GERD Clinical Trial Landscape
Data updated: May 20, 2026
146 clinical trials tracked since 2008
GERD is being studied across 146 clinical trials registered since 2008, with 17 programs currently active. The competitive pipeline includes 6 active Phase 3 trials, 4 active Phase 2 trials, and 3 active Phase 1 trials. Top industry sponsors include Cinclus Pharma Holding AB, Takeda, Addpharma Inc..
17 active
/
146 total (since 2008)
3
Phase 1 Active
45 total
4
Phase 2 Active
29 total
6
Phase 3 Active
45 total
5
Phase 4 Active
33 total
Top Industry Sponsors
Sorted by active Active Done Failed
Cinclus Pharma Holding AB 2 2 0
Takeda 1 10 2
Addpharma Inc. 1 3 0
Onconic Therapeutics Inc. 1 1 0
Daewoong Pharmaceutical Co. LTD. 1 1 0
+ 10 more sponsors — see full table below
Featured Phase 3 Trials
NCT01696734 RECRUITING
Domperidone in Treating Patients With Gastrointestinal Disorders
M.D. Anderson Cancer Center n=200
NCT07063576 RECRUITING
Effect of Baclofen in Management of Patients With Gastroesophageal Reflux Disease Symptoms
Adnan Imtiaj Rahul n=60
NCT07310927 COMPLETED
Alginate vs Sucralfate for GERD Symptomatic Relief
CMH Lahore Medical College and Institute of Dentistry n=140
NCT01869491 COMPLETED
Compound Sodium Alginate Double Action Chewable Tablet Symptomatic Relief Study
Reckitt Benckiser Healthcare (UK) Limited n=1,107
NCT01872897 COMPLETED
Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients
Reckitt Benckiser Healthcare (UK) Limited n=45
+ 40 more Phase 3 trials — see full database below
GERD — Trials Started by Year (last 10 years)
2016 6
2017 10
2018 8
2019 3
2020 4
2021 6
2022 3
2023 6
2024 7
2025 10
2026 2
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
Cinclus Pharma Holding AB 4
Takeda 13
Addpharma Inc. 4
Onconic Therapeutics Inc. 2
Daewoong Pharmaceutical Co. LTD. 2
Valenta Pharm JSC 1
Carnot Laboratories 1
AstraZeneca 10
Eisai Inc. 6
Reckitt Benckiser Healthcare (UK) Limited 4
Active Trials by Phase
Phase 1 3
Phase 2 4
Phase 3 6
Phase 4 5
Enrollment Size Distribution
1-50 62
51-200 39
201-500 23
501-1k 9
1k+ 5
All Industry Sponsors
Sorted by active Active Done Failed
Cinclus Pharma Holding AB 2 2 0
Takeda 1 10 2
Addpharma Inc. 1 3 0
Onconic Therapeutics Inc. 1 1 0
Daewoong Pharmaceutical Co. LTD. 1 1 0
Valenta Pharm JSC 1 0 0
Carnot Laboratories 1 0 0
AstraZeneca 0 10 0
Eisai Inc. 0 6 0
Reckitt Benckiser Healthcare (UK) Limited 0 3 1
Phathom Pharmaceuticals, Inc. 0 4 0
Neutec Ar-Ge San ve Tic A.Ş 0 3 1
Chong Kun Dang Pharmaceutical 0 4 0
Bayer 0 3 0
Pfizer 0 1 2
NCT01696734 RECRUITING
Domperidone in Treating Patients With Gastrointestinal Disorders
M.D. Anderson Cancer Center n=200
NCT07313774 NOT YET RECRUITING
A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Maintenance of Healing in Participants With Healed Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)
Cinclus Pharma Holding AB n=1,050
NCT07037875 NOT YET RECRUITING
A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)
Cinclus Pharma Holding AB n=500
NCT07160790 NOT YET RECRUITING
Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 in Patients With Non-erosive Gastroesophageal Reflux Disease
Onconic Therapeutics Inc. n=321
NCT07063576 RECRUITING
Effect of Baclofen in Management of Patients With Gastroesophageal Reflux Disease Symptoms
Adnan Imtiaj Rahul n=60
NCT07049315 NOT YET RECRUITING
Mandibular Advancement Devices for Reflux in Obstructive Sleep Apnea
Tuiuti University of Paraná n=40
NCT07310927 COMPLETED
Alginate vs Sucralfate for GERD Symptomatic Relief
CMH Lahore Medical College and Institute of Dentistry n=140
NCT01869491 COMPLETED
Compound Sodium Alginate Double Action Chewable Tablet Symptomatic Relief Study
Reckitt Benckiser Healthcare (UK) Limited n=1,107
NCT01872897 COMPLETED
Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients
Reckitt Benckiser Healthcare (UK) Limited n=45
NCT05195528 COMPLETED
A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)
Phathom Pharmaceuticals, Inc. n=776
NCT02135107 COMPLETED
A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients
Eisai Co., Ltd. n=517
NCT00838526 COMPLETED
Rabeprazole Extended-Release 50 mg vs. Ranitidine 150 mg for Maintenance of Healed Erosive Gastroesophageal Reflux Disease (GERD)
Eisai Inc. n=240
NCT03561090 TERMINATED
A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
Ironwood Pharmaceuticals, Inc. n=495
NCT03561883 COMPLETED
Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
Ironwood Pharmaceuticals, Inc. n=609
NCT03367195 TERMINATED
Efficacy and Safety of DLBS2411 in the Management of GERD
Dexa Medica Group n=32
NCT04080726 COMPLETED
Efficacy and Safety of HIP1601 Capsule
Hanmi Pharmaceutical Company Limited n=213
NCT01265550 COMPLETED
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
VA Office of Research and Development n=366
NCT02954848 COMPLETED
Phase 3 Study of TAK-438 10 mg in the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)
Takeda n=484
NCT02873689 COMPLETED
Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients
Takeda n=217
NCT03516188 COMPLETED
Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants
Universiti Sains Malaysia n=24
NCT00857597 TERMINATED
Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment
University of Pittsburgh n=60
NCT02619747 TERMINATED
Compound Sodium Alginate Oral Suspension Sachet 4-hour Esophageal pH Study in GERD Patients
Reckitt Benckiser Healthcare (UK) Limited n=16
NCT02860624 COMPLETED
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
Livzon Pharmaceutical Group Inc. n=550
NCT02623062 COMPLETED
Compound Sodium Alginate Oral Suspension Sachet Symptomatic Relief Study
Reckitt Benckiser Healthcare (UK) Limited n=644
NCT00658632 COMPLETED
Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Mild to Moderate Erosive Gastroesophageal Reflux Disease (GERD)
Eisai Inc. n=1,397
NCT00839306 COMPLETED
Rabeprazole Extended Release 50 mg Versus Ranitidine 150 mg for Maintenance of Healed Erosive Gastroesophageal Reflux Disease (GERD)
Eisai Inc. n=240
NCT00911534 COMPLETED
Comparing the Efficacy, Safety, and Tolerability of Rabeprazole ER 50 mg With Placebo in Subjects With Symptomatic Gastroesophageal Reflux Disease (sGERD)
Eisai Inc. n=305
NCT00734747 COMPLETED
Safety and Efficacy the Medigus SRS Endoscopic Stapling System in Gastroesophageal Reflux Disease (GERD)
Aviel Roy-Shapira, M.D. n=72
NCT00728481 COMPLETED
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
Mayo Clinic n=51
NCT00658775 COMPLETED
Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)
Eisai Inc. n=1,069
NCT00658528 COMPLETED
Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)
Eisai Inc. n=1,061
NCT01710462 WITHDRAWN
Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease
Eurofarma Laboratorios S.A.
NCT01753128 COMPLETED
Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn
Mahidol University n=83
NCT01474369 COMPLETED
Efficacy of TAK-438 Compared to Placebo in the Treatment of Non-Erosive Gastroesophageal Reflux Disease
Takeda n=827
NCT01370538 COMPLETED
Efficacy of Esomeprazole in Patients With Frequent Heartburn
AstraZeneca n=341
NCT01370525 COMPLETED
Efficacy of Esomeprazole in Patients With Frequent Heartburn
AstraZeneca n=340
NCT00787891 COMPLETED
A Study of the Safety and Effectiveness of Rabeprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Pediatric Patients
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. n=127
NCT01065649 COMPLETED
Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients
Universidade de Passo Fundo n=20
NCT01132638 COMPLETED
Pantoprazole Magnesium 40 mg Versus Esomeprazole 40 mg in Patients With Erosive Gastroesophageal Reflux Disease
Takeda n=713
NCT01338077 COMPLETED
Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease
Chang Gung Memorial Hospital n=195
NCT01391715 WITHDRAWN
Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD
Inje University
NCT01509261 COMPLETED
Efficacy Study of Ilaprazole to Treat Erosive Esophgitis
Il-Yang Pharm. Co., Ltd. n=292
NCT01400945 COMPLETED
Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease
Ahn-Gook Pharmaceuticals Co.,Ltd n=154
NCT00674245 COMPLETED
Effect of Pantoprazole 40mg Daily vs Placebo on Power Spectral Analysis of the Sleep EEG of Patients With GERD.
Southern Arizona VA Health Care System n=40
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only