Cirrhosis Clinical Trial Landscape
Data updated: May 20, 2026
351 clinical trials tracked since 2008
Cirrhosis is being studied across 351 clinical trials registered since 2008, with 85 programs currently active. The competitive pipeline includes 24 active Phase 3 trials, 34 active Phase 2 trials, and 19 active Phase 1 trials. Top industry sponsors include Yaqrit Ltd, Gilead, AstraZeneca.
85 active
/
351 total (since 2008)
19
Phase 1 Active
73 total
34
Phase 2 Active
153 total
24
Phase 3 Active
99 total
19
Phase 4 Active
72 total
Top Industry Sponsors
Sorted by active Active Done Failed
Yaqrit Ltd 2 0 0
Gilead 1 3 2
AstraZeneca 1 3 1
Boehringer Ingelheim 1 2 1
Noorik Biopharmaceuticals AG 1 0 1
+ 10 more sponsors — see full table below
Featured Phase 3 Trials
NCT03301506 ACTIVE NOT RECRUITING
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
Gilead Sciences n=340
NCT04526665 ACTIVE NOT RECRUITING
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
Ipsen n=161
NCT06461208 RECRUITING
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
King's College London n=300
NCT05056220 RECRUITING
Personalized Long-term Human Albumin Treatment in Patients With Decompensated Cirrhosis and Ascites
Aleksander Krag n=240
NCT03654053 ACTIVE NOT RECRUITING
Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis
VA Office of Research and Development n=142
+ 94 more Phase 3 trials — see full database below
Cirrhosis — Trials Started by Year (last 10 years)
2016 17
2017 20
2018 24
2019 14
2020 15
2021 22
2022 14
2023 23
2024 28
2025 17
2026 13
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
Yaqrit Ltd 2
Gilead 6
AstraZeneca 5
Boehringer Ingelheim 4
Noorik Biopharmaceuticals AG 2
Zydus Therapeutics Inc. 2
Madrigal Pharmaceuticals, Inc. 2
Pharmicell Co., Ltd. 2
Ipsen 1
Shanghai Huicun Medical Technology Co., Ltd. 1
Active Trials by Phase
Phase 1 19
Phase 2 34
Phase 3 24
Phase 4 19
Enrollment Size Distribution
1-50 164
51-200 122
201-500 39
501-1k 8
1k+ 2
All Industry Sponsors
Sorted by active Active Done Failed
Yaqrit Ltd 2 0 0
Gilead 1 3 2
AstraZeneca 1 3 1
Boehringer Ingelheim 1 2 1
Noorik Biopharmaceuticals AG 1 0 1
Zydus Therapeutics Inc. 1 1 0
Madrigal Pharmaceuticals, Inc. 1 1 0
Pharmicell Co., Ltd. 1 1 0
Ipsen 1 0 0
Shanghai Huicun Medical Technology Co., Ltd. 1 0 0
PharmaIN 1 0 0
Vir Biotechnology, Inc. 1 0 0
Can-Fite BioPharma 1 0 0
Asia Cell Therapeutics (Shanghai) Co., Ltd. 1 0 0
AbbVie 0 8 0
NCT03301506 ACTIVE NOT RECRUITING
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
Gilead Sciences n=340
NCT04526665 ACTIVE NOT RECRUITING
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
Ipsen n=161
NCT07347275 NOT YET RECRUITING
A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.
Yaqrit Ltd n=72
NCT07529262 NOT YET RECRUITING
Can Aspirin Reduce the Risk of HCC in Cirrhosis: The AspiRe HCC Trial
Curtin University n=890
NCT06461208 RECRUITING
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
King's College London n=300
NCT07395141 NOT YET RECRUITING
Albumin in Acute Variceal Bleeding
King George's Medical University n=60
NCT05056220 RECRUITING
Personalized Long-term Human Albumin Treatment in Patients With Decompensated Cirrhosis and Ascites
Aleksander Krag n=240
NCT03654053 ACTIVE NOT RECRUITING
Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis
VA Office of Research and Development n=142
NCT06007846 RECRUITING
A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer
Inova Health Care Services n=12
NCT06121479 ENROLLING BY INVITATION
Oral Branched-chain Amino Acid Supplementation for Decompensated Cirrhotic Patients
Mahidol University n=30
NCT06121492 ENROLLING BY INVITATION
Oral Branched-chain Amino Acid Supplementation for Cirrhotic Patients With Sarcopenia
Mahidol University n=86
NCT03633279 ACTIVE NOT RECRUITING
Treatment of Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child C
Dayanand Medical College and Hospital n=96
NCT05500222 ACTIVE NOT RECRUITING
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
Madrigal Pharmaceuticals, Inc. n=700
NCT06263816 NOT YET RECRUITING
Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial
University Hospital, Tours n=290
NCT05201404 RECRUITING
Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis
Can-Fite BioPharma n=471
NCT02984124 ACTIVE NOT RECRUITING
Communication During Hospitalization About Resuscitation Trial
University of Vermont n=182
NCT06814626 RECRUITING
Role of Nutritional Intervention for the Treatment of Sarcopenia in Cirrhotic Patients with Refractory Ascites Candidate to Transjugular Intrahepatic Portosystemic Shunt Placement and Identification of Prognostic Factors Related to Clinical Outcome
The Mediterranean Institute for Transplantation and Advanced Specialized Therapies n=72
NCT06818279 NOT YET RECRUITING
Compare the Efficacy and Safety of Dabigatran and Enoxaparin in Patients With Portal Vein Thrombosis With Cirrhosis
Institute of Liver and Biliary Sciences, India n=120
NCT04932577 RECRUITING
Faecal Microbiota Transplantation for Liver Cirrhosis
University of Aarhus n=220
NCT05769868 RECRUITING
Efficacy of Esmolol in the Identification of Cardiovascular Disorders by Cirrhosis, Diabetes Mellitus and Cardiotoxic Treatments
Consorcio Centro de Investigación Biomédica en Red (CIBER) n=1,000
NCT06533852 NOT YET RECRUITING
Fecal Microbiome Transplantation in Cirrhosis: Trial in Patients With Decompensated Cirrhosis
Consorcio Centro de Investigación Biomédica en Red (CIBER) n=190
NCT04689152 RECRUITING
Clinical Trial to Evaluate the Efficacy and Safety of Cellgram-LC Administration in Patients With Alcoholic Cirrhosis
Pharmicell Co., Ltd. n=200
NCT02423395 RECRUITING
Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Sherief Abd-Elsalam n=100
NCT02016196 COMPLETED
Rifaximin vs Placebo for the Prevention of Encephalopathy in Patients Treated by TIPS
University Hospital, Toulouse n=211
NCT06478602 COMPLETED
Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis
Cristian Ichim n=19
NCT04365868 TERMINATED
Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis
Galectin Therapeutics Inc. n=357
NCT04244877 WITHDRAWN
Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility
MetroHealth Medical Center
NCT05080465 COMPLETED
Long Term Follow up Mesenchymal Stem Cell Therapy for Patients Virus-related Liver Cirrhosis
Ukraine Association of Biobank n=700
NCT05253287 COMPLETED
Growth Hormone in Decompensated Liver Cirrhosis
Post Graduate Institute of Medical Education and Research, Chandigarh n=96
NCT05794555 COMPLETED
LiveSMART Trial to Prevent Falls in Patients With Cirrhosis
University of Michigan n=230
NCT07072572 COMPLETED
Lung Point of Care Ultrasound to Guide Albumin Administration in Cirrhosis
Centro Medico Issemym n=72
NCT03451292 COMPLETED
Effects of Long-Term Administration of Human Albumin in Participants With Decompensated Cirrhosis and Ascites
Grifols Therapeutics LLC n=410
NCT06000748 TERMINATED
NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients
University of California, San Francisco n=6
NCT03069131 COMPLETED
Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites
Centre Hospitalier Universitaire de Besancon n=160
NCT06355479 COMPLETED
A Study to Evaluate the Efficacy and Safety of OsrHSA in Patients of Hepatic Cirrhosis With Hypoalbuminemia
Healthgen Biotechnology Corp. n=328
NCT02862249 COMPLETED
Trial of Faecal Microbiota Transplantation in Cirrhosis
King's College London n=32
NCT05061992 COMPLETED
A Trial to Improve Quality of Life in People With Cirrhosis
University of Michigan n=56
NCT02837939 WITHDRAWN
Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction
Martin Janičko
NCT03439254 COMPLETED
Study Evaluating the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis
Intercept Pharmaceuticals n=919
NCT05674877 COMPLETED
Opioid Sparing Anesthesia in Patients With Liver Cirrhosis Undergoing Liver Resection
Cairo University n=100
NCT02824354 WITHDRAWN
Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence.
Centre Hospitalier Universitaire, Amiens
NCT01045525 COMPLETED
Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic Liversiderosis
Rennes University Hospital n=274
NCT03420144 COMPLETED
Growth Hormone Therapy in Liver Cirrhosis
Post Graduate Institute of Medical Education and Research, Chandigarh n=76
NCT02596880 COMPLETED
Sofosbuvir, Daclatasvir, Ribavirin for Hepatitis C Virus (HCV) Cirrhotics
Tehran University of Medical Sciences n=100
NCT02823353 COMPLETED
Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis
Xijing Hospital of Digestive Diseases n=117
NCT04775329 TERMINATED
Primary Prophylaxis for Spontaneous Bacterial Peritonitis
Changi General Hospital n=2
NCT04113317 COMPLETED
Granulocyte-Colony Stimulating Factor (G-CSF) as Optimizing Therapy for Pediatric Liver Transplantation
Fakultas Kedokteran Universitas Indonesia n=52
NCT03368066 COMPLETED
Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?
University of Virginia n=100
NCT03154476 COMPLETED
Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study
Mayo Clinic n=20
NCT02738138 COMPLETED
A Study to Evaluate the Efficacy and Safety of Experimental Drugs ABT- 493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1-6 Infection and Human Immunodeficiency Virus -1 Coinfection (EXPEDITION-2)
AbbVie n=153
NCT02642432 COMPLETED
A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1, 2, 4, 5 or 6 Infection and Compensated Cirrhosis
AbbVie n=146
NCT01704755 COMPLETED
A Study to Evaluate the Safety and Efficacy of ABT-450/Ritonavir/ABT-267; (ABT-267 Also Known as Ombitasvir) and ABT-333 (Also Known as Dasabuvir) Coadministered With Ribavirin (RBV) in Hepatitis C Virus (HCV) Genotype 1-infected Adults With Compensated Cirrhosis
AbbVie (prior sponsor, Abbott) n=381
NCT01939197 COMPLETED
A Multipart, Open-label Study to Evaluate the Safety and Efficacy of ABT-450/r/ABT-267 With and Without ABT-333 Coadministered With and Without Ribavirin in Adult With Genotype 1 or 4 Hepatitis C Virus (HCV) Infection and Human Immunodeficiency Virus, Type 1 Coinfection
AbbVie n=318
NCT02219503 COMPLETED
A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir in Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis
AbbVie n=60
NCT01473524 COMPLETED
Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis
Intercept Pharmaceuticals n=217
NCT04155515 COMPLETED
A Phase III Study to Evaluate Efficacy and Safety of TG-2349 in Combination With DAG181 and RBV for HCV Type I Patients
Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd. n=370
NCT02602210 TERMINATED
Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis
Universitaire Ziekenhuizen KU Leuven n=100
NCT04140591 TERMINATED
Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis
Taipei Veterans General Hospital, Taiwan n=10
NCT01271660 COMPLETED
A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis
Seoul National University Boramae Hospital n=60
NCT00746486 TERMINATED
Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC)
Dr. Falk Pharma GmbH n=62
NCT02597166 COMPLETED
Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infection
University Health Network, Toronto n=14
NCT03695705 COMPLETED
Rifaximin and Norfloxacin for Prevention of SBP in Adults With Decompensated Cirrhosis
Post Graduate Institute of Medical Education and Research, Chandigarh n=142
NCT01884415 COMPLETED
Phase III, Study to Evaluate the Efficacy of Two Different HBV Vaccination Schemes in Patients With Hepatic Cirrhosis
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla n=112
NCT02705534 COMPLETED
Sofosbuvir, Ledipasvir, Ribavirin for Hepatitis C Cirrhotics, Genotype 1
Tehran University of Medical Sciences n=50
NCT02271295 SUSPENDED
Impact on Morbidity and Mortality of Prophylactic Dosing of Low Molecular Heparin in Child-Pugh B Cirrhotic Patients
Assistance Publique - Hôpitaux de Paris n=16
NCT02207088 COMPLETED
Ombitasvir/ABT-450/Ritonavir and Dasabuvir With or Without Ribavirin in HCV Genotype 1-Infected Adults With Chronic Kidney Disease
AbbVie n=68
NCT02442284 COMPLETED
A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With or Without Ribavirin in US Veterans With Genotype 1 Chronic Hepatitis C Virus Infection
AbbVie n=99
NCT02173288 COMPLETED
Role of Midodrine and Tolvaptan in Patients With Cirrhosis With Refractory or Recurrent Ascites
Post Graduate Institute of Medical Education and Research, Chandigarh n=50
NCT02451033 COMPLETED
Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study
Post Graduate Institute of Medical Education and Research, Chandigarh n=65
NCT02219477 COMPLETED
A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With Ribavirin in Adults With Genotype 1 and Ombitasvir/Paritaprevir/Ritonavir With Ribavirin in Adults With Genotype 4 Chronic Hepatitis C Virus Infection and Decompensated Cirrhosis
AbbVie n=36
NCT01804829 COMPLETED
Civacir® Polyclonal Immune Globulin (IgG) to Prevent Hepatitis C Virus (HCV) Recurrence in Liver Transplant Patients.
Biotest Pharmaceuticals Corporation n=80
NCT03070353 COMPLETED
Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury
Ramathibodi Hospital n=10
NCT02319200 TERMINATED
Primary Prevention Hepatocellular Carcinoma by Metformin
Assistance Publique - Hôpitaux de Paris n=11
NCT02642003 COMPLETED
To Assess the Efficacy of Granulocyte Colony Stimulating Factor Versus Standard Medical Therapy in Patients of Decompensated Cirrhosis
Sir Ganga Ram Hospital n=259
NCT01048788 COMPLETED
A Trial of OPC-41061 in Patients With Hepatic Edema - Investigation of the Safety of Treatment at 7.5 mg Beyond 7 Days and of the Effect of Dose Escalation to 15 mg
Otsuka Pharmaceutical Co., Ltd. n=51
NCT01037959 TERMINATED
Norfloxacin Therapy for Patients With Cirrhosis and Severe Liver Failure
Assistance Publique - Hôpitaux de Paris n=291
NCT00986817 COMPLETED
Terlipressin in Cirrhotic Patients With Recidivation Ascites Treated With Paracentesis and Albumin
Assistance Publique - Hôpitaux de Paris n=82
NCT01342705 TERMINATED
Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis
Assistance Publique - Hôpitaux de Paris n=17
NCT01434108 COMPLETED
Effects of the Administration of Ornithine Phenylacetate in Patients With Cirrhosis and Upper Gastrointestinal Bleeding
Hospital Universitari Vall d'Hebron Research Institute n=48
NCT01095185 COMPLETED
Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding
Juan A. Arnaiz n=150
NCT01242280 COMPLETED
Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding.
Hospital Clinic of Barcelona n=28
NCT01455246 TERMINATED
Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis
University of Padova n=32
NCT01676285 COMPLETED
Metoprolol Succinate in Cardiac Remodeling Related to Cirrhosis
University of Sao Paulo n=125
NCT01157845 COMPLETED
Use of Methacetin Breath Test to Predict Liver Failure in Patients With Cirrhosis
Virginia Commonwealth University n=165
NCT01359813 TERMINATED
Albumin Administration in Cirrhotic Patients With Bacterial Infection and a Systemic Inflammatory Response Syndrome Unrelated to Spontaneous Bacterial Peritonitis
Centre Hospitalier Universitaire de Besancon n=193
NCT02134626 COMPLETED
Simvastatin Effect on Portal Hypertension
Universidade Federal do Rio de Janeiro n=34
NCT01050530 COMPLETED
A Trial to Investigate the Efficacy of OPC-41061 Administered at a Dose of 7.5 mg in Patients With Hepatic Edema
Otsuka Pharmaceutical Co., Ltd. n=162
NCT01114828 COMPLETED
A Study to Investigate Pharmacodynamics and Pharmacokinetics of OPC-41061 in Patients With Hepatic Edema
Otsuka Pharmaceutical Co., Ltd. n=40
NCT01556646 COMPLETED
Effect of Tolvaptan on Cognitive Function in Cirrhosis
Hunter Holmes Mcguire Veteran Affairs Medical Center n=25
NCT01456286 COMPLETED
Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension
Fundacion Clinic per a la Recerca Biomédica n=42
NCT01857284 COMPLETED
Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis
Beijing Friendship Hospital n=216
NCT01311167 TERMINATED
Treatment of Sodium Retention in Liver Cirrhosis With Dexamethasone
Insel Gruppe AG, University Hospital Bern n=2
NCT01440829 COMPLETED
The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS
Air Force Military Medical University, China n=40
NCT01349348 COMPLETED
Phase III Study of Tolvaptan Tablet to Treat Cirrhosis Ascites
Otsuka Beijing Research Institute n=535
NCT01006031 COMPLETED
Retreatment With High Doses of pegIFN Alfa-2a and Ribavirin of Previous Nonresponders HIV-coinfected Patients With Cirrhosis Due to HCV 1-4
Sociedad Andaluza de Enfermedades Infecciosas n=25
NCT00794482 COMPLETED
Multi-national Cirrhosis Study to Characterise the Association Between the Pharmacokinetics of NRL972 and Disease Severity.
Norgine n=1,200
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only