Hypothyroidism Clinical Trial Landscape
Data updated: May 20, 2026
41 clinical trials tracked since 2008
Hypothyroidism is being studied across 41 clinical trials registered since 2008, with 6 programs currently active. The competitive pipeline includes 4 active Phase 3 trials, 3 active Phase 2 trials, and 0 active Phase 1 trials. Top industry sponsors include AbbVie.
6 active
/
41 total (since 2008)
0
Phase 1 Active
0 total
3
Phase 2 Active
16 total
4
Phase 3 Active
10 total
1
Phase 4 Active
21 total
Top Industry Sponsors
Sorted by active Active Done Failed
AbbVie 1 1 0
Featured Phase 3 Trials
NCT06345339 RECRUITING
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
AbbVie n=2,800
NCT05682482 RECRUITING
LT4/LT3 Combination Therapy Versus LT4 Monotherapy in Patients with Autoimmune Hypothyroidism.
M. Medici n=600
NCT05316922 RECRUITING
TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano n=68
NCT06276205 COMPLETED
Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
King Edward Medical University n=62
+ 5 more Phase 3 trials — see full database below
Hypothyroidism — Trials Started by Year (last 10 years)
2016 0
2017 2
2018 4
2019 2
2020 2
2021 4
2022 4
2023 2
2024 4
2025 0
2026 1
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
AbbVie 2
IBSA Institut Biochimique SA 2
Neuvosyn Laboratories, LLC 1
Bracco Diagnostics, Inc 1
Xeris Pharmaceuticals 1
Sention Therapeutics, LLC 1
GE Healthcare 1
Takeda 1
Merck KGaA, Darmstadt, Germany 1
Ipe, LLC 1
Active Trials by Phase
Phase 2 3
Phase 3 4
Phase 4 1
Enrollment Size Distribution
1-50 13
51-200 14
201-500 8
501-1k 2
1k+ 1
All Industry Sponsors
Sorted by active Active Done Failed
AbbVie 1 1 0
NCT06345339 RECRUITING
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
AbbVie n=2,800
NCT05682482 RECRUITING
LT4/LT3 Combination Therapy Versus LT4 Monotherapy in Patients with Autoimmune Hypothyroidism.
M. Medici n=600
NCT05316922 RECRUITING
TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano n=68
NCT06276205 COMPLETED
Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
King Edward Medical University n=62
NCT03053115 COMPLETED
Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients
Azienda USL Modena n=160
NCT02548715 WITHDRAWN
Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery
University of Alberta
NCT03898622 COMPLETED
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Hospital Civil de Guadalajara n=32
NCT02090907 COMPLETED
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Isfahan University of Medical Sciences n=50
NCT00921050 COMPLETED
Subclinical Hypothyroidism and Mind in the Elderly
Universidad Autonoma de Nuevo Leon n=70
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only