NCT07584967 NOT YET RECRUITING A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
AnaCardio AB
NCT06991257 RECRUITING A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Pfizer
NCT07269717 RECRUITING A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction
Shandong Suncadia Medicine Co., Ltd.
NCT06122779 RECRUITING Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Bristol-Myers Squibb
NCT07576257 NOT YET RECRUITING OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosili-cate in Heart Failure -Extension (OPRA-HF Extension)
Sahlgrenska University Hospital
NCT06762964 RECRUITING CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation
Mayo Clinic
NCT05177822 ACTIVE NOT RECRUITING Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure
Virginia Commonwealth University
NCT05562167 RECRUITING The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
Washington University School of Medicine
NCT06195982 ENROLLING BY INVITATION Ketones in Heart Failure With Reduced Ejection Fraction
Duke University
NCT06053580 RECRUITING Repurposing Valsartan May Protect Against Pulmonary Hypertension
University of Washington
NCT07560436 RECRUITING Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
King's College London
NCT07083011 RECRUITING A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
Mayo Clinic
NCT06655480 RECRUITING Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
NCT07304817 RECRUITING Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)
University Medical Center Groningen
NCT05138575 RECRUITING SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
University of Pennsylvania
NCT05719714 RECRUITING Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Northwestern University
NCT07318103 RECRUITING Phase II Clinical Study of HRS-9057 Injection in Patients With Heart Failure-induced Fluid Retention
Fujian Shengdi Pharmaceutical Co., Ltd.
NCT06815471 RECRUITING CRF2 Agonist for the Treatment of Worsening Heart Failure
Corteria Pharmaceuticals
NCT06435156 RECRUITING Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
University of Dundee
NCT07499037 NOT YET RECRUITING Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO
University Hospital Ostrava
NCT06556810 ACTIVE NOT RECRUITING IC14 for Treatment of Acute Decompensated Heart Failure
Implicit Bioscience
NCT06965621 NOT YET RECRUITING 18F-mFBG Imaging for Myocardial Sympathetic Innervation
Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)
NCT06616974 RECRUITING A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
Tectonic Therapeutic
NCT05194111 RECRUITING Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
Virginia Commonwealth University
NCT07273838 RECRUITING Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
Yale University
NCT07471698 NOT YET RECRUITING hiPSC-CMs-loaded Chitosan Patch to Treat Severe Chronic Ischemic Heart Disease
HELP Therapeutics Co., Ltd.
NCT06979375 RECRUITING A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
Novo Nordisk A/S
NCT06979362 RECRUITING A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Novo Nordisk A/S
NCT07461961 NOT YET RECRUITING CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock
Brigham and Women's Hospital
NCT05371496 ENROLLING BY INVITATION Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction
Mayo Clinic
NCT07443696 RECRUITING PET Myocardial Fatty-acid Metabolic Imaging With XTR003 Injection and 18F-FDG to Assess Myocardial Viability in Ischemic Cardiomyopathy
Sinotau Pharmaceutical Group
NCT06130059 RECRUITING Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
University of Texas Southwestern Medical Center
NCT07029503 RECRUITING Swedish Cardiac And Renal Failure Study-1
Karolinska Institutet
NCT04396899 RECRUITING Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure
University Medical Center Goettingen
NCT07202000 NOT YET RECRUITING EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
Massachusetts General Hospital
NCT06340048 ACTIVE NOT RECRUITING Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure
HELP Therapeutics Co., Ltd.
NCT06017609 ACTIVE NOT RECRUITING Evaluate Efficacy, Safety and Tolerability of JTT-861 in Subjects With Heart Failure With Reduced Ejection Fraction
Akros Pharma Inc.
NCT07394270 NOT YET RECRUITING Effect of Add-on L-Arginine Therapy on Heart Failure Patients
German University in Cairo
NCT07372040 RECRUITING Add-on Diuretics in Acute Decompensated Heart Failure
Tanta University
NCT06080074 RECRUITING Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
Stanford University
NCT06154044 RECRUITING Cell Therapy and Myocardial Recovery in Heart Failure Patients Undergoing Left Ventricular Assist Device Support
University Medical Centre Ljubljana
NCT05888233 RECRUITING Allopurinol Improves Heart Function in African Americans With Resistant Hypertension
VA Office of Research and Development
NCT07359872 NOT YET RECRUITING Relaxin Therapy for Atrial Fibrillation
Deeptankar DeMazumder
NCT03383419 RECRUITING Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients
Baylor Research Institute
NCT07347197 NOT YET RECRUITING Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study)
Heartseed Inc.
NCT06793371 RECRUITING AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Cytokinetics
NCT07265349 RECRUITING A Phase I/II Clinical Trial of Intramyocardial Injection of HucMSCs for the Treatment of Chronic Heart Failure
Tasly Pharmaceutical Group Co., Ltd
NCT06820099 RECRUITING Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity
Shandong Suncadia Medicine Co., Ltd.
NCT04481919 ACTIVE NOT RECRUITING Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)
Vanderbilt University Medical Center
NCT05925608 ACTIVE NOT RECRUITING Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cells
BioCardia, Inc.
NCT05598333 ACTIVE NOT RECRUITING Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure
AskBio Inc
NCT07245069 RECRUITING Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer Patients
University Medical Centre Ljubljana
NCT06391710 ACTIVE NOT RECRUITING HRS9531 Injection in Obese Subjects With Heart Failure With Preserved Ejection Fraction
Fujian Shengdi Pharmaceutical Co., Ltd.
NCT05279742 ENROLLING BY INVITATION Enhancing the Natriuretic Peptide System in HFpEF
Horng Chen
NCT04438213 RECRUITING Ertugliflozin in Chronic Heart Failure
Yale University
NCT05450328 NOT YET RECRUITING Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation
Montreal Heart Institute
NCT04945018 ACTIVE NOT RECRUITING A Study of iPS Cell-derived Cardiomyocyte Spheroids (HS-001) in Patients With Heart Failure (LAPiS Study)
Heartseed Inc.
NCT06570473 RECRUITING Feasibility Trial for a Right Ventricular Failure Platform Trial
University of Alberta
NCT06937320 ENROLLING BY INVITATION Chronic Exogenous Ketosis in HFpEF
Duke University
NCT06369298 RECRUITING Study of JK07 in Patients With Chronic Heart Failure
Salubris Biotherapeutics Inc
NCT06601465 RECRUITING COgnitioN With VERiciGuat Evaluation in Heart Failure
University of Alberta
NCT07064525 ENROLLING BY INVITATION Evaluate the Efficacy and Safety of SPC1001 Low in Patients With Essential Hypertension
Shin Poong Pharmaceutical Co. Ltd.
NCT06862908 RECRUITING A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity
Innovent Biologics (Suzhou) Co. Ltd.
NCT05925634 RECRUITING Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
Baystate Medical Center
NCT04789239 ACTIVE NOT RECRUITING OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failure
Michael Fu
NCT05384847 ACTIVE NOT RECRUITING Effects of Triiodothyronine (T3) in Ischemic Heart Failure
Emory University
NCT05687058 RECRUITING Empagliflozin in ESKD - A Feasibility Study
University of Mississippi Medical Center
NCT07037524 NOT YET RECRUITING Low Dose Radiotherapy for Heart Failure
Hospital do Coracao
NCT06653725 RECRUITING Exogenous KETOne Supplements in Patients Hospitalized for Acute Heart Failure
Aarhus University Hospital
NCT04913805 RECRUITING Matching Perfusion and Metabolic Activity in HFpEF
University of Pennsylvania
NCT03994874 RECRUITING Peritoneal Ultrafiltration in Cardio Renal Syndrome.
Iperboreal Pharma Srl
NCT04680442 RECRUITING Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
Population Health Research Institute
NCT06866600 NOT YET RECRUITING IPSC-CMs Combined with LVAD or CABG for the Treatment of Heart Failure
HELP Therapeutics Co., Ltd.
NCT03629340 RECRUITING Metformin for Pulmonary Hypertension HFpEF
University of California, San Francisco
NCT06851949 RECRUITING Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
Cardiac Success
NCT06645691 RECRUITING Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body
National Heart Centre Singapore
NCT06240403 NOT YET RECRUITING Digoxin and Senolysis in Heart Failure and Diabetes Mellitus
University of Leeds
NCT06705023 RECRUITING Study to Assess Safety and Efficacy of Treating Symptomatic, Ischemic, Chronic Congestive Heart Failure Patients with an LVEF of ≤40% with Fresh, Uncultured, Autologous, Adipose-derived Regenerative Cells Isolated from Lipoaspirate.
Ralf Rothoerl
NCT06097481 NOT YET RECRUITING Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF)
University of Colorado, Denver
NCT05408559 RECRUITING Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Texas Tech University Health Sciences Center
NCT06669169 NOT YET RECRUITING Efficacy and Safety of Jia Shen Tablets in Chronic Heart Failure
Tasly Pharmaceutical Group Co., Ltd
NCT06541509 RECRUITING Mechanisms of Semaglutide Therapy in Heart Failure Patients
University Medical Centre Ljubljana
NCT06522594 RECRUITING REMAP ECMO - Beta Receptor Modulation Trial
Erasmus Medical Center
NCT06501768 RECRUITING Cardiovascular Genistein Therapy for Heart Failure Inflammation
University Medical Centre Ljubljana
NCT04703842 RECRUITING Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Sardocor Corp.
NCT06081049 RECRUITING The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)
Tor Biering-Sørensen
NCT05966415 RECRUITING Endocalyx for Heart Failure
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT05732051 RECRUITING Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients
University Hospital, Akershus
NCT07594145 NOT YET RECRUITING Precision T1D Platform - New Therapies for Cardio-Renal Complications
Oregon Health and Science University
NCT05642507 COMPLETED Phase Ib/IIa Trial With AC01 in Patients With HFrEF
AnaCardio AB
NCT05093959 COMPLETED Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences
NCT05350969 COMPLETED Study to Assess Efficacy and Safety of CDR132L in Patients With Reduced Left Ventricular Ejection Fraction After Myocardial Infarction
Cardior Pharmaceuticals GmbH
NCT06176794 WITHDRAWN Immediate Release Torsemide Versus Extended Release Torsemide After Salty Meal
Sarfez Pharmaceuticals, Inc.
NCT05637398 COMPLETED Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction
I.M. Sechenov First Moscow State Medical University
NCT03624010 COMPLETED Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients
Tenax Therapeutics, Inc.
NCT06795399 WITHDRAWN A Proof-of-concept Trial for OPC 131461 in Patients Hospitalized for Worsening Heart Failure
Otsuka Pharmaceutical Development & Commercialization, Inc.
NCT03508232 COMPLETED Doxycycline to Protect Heart Muscle After Heart Attacks
University of Alberta
NCT06840275 WITHDRAWN ASCs in Recently Diagnosed Non-ischemic Heart Failure
Cell to Cure ApS
NCT05419115 COMPLETED Use of a Novel SUBCUTaneous Preparation of Furosemide to Facilitate Early Supported Discharge of Patients With Heart Failure
NHS Greater Glasgow and Clyde
NCT05492500 TERMINATED A Study of Ponsegromab in People With Heart Failure
Pfizer
NCT06206512 COMPLETED Effect of Extended Release Torsemide in Patients With Congestive Heart Failure and Overactive Bladder
Sarfez Pharmaceuticals, Inc.
NCT04153136 COMPLETED The ENCHANTMENT HIV Study
Massachusetts General Hospital
NCT06299826 COMPLETED A Phase IIb Study of AZD5462 in Patients With Chronic Heart Failure
AstraZeneca
NCT05592275 TERMINATED A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
Eli Lilly and Company
NCT05764564 COMPLETED External Body Pressure in Heart Failure With Preserved Ejection Fraction
Duke University
NCT06142383 TERMINATED A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure
Novartis Pharmaceuticals
NCT07221513 WITHDRAWN Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension
Salubris Biotherapeutics Inc
NCT06237309 TERMINATED REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction
Regeneron Pharmaceuticals
NCT06036914 COMPLETED A Study of Ultra High Dose Diuretics to Treat Heart Failure
Mayo Clinic
NCT05953831 WITHDRAWN Reverse Remodeling Effects of CDR132L in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Cardiac Hypertrophy
Cardior Pharmaceuticals GmbH
NCT06731738 COMPLETED Mangafodipir - an Intracellular Contrast Agent for Magnetic Resonance Imaging (MRI): Measuring Manganese Uptake Rate in Heart Failure Patients With Preserved Ejection Fraction (HFpEF) Patients.
IC TARGETS AS
NCT06029712 COMPLETED Heart Failure Polypill at a Safety Net Hospital
University of California, San Francisco
NCT04318145 TERMINATED Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects
Palatin Technologies, Inc
NCT04633005 COMPLETED Polypill Strategy for Heart Failure With Reduced Ejection Fraction
University of Texas Southwestern Medical Center
NCT06215586 COMPLETED Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
Cardurion Pharmaceuticals, Inc.
NCT06215911 COMPLETED A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)
Cardurion Pharmaceuticals, Inc.
NCT05615363 COMPLETED A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])
Otsuka Pharmaceutical Co., Ltd.
NCT06195930 COMPLETED A Study to Learn How Safe Starting Vericiguat at a Dose of 5 Milligrams is in Participants With Chronic Heart Failure With Reduced Ejection Fraction
Bayer
NCT05737940 COMPLETED A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2
AstraZeneca
NCT07169981 COMPLETED Effect of Empagliflozin 10 vs 25 mg on LV Remodeling in Diabetic Patients With Anterior STEMI With Reduced LVEF
Ain Shams University
NCT04306588 WITHDRAWN Accessing Mobility Using Wearable Sensors
Baylor College of Medicine
NCT03763136 COMPLETED Treating Heart Failure With hPSC-CMs
HELP Therapeutics Co., Ltd.
NCT03797001 COMPLETED Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2
Virginia Commonwealth University
NCT03511248 TERMINATED Effect of Dietary Nitrate Ingestion in Heart Failure
Queen Mary University of London
NCT05528588 COMPLETED Furoscix in Heart Failure Patients With Diuretic Resistance
University of Texas Southwestern Medical Center
NCT04737265 COMPLETED Pilot Study of an NTproBNP Guided Strategy of Cardioprotection
Abramson Cancer Center at Penn Medicine
NCT04826159 COMPLETED IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)
Imbria Pharmaceuticals, Inc.
NCT05353166 COMPLETED REGN5381 in Heart Failure Adult Participants With Elevated Pulmonary Capillary Wedge Pressure
Regeneron Pharmaceuticals
NCT03159988 SUSPENDED Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients
University of Arizona
NCT03928158 COMPLETED LCZ696 in Advanced LV Hypertrophy and HFpEF
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
NCT02797184 COMPLETED Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response
Washington University School of Medicine
NCT05312021 WITHDRAWN Selective PDE9 Inhibition With IMR-687 in Adults With Heart Failure With Preserved Ejection Fraction
Cardurion Pharmaceuticals, Inc.
NCT02943590 COMPLETED STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
Massachusetts General Hospital
NCT03180450 SUSPENDED The Study of Heart Failure With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-HF)
Sclnow Biotechnology Co., Ltd.
NCT03416270 COMPLETED ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure
University Health Network, Toronto
NCT04325594 COMPLETED The Application of the Umbilical Cord Mesenchymal Stem Cells in the Complex Treatment of Non-ischemic Heart Failure
The Research-Clinical Center for Cardiac Surgery and Transplantology LLP
NCT05672134 COMPLETED Evaluation of GeranylGeranylAcetone in Heart Failure With Preserved Ejection Fraction
Amsterdam UMC, location VUmc
NCT03153111 COMPLETED A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Actelion
NCT04766892 COMPLETED A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT
Bristol-Myers Squibb
NCT03476460 COMPLETED Sodium Chloride and Contrast Nephropathy
Hospital Universitario Ramon y Cajal
NCT03988621 COMPLETED Improving Self-care of Heart Failure Caregivers
University of Pennsylvania
NCT03760588 COMPLETED Prevention of Cardiac Dysfunction During Breast Cancer Therapy
Torbjorn Omland
NCT01251406 COMPLETED Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure
Zensun Sci. & Tech. Co., Ltd.
NCT03714815 TERMINATED A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Actelion
NCT05042973 COMPLETED The Metabolic Effects of Empagliflozin in Patients With High Risk of Heart Failure
Jacob Moller
NCT05084235 COMPLETED The Cardiac Effects of Empagliflozin in Patients With High Risk of Heart Failure
Jacob Moller
NCT04983043 COMPLETED Efficacy and Safety of QiShen YiQi Dripping Pills in Chronic Heart Failure
Tasly Pharmaceutical Group Co., Ltd
NCT04944706 COMPLETED Efficacy and Safety of Qishenyiqi Dripping Pills for Treating Chronic Heart Failure With Preserved Ejection Fraction
Tasly Pharmaceutical Group Co., Ltd
NCT04111536 COMPLETED Developing Oral LT3 Therapy for Heart Failure - HFpEF
University of Pennsylvania
NCT03611153 COMPLETED Myeloperoxidase (MPO) Inhibitor A_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF)
Mayo Clinic
NCT04112316 COMPLETED Developing Oral LT3 Therapy for Heart Failure - HFrEF
University of Pennsylvania
NCT05409183 TERMINATED Effectiveness of CRD-740 in Heart Failure
Cardurion Pharmaceuticals, Inc.
NCT01682356 COMPLETED Dietary Nitrate for Heart Failure
Washington University School of Medicine
NCT06264310 COMPLETED To Evaluate the Safety, Tolerability and Efficacy of R2R01 Combined With SOC as Compared to SOC Alone in Outpatients With Worsening Heart Failure (WHF)
River 2 Renal Corp.
NCT04633460 COMPLETED Acute Effects of Exogenous Ketone Ester Administration in Heart Failure
University of Pennsylvania
NCT03541603 COMPLETED Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF
Tenax Therapeutics, Inc.
NCT04595370 COMPLETED Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease
AstraZeneca
NCT04865978 COMPLETED Evaluation of the Hemocompatibility of the Direct Oral Anti-Coagulant Apixaban in Left Ventricular Assist Devices
Palak Shah
NCT05964738 COMPLETED Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction
Maimónides Biomedical Research Institute of Córdoba
NCT05277415 COMPLETED Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Heart Failure
Lars Lund
NCT03370887 COMPLETED AZD8601 Study in CABG Patients
AstraZeneca
NCT03525379 COMPLETED Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function in Patients With Heart Failure
University of Alberta
NCT05284617 COMPLETED Exploratory Ph 2A, Double-Blind, Placebo-Controlled Dose Escalation Study of Safety, Tolerability, PD, & PK of HU6 for Subjects With Obese HFpEF
Rivus Pharmaceuticals, Inc.
NCT03259165 TERMINATED Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
Indiana University
NCT03554291 COMPLETED Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension
University of Washington
NCT02941705 COMPLETED Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
Cedars-Sinai Medical Center
NCT03331861 TERMINATED Metformin in Heart Failure Without Diabetes
Columbia University
NCT03015402 COMPLETED Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
University of Pittsburgh
NCT03136198 COMPLETED B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial
Indiana University
NCT03245255 COMPLETED Noninvasive Real-time Intracardiac Pressure Measurements Using Subharmonic Ultrasound
Thomas Jefferson University
NCT04640493 WITHDRAWN SGLT2-Inhibitors for Sleep Apnea in Heart Failure
Columbia University
NCT03200860 COMPLETED Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure
University Medical Center Groningen
NCT05768100 COMPLETED Hemodynamic Effects of Modulating Circulating Ketone Bodies With 1,3-butanediol
Aarhus University Hospital
NCT06024889 COMPLETED Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure.
Johannes Grand
NCT02840799 COMPLETED Effect of KNO3 Compared to KCl on Oxygen UpTake in Heart Failure With Preserved Ejection Fraction (KNO3CK OUT HFPEF)
University of Pennsylvania
NCT05126836 COMPLETED Cilostazol for HFpEF
University of Minnesota
NCT04956809 COMPLETED Effect of Dapagliflozin on Submaximal Exercise Tolerance in Heart Failure
University of Pennsylvania
NCT04992832 COMPLETED Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction(PRIME-HFrEF Study)
Shanghai East Hospital
NCT05161676 COMPLETED Metabolic Effects of Chronic Ketosis (KETO-CHF Metabolic)
University of Aarhus
NCT05161650 COMPLETED Hemodynamic Effects of Chronic Ketosis.
University of Aarhus
NCT05139615 TERMINATED A Study to Assess the Hemodynamic Effects, Safety, Tolerability, and Pharmacokinetics of Intravenous APD418 in Adult Participants With Heart Failure With Reduced Ejection Fraction
Pfizer
NCT01182805 COMPLETED Radiofrequency-based Speckle Tracking Echocardiography to Evaluate Diastolic Function
University of Michigan
NCT04730947 COMPLETED Dapagliflozin (DAPA) Effects in HFpEF
Mayo Clinic
NCT00745316 TERMINATED Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency
Biogen
NCT04836182 COMPLETED A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Participants With Chronic Heart Failure With Reduced Ejection Fraction
Ionis Pharmaceuticals, Inc.
NCT06003972 COMPLETED Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Hadassah Medical Organization
NCT04782245 WITHDRAWN Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
Hospices Civils de Lyon
NCT04593823 COMPLETED Avoiding Treatment in the Hospital With Furoscix for the Management of Congestion in Heart Failure - A Pilot Study
scPharmaceuticals, Inc.
NCT02633644 TERMINATED Endovascular NeuromoDulation Treatment fOr Heart Failure Patients (ENDO-HF)
Enopace Biomedical
NCT04327024 COMPLETED Study of Verinurad in Heart Failure With Preserved Ejection Fraction
AstraZeneca
NCT04575428 COMPLETED Splanchnic Nerve Block for Therapy of Chronic Heart Failure (Splanchnic III)
Duke University
NCT02617446 COMPLETED The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure
Windtree Therapeutics
NCT02923609 COMPLETED Cell Therapy in HFpEF
University Medical Centre Ljubljana
NCT02713126 COMPLETED Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure With Preserved Ejection Fraction (HFpEF) (INABLE-Training)
Barry Borlaug
NCT04857931 TERMINATED Colchicine in HFpEF
Montreal Heart Institute
NCT04192214 COMPLETED The Persistence of Autoantibody Neutralisation by BC 007 in Patients With Chronic HFrEF and Autoantibodies Against the Beta1-Adrenergic Receptor
Berlin Cures GmbH
NCT03791593 COMPLETED EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot
Fundació Institut Germans Trias i Pujol
NCT00534703 TERMINATED Investigation of the Safety and Feasibility of AAV1/SERCA2a Gene Transfer in Patients With Chronic Heart Failure
Imperial College London
NCT03447990 COMPLETED v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491
Bristol-Myers Squibb
NCT03372954 COMPLETED Retrograde Application of Bone Marrow Aspirate Concentrate
University Hospital Ostrava
NCT05633758 WITHDRAWN Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure
Scripps Health
NCT03423342 COMPLETED Nicotinamide Riboside in Systolic Heart Failure
University of Washington
NCT03554200 TERMINATED EMPA Acute Heart Failure
RWTH Aachen University
NCT04515290 COMPLETED A Phase IIa Clinical Trial on TSG-01 in the Treatment of Chronic Heart Failure in Patients With Coronary Heart Disease.
Shanghai Hongyitang Biopharmaceutical Technology Co. Ltd.
NCT03254485 COMPLETED A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)
Akebia Therapeutics
NCT03092284 COMPLETED Allogeneic Stem Cell Therapy in Heart Failure
JKastrup
NCT04318093 COMPLETED Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart Failure
Bristol-Myers Squibb
NCT02808585 COMPLETED Study to Assess the Safety, Tolerability and PK/PD After 4 Weekly SC Injections of PB1046 in Subjects With Stable HFrEF
PhaseBio Pharmaceuticals Inc.
NCT05330013 WITHDRAWN The Effect of Inflammation in Heart Failure
National Heart, Lung, and Blood Institute (NHLBI)
NCT01516346 COMPLETED Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction
Corporal Michael J. Crescenz VA Medical Center
NCT02769611 WITHDRAWN Ruboxistaurin in New York Heart Failure Classification III-IV Patients
University of Tennessee
NCT03901729 COMPLETED A Trial to Study BAY1753011 in Patients With Congestive Heart Failure
Bayer
NCT02502747 WITHDRAWN RIGENERA 2.0 Trial
Catholic University of the Sacred Heart
NCT03133793 COMPLETED CoQ10 and D-ribose in Patients With Diastolic Heart Failure
University of Kansas Medical Center
NCT02556450 COMPLETED Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure
ACS Biomarker
NCT01345656 COMPLETED BAY94-8862 Dose Finding Trial in Subjects With Chronic Heart Failure and Mild (Part A) or Moderate (Part B) Chronic Kidney Disease
Bayer
NCT04703361 COMPLETED Effects of Ketones and Niacin in Heart Failure Patients
University of Aarhus
NCT03146741 COMPLETED Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors (HCV)
University of Pennsylvania
NCT04384653 COMPLETED Crossover Study to Compare the Pharmacokinetics and Bioavailability of a Novel Furosemide Regimen Administered Subcutaneously vs. the Same Dose Administered Intravenously in Subjects With Chronic Heart Failure
SQ Innovation, Inc.
NCT01786512 COMPLETED COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
Cytokinetics
NCT04049045 COMPLETED Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure
Christian Schulze
NCT01077167 WITHDRAWN Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients
Cytokinetics
NCT01300013 COMPLETED Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
Cytokinetics
NCT02695420 COMPLETED Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction
Cytokinetics
NCT03756285 TERMINATED Safety and Tolerability Study of AZD4831 in Patients With Heart Failure.
AstraZeneca
NCT01955694 COMPLETED Phase IIb Safety and Efficacy Study of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone
Bayer
NCT03784963 TERMINATED Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD
University of Chicago
NCT01807221 COMPLETED Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone
Bayer
NCT03532009 TERMINATED Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure
AstraZeneca
NCT00868439 COMPLETED Evaluation of Patiromer in Heart Failure Patients
Relypsa, Inc.
NCT01130597 COMPLETED Evaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney Disease
Relypsa, Inc.
NCT03342833 COMPLETED Blood Flow Restriction Training in Chronic Heart Failure: an Effective Training Strategy?
University of Leeds
NCT03453853 COMPLETED Atrial Functional Mitral Regurgitation Response In Mitral Loop Cerclage Annuloplasty (AFRICA Study)
Tau-MEDICAL Co., Ltd.
NCT01951625 COMPLETED Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED)
Bayer
NCT01951638 COMPLETED Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure and Preserved Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-PRESERVED)
Bayer
NCT03730961 COMPLETED An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic
Bristol-Myers Squibb
NCT02673164 COMPLETED Stem Cell Therapy in IschEmic Non-treatable Cardiac Disease
JKastrup
NCT03547583 COMPLETED Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF
Bayer
NCT03016325 COMPLETED Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure
Bristol-Myers Squibb
NCT02696967 COMPLETED A Study of CLR325 in Chronic Stable Heart Failure Patients.
Novartis Pharmaceuticals
NCT03387215 COMPLETED Randomized, Double-Blind, Placebo-Controlled, Safety and Tolerability Study of ITI-214 in Patients With Heart Failure
Intra-Cellular Therapies, Inc.
NCT00913653 COMPLETED Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable Heart Failure
Novartis Pharmaceuticals
NCT01546532 COMPLETED Renal Hemodynamic Effects of RLX030A in Subjects With Chronic Heart Failure (CHF)
Novartis Pharmaceuticals
NCT02744339 COMPLETED Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
Medical University of Vienna
NCT03565328 TERMINATED The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
National Heart, Lung, and Blood Institute (NHLBI)
NCT01876433 COMPLETED Beta 3 Agonist Treatment in Heart Failure
Henning Bundgaard
NCT03128528 COMPLETED Analysing the Effect of Empagliflozin on Reduction of Tissue Sodium Content in Patients With Chronic Heart Failure
University of Erlangen-Nürnberg Medical School
NCT02914665 COMPLETED A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart Failure
Stealth BioTherapeutics Inc.
NCT03357731 COMPLETED A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function
Bristol-Myers Squibb
NCT03453151 COMPLETED Abdominal Nerve Blockade in Chronic Heart Failure.
Duke University
NCT02788747 COMPLETED Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction
Stealth BioTherapeutics Inc.
NCT02964650 COMPLETED Optimising Pacemaker Therapy for Contractility
University of Leeds
NCT00869024 COMPLETED Stem Cell Therapy in Patients With Severe Heart Failure & Undergoing Left Ventricular Assist Device Placement
University of Minnesota
NCT00721045 COMPLETED A Phase II Dose-escalation Study to Assess the Feasibility and Safety of Transendocardial Delivery of Three Different Doses of Allogeneic Mesenchymal Precursor Cells (MPCs)in Subjects With Heart Failure
Mesoblast, Ltd.
NCT02547766 COMPLETED Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices
University of Utah
NCT02359227 COMPLETED Safety Study of Cenderitide in Stable Chronic Heart Failure
Capricor Inc.
NCT02603614 COMPLETED Safety Study of Cenderitide in Chronic Stable Heart Failure With Moderate Renal Impairment
Capricor Inc.
NCT03198585 COMPLETED Empagliflozin in Heart Failure Patients With Reduced Ejection Fraction
Morten Schou
NCT02918552 COMPLETED Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction
Gladwin, Mark, MD
NCT00748579 TERMINATED Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency
Cytokinetics
NCT00972569 COMPLETED Low Dose Intravenous (IV) Infusion of BNP in the Presence and Absence of Acute Type V Phosphodiesterase (PDE V) in Improving Renal Function in Hospitalized Chronic Heart Failure (CHF) Patients With Renal Dysfunction
Mayo Clinic
NCT02467387 COMPLETED A Study to Assess the Effect of Intravenous Dose of (aMBMC) to Subjects With Non-ischemic Heart Failure
CardioCell LLC
NCT02362646 COMPLETED Safety & Efficacy of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in LVAD Recipients
Annetine Gelijns
NCT03665350 TERMINATED Insulin Treatment in Diabetic Older People With Heart Failure.
Mario Negri Institute for Pharmacological Research
NCT01945606 COMPLETED Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker
Bayer
NCT01069510 COMPLETED Spironolactone in Adult Congenital Heart Disease
Oregon Health and Science University
NCT02157506 COMPLETED A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure
Bristol-Myers Squibb
NCT03098979 COMPLETED A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Preserved Ejection Fraction
Bayer
NCT03243942 COMPLETED Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement
Thomas Jefferson University
NCT02949531 COMPLETED Use of Oxygen in Heart Failure With Preserved Ejection Fraction
Hull University Teaching Hospitals NHS Trust
NCT03217331 COMPLETED CRD-102 for Right Heart Failure in Patients With Left Ventricular Assist Devices
Cardiora Pty. Ltd.
NCT02151383 TERMINATED Pharmacokinetics & Safety of Serelaxin on Top of Standard of Care Therapy in Pediatric Patients With Acute Heart Failure
Novartis Pharmaceuticals
NCT02040233 COMPLETED Multiple Dose Study in Heart Failure of BAY 1067197
Bayer
NCT03062176 WITHDRAWN Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease
Virginia Commonwealth University
NCT02992288 COMPLETED A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Reduced Ejection Fraction
Bayer
NCT01156974 COMPLETED Care Guides in the Primary Care Office (Phase II)
Allina Health System
NCT01431313 COMPLETED Inhaled Nitrite in Subjects With Pulmonary Hypertension
Schmidhofer, Mark, MD
NCT03882710 COMPLETED Metoprolol XR in Heart Failure With Normal Ejection Fraction
Post Graduate Institute of Medical Education and Research, Chandigarh
NCT02742129 COMPLETED Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF
Adrian Hernandez
NCT00927784 TERMINATED Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD
Icahn School of Medicine at Mount Sinai
NCT03170219 TERMINATED Subcutaneous Furosemide in Acute Decompensated Heart Failure: The SUBQ-HF Study
Adrian Hernandez
NCT01956006 COMPLETED Pilot Study of Slow Release Oral Milrinone in Patients With Advanced Heart Failure
The Alfred
NCT01787851 WITHDRAWN Study of the Acute Effects of Triheptanoin in Heart Failure
University of Texas Southwestern Medical Center
NCT02780180 TERMINATED QUantum Genomics Incremental Dosing in Heart Failure - QUID-HF
Quantum Genomics SA
NCT03415906 WITHDRAWN Influences of Angiotensin-neprilysin Inhibition on Sympathetic Activity in Heart Failure
Hannover Medical School
NCT02625922 TERMINATED Study of the Effect of Serelaxin on High-sensitivity Cardiac Troponin I (Hs-cTnI) Release in Patients With Chronic Heart Failure
Novartis Pharmaceuticals
NCT02457260 COMPLETED Oral Nitrite for Older Heart Failure Patients
Gladwin, Mark, MD
NCT02497937 COMPLETED A Study to Evaluate the Effect of the Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Blocker, GSK2798745, on Pulmonary Gas Transfer and Respiration in Patients With Congestive Heart Failure
GlaxoSmithKline
NCT01252810 COMPLETED Safety Study of GE-145 320 mg I/mL Injection vs. Iopamidol 370 mg I/mL in Elderly Subjects Undergoing Coronary Procedure
GE Healthcare
NCT00682565 COMPLETED PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina
Cytokinetics
NCT01966601 COMPLETED A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure
Trevena Inc.
NCT01370564 COMPLETED Feasibility of an Integrated Patient Care (IPC) System Using Daily Filling Pressures
Medtronic Cardiac Rhythm and Heart Failure
NCT02350725 COMPLETED Furosemide Pharmacodynamics and Pharmacokinetics After Subcutaneous or Oral Administration
scPharmaceuticals, Inc.
NCT02173548 COMPLETED Interleukin-1 Blockade in HF With Preserved EF
Virginia Commonwealth University
NCT03557255 COMPLETED Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer Surgeries
National Cancer Institute, Egypt
NCT02810132 COMPLETED Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure
Aarhus University Hospital
NCT01544998 COMPLETED Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure
Mayo Clinic
NCT02113033 COMPLETED VAgal Nerve Stimulation: safeGUARDing Heart Failure Patients
LivaNova
NCT00787059 COMPLETED AC6 Gene Transfer for CHF
Hammond, H. Kirk, M.D.
NCT01469988 TERMINATED The VO2 Increase With Testosterone Addition - Heart Failure (VITA-HF) Trial
University of Alberta
NCT00869869 WITHDRAWN Melatonin Supplementation to Improve Sleep in Patients With Heart Failure
Brigham and Women's Hospital
NCT03005184 WITHDRAWN Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2
Vanderbilt University Medical Center
NCT00812253 COMPLETED Intensive Glycemic Control for Congestive Heart Failure Exacerbation
Kathleen Dungan
NCT03073356 COMPLETED Ketones in Heart Failure - Effects on Cardiac Efficiency
University of Aarhus
NCT03079518 COMPLETED Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency
RWTH Aachen University
NCT01300650 COMPLETED Pilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Heart Failure
Virginia Commonwealth University
NCT02452515 COMPLETED A Single-blind Pilot Study to Investigate Safety and Tolerability of the Chymase Inhibitor BAY1142524 in Clinically Stable Patients With Left-ventricular Dysfunction
Bayer
NCT02804035 COMPLETED Pilot Study for First Clinical Use of sc2Wear Furosemide Combination Product
scPharmaceuticals, Inc.
NCT02256345 COMPLETED Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF
University of Pennsylvania
NCT02454751 COMPLETED The Use of Intranasal Fentanyl for the Treatment of Incident Dyspnea in Congestive Heart Failure: A Prospective Trial
St. Boniface Hospital
NCT02814097 COMPLETED A Study to Evaluate the Effects of 4 Weeks Treatment With Subcutaneous Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Preserved Ejection Fraction
Stealth BioTherapeutics Inc.
NCT02262078 COMPLETED Inhaled Sodium Nitrite on Heart Failure With Preserved Ejection Fraction
Mayo Clinic
NCT01966887 TERMINATED AAV1-CMV-Serca2a GENe Therapy Trial in Heart Failure
Assistance Publique - Hôpitaux de Paris
NCT01357850 COMPLETED A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Metabolism, Myocardial Function, and Exercise Capacity in Patients With NYHA Class II/III Congestive Heart Failure
GlaxoSmithKline
NCT01415921 COMPLETED Safety Study of Pyridostigmine in Heart Failure
NYU Langone Health
NCT01102140 TERMINATED The Impact of Pomegranate Extract on Chronic Cardiomyopathy Complicated by Renal Insufficiency (ImPrOVE): a Pilot Study
Jennifer Cowger , MD, MS
NCT01187836 COMPLETED Study to Evaluate the Effects of TRV120027 in Patients With Heart Failure
Trevena Inc.
NCT02235077 COMPLETED Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure
Duke University
NCT01636570 COMPLETED Vitamin D3 Supplementation for Heart Failure Patients
Heidi Moretti, MS, RD
NCT02299726 WITHDRAWN Early Aldosterone Blockade in Acute Heart Failure: An Exploratory Safety Study
Indiana University
NCT01438086 COMPLETED Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack
University College Cork
NCT02721511 WITHDRAWN A Study to Investigate the Safety and Efficacy of a Novel Furosemide Regimen
Todd M Koelling, MD
NCT01733017 COMPLETED Nutrition Intervention to Decrease Symptoms in Patients With Heart Failure
Terry Lennie
NCT01800968 COMPLETED Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)
Duke University
NCT02346422 TERMINATED A Phase 1/2 Study of High-dose Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
Celladon Corporation
NCT01213251 COMPLETED Post-Myocardial Infarction Remodeling Prevention Therapy
Medtronic Cardiac Rhythm and Heart Failure
NCT02053493 COMPLETED Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction
Adrian Hernandez
NCT01096043 COMPLETED A Dose-Defining Study of CXL-1020 in Patients With Systolic Heart Failure
Bristol-Myers Squibb
NCT01982292 COMPLETED Safety of Repeat Doses of IV Serelaxin in Subjects With Chronic Heart Failure
Novartis Pharmaceuticals
NCT02596477 TERMINATED Evaluation of Vepoloxamer in Chronic Heart Failure
Mast Therapeutics, Inc.
NCT02466100 COMPLETED Goals of Care Communication
University of Washington
NCT01619891 COMPLETED VitamIN D Treating patIents With Chronic heArT failurE
University of Leeds
NCT01425580 COMPLETED Liraglutide and Heart Failure in Type 2 Diabetes
Thomas Nystrom
NCT01858480 WITHDRAWN Study To Evaluate D-Ribose For The Treatment of Congestive Heart Failure
RiboCor, Inc.
NCT01092325 COMPLETED Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure
Bristol-Myers Squibb
NCT01175018 COMPLETED Anakinra to Prevent Adverse Post-infarction Remodeling (2)
Virginia Commonwealth University
NCT00738517 WITHDRAWN Immunoadsorption and Immunoglobulin Substitution for Heart Failure After Myocardial Infarction
University Medicine Greifswald
NCT01643330 COMPLETED A Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
Celladon Corporation
NCT01932606 COMPLETED Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction
Barry Borlaug
NCT01954160 TERMINATED Study of Renal Denervation in Patients With Heart Failure
Adrian Hernandez
NCT01074099 TERMINATED Feasibility Study of BMAC Enhanced CABG
Harvest Technologies
NCT01946542 TERMINATED Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure
Jason Allen, Ph.D.
NCT01467232 COMPLETED IMPACT-CABG Trial: IMPlantation of Autologous CD133+ sTem Cells in Patients Undergoing Coronary Artery Bypass Grafting
University Health Network, Toronto
NCT00839228 COMPLETED Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome
University of Aberdeen
NCT01112579 COMPLETED Determining the Feasibility of Spinal Cord Neuromodulation for the Treatment of Chronic Heart Failure
Medtronic Cardiac Rhythm and Heart Failure
NCT00729222 COMPLETED Hemodynamic Effects of Rolofylline in the Treatment of Patients With Heart Failure (7418-503)
Merck Sharp & Dohme LLC
NCT01922089 COMPLETED Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients
Novartis Pharmaceuticals
NCT01085175 WITHDRAWN Trial to Determine Imaging Parameters of LMI1195 in Heart Failure Patients at Low and High Risk of Defibrillator Firing
Lantheus Medical Imaging
NCT02002702 COMPLETED Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients
Novartis Pharmaceuticals
NCT01064037 TERMINATED A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
Bayer
NCT01065077 TERMINATED BAY58-2667 Dose Finding Trial Investigating Fixed Doses in Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
Bayer
NCT01067859 TERMINATED A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
Bayer
NCT01814319 COMPLETED Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure
University of Cincinnati
NCT00887588 COMPLETED LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction
Novartis Pharmaceuticals
NCT01887353 TERMINATED The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure
Intermountain Health Care, Inc.
NCT00982423 COMPLETED The Effects of Decreasing the Lasix Dose on the Cardiorenal System
Mayo Clinic
NCT01088854 COMPLETED Acute Effect of Continuous Positive Airway Pressure in Heart Failure
UPECLIN HC FM Botucatu Unesp
NCT02436161 COMPLETED Effectiveness of a Multidisciplinary Care Management Program for High-risk Patients With Heart Failure (PROMIC)
Basque Health Service
NCT01442129 COMPLETED The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation
Deborah Ascheim
NCT01919177 COMPLETED Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity
Corporal Michael J. Crescenz VA Medical Center
NCT01894750 COMPLETED Building Skill in Heart Failure Self-care: A Community Based Intervention
NYU Langone Health
NCT01350310 COMPLETED Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy
University Medical Centre Ljubljana
NCT01696890 TERMINATED Integration of Follow-up by First and Second Line Practitioners by Telemonitoring in Heart Failure.
Jessa Hospital
NCT00644410 COMPLETED Autologous Mesenchymal Stromal Cell Therapy in Heart Failure
Rigshospitalet, Denmark
NCT01270646 COMPLETED Impact of Intraventricular Electrical Activation in Resynchronization Therapy
University Hospital, Bordeaux
NCT01213784 COMPLETED Optimized Glycemic Control in Heart Failure Patients With DM2:"Effect on Left Ventricular Function and Skeletal Muscle"
University of Aarhus
NCT01823887 COMPLETED Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) Study
Cyberonics, Inc.
NCT01849094 COMPLETED Evaluating the Safety, Pharmacokinetics and Haemodynamic Effect of a Slow Release Oral Formulation of Milrinone
The Alfred
NCT01812512 WITHDRAWN Telehealth Self Management for CHF
US Department of Veterans Affairs
NCT00757055 WITHDRAWN If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure
St Vincent's University Hospital, Ireland
NCT00987415 COMPLETED Using Allopurinol to Relieve Symptoms in Patients With Heart Failure and High Uric Acid Levels
Duke University
NCT00838253 WITHDRAWN Safety and Efficacy Study of Istaroxime in Acute Decompensated Heart Failure Patients
Debiopharm International SA
NCT01434134 COMPLETED Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy
University Hospital, Akershus
NCT01132846 COMPLETED Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study
Duke University
NCT01935622 TERMINATED Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
Virginia Commonwealth University
NCT01543854 COMPLETED Hemodynamic Responses to RLX030 Infusion in Subjects With Acute Heart Failure
Novartis Pharmaceuticals
NCT01061580 TERMINATED BMAC Enhanced Coronary Artery Bypass Grafting (CABG)
Harvest Technologies
NCT00555685 COMPLETED Hypertonic Saline Solution in Heart Failure
University of Sao Paulo
NCT00957541 COMPLETED Evaluation of a Diagnostic Feature in a Cardiac Resynchronization Therapy (CRT) Device
ELA Medical, Inc.
NCT01798745 WITHDRAWN A Study to Assess the Pharmacokinetics and Pharmacodynamics of JNJ-54452840 in Participants With Heart Failure and Anti-beta1-adrenergic Receptor Autoantibodies
Janssen Research & Development, LLC
NCT01235273 SUSPENDED Treatment of the lOw IGF-1 Syndrome aSsociated With Chronic Heart fAilure: A Randomized, Placebo-Controlled, Double-Blind Study.
Federico II University
NCT01440517 TERMINATED Results of Tc99m-Maraciclatide Scintigraphy in Subjects With Diabetes Mellitus and Heart Failure With Preserved Left Ventricular Ejection Fraction
GE Healthcare
NCT00812487 COMPLETED Glycemic Control and Variability for Congestive Heart Failure Exacerbation
Kathleen Dungan
NCT01981655 COMPLETED 0.5M Na Lactate Solution in Acute Heart Failure (AHF)
Nepean Blue Mountains Local Health District
NCT01939236 COMPLETED Traditional Chinese Medicine for Treatment of Chronic Heart Failure
Beijing University of Chinese Medicine
NCT00680706 COMPLETED Thiamine and Acute Decompensated Heart Failure: Pilot Study
Baystate Medical Center
NCT00691834 WITHDRAWN Safety and Efficacy on Cell-based Therapy in Patients With Recent Large Acute Myocardial Infarction
Duke University
NCT01120210 COMPLETED A Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of an Intravenous Solution of JNJ-39588146 or Placebo in Patients With Heart Failure
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT00881439 TERMINATED Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal Impairment
University Medical Center Groningen
NCT01829607 COMPLETED Functional Electrical Stimulation of Peripheral Muscles in Heart Failure With Preserved Left Ventricular Ejection Fraction
Attikon Hospital
NCT01265524 COMPLETED Evaluation of CLP in Heart Failure Patients With Chronic Kidney Disease
Sorbent Therapeutics
NCT01092130 COMPLETED Study to Investigate the Effects of Vitamin D Administration on Plasma Renin Activity in Patients With Stable Chronic Heart Failure
University Medical Center Groningen
NCT00941681 COMPLETED Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure
Cytokinetics
NCT01301313 TERMINATED Efficacy and Safety of Levosimendan in Severe Acute Heart Failure in Critical Children
Jose Luis Vazquez Martinez
NCT01192373 COMPLETED Modulation of Free Fatty Acids in Heart Failure Patients With Diabetes: "Effect on Left Ventricular Function"
University of Aarhus
NCT01125514 COMPLETED A Study to Investigate the Pharmacodynamic and Pharmacokinetic Interaction Between Aliskiren and Furosemide in Patients With Heart Failure
Novartis Pharmaceuticals
NCT00923156 COMPLETED Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart Failure
Novartis Pharmaceuticals
NCT01163734 COMPLETED Ranolazine in Diastolic Heart Failure
Gilead Sciences
NCT00957034 TERMINATED Assessing the Safety/Efficacy of Transdermal Testosterone in Female Patients With Symptomatic Heart Failure
Warner Chilcott
NCT01500343 COMPLETED A Pilot Study of Probiotic Saccharomyces Boulardii Use in Chronic Heart Failure Patients. Estudo PROICA
Universidade Federal Fluminense
NCT00841139 COMPLETED Metabolic Manipulation in Chronic Heart Failure
University Hospital Birmingham NHS Foundation Trust
NCT01185925 COMPLETED Exercise Oscillatory Breathing and Sildenafil in Heart Failure
University of Milan
NCT00654966 COMPLETED Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers
Monash University
NCT00881777 TERMINATED Feasibility Study of Radiofrequency Heating of Cardiac Infarction Scar to Treat Heart Failure
CoRepair, Inc.
NCT01055912 COMPLETED Study to Evaluate the Effects of Oral Administration of Lixivaptan in Patients With Congestive Heart Failure
CardioKine Inc.
NCT01071772 COMPLETED The Effect of Hyperglycemia on LV Function and Exercise Capacity in Diabetics With and Without Heart Failure.
University of Aarhus
NCT00787293 SUSPENDED Study of Safety and Efficacy of the Percutaneous Reduction of Mitral Valve Regurgitation in Heart Failure Patients
Viacor
NCT00604331 COMPLETED Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Herzzentrum Goettingen
NCT00839007 COMPLETED Study to Assess the Safety and Efficacy of CD-NP in the Treatment of Patients With Acute Decompensated Heart Failure
Nile Therapeutics
NCT00744341 TERMINATED Safety and Efficacy Study to Evaluate the Effect of SLV320 on Renal Function in Patients With Worsening Heart Failure
Solvay Pharmaceuticals
NCT00346177 WITHDRAWN Stem Cell Study for Patients With Heart Failure
Losordo, Douglas, M.D.
NCT00694720 TERMINATED Evaluation of the Effect of AVE0657 in Cheynes-Stokes Breathing Syndrome Patients
Sanofi
NCT00699712 COMPLETED Study to Assess Hemodynamic Effects, Safety and Tolerability of Chimeric Natriuretic Peptide (CD-NP) in Patients With Stabilized Acute Heart Failure (AHF)
Nile Therapeutics
NCT00662116 TERMINATED Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I)
Synvista Therapeutics, Inc
NCT00739687 TERMINATED Safety & Efficacy of ALT-711 (Alagebrium) in Chronic Heart Failure
Synvista Therapeutics, Inc