antineoplaston Therapy on the QT/QTc Interval In Subjects With Diffuse, Intrinsic, Brainstem Glioma
Burzynski Research Institute n=30
NCT02887040 NOT YET RECRUITING
Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma
Burzynski Research Institute n=92
NCT07165262 ACTIVE NOT RECRUITING
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Children's Cancer Hospital Egypt 57357 n=88
NCT07004075 NOT YET RECRUITING
FCN-159 Monotherapy Versus Chemotherapy by Investigator's Choice in Pediatric Low-grade Glioma Patients With BRAF Alteration
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. n=102
NCT06750458 NOT YET RECRUITING
Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients
Tanta University n=75
NCT04164901 ACTIVE NOT RECRUITING
Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)
Institut de Recherches Internationales Servier n=331
NCT02455245 ACTIVE NOT RECRUITING
A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma
Alicia Lenzen n=95
NCT05897658 NOT YET RECRUITING
Levetiracetam Prophylaxis in Brain Tumor Resection Pilot
Hamilton Health Sciences Corporation n=70
NCT05512403 RECRUITING
Evaluation of Diagnostic Performances of 18F-FDOPA PET KInetics
Central Hospital, Nancy, France n=88
NCT05271240 RECRUITING
Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM
Northwell Health n=432
NCT06330337 RECRUITING
Effect of Electroacupuncture Combined With Paclitaxel Clinical Efficacy of Patients With Recurrence of High-grade Glioma
The Third Affiliated hospital of Zhejiang Chinese Medical University n=58
NCT03534050 RECRUITING
Neuropsychological and Oncological Outcomes in Grade 2 or 3 Glioma Patients Undergoing Postoperative Modern Radiotherapy
Chang Gung Memorial Hospital n=80
NCT04316039 RECRUITING
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery
West China Hospital n=250
NCT06417281 COMPLETED
Photodynamic Diagnosis for Malignant Brain Glioma With 5-Aminolevulinic Acid（5-ALA）
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. n=86
NCT03149575 TERMINATED
VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM
DelMar Pharmaceuticals, Inc. n=2
NCT02040376 COMPLETED
Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma
The Hospital for Sick Children n=24
NCT04588246 TERMINATED
Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery
NRG Oncology n=19
NCT01236560 COMPLETED
Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma
National Cancer Institute (NCI) n=101
NCT01502280 COMPLETED
Fluorescence-guided Surgery for Low- and High-grade Gliomas
St. Joseph's Hospital and Medical Center, Phoenix n=127
NCT00716976 COMPLETED
Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy
Children's Oncology Group n=131
NCT02879682 COMPLETED
nTMS for Motor Mapping of Rolandic Lesions
Technical University of Munich n=330
NCT02617589 COMPLETED
An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)
Bristol-Myers Squibb n=560
NCT03763422 TERMINATED
Trial in Low Grade Glioma Patients: Wait or Treat
European Organisation for Research and Treatment of Cancer - EORTC n=19
NCT03042416 COMPLETED
18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety
University of Alberta n=400
NCT02892708 COMPLETED
Impact of Surgery on the Treatment of Supratentorial Malignant Gliomas in Subjects Aged 70 and Over
Assistance Publique - Hôpitaux de Paris n=107
NCT01014767 TERMINATED
Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors
Tufts Medical Center n=27
NCT01601314 COMPLETED
Perioperative Magnesium Sulphate as a Cerebral Protector in Neurosurgical Patients
Sara Varea n=55
NCT01260103 WITHDRAWN
Phase 3 Study of ANP Therapy vs. TMZ for Optic Pathway Glioma
Burzynski Research Institute
NCT01460706 COMPLETED
Imaging Malignant Glioma With 68Ga-DOTATOC PET/CT
Turku University Hospital n=30
NCT01635140 COMPLETED
Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children
Children's Cancer Hospital Egypt 57357 n=64
NCT01167322 COMPLETED
Study of NPC-07 for Fluorescence-guided Resection of Malignant Gliomas
Nobelpharma n=45
NCT02465060 ACTIVE NOT RECRUITING
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
National Cancer Institute (NCI)
NCT03919071 ACTIVE NOT RECRUITING
Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma
National Cancer Institute (NCI)
NCT06528691 RECRUITING
Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors
St. Jude Children's Research Hospital
NCT01089101 ACTIVE NOT RECRUITING
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
National Cancer Institute (NCI)
NCT05099003 RECRUITING
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
National Cancer Institute (NCI)
NCT06161519 RECRUITING
PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications
National Cancer Institute (NCI)
NCT07416188 RECRUITING
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
National Institute of Neurological Disorders and Stroke (NINDS)
NCT05859334 RECRUITING
Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment
National Cancer Institute (NCI)
NCT07539441 RECRUITING
A Study of Mirdametinib in People With Central Nervous System Tumors
Memorial Sloan Kettering Cancer Center
NCT03213652 ACTIVE NOT RECRUITING
Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT03210714 ACTIVE NOT RECRUITING
Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT05096481 RECRUITING
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
Nationwide Children's Hospital
NCT07326566 RECRUITING
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Black Diamond Therapeutics, Inc.
NCT07003542 RECRUITING
A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas
Case Comprehensive Cancer Center
NCT03180502 ACTIVE NOT RECRUITING
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
NRG Oncology
NCT06804655 NOT YET RECRUITING
Pharmacoscopy for Patients With Refractory Primary Brain Tumors
University of Zurich
NCT07567469 NOT YET RECRUITING
A Safety and Efficacy Study of Combined Fianlimab + Cemiplimab in Children and Young Adults With Recurrent or Progressive High-Grade Glioma or Posterior Fossa-A Ependymoma
Regeneron Pharmaceuticals
NCT04870944 RECRUITING
CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Children's Oncology Group
NCT05629702 RECRUITING
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
University of Birmingham
NCT04284774 ACTIVE NOT RECRUITING
Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial
National Cancer Institute (NCI)
NCT03155620 ACTIVE NOT RECRUITING
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
National Cancer Institute (NCI)
NCT04195555 ACTIVE NOT RECRUITING
Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT04145115 ACTIVE NOT RECRUITING
A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden
National Cancer Institute (NCI)
NCT03581292 ACTIVE NOT RECRUITING
Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations
National Cancer Institute (NCI)
NCT04320888 ACTIVE NOT RECRUITING
Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial
National Cancer Institute (NCI)
NCT05588141 RECRUITING
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
National Cancer Institute (NCI)
NCT07562971 NOT YET RECRUITING
Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)
UMC Utrecht
NCT07110246 RECRUITING
Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas
University of California, San Francisco
NCT06667726 RECRUITING
An Investigational Scan (18F-DOPA PET/CT) for Improving the Clinical Management of Brain Tumors
Mayo Clinic
NCT04222062 RECRUITING
A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease
University of Nebraska
NCT05128903 ACTIVE NOT RECRUITING
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
St. Jude Children's Research Hospital
NCT03363217 ACTIVE NOT RECRUITING
Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.
St. Justine's Hospital
NCT00840047 ACTIVE NOT RECRUITING
Methionine PET/CT Studies In Patients With Cancer
St. Jude Children's Research Hospital
NCT03213704 ACTIVE NOT RECRUITING
Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT03698994 ACTIVE NOT RECRUITING
Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT05843253 RECRUITING
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Nationwide Children's Hospital
NCT07243470 RECRUITING
Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors
Centre Leon Berard
NCT05615623 ACTIVE NOT RECRUITING
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
InSightec
NCT06413706 ACTIVE NOT RECRUITING
A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy
Eli Lilly and Company
NCT05630209 ACTIVE NOT RECRUITING
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)
InSightec
NCT05278208 RECRUITING
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
Nationwide Children's Hospital
NCT06465199 RECRUITING
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Milton S. Hershey Medical Center
NCT02800486 RECRUITING
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Northwell Health
NCT07468136 NOT YET RECRUITING
Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas
Mayo Clinic
NCT06810544 RECRUITING
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Tango Therapeutics, Inc.
NCT06329570 RECRUITING
Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)
NaviFUS Corporation
NCT07206849 NOT YET RECRUITING
Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)
Nationwide Children's Hospital
NCT07383649 RECRUITING
Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection
The Methodist Hospital Research Institute
NCT06478212 ACTIVE NOT RECRUITING
Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma
Institut de Recherches Internationales Servier
NCT03678883 ACTIVE NOT RECRUITING
9-ING-41 in Patients With Advanced Cancers
Actuate Therapeutics Inc.
NCT07501156 RECRUITING
H3K27M-specific Immune Effector Cells Targeting DMG/DIPG
Shenzhen Geno-Immune Medical Institute
NCT06838676 RECRUITING
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
Nationwide Children's Hospital
NCT07126990 ENROLLING BY INVITATION
Clinical Study of a Novel Oncolytic Virus Ad-TD-nsIL12 in the Treatment of Primary High-grade Glioma
Xiaorong Wu
NCT06763965 ENROLLING BY INVITATION
Evaluating the Safety and Efficacy of BioTTT001 in Patients With Recurrent/Progressive High-grade Glioma.
Beijing Bio-Targeting Therapeutics Technology Co., Ltd
NCT04085887 RECRUITING
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
Stanford University
NCT04458272 ACTIVE NOT RECRUITING
A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma
Daiichi Sankyo Co., Ltd.
NCT07132190 RECRUITING
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
Ayal A. Aizer, MD
NCT05733572 ACTIVE NOT RECRUITING
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)
Benedetto Falsini
NCT04899908 ACTIVE NOT RECRUITING
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Brigham and Women's Hospital
NCT05500391 RECRUITING
Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote Monitoring
Centre Oscar Lambret
NCT07470606 NOT YET RECRUITING
Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain
The University of Texas Health Science Center at San Antonio
NCT06504381 RECRUITING
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma
University of California, San Francisco
NCT06639607 NOT YET RECRUITING
PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma
Washington University School of Medicine
NCT05660408 ACTIVE NOT RECRUITING
RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors
University of Florida
NCT05188508 RECRUITING
Pembrolizumab, Olaparib, and Temozolomide for People With Glioma
Memorial Sloan Kettering Cancer Center
NCT05607407 RECRUITING
Methimazole in Patients With Progressive Glioblastoma
Case Comprehensive Cancer Center
NCT06058988 RECRUITING
Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer
Memorial Sloan Kettering Cancer Center
NCT05345002 RECRUITING
All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma
Stephen Bagley, MD, MSCE
NCT07424092 ACTIVE NOT RECRUITING
Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors
Clinica Universidad de Navarra, Universidad de Navarra
NCT03212274 ACTIVE NOT RECRUITING
Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations
National Cancer Institute (NCI)
NCT06666348 RECRUITING
Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK
St. Justine's Hospital
NCT06132685 RECRUITING
Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Emory University
NCT03510208 RECRUITING
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
Stanford University
NCT04478279 ACTIVE NOT RECRUITING
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
Sapience Therapeutics
NCT07389278 NOT YET RECRUITING
Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)
Sabine Mueller, MD, PhD
NCT04923126 RECRUITING
SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma
St. Jude Children's Research Hospital
NCT04201457 ACTIVE NOT RECRUITING
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration
Pediatric Brain Tumor Consortium
NCT06208657 RECRUITING
Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
Australian & New Zealand Children's Haematology/Oncology Group
NCT06630260 RECRUITING
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
Institute of Cancer Research, United Kingdom
NCT06907485 NOT YET RECRUITING
A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients
Costas Hadjipanayis
NCT05077735 RECRUITING
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Mayo Clinic
NCT07338539 RECRUITING
BIO-SHORT: Biologically Guided Short-Course Hypofractionated RT for Poor-Prognosis GBM
Tata Memorial Centre
NCT04623931 RECRUITING
Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas
M.D. Anderson Cancer Center
NCT06444412 RECRUITING
An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma
Mayo Clinic
NCT04049669 ACTIVE NOT RECRUITING
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Theodore S. Johnson
NCT06991101 RECRUITING
Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
Baptist Health South Florida
NCT05009992 RECRUITING
Combination Therapy for the Treatment of Diffuse Midline Gliomas
University of California, San Francisco
NCT05956821 RECRUITING
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
University of Miami
NCT05554302 RECRUITING
Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis
Baptist Health South Florida
NCT03687957 ACTIVE NOT RECRUITING
rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temozolomide
Washington University School of Medicine
NCT03718767 ACTIVE NOT RECRUITING
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype
National Cancer Institute (NCI)
NCT07243340 NOT YET RECRUITING
A Phase I/IIa Study of C5252 in Patients With Intracranial Tumor
ImmVira Pharma Co. Ltd
NCT04299191 RECRUITING
Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors
Laminar Pharmaceuticals
NCT06521567 ACTIVE NOT RECRUITING
A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer
GlaxoSmithKline
NCT06011109 RECRUITING
Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab
Aveta Biomics, Inc.
NCT03935685 ACTIVE NOT RECRUITING
Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ
University of California, Irvine
NCT06492486 NOT YET RECRUITING
Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow
Tata Memorial Centre
NCT06377696 RECRUITING
Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy
Mayo Clinic
NCT04910022 ACTIVE NOT RECRUITING
Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma
Nerviano Medical Sciences
NCT07120984 NOT YET RECRUITING
A Study to Evaluate the Safety and Efficacy of L19TNF With Alkylating Chemotherapy for Patients With Recurrent IDH-mutant Astrocytoma or Oligodendroglioma
Philogen S.p.A.
NCT05180825 RECRUITING
Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy
University Hospital, Strasbourg, France
NCT02691923 RECRUITING
Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker
David W. Roberts
NCT04175301 ACTIVE NOT RECRUITING
Effect H2 Water on QoL of Patients Receiving Radiotherapy for High Grade Gliomas.
Stony Brook University
NCT03220646 ACTIVE NOT RECRUITING
Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT03175224 RECRUITING
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Apollomics Inc.
NCT06818331 RECRUITING
Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-arm Trial
The Third Affiliated hospital of Zhejiang Chinese Medical University
NCT06999148 ENROLLING BY INVITATION
Study on The Sensitizing Effect of Sonodynamic Therapy on The Treatment of Brainstem Glioma With Radiotherapy and Chemotherapy and Survival Analysis
Yingjuan Zheng
NCT06264388 RECRUITING
DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
Ashish Shah
NCT06712875 RECRUITING
MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas
Ann & Robert H Lurie Children's Hospital of Chicago
NCT06016452 RECRUITING
A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma
Tata Memorial Centre
NCT04775485 RECRUITING
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
Day One Biopharmaceuticals, Inc.
NCT06687681 RECRUITING
Injection of Active Allogeneic Natural Killer Cells in Patients With Gliomas
Marzieh Ebrahimi
NCT02861898 RECRUITING
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Northwell Health
NCT03213002 RECRUITING
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
Northwell Health
NCT06678867 NOT YET RECRUITING
The Use of 5-ALA in Paediatric Patients With High Grade Brain Tumours
University College, London
NCT01906385 RECRUITING
Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)
Plus Therapeutics
NCT06801730 RECRUITING
Irinotecan Liposomes Combined With Bevacizumab in the Treatment of Recurrent Glioma
Zhifeng Tian,MD
NCT06703255 RECRUITING
A Phase 2 Study of HX301 in Patients with High-grade Giloma
Hangzhou Hanx Biopharmaceuticals, Ltd.
NCT03709680 ACTIVE NOT RECRUITING
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Pfizer
NCT04758533 ACTIVE NOT RECRUITING
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
Hospital Infantil Universitario Niño Jesús, Madrid, Spain
NCT06172595 RECRUITING
FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma
Singapore General Hospital
NCT06160206 RECRUITING
Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma
Academic and Community Cancer Research United
NCT06684795 RECRUITING
FG001 in Subjects with Meningiomas or Presumed Low-Grade Gliomas Scheduled for Neurosurgery
Rigshospitalet, Denmark
NCT06640582 RECRUITING
TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
Essen Biotech
NCT04267978 RECRUITING
Study of Recombinant Human Endostatin Combined with Temozolomide and Irinotecan in Recurrent Gliomas
Beijing Sanbo Brain Hospital
NCT05139043 ACTIVE NOT RECRUITING
Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors
City of Hope Medical Center
NCT06258018 NOT YET RECRUITING
Niraparib and Temozolomide in Patients Glioblastoma
Armando Santoro, MD
NCT03991832 RECRUITING
Study of Olaparib and Durvalumab in IDH-Mutated Solid Tumors
University Health Network, Toronto
NCT04911621 ACTIVE NOT RECRUITING
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma
University Hospital, Antwerp
NCT06051240 RECRUITING
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Region Stockholm
NCT02840409 ACTIVE NOT RECRUITING
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)
The Hospital for Sick Children
NCT05964569 RECRUITING
Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma
University Hospital Heidelberg
NCT06159478 RECRUITING
Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)
National Cancer Center, Japan
NCT05366062 NOT YET RECRUITING
ERC1671 to Treat Malignant Gliomas When Given in Combination With GM-CSF, Cyclophosphamide, Bevacizumab and Pembrolizumab
Epitopoietic Research Corporation
NCT07599371 RECRUITING
A Prospective, Single-arm Clinical Study on the Safety and Efficacy of Ivoximab Combined With Temozolomide in the Treatment of Relapsed/Refractory Glioma
The First Affiliated Hospital of Zhengzhou University
NCT07589257 RECRUITING
A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma
Guangzhou Virotech Pharmaceutical Co., Ltd.
NCT03213678 COMPLETED
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT04817254 COMPLETED
Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
National Cancer Institute (NCI)
NCT03952598 SUSPENDED
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy
National Cancer Institute (NCI)
NCT03213665 COMPLETED
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT02153957 COMPLETED
Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors
National Cancer Institute (NCI)
NCT03526250 COMPLETED
Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT01743950 TERMINATED
A Phase II Study of Pulse Reduced Dose Rate Radiation Therapy With Bevacizumab
University of Wisconsin, Madison
NCT02942264 TERMINATED
Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma
National Cancer Institute (NCI)
NCT04482933 WITHDRAWN
HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma
Pediatric Brain Tumor Consortium
NCT06322342 COMPLETED
Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent
Reveal Pharmaceuticals Inc.
NCT04738162 COMPLETED
Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Brain Tumors
Universität Münster
NCT03532295 COMPLETED
Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas
Washington University School of Medicine
NCT03746080 COMPLETED
Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma
Lawrence D Recht
NCT06855628 SUSPENDED
Assessment of Novel Metabolic Imaging Modalities as A Predictor Of Therapeutic EfficacyiIn Glioblastoma (GBM)
Stanford University
NCT03868943 TERMINATED
Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma
Wake Forest University Health Sciences
NCT01991977 COMPLETED
18F-DOPA-PET in Finding Tumors in Patients With Newly Diagnosed Gliomas Undergoing Radiation Therapy
Mayo Clinic
NCT06439420 COMPLETED
CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial
Virginia Commonwealth University
NCT02742883 SUSPENDED
A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG)
Burzynski Research Institute
NCT03050736 COMPLETED
Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression
Kintara Therapeutics, Inc.
NCT01478178 COMPLETED
Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma
Kintara Therapeutics, Inc.
NCT02717962 COMPLETED
Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting
Kintara Therapeutics, Inc.
NCT03330197 TERMINATED
A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG
Alaunos Therapeutics
NCT04388475 COMPLETED
Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma
Oblato, Inc.
NCT03890952 COMPLETED
Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma
Ulrik Lassen
NCT03778294 COMPLETED
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy
Mayo Clinic
NCT02781792 COMPLETED
Temozolomide Chronotherapy for High Grade Glioma
Washington University School of Medicine
NCT04740190 COMPLETED
Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd
The University of Hong Kong
NCT02655601 COMPLETED
Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001
BioMimetix JV, LLC
NCT04479241 COMPLETED
LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma
Istari Oncology, Inc.
NCT01288235 COMPLETED
Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation
Massachusetts General Hospital
NCT04875975 TERMINATED
A Study to Test the Efficacy, Safety, and Pharmacokinetics of Rozanolixizumab in Adult Study Participants With Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis
UCB Biopharma SRL
NCT02311582 COMPLETED
MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas
Washington University School of Medicine
NCT03665545 COMPLETED
Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma
University Hospital, Geneva
NCT03095248 TERMINATED
Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors
Children's Hospital Medical Center, Cincinnati
NCT03690869 TERMINATED
REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma
Regeneron Pharmaceuticals
NCT04544007 TERMINATED
A Phase II Trial of Poly-ICLC for Low-Grade Gliomas
University of Alabama at Birmingham
NCT04897880 TERMINATED
A Study of Panobinostat in Pediatric Patients With Solid Tumors Including MRT/ATRT
Australian & New Zealand Children's Haematology/Oncology Group
NCT05737212 TERMINATED
Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas
Dawonmedax Co., Ltd.
NCT01894061 COMPLETED
NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma
Case Comprehensive Cancer Center
NCT03220035 COMPLETED
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT01814813 TERMINATED
Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery
Alliance for Clinical Trials in Oncology
NCT02960230 COMPLETED
H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas
Sabine Mueller, MD, PhD
NCT03914742 COMPLETED
BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02465268 COMPLETED
Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme
University of Florida
NCT01553149 COMPLETED
Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma
National Cancer Institute (NCI)
NCT03276676 TERMINATED
[18F]Fluciclovine and [18F]FLT PET/CT Assessment of Primary High-Grade Brain Tumors
University of Utah
NCT05500508 TERMINATED
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Aminex Therapeutics, Inc.
NCT03233204 COMPLETED
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)
National Cancer Institute (NCI)
NCT04267146 COMPLETED
Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma
Gustave Roussy, Cancer Campus, Grand Paris
NCT02372409 TERMINATED
Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors
Washington University School of Medicine
NCT03973918 TERMINATED
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05123534 SUSPENDED
A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG
SonALAsense, Inc.
NCT01204684 COMPLETED
Dendritic Cell Vaccine for Patients With Brain Tumors
Jonsson Comprehensive Cancer Center
NCT01774253 TERMINATED
Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma
Giselle Sholler
NCT04497142 COMPLETED
Effect of Perampanel on Peritumoral Hyperexcitability in HGG
Dana-Farber Cancer Institute
NCT01817751 COMPLETED
Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma
Virginia Commonwealth University
NCT01837862 COMPLETED
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Julie Krystal
NCT03326388 COMPLETED
Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours
Great Ormond Street Hospital for Children NHS Foundation Trust
NCT03925246 COMPLETED
Efficacy of Nivolumab for Recurrent IDH Mutated High-Grade Gliomas
Assistance Publique - Hôpitaux de Paris
NCT02052648 COMPLETED
Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors
NewLink Genetics Corporation
NCT02768337 TERMINATED
Cambridge Brain Mets Trial 1
Cambridge University Hospitals NHS Foundation Trust
NCT01811498 COMPLETED
Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM
Northwell Health
NCT01854554 COMPLETED
Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)
M.D. Anderson Cancer Center
NCT02684058 COMPLETED
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors
Novartis Pharmaceuticals
NCT02839720 COMPLETED
Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma
National Cancer Institute (NCI)
NCT03027388 COMPLETED
Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma
National Cancer Institute (NCI)
NCT03190967 TERMINATED
T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery
National Cancer Institute (NCI)
NCT04659421 COMPLETED
Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade Gliomas
Beijing Sanbo Brain Hospital
NCT03194906 COMPLETED
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors
St. Jude Children's Research Hospital
NCT01466686 COMPLETED
Low Dose Radiation Therapy for Glioblastoma Multiforme
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT01290692 COMPLETED
Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma
TVAX Biomedical
NCT03779230 COMPLETED
Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse
Philogen S.p.A.
NCT02661282 COMPLETED
Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma
M.D. Anderson Cancer Center
NCT01081223 COMPLETED
Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma
TVAX Biomedical
NCT03436433 TERMINATED
Seizure Prophylaxis in Patients With Glioma or Brain Metastasis
Duke University
NCT04730349 TERMINATED
A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer
Bristol-Myers Squibb
NCT03242824 COMPLETED
The Utility of 18F-DOPA-PET in the Treatment of Recurrent High-grade Glioma
Mayo Clinic
NCT05222165 WITHDRAWN
Study With Infigratinib in Subjects With Advanced Solid and CNS Tumors or Recurrent or Progressive Low-Grade Glioma With Selected FGFR1-3 Alterations
Helsinn Healthcare SA
NCT01792310 COMPLETED
A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours
Laminar Pharmaceuticals
NCT01986348 TERMINATED
Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas
Karyopharm Therapeutics Inc
NCT02023905 TERMINATED
Everolimus With and Without Temozolomide in Adult Low Grade Glioma
University of California, San Francisco
NCT01730950 COMPLETED
Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma
Radiation Therapy Oncology Group
NCT04851834 TERMINATED
NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma
Xennials Therapeutics Australia Pty Ltd
NCT02858895 COMPLETED
Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma
Medicenna Therapeutics, Inc.
NCT01469247 COMPLETED
Diffuse Intrinsic Pontine Glioma (DIPG) Reirradiation (ReRT)
M.D. Anderson Cancer Center
NCT02885324 TERMINATED
Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children
Indiana University
NCT03352427 TERMINATED
Study of Dasatinib in Combination With Everolimus for Children and Young Adults With Gliomas Harboring Platelet-Derived Growth Factor Receptor (PDGFR) Alterations
University of Michigan Rogel Cancer Center
NCT01884740 TERMINATED
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Weill Medical College of Cornell University
NCT01609790 COMPLETED
Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors
National Cancer Institute (NCI)
NCT02663271 TERMINATED
TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma
University of Florida
NCT02330562 COMPLETED
Stage 1: Marizomib + Bevacizumab in WHO Gr IV GBM; Stage 2: Marizomib Alone; Stage 3: Combination of Marizomib and Bevacizumab
Celgene
NCT01434602 COMPLETED
Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas
National Cancer Institute (NCI)
NCT02794883 COMPLETED
Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma
Northwestern University
NCT01004874 COMPLETED
Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma
Duke University
NCT02750891 COMPLETED
A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas
Sumitomo Pharma Co., Ltd.
NCT01012609 COMPLETED
External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas
Memorial Sloan Kettering Cancer Center
NCT03566199 COMPLETED
MTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Sabine Mueller, MD, PhD
NCT03234309 WITHDRAWN
Ferumoxytol in Magnetic Resonance Imaging of Pediatric Patients With Brain Tumors
OHSU Knight Cancer Institute
NCT01189266 COMPLETED
Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma
National Cancer Institute (NCI)
NCT02844439 COMPLETED
Study of Tesevatinib Monotherapy in Patients With Recurrent Glioblastoma
Kadmon Corporation, LLC
NCT00871923 COMPLETED
Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer
M.D. Anderson Cancer Center
NCT01110876 TERMINATED
Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)
M.D. Anderson Cancer Center
NCT00879437 COMPLETED
Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma
Baylor College of Medicine
NCT01051557 COMPLETED
Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma
National Cancer Institute (NCI)
NCT02798406 COMPLETED
Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects
DNAtrix, Inc.
NCT01520870 COMPLETED
Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT.
Grupo Español de Investigación en Neurooncología
NCT02743078 TERMINATED
Optune® Plus Bevacizumab in Bevacizumab-Refractory Recurrent Glioblastoma
RTOG Foundation, Inc.
NCT02260531 COMPLETED
Cabozantinib +/- Trastuzumab In Breast Cancer Patients w/ Brain Metastases
Dana-Farber Cancer Institute
NCT02481960 TERMINATED
Study of Intraparenchymal Therapy With Irinotecan Drug Eluting Beads as Adjunct to Recurrent Surgically Resectable High Grade Glioma
Boston Scientific Corporation
NCT02805179 COMPLETED
A Study of High-Dose Chemoradiation Using Biologically-Based Target Volume Definition in Patients With Glioblastoma
University of Michigan Rogel Cancer Center
NCT02273739 COMPLETED
Study of Orally Administered Enasidenib (AG-221) in Adults With Advanced Solid Tumors, Including Glioma, or Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation
Celgene
NCT02758366 TERMINATED
Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma
Meyer Children's Hospital IRCCS
NCT01125046 COMPLETED
Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas
Northwestern University
NCT01024907 COMPLETED
Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas
Abramson Cancer Center at Penn Medicine
NCT02197637 COMPLETED
Phase II Trial of Oral Vinorelbine in Children With Recurrent or Progressive Unresectable Low-Grade Glioma
Centre Oscar Lambret
NCT02607124 TERMINATED
A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy
Children's Hospital Medical Center, Cincinnati
NCT01635283 COMPLETED
Vaccine for Patients With Newly Diagnosed or Recurrent Low-Grade Glioma
Jonsson Comprehensive Cancer Center
NCT00883688 COMPLETED
Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma
M.D. Anderson Cancer Center
NCT01390948 COMPLETED
A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma
Hoffmann-La Roche
NCT02540161 COMPLETED
Phase 2 Study of Sym004 for Adult Patients With Recurrent Glioblastoma
Annick Desjardins
NCT02575261 WITHDRAWN
CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
Fuda Cancer Hospital, Guangzhou
NCT03252171 WITHDRAWN
CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients
Fuda Cancer Hospital, Guangzhou
NCT04406610 WITHDRAWN
CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients
Fuda Cancer Hospital, Guangzhou
NCT00795665 COMPLETED
Bevacizumab and Carmustine in Treating Patients With Relapsed or Progressive High-Grade Glioma
University of California, Davis
NCT01140568 COMPLETED
Study of Platelet Derived Growth Factor Receptor (PDGFR) in Recurrent Malignant Gliomas
David Piccioni, M.D., Ph.D
NCT02855086 TERMINATED
Cetuximab-IRDye 800CW in Detecting Tumors in Patients With Malignant Glioma Undergoing Surgery
Eben Rosenthal
NCT01067469 COMPLETED
Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)
M.D. Anderson Cancer Center
NCT00763750 COMPLETED
PPX, Temozolomide, and Concurrent Radiation for Newly Diagnosed Brain Tumors
howard safran
NCT03973879 WITHDRAWN
Combination of PVSRIPO and Atezolizumab for Adults With Recurrent Malignant Glioma
Darell Bigner
NCT01158651 COMPLETED
Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas
University of Alabama at Birmingham
NCT02754362 WITHDRAWN
A Toll-like Receptor Agonist as an Adjuvant to Tumor Associated Antigens (TAA) Mixed With Montanide ISA-51 VG With Bevacizumab for Patients With Recurrent Glioblastoma
NYU Langone Health
NCT02496741 COMPLETED
Metformin And Chloroquine in IDH1/2-mutated Solid Tumors
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT02541370 COMPLETED
Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
Chinese PLA General Hospital
NCT01806675 COMPLETED
18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy
Sanjiv Sam Gambhir
NCT02689336 WITHDRAWN
Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors
Washington University School of Medicine
NCT01182350 TERMINATED
Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG)
Karen D. Wright MD
NCT00900757 COMPLETED
Intravenous Palonosetron With Radiotherapy and Concomitant Temozolomide
Duke University
NCT01065805 TERMINATED
A Study to Demonstrate the Safety and Preliminary Efficacy of 18F-FLT in Patients With Solid Tumours or Lymphoma
AHS Cancer Control Alberta
NCT01454596 COMPLETED
CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII
National Cancer Institute (NCI)
NCT01966809 TERMINATED
Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas
Harry T Whelan, MD
NCT03632317 WITHDRAWN
A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With Gliomas
University of Michigan Rogel Cancer Center
NCT01580969 COMPLETED
Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma
University of Utah
NCT01514201 COMPLETED
Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas
National Cancer Institute (NCI)
NCT01403610 COMPLETED
Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab
The University of Texas Health Science Center at San Antonio
NCT01116661 TERMINATED
Safety Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Tumors of the Brain
University of California, San Francisco
NCT01497860 COMPLETED
Vinorelbine for Children With Progressive or Recurrent Low-grade Gliomas
Eugene Hwang
NCT03181581 TERMINATED
Improving Ultrasound Images in Brain Tumour Surgery With the Use of an Acoustic Coupling Fluid Mimicking Brain Tissue.
St. Olavs Hospital
NCT01044966 TERMINATED
A Study of Intraventricular Liposomal Encapsulated Ara-C (DepoCyt) in Patients With Recurrent Glioblastoma
Medical University of South Carolina
NCT01977677 COMPLETED
Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma
Lawrence Recht
NCT02253212 COMPLETED
Safety of BBB Opening With the SonoCloud
Assistance Publique - Hôpitaux de Paris
NCT00782626 COMPLETED
Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas
Dana-Farber Cancer Institute
NCT00679354 COMPLETED
Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy
National Cancer Institute (NCI)
NCT01266031 COMPLETED
Phase I/II Adaptive Randomized Trial of Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent Glioblastoma
National Cancer Institute (NCI)
NCT01575275 TERMINATED
Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme
Michael Vogelbaum, MD, PhD
NCT01229644 TERMINATED
Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult Gliomas
Arog Pharmaceuticals, Inc.
NCT01450826 COMPLETED
Emend and Ondansetron Compared to Ondansetron Alone to Prevent CINV in Glioma Patients Receiving Temozolomide
Katy Peters
NCT01648348 COMPLETED
Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme
National Cancer Institute (NCI)
NCT00782756 COMPLETED
Bevacizumab, Temozolomide and Hypofractionated Radiotherapy for Patients With Newly Diagnosed Malignant Glioma
Memorial Sloan Kettering Cancer Center
NCT02971319 COMPLETED
Technical Performance Assessment of Tc-99m Tetrofosmin for Differentiation of Recurrence vs Radiation Necrosis in Patients With Glioma
Proactina S.A.
NCT01740570 WITHDRAWN
Phase I/II Cabazitaxel for Recurrent Malignant Glioma
M.D. Anderson Cancer Center
NCT02348255 WITHDRAWN
NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma Multiforme in First Relapse
University of California, Davis
NCT01753713 COMPLETED
Dovitinib in Treating Patients With Recurrent or Progressive Glioblastoma
Manmeet Ahluwalia, MD
NCT02987010 WITHDRAWN
Phase 2 Study of IDH305 in Low Grade Gliomas
University of Texas Southwestern Medical Center
NCT00980343 COMPLETED
GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery
National Cancer Institute (NCI)
NCT00727506 COMPLETED
BIBW 2992 (Afatinib) With or Without Daily Temozolomide in the Treatment of Patients With Recurrent Malignant Glioma
Boehringer Ingelheim
NCT00540722 COMPLETED
Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
National Cancer Institute (NCI)
NCT01465347 COMPLETED
Safety and Efficacy of Trans Sodium Crocetinate (TSC) With Radiation and Temozolomide in Newly Diagnosed Glioblastoma
Diffusion Pharmaceuticals Inc
NCT00823797 COMPLETED
Bendamustine Hydrochloride in Treating Patients With Recurrent or Progressive Anaplastic Glioma
University of Washington
NCT01413438 WITHDRAWN
Bevacizumab With or Without Surgery for Adult Glioblastomas
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00638963 TERMINATED
Temozolomide as a Prophylaxis Against Brain Recurrence in Participants With Metastatic Breast Cancer (P05225 AM2)
Merck Sharp & Dohme LLC
NCT01122901 TERMINATED
Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma
National Cancer Institute (NCI)
NCT01125800 COMPLETED
A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB
Novartis Pharmaceuticals
NCT00859222 COMPLETED
LBH589 and Bevacizumab in Patients With Recurrent High Grade Glioma
Patrick Y. Wen, MD
NCT01738646 COMPLETED
Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients
Duke University
NCT01338857 TERMINATED
Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas
NYU Langone Health
NCT01220271 COMPLETED
A Study Combining LY2157299 With Temozolomide-based Radiochemotherapy in Patients With Newly Diagnosed Malignant Glioma
Eli Lilly and Company
NCT01113463 TERMINATED
TPI 287 in Patients With Recurrent Glioblastoma Multiforme
M.D. Anderson Cancer Center
NCT01248754 COMPLETED
Positron Emission Tomography (PET) With 3,4-dihydroxy-6-18F-fluoro-L-enylalanine (18F-FDOPA) Study
Alan Nichol
NCT02047747 TERMINATED
A Phase II Study of Dacomitinib in Progressive Brain Metastases
David Piccioni, M.D., Ph.D
NCT02898012 COMPLETED
Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status
Assistance Publique - Hôpitaux de Paris
NCT01105702 TERMINATED
Temodar (Temozolomide), Bevacizumab, Lithium and Radiation for High Grade Glioma
NYU Langone Health
NCT00766467 COMPLETED
A Randomized Placebo-Controlled Trial of Armodafinil (Nuvigil) for Fatigue in Patients With Malignant Gliomas
Eudocia Quant Lee, MD
NCT02099487 COMPLETED
Hypofractionated Imrt (Vmat-Ra) For Elderly Patients With Newly Diagnosed High Grade Glioma
Istituto Clinico Humanitas
NCT01445691 WITHDRAWN
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Constantinos Hadjipanayis
NCT01351519 TERMINATED
A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors
MultiCare Health System Research Institute
NCT02521090 WITHDRAWN
EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma
Barbara Ann Karmanos Cancer Institute
NCT01189240 TERMINATED
RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma
National Cancer Institute (NCI)
NCT00846456 COMPLETED
Safe Study of Dendritic Cell (DC) Based Therapy Targeting Tumor Stem Cells in Glioblastoma
Oslo University Hospital
NCT01462695 COMPLETED
Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma
National Cancer Institute (NCI)
NCT01777633 COMPLETED
Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Hadassah Medical Organization
NCT01582516 COMPLETED
Safety Study of Replication-competent Adenovirus (Delta-24-rgd) in Patients With Recurrent Glioblastoma
Erasmus Medical Center
NCT01386580 COMPLETED
An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.
BBB-Therapeutics B.V.
NCT00641706 COMPLETED
Vorinostat and Bortezomib in Treating Patients With Progressive, Recurrent Glioblastoma Multiforme
National Cancer Institute (NCI)
NCT00636805 TERMINATED
Aloxi for Prevention of Chemotherapy Induced Nausea and Vomiting in Malignant Glioma Patients Receiving Irinotecan With Bevacizumab
Duke University
NCT01778088 WITHDRAWN
Open-Label Study of I-131-CLR1404 in Subjects With Recurrent Glioma
Cellectar Biosciences, Inc.
NCT01400958 TERMINATED
Nuvigil or Placebo in Newly Diagnosed Malignant Glioma
H. Lee Moffitt Cancer Center and Research Institute
NCT00919737 COMPLETED
Study of NPC-08 is to Treat for Newly-Diagnosed Malignant Glioma and Recurrent Glioblastoma Multiforme
Nobelpharma
NCT00953121 COMPLETED
Bevacizumab Plus Irinotecan Plus Carboplatin for Recurrent Malignant Glioma (MG)
Annick Desjardins
NCT01205334 TERMINATED
Administration of CMV-Specific Cytotoxic T Cells in Patients With Glioblastoma Multiforme
Baylor College of Medicine
NCT01369121 TERMINATED
Tolerability Study of Xerecept® in Pediatric Patients
Celtic Pharma Development Services
NCT00717197 COMPLETED
Study of Capecitabine to Treat Recurrent High Grade Gliomas
University of Florida
NCT00870181 COMPLETED
ADV-TK Improves Outcome of Recurrent High-Grade Glioma
Huazhong University of Science and Technology
NCT00939991 COMPLETED
Suberoylanilide Hydroxamic Acid (SAHA), Bevacizumab, Daily Temozolomide for Recurrent Malignant Gliomas
Katy Peters
NCT01095094 TERMINATED
Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma
Case Comprehensive Cancer Center
NCT00735436 TERMINATED
A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)
Duke University
NCT00624728 COMPLETED
Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP)
University Hospital, Bordeaux
NCT06673329 RECRUITING
Brodalumab in the Treatment of Immune-Related Adverse Events
Brian Henick, MD
NCT02359565 ACTIVE NOT RECRUITING
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
National Cancer Institute (NCI)
NCT07422363 NOT YET RECRUITING
Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma
National Cancer Institute (NCI)
NCT05538130 RECRUITING
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
Pfizer
NCT02192359 ACTIVE NOT RECRUITING
Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas
City of Hope Medical Center
NCT06964737 RECRUITING
Anti-GARP Chimeric Antigen Receptor T Cell Therapy for the Treatment of Recurrent Grade III or IV Gliomas
Ohio State University Comprehensive Cancer Center
NCT05565118 RECRUITING
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
Case Comprehensive Cancer Center
NCT07441707 RECRUITING
A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain Tumours
Ipsen
NCT05293197 RECRUITING
Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients
Assistance Publique - Hôpitaux de Paris
NCT06894979 RECRUITING
Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma
Children's Oncology Group
NCT05355701 RECRUITING
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
Pfizer
NCT07076498 RECRUITING
Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation
M.D. Anderson Cancer Center
NCT05835687 RECRUITING
Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors
St. Jude Children's Research Hospital
NCT06410248 RECRUITING
Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma
Northwestern University
NCT03465618 ACTIVE NOT RECRUITING
A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT07464925 RECRUITING
A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma
Tetragon Biosciences Ltd
NCT05283109 ACTIVE NOT RECRUITING
ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM
Mustafa Khasraw, MBChB, MD, FRCP, FRACP
NCT04540107 RECRUITING
Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma
Susan Chang
NCT04837547 ACTIVE NOT RECRUITING
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
University of Florida
NCT04099797 RECRUITING
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Baylor College of Medicine
NCT03011671 ACTIVE NOT RECRUITING
Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma
University of Chicago
NCT04573140 RECRUITING
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
University of Florida
NCT07551336 RECRUITING
Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma
Beijing Biotech
NCT03170141 ENROLLING BY INVITATION
Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
Shenzhen Geno-Immune Medical Institute
NCT05030298 RECRUITING
Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial
Mayo Clinic
NCT04521686 ACTIVE NOT RECRUITING
Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations
Eli Lilly and Company
NCT04689048 RECRUITING
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Baptist Health South Florida
NCT07541781 NOT YET RECRUITING
Sitagliptin in Recurrent/Progressive Grade 4 Glioma
Kailin Yang, MD, PhD
NCT06326411 RECRUITING
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
Nested Therapeutics, Inc
NCT05698524 RECRUITING
A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma
University of Nebraska
NCT06126744 RECRUITING
Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252
Duke University
NCT03911388 RECRUITING
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
M.D. Anderson Cancer Center
NCT04185038 RECRUITING
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Seattle Children's Hospital
NCT06344130 RECRUITING
Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
National Cancer Institute (NCI)
NCT04978727 ACTIVE NOT RECRUITING
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Children's Oncology Group
NCT05521984 RECRUITING
Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)
Washington University School of Medicine
NCT05478837 ACTIVE NOT RECRUITING
Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma
University of California, San Francisco
NCT03605550 ACTIVE NOT RECRUITING
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Nationwide Children's Hospital
NCT06482905 RECRUITING
Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.
Tcelltech Inc.
NCT05413304 ACTIVE NOT RECRUITING
Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis
National Cancer Institute (NCI)
NCT02852655 ACTIVE NOT RECRUITING
A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, Pembrolizumab (MK-3475), In Patients With Surgically Accessible Recurrent/Progressive Glioblastoma
Dana-Farber Cancer Institute
NCT07481721 NOT YET RECRUITING
IL13Rα2 CAR-T Cells Secreting Anti-PD-L1 Antibody for Recurrent Malignant Glioma
Ming Yang
NCT03478462 ACTIVE NOT RECRUITING
Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas
Cellectar Biosciences, Inc.
NCT07480941 RECRUITING
Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma
Beijing Biotech
NCT05610891 ACTIVE NOT RECRUITING
Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG
Cellectar Biosciences, Inc.
NCT05916313 ACTIVE NOT RECRUITING
A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3
Boehringer Ingelheim
NCT04943848 RECRUITING
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Ann & Robert H Lurie Children's Hospital of Chicago
NCT04732065 RECRUITING
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
Sabine Mueller, MD, PhD
NCT07472790 NOT YET RECRUITING
A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Glioma
Beijing Bio-Targeting Therapeutics Technology Co., Ltd
NCT03749187 ACTIVE NOT RECRUITING
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas
University of California, San Francisco
NCT06946680 ACTIVE NOT RECRUITING
IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Pediatric High-grade Glioma (HGG)
University of Florida
NCT06914479 RECRUITING
Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors
University of Michigan Rogel Cancer Center
NCT06193759 RECRUITING
Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)
Children's National Research Institute
NCT07457307 NOT YET RECRUITING
Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac
NYU Langone Health
NCT02389309 ACTIVE NOT RECRUITING
Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors
M.D. Anderson Cancer Center
NCT07455045 NOT YET RECRUITING
A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
NCT03896568 RECRUITING
MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma
M.D. Anderson Cancer Center
NCT04510051 RECRUITING
CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children
City of Hope Medical Center
NCT03152318 ACTIVE NOT RECRUITING
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
Dana-Farber Cancer Institute
NCT07438860 NOT YET RECRUITING
Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG
Tiffany Hodges
NCT06104488 RECRUITING
A Study of Avutometinib for People With Solid Tumor Cancers
Memorial Sloan Kettering Cancer Center
NCT03514069 ACTIVE NOT RECRUITING
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma
Case Comprehensive Cancer Center
NCT06342908 ACTIVE NOT RECRUITING
A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma
Jonsson Comprehensive Cancer Center
NCT06650163 RECRUITING
Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors
Jonsson Comprehensive Cancer Center
NCT04459273 ACTIVE NOT RECRUITING
Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers
Jonsson Comprehensive Cancer Center
NCT03030066 ACTIVE NOT RECRUITING
Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas
Daiichi Sankyo
NCT03389230 ACTIVE NOT RECRUITING
Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma
City of Hope Medical Center
NCT07087002 RECRUITING
GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults
Stanford University
NCT04196413 RECRUITING
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)
Stanford University
NCT06357377 NOT YET RECRUITING
A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors
Neonc Technologies, Inc.
NCT03830151 RECRUITING
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
M.D. Anderson Cancer Center
NCT07331064 NOT YET RECRUITING
Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor
Sarah Rumler
NCT05106296 RECRUITING
Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer
Theodore S. Johnson
NCT06724926 ACTIVE NOT RECRUITING
Concurrent Azeliragon With Craniospinal Irradiation
NYU Langone Health
NCT07306299 RECRUITING
A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT04165941 ACTIVE NOT RECRUITING
Novel Gamma-Delta (γδ)T Cell Therapy for Treatment of Patients With Newly Diagnosed Glioblastoma
University of Alabama at Birmingham
NCT07031765 ACTIVE NOT RECRUITING
Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma
University of Florida
NCT04541082 RECRUITING
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Jazz Pharmaceuticals
NCT03500991 ACTIVE NOT RECRUITING
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors
Seattle Children's Hospital
NCT05686798 RECRUITING
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
Henry Ford Health System
NCT07254845 NOT YET RECRUITING
A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS
VPIX Medical
NCT05768880 ACTIVE NOT RECRUITING
Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors
Seattle Children's Hospital
NCT07223034 RECRUITING
A Study of 177Lu-PSMA-617 in People With Gliomas
Memorial Sloan Kettering Cancer Center
NCT04214392 ACTIVE NOT RECRUITING
Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma
City of Hope Medical Center
NCT06169280 RECRUITING
Repeated Neural Stem Cell Based Virotherapy for Newly Diagnosed High Grade Glioma
Northwestern University
NCT04794972 RECRUITING
A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory or Metastatic Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT04772456 RECRUITING
Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas
University of Maryland, Baltimore
NCT04808245 ACTIVE NOT RECRUITING
A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
German Cancer Research Center
NCT07179328 RECRUITING
Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy
Sunnybrook Health Sciences Centre
NCT02442297 ACTIVE NOT RECRUITING
T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors
Baylor College of Medicine
NCT02208362 ACTIVE NOT RECRUITING
Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
City of Hope Medical Center
NCT06455189 NOT YET RECRUITING
Magnetic Resonance Fingerprinting Guided Extended Resection in Glioblastomas
Case Comprehensive Cancer Center
NCT07118176 RECRUITING
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
Jonsson Comprehensive Cancer Center
NCT06624371 RECRUITING
Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
Emory University
NCT05609994 RECRUITING
ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas
Katy Peters, MD, PhD
NCT05857969 RECRUITING
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Florida International University
NCT03299309 ACTIVE NOT RECRUITING
PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma
Daniel Landi
NCT06773481 RECRUITING
BC008-1A Injection for Recurrent CNS WHO G4 Glioma
Sichuan Luzhou Buchang Biopharmaceutical Co., Ltd.
NCT06896110 ENROLLING BY INVITATION
Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma
Andrew P. Groves
NCT05226494 RECRUITING
Safety and Tolerability of Fb-PMT in Recurrent Glioblastoma
NanoPharmaceuticals LLC
NCT06807619 RECRUITING
A Study of Sotorasib in People With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT06048094 RECRUITING
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Baptist Health South Florida
NCT04254419 RECRUITING
Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells
Nationwide Children's Hospital
NCT04547777 RECRUITING
Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma
Darell Bigner
NCT04323046 RECRUITING
Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults
Sabine Mueller, MD, PhD
NCT03652545 ACTIVE NOT RECRUITING
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Catherine Bollard
NCT06632236 RECRUITING
5G-EMERALD: Amivantamab in Malignant Brain Tumours
Institute of Cancer Research, United Kingdom
NCT03598244 ACTIVE NOT RECRUITING
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
National Cancer Institute (NCI)
NCT06221553 RECRUITING
Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
Chulalongkorn University
NCT05460507 RECRUITING
Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment
Plus Therapeutics
NCT06867978 NOT YET RECRUITING
Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.
VPIX Medical
NCT05298995 RECRUITING
GD2-CAR T Cells for Pediatric Brain Tumours
Bambino Gesù Hospital and Research Institute
NCT06737146 NOT YET RECRUITING
Study of MT027 in Patients with Recurrent or Progressive High-grade Glioma
Suzhou Maximum Bio-tech Co., Ltd.
NCT05561374 ACTIVE NOT RECRUITING
Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma
Oblato, Inc.
NCT06585527 RECRUITING
Clinical Study on the Safety and Efficacy of TS-2021 in the Treatment of Recurrent Malignant Glioma
Beijing Neurosurgical Institute
NCT04842812 RECRUITING
Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors
Second Affiliated Hospital of Guangzhou Medical University
NCT06305910 RECRUITING
CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
OX2 Therapeutics
NCT05717699 RECRUITING
Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
Capital Medical University
NCT05717712 RECRUITING
Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
Capital Medical University
NCT05363826 RECRUITING
Intracavitary Photodynamic Therapy as an Adjuvant to Resection of Glioblastoma or Gliosarcoma Using IV Photobac®
Photolitec LLC
NCT06860594 SUSPENDED
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
National Cancer Institute (NCI)
NCT05887882 SUSPENDED
Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors
Sabine Mueller, MD, PhD
NCT03334305 TERMINATED
Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas
University of Florida
NCT04485559 SUSPENDED
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
University of California, San Francisco
NCT02115074 COMPLETED
Safety of Fluvastatin-Celebrex Association in Low-grade and High Grade Optico-chiasmatic Gliomas
Centre Oscar Lambret
NCT01165333 COMPLETED
Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma
Centre Oscar Lambret
NCT03343197 COMPLETED
Study of AG-120 and AG-881 in Subjects With Low Grade Glioma
Institut de Recherches Internationales Servier
NCT02481154 COMPLETED
Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation
Institut de Recherches Internationales Servier
NCT02073994 COMPLETED
Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation
Institut de Recherches Internationales Servier
NCT02909777 COMPLETED
Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma
Dana-Farber Cancer Institute
NCT04309552 SUSPENDED
Tumor Hypoxia and Proliferation in Patients With High-Grade Glioma
Weill Medical College of Cornell University
NCT03262636 COMPLETED
Two-Part Study to Evaluate the Safety and Efficacy of Image Guided Surgery Using Indocyanine Green for Intramolecular Imaging of Nervous System Tumors Compared to Standard of Care, (TumorGlow)
University of Pennsylvania
NCT06193174 TERMINATED
Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)
University of Alabama at Birmingham
NCT04295759 COMPLETED
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas
Pediatric Brain Tumor Consortium
NCT03638167 COMPLETED
EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors
Seattle Children's Hospital
NCT06806228 SUSPENDED
Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status)
Petrov, Andrey
NCT03396575 TERMINATED
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
University of Florida
NCT03426891 COMPLETED
Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma
H. Lee Moffitt Cancer Center and Research Institute
NCT06468605 WITHDRAWN
Safety, Tolerability and Efficacy of JCXH-211 in Patients With Recurrent or Progressive High-Grade Glioma
Duke University
NCT06501911 WITHDRAWN
A Study of Bicalutamide With Brain Re-irradiation to Treat Recurrent/Progressive High Grade Glioma
University of Nebraska
NCT04239092 TERMINATED
9-ING-41 in Pediatric Patients With Refractory Malignancies.
Actuate Therapeutics Inc.
NCT05169944 COMPLETED
Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors
University of California, San Francisco
NCT05362409 COMPLETED
Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma
Alpheus Medical, Inc.
NCT04804709 TERMINATED
Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)
Columbia University
NCT04749641 COMPLETED
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Yang Zhang
NCT02507583 COMPLETED
Antisense102: Pilot Immunotherapy for Newly Diagnosed Malignant Glioma
david andrews
NCT01324635 TERMINATED
Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT01550523 COMPLETED
Pilot Immunotherapy Trial for Recurrent Malignant Gliomas
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT02186509 COMPLETED
Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT04222309 SUSPENDED
Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)
Northwell Health
NCT02420613 COMPLETED
Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma
M.D. Anderson Cancer Center
NCT03893903 COMPLETED
AMPLIFYing NEOepitope-specific VACcine Responses in Progressive Diffuse Glioma
German Cancer Research Center
NCT05457959 WITHDRAWN
Peptide-Pulsed Dendritic Cell Vaccination in Combination With Nivolumab and Ipilimumab for the Treatment of Recurrent and/or Progressive Diffuse Hemispheric Glioma, H3 G34-mutant
Jonsson Comprehensive Cancer Center
NCT03576612 COMPLETED
GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas
Candel Therapeutics, Inc.
NCT03654716 COMPLETED
Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer
Dana-Farber Cancer Institute
NCT01638533 COMPLETED
Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction
National Cancer Institute (NCI)
NCT04023669 COMPLETED
Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors
St. Jude Children's Research Hospital
NCT02323880 COMPLETED
Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas
Children's Oncology Group
NCT04771897 TERMINATED
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Bexion Pharmaceuticals, Inc.
NCT01130077 COMPLETED
A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction with Poly-ICLC in Pediatric Gliomas
James Felker
NCT06463184 WITHDRAWN
Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG)
H. Lee Moffitt Cancer Center and Research Institute
NCT05892653 TERMINATED
A Study of ABM-1310 in Patients With BRAF V600-Mutant Relapsed and Drug Resistant Primary Malignant Brain Tumors
ABM Therapeutics Shanghai Company Limited
NCT02549833 COMPLETED
Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma
Jennie Taylor
NCT02101905 COMPLETED
Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma
National Cancer Institute (NCI)
NCT04525014 TERMINATED
RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors
EpicentRx, Inc.
NCT04521946 WITHDRAWN
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
M.D. Anderson Cancer Center
NCT03990597 WITHDRAWN
StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord
M.D. Anderson Cancer Center
NCT03936465 COMPLETED
Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitors BMS-986158 and BMS-986378 in Pediatric Cancer
Dana-Farber Cancer Institute
NCT01246869 TERMINATED
Assessment of Primary and Metastatic Brain Tumor Hypoxia With Fluoromisonidazole, FDG and Water
University of Utah
NCT01811992 COMPLETED
Combined Cytotoxic and Immune-Stimulatory Therapy for Glioma
University of Michigan Rogel Cancer Center
NCT05773664 WITHDRAWN
Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients with Glioblastoma
City of Hope Medical Center
NCT03407781 COMPLETED
IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Lower Grade Glioma
Deling Li
NCT02924038 TERMINATED
A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)
Nicholas Butowski
NCT05082493 WITHDRAWN
A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas
WPD Pharmaceuticals Sp. z o.o.
NCT03434262 COMPLETED
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
St. Jude Children's Research Hospital
NCT02717455 COMPLETED
Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma
Pediatric Brain Tumor Consortium
NCT05120960 WITHDRAWN
A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors
M.D. Anderson Cancer Center
NCT03043391 COMPLETED
Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children
Istari Oncology, Inc.
NCT04901806 TERMINATED
Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors
Pyramid Biosciences
NCT03705351 TERMINATED
Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM
Providence Health & Services
NCT04341311 TERMINATED
Phase I Study of Marizomib + Panobinostat for Children With DIPG
Dana-Farber Cancer Institute
NCT01661400 COMPLETED
Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors
Washington University School of Medicine
NCT01922076 COMPLETED
Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas
National Cancer Institute (NCI)
NCT02457845 COMPLETED
HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors
Gregory K. Friedman, MD
NCT01502917 COMPLETED
Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
Y-mAbs Therapeutics
NCT03425292 COMPLETED
A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer
Saint John's Cancer Institute
NCT02644460 COMPLETED
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Emory University
NCT02833701 TERMINATED
Bevacizumab and Ascorbic Acid in Patients Treating With Recurrent High Grade Glioma
University of Nebraska
NCT02313272 COMPLETED
Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas
H. Lee Moffitt Cancer Center and Research Institute
NCT02780804 COMPLETED
Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors
National Cancer Institute (NCI)
NCT03971734 TERMINATED
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02658981 COMPLETED
Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02659800 TERMINATED
Study of the Effect NT-I7 on CD4 Counts in Patients With High Grade Gliomas
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02575794 COMPLETED
Terameprocol in Treating Patients With Recurrent High Grade Glioma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00634231 COMPLETED
A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors
Candel Therapeutics, Inc.
NCT04608812 TERMINATED
Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection
OncoSynergy, Inc.
NCT04456140 COMPLETED
Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study
Mayo Clinic
NCT04541225 TERMINATED
Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors
Nuvation Bio Inc.
NCT02022644 COMPLETED
Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma
University of California, San Francisco
NCT02209376 TERMINATED
Autologous T Cells Redirected to EGFRVIII-With a Chimeric Antigen Receptor in Patients With EGFRVIII+ Glioblastoma
University of Pennsylvania
NCT01257594 COMPLETED
EGFR Inhibition Using Weekly Erlotinib for Recurrent Malignant Gliomas
Andrew B Lassman, MD
NCT02238496 COMPLETED
Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas
Andrew B Lassman, MD
NCT04091503 COMPLETED
Evaluate the Safety and Effectiveness of Intranasal Administration of Temozolomide in Patients With Glioblastoma
Center Trials & Treatment Europe
NCT02444546 COMPLETED
Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors
Mayo Clinic
NCT03178032 COMPLETED
Oncolytic Adenovirus, DNX-2401, for Naive Diffuse Intrinsic Pontine Gliomas
Clinica Universidad de Navarra, Universidad de Navarra
NCT03086616 COMPLETED
CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG) (PNOC 009)
Sabine Mueller, MD, PhD
NCT04089449 COMPLETED
A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas
Prelude Therapeutics
NCT04205357 COMPLETED
Sulfasalazine and Stereotactic Radiosurgery for Recurrent Glioblastoma
Haukeland University Hospital
NCT04334863 COMPLETED
WP1066 in Children With Refractory and Progressive or Recurrent Malignant Brain Tumors
Emory University
NCT03072134 COMPLETED
Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma
Northwestern University
NCT02829931 COMPLETED
Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas
H. Lee Moffitt Cancer Center and Research Institute
NCT04430842 COMPLETED
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
Quadriga Biosciences, Inc.
NCT03355794 COMPLETED
A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)
Children's Hospital Medical Center, Cincinnati
NCT04200066 WITHDRAWN
A Study of Maprotiline in Combination With Tamoxifen and Temozolomide for Recurrent Glioblastoma
University of Rochester
NCT01808820 COMPLETED
Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma
Macarena De La Fuente, MD
NCT02644291 COMPLETED
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02808416 COMPLETED
Personalized Cellular Vaccine for Brain Metastases (PERCELLVAC3)
Guangdong 999 Brain Hospital
NCT02415153 COMPLETED
Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors
National Cancer Institute (NCI)
NCT01904123 COMPLETED
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain
M.D. Anderson Cancer Center
NCT01891747 COMPLETED
A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma
Vanderbilt-Ingram Cancer Center
NCT02526017 COMPLETED
Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers
Five Prime Therapeutics, Inc.
NCT01222754 COMPLETED
Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas
National Cancer Institute (NCI)
NCT02010606 COMPLETED
Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma
Cedars-Sinai Medical Center
NCT02015819 COMPLETED
Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas
City of Hope Medical Center
NCT01058850 TERMINATED
Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic Pontine Gliomas
Paul Graham Fisher
NCT03387020 COMPLETED
Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors
Pediatric Brain Tumor Consortium
NCT00747253 COMPLETED
Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors
Monteris Medical
NCT03068832 WITHDRAWN
Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors
Washington University School of Medicine
NCT01729260 COMPLETED
Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02433392 TERMINATED
Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.
Boston Scientific Corporation
NCT02903069 COMPLETED
Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer
Celgene
NCT02255461 TERMINATED
Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors
Pediatric Brain Tumor Consortium
NCT03615404 COMPLETED
Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma
Gary Archer Ph.D.
NCT02029690 TERMINATED
Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin
Polaris Group
NCT02502708 COMPLETED
Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors
NewLink Genetics Corporation
NCT02598011 WITHDRAWN
A Study of the Safety of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Newly Diagnosed High Grade Glioma Receiving Standard of Care
Tocagen Inc.
NCT01400672 TERMINATED
Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Stem Glioma
Masonic Cancer Center, University of Minnesota
NCT02978261 COMPLETED
Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas
Beijing Pearl Biotechnology Limited Liability Company
NCT00994071 COMPLETED
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors
National Cancer Institute (NCI)
NCT01392209 COMPLETED
Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma
Memorial Sloan Kettering Cancer Center
NCT02045368 COMPLETED
Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
IGF Oncology, LLC
NCT02272270 COMPLETED
Phase I Newly Diagnosed GBM With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide (D-TERMINED)
University of Utah
NCT01020292 COMPLETED
A Trial of the Protease Inhibitor Nelfinavir and Concurrent Radiation and Temozolomide in Patients With WHO Grade IV Glioma
Abramson Cancer Center at Penn Medicine
NCT02105233 COMPLETED
Improving Ultrasound Images in Brain Tumor Surgery With the Use of Brain Mimicking Fluid
St. Olavs Hospital
NCT01688401 COMPLETED
Intra-arterial Chemotherapy for the Treatment of Progressive Diffuse Intrinsic Pontine Gliomas (DIPG).
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT01644773 COMPLETED
Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
St. Jude Children's Research Hospital
NCT02458339 COMPLETED
Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors
The University of Texas Health Science Center, Houston
NCT01682746 COMPLETED
Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors
Harry T Whelan, MD
NCT02454634 COMPLETED
Phase I Trial of IDH1 Peptide Vaccine in IDH1R132H-mutated Grade III-IV Gliomas
National Center for Tumor Diseases, Heidelberg
NCT01967758 COMPLETED
Phase I Study of Safety and Immunogenicity of ADU-623
Providence Health & Services
NCT02176720 TERMINATED
Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
The Methodist Hospital Research Institute
NCT01103375 TERMINATED
Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant Glioma
Wake Forest University Health Sciences
NCT00805376 COMPLETED
DNX-2401 (Formerly Known as Delta-24-RGD-4C) for Recurrent Malignant Gliomas
DNAtrix, Inc.
NCT00880061 TERMINATED
An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-grade Glioma
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01644955 COMPLETED
Carboplatin in Treating Patients With Recurrent High-Grade Gliomas
James Elder
NCT00628940 COMPLETED
PET Imaging of High-grade Glioma Using 18F-fluoromethylcholine: a Tool for the Early Detection of Tumour Recurrence After Combined Radiochemotherapy?
University Ghent
NCT02305056 TERMINATED
Study of Tumor Metabolism by Isotopic Tagging in Patients With High-grade Glioma (CARBONOMIC)
University Hospital, Grenoble
NCT01234740 COMPLETED
Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases
City of Hope Medical Center
NCT01171469 COMPLETED
Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor
Masonic Cancer Center, University of Minnesota
NCT02122822 COMPLETED
Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
Cure&Sure Biotech Co., LTD
NCT01339039 TERMINATED
Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma
Patrick Y. Wen, MD
NCT01172964 COMPLETED
A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas
City of Hope Medical Center
NCT00946673 COMPLETED
Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer
Stanford University
NCT01130623 WITHDRAWN
A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors
National Cancer Institute (NCI)
NCT01182883 WITHDRAWN
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors
National Cancer Institute (NCI)
NCT00694330 COMPLETED
Vaccination With Lethally Irradiated Glioma Cells Mixed With GM-K562 Cells in Patients Undergoing Craniotomy For Recurrent Tumor
Massachusetts General Hospital
NCT01393912 COMPLETED
PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma
St. Jude Children's Research Hospital
NCT01792505 COMPLETED
Dendritic Cell Vaccine With Imiquimod for Patients With Malignant Glioma
Cedars-Sinai Medical Center
NCT01902771 TERMINATED
Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors
Edward Ziga
NCT01250470 COMPLETED
Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma
Roswell Park Cancer Institute
NCT01148966 TERMINATED
Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors
University of Washington
NCT01502605 TERMINATED
Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02371031 TERMINATED
FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas
Washington University School of Medicine
NCT01999270 COMPLETED
Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors
Washington University School of Medicine
NCT01522820 COMPLETED
Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors
Roswell Park Cancer Institute
NCT02861222 COMPLETED
Myocet® in Children With Relapsed or Refractory Non-brainstem Malignant Glioma
Central Hospital, Nancy, France
NCT01989052 TERMINATED
Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma
Annick Desjardins
NCT01144247 COMPLETED
Cellular Immunotherapy Study for Brain Cancer
Jonsson Comprehensive Cancer Center
NCT01639612 COMPLETED
Pilot Study of Bone Marrow/Stem Cells in Grade IV Malignant Glioma
Henry Friedman
NCT02234297 COMPLETED
Safety Study of BLZ-100 in Adult Subjects With Glioma Undergoing Surgery
Blaze Bioscience Inc.
NCT01954030 TERMINATED
Phase 1/2 CTO + Bevacizumab for Recurrent Glioma Post-Bevacizumab Failure
Annick Desjardins
NCT01119599 COMPLETED
RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma
National Cancer Institute (NCI)
NCT01111097 COMPLETED
Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors
University of Florida
NCT01598454 COMPLETED
Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides
Laboratorio Elea Phoenix S.A.
NCT01082926 COMPLETED
Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2
City of Hope Medical Center
NCT01861990 WITHDRAWN
Valproic Acid in Childhood Progressive Brain Tumors
Medical University of South Carolina
NCT01122888 TERMINATED
Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or Glioblastoma Multiforme
National Cancer Institute (NCI)
NCT00979862 COMPLETED
Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma
National Cancer Institute (NCI)
NCT00996723 COMPLETED
Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)
St. Jude Children's Research Hospital
NCT01131234 COMPLETED
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
National Cancer Institute (NCI)
NCT01378481 TERMINATED
High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating Patients With Recurrent Glioma
National Cancer Institute (NCI)
NCT01088763 TERMINATED
Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia
National Cancer Institute (NCI)
NCT00946335 COMPLETED
ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors
National Cancer Institute (NCI)
NCT00650923 COMPLETED
Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
National Cancer Institute (NCI)
NCT00929903 COMPLETED
Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment
National Cancer Institute (NCI)
NCT00994500 COMPLETED
Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma
National Cancer Institute (NCI)
NCT01076530 COMPLETED
Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors
National Cancer Institute (NCI)
NCT01269411 TERMINATED
RO4929097 in Treating Patients With Recurrent Invasive Gliomas
National Cancer Institute (NCI)
NCT00734864 WITHDRAWN
Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma
Annick Desjardins
NCT00826930 TERMINATED
Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma
Diffusion Pharmaceuticals Inc
NCT00909558 SUSPENDED
Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on Cancer
Envita Medical Center, Inc.
NCT07486713 RECRUITING
Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies
Rigel Pharmaceuticals
NCT07225101 RECRUITING
Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures
University of Michigan
NCT07049094 RECRUITING
The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy
Zhejiang University
NCT05926336 RECRUITING
The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
Kaohsiung Medical University Chung-Ho Memorial Hospital
NCT06625047 COMPLETED
Comparing Telehealth and In-person Assessments in Glioma Patients Receiving Oral Chemotherapy
Mayo Clinic
NCT04266665 COMPLETED
Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome
Georgia Tsaousi
NCT04650204 TERMINATED
Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy
Mayo Clinic
NCT02334722 COMPLETED
1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients
University of Florida
NCT02964416 COMPLETED
Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery
Aga Khan University
NCT02193568 COMPLETED
Light Sedation or Intubated General Anesthesia in Patients With Brain Cancer Undergoing Craniotomy
Ohio State University Comprehensive Cancer Center
NCT02363933 COMPLETED
Perampanel in Seizure Patients With Primary Glial Brain Tumors
Duke University
NCT03318471 COMPLETED
Magnesium Sulphate for Attenuation of Hemodynamic Pressor Response After Myfield's Clamp Application
El-Sahel Teaching Hospital
NCT02034708 COMPLETED
Efficacy Evaluation of Dotarem®-Enhanced MRI Compared to Gadovist®/Gadavist®-Enhanced MRI in the Diagnosis of Brain Tumors
Guerbet
NCT02558569 COMPLETED
The Use of Fentanyl in General Anesthesia for Craniotomy With or Without 0.5% Levobupivacaine Scalp Block
Mahidol University
NCT02708056 COMPLETED
Sugammadex Given for the Reversal of Rocuronium Induced Neuromuscular Blockade Under Sevoflurane Anesthesia in Infants
Baskent University
NCT00952081 COMPLETED
A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients
NYU Langone Health
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