Insomnia Clinical Trial Landscape

Data updated: May 20, 2026

263 clinical trials tracked since 2008

Insomnia is being studied across 263 clinical trials registered since 2008, with 59 programs currently active. The competitive pipeline includes 10 active Phase 3 trials, 28 active Phase 2 trials, and 7 active Phase 1 trials. Top industry sponsors include Shanghai Haiyan Pharmaceutical Technology Co., Ltd., Merck, Sequential Medicine Ltd.

59 active

263 total (since 2008)

Phase 1 Active

47 total

Phase 2 Active

97 total

Phase 3 Active

65 total

Phase 4 Active

70 total

Top Industry Sponsors

Sorted by active Active Done Failed

Shanghai Haiyan Pharmaceutical Technology Co., Ltd. 4 4 0

Merck 1 12 0

Sequential Medicine Ltd 1 2 1

Vanda Pharmaceuticals 1 1 0

RDC Clinical Pty Ltd 1 0 0

+ 10 more sponsors — see full table below

Featured Phase 3 Trials

NCT06655883 RECRUITING

A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)

Merck Sharp & Dohme LLC n=300

NCT06619912 RECRUITING

Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients

Xijing Hospital n=686

NCT06975514 RECRUITING

Safety and Efficacy Study of YZJ-1139 Tablets in Insomnia Disorder

Shanghai Haiyan Pharmaceutical Technology Co., Ltd. n=60

NCT05840822 RECRUITING

Evaluating Efficacy and Safety of CBD TPM Capsules for Use in Insomnia

Avecho Biotechnology n=519

NCT06953869 RECRUITING

Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia

Vanda Pharmaceuticals n=420

+ 60 more Phase 3 trials — see full database below

Insomnia — Trials Started by Year (last 10 years)

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Merck

Sequential Medicine Ltd

Vanda Pharmaceuticals

RDC Clinical Pty Ltd

Apsen Farmaceutica S.A.

Proactive Life Inc

Reconnect Labs

Avecho Biotechnology

Nyree Penn

Active Trials by Phase

Phase 1

Phase 2

Phase 3

Phase 4

Enrollment Size Distribution

1-50

100

51-200

201-500

501-1k

1k+

All Industry Sponsors

Sorted by active Active Done Failed

Shanghai Haiyan Pharmaceutical Technology Co., Ltd. 4 4 0

Merck 1 12 0

Sequential Medicine Ltd 1 2 1

Vanda Pharmaceuticals 1 1 0

RDC Clinical Pty Ltd 1 0 0

Apsen Farmaceutica S.A. 1 0 0

Proactive Life Inc 1 0 0

Reconnect Labs 1 0 0

Avecho Biotechnology 1 0 0

Nyree Penn 1 0 0

Afasci Inc 1 0 0

Nanjing Chia-tai Tianqing Pharmaceutical 1 0 0

ProofPilot 1 0 0

Jiangsu Hansoh Pharmaceutical Co., Ltd. 1 0 0

Idorsia Pharmaceuticals Ltd. 0 8 0

NCT06655883 RECRUITING

A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)

Merck Sharp & Dohme LLC n=300

NCT06619912 RECRUITING

Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients

Xijing Hospital n=686

NCT06975514 RECRUITING

Safety and Efficacy Study of YZJ-1139 Tablets in Insomnia Disorder

Shanghai Haiyan Pharmaceutical Technology Co., Ltd. n=60

NCT05840822 RECRUITING

Evaluating Efficacy and Safety of CBD TPM Capsules for Use in Insomnia

Avecho Biotechnology n=519

NCT06953869 RECRUITING

Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia

Vanda Pharmaceuticals n=420

NCT06062953 RECRUITING

Efficacy of Melatonin, Low-dose Quetiapine, or Placebo in Patients With Psychiatric Disorders and Comorbid Insomnia

Lone Baandrup n=255

NCT06859190 RECRUITING

Efficacy of Auricular Pressure Beans with Electroacupuncture and Estazolam Treating Insomnia Caused by Cancer

Qinghai Red Cross Hospital n=60

NCT04050176 ACTIVE NOT RECRUITING

Use of Blinded Tapering for Hypnotic Discontinuation

National Jewish Health n=260

NCT06512363 NOT YET RECRUITING

A Study of Ramelteon in Chinese Patients With Chronic Insomnia

Nanjing Chia-tai Tianqing Pharmaceutical n=280

NCT07587385 NOT YET RECRUITING

A Study of HS-10506 in Chinese Patients With Insomnia Disorder

Jiangsu Hansoh Pharmaceutical Co., Ltd. n=732

NCT06476392 COMPLETED

Melatonin fOr CHronic bAck Pain (The MOCHA Trial)

Odense University Hospital n=220

NCT03668041 COMPLETED

National Adaptive Trial for PTSD Related Insomnia

VA Office of Research and Development n=673

NCT07028697 COMPLETED

A Study to Evaluate the Efficacy and Safety of Daridorexant in Participants With Insomnia Disorder

Nxera Pharma Korea Co., Ltd. n=164

NCT04451668 COMPLETED

An Open Label Study of FT218 in Subjects With Narcolepsy

Avadel n=184

NCT04759703 TERMINATED

Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD

Massachusetts General Hospital n=75

NCT01549899 COMPLETED

Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia

Daniel J. Taylor, Ph.D. n=185

NCT05453136 COMPLETED

Phase III Study of TS-142 in Patients with Insomnia

Taisho Pharmaceutical Co., Ltd. n=1,155

NCT05461352 COMPLETED

Long-Term Study of TS-142 in Patients with Insomnia

Taisho Pharmaceutical Co., Ltd. n=401

NCT06756971 WITHDRAWN

DISE in Pediatric Sleep Disordered Breathing

University of Iowa

NCT02783729 COMPLETED

Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)

Eisai Inc. n=1,006

NCT06010693 COMPLETED

A Study of Daridorexant in Chinese Patients With Insomnia Disorder

Jiangsu Simcere Pharmaceutical Co., Ltd. n=206

NCT03682185 COMPLETED

The Healthy Patterns Sleep Study

University of Pennsylvania n=421

NCT03338764 WITHDRAWN

An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia

Sequential Medicine Ltd

NCT05015803 COMPLETED

Enhanced CBTi for Older Adult Sleep and Cognition

Penn State University n=60

NCT03534284 COMPLETED

Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis

University of Washington n=126

NCT03771664 TERMINATED

A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomnia

Biogen n=87

NCT03373201 COMPLETED

Evaluating the Effects of Tasimelteon vs. Placebo on Jet Lag Type Insomnia

Vanda Pharmaceuticals n=320

NCT03545191 COMPLETED

Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects With Insomnia Disorder

Idorsia Pharmaceuticals Ltd. n=930

NCT03575104 COMPLETED

Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep

Idorsia Pharmaceuticals Ltd. n=924

NCT03679884 COMPLETED

Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep

Idorsia Pharmaceuticals Ltd. n=804

NCT02333149 WITHDRAWN

Melatonin in Youth: N-of-1 Trials in a Stimulant-treated Attention Deficit Hyperactivity Disorder (ADHD) Population

University of Alberta

NCT03478306 COMPLETED

Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm

Glostrup University Hospital, Copenhagen n=31

NCT04009577 COMPLETED

A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia

Eisai Inc. n=53

NCT00561574 COMPLETED

A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001)

Merck Sharp & Dohme LLC n=259

NCT03075241 COMPLETED

Z-Drugs for Sleep Disorders in Alzheimer's Disease

Brasilia University Hospital n=62

NCT02952820 COMPLETED

Long-term Study of Lemborexant in Insomnia Disorder (SUNRISE 2)

Eisai Inc. n=971

NCT01097629 COMPLETED

Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study B (MK-4305-029)

Merck Sharp & Dohme LLC n=1,020

NCT03331042 COMPLETED

SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia.

Sequential Medicine Ltd n=85

NCT00631657 COMPLETED

A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002)

Merck Sharp & Dohme LLC n=460

NCT01097616 COMPLETED

Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study A (MK-4305-028)

Merck Sharp & Dohme LLC n=1,023

NCT01021813 COMPLETED

A Long Term Safety Study of Suvorexant in Participants With Primary Insomnia (MK-4305-009 AM3)

Merck Sharp & Dohme LLC n=781

NCT02139098 TERMINATED

Alternative Dosing Regimens in the Pharmacotherapy of Insomnia

Philipps University Marburg n=23

NCT00857220 COMPLETED

Long Term Safety Study of Study Drug (Eszopiclone) in Children and Adolescents With ADHD -Associated Insomnia

Sumitomo Pharma America, Inc. n=304

NCT02232256 WITHDRAWN

The Efficacy of CALPXT96™in Improving Sleep Quality in Patients With Chronic Non-cancer Pain

9305-9954 Quebec Inc

NCT01804036 COMPLETED

Two Contrasting Interventions for Sleep Management

University of Utah n=72

NCT01438697 COMPLETED

An Interactive Internet Intervention for Adults With Insomnia

University of Virginia n=303

NCT00945412 WITHDRAWN

Topical Microporous Polysaccharide Hemospheres Versus Electrocautery for Control of Pediatric Post-Tonsillectomy Bleeding

Massachusetts Eye and Ear Infirmary

NCT01667822 COMPLETED

Cognitive Behavioral Therapy, Guided Self Help Versus Individual Therapy

Karolinska Institutet n=396

NCT02747979 COMPLETED

The Effect and Safety of Hemodialysis and Hemoperfusion on Severe Renal Osteopathy and Itching in Uremia Patients

Sun Yat-sen University n=20

NCT00608985 COMPLETED

Almorexant (ACT 078573) in Adult Subjects With Chronic Primary Insomnia

Midnight Pharma, LLC n=709

NCT00805350 COMPLETED

Efficacy and Safety of Eplivanserin 5mg/Day in Insomnia Characterized by Sleep Maintenance Difficulties

Sanofi n=637

NCT01667809 COMPLETED

CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care

Karolinska Institutet n=5

NCT01636791 COMPLETED

CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care

Karolinska Institutet n=211

NCT01100164 COMPLETED

A Non-inferiority Study With Two Treatment Arms Eszopiclone 3 mg Versus Zopiclone 7.5 mg - for the Treatment of Insomnia

Eurofarma Laboratorios S.A. n=263

NCT01545414 COMPLETED

Internet-CBT (Cognitive Behavioral Therapy) for Depression and Anxiety in Parkinsons Disease

Karolinska Institutet n=150

NCT01955850 COMPLETED

Online or Face-to-face Treatment for Insomnia?

VU University of Amsterdam n=90

NCT01161108 COMPLETED

Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities

The Hospital for Sick Children n=13

NCT00856973 COMPLETED

Safety & Efficacy Study of Study Drug (Eszopiclone) in Children and Adolescents With Attention-deficit/Hyperactivity Disorder - Associated Insomnia

Sumitomo Pharma America, Inc. n=486

NCT00869167 TERMINATED

Ramelteon for Insomnia Comorbid With Asthma

Northwestern University n=2

NCT00770510 COMPLETED

A Phase II/III Study of SEP-190 (Eszopiclone) in Patients With Primary Insomnia (Study 190-126)

Eisai Co., Ltd. n=192

NCT01224912 COMPLETED

Internet Delivered Self-Help CBT for Insomnia

Utrecht University n=479

NCT01456637 COMPLETED

Online Self-Help Intervention for Insomnia: With or Without Feedback

Utrecht University n=262

NCT00770692 COMPLETED

A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150)

Eisai Co., Ltd. n=369

NCT01142258 COMPLETED

Trazodone for Sleep Disorders in Alzheimer's Disease

Brasilia University Hospital n=40

NCT01468038 COMPLETED

A Double-blind Placebo Controlled Trial of Sentra PM, a Medical Food

Targeted Medical Pharma n=111

NCT06843187 RECRUITING

Lemborexant for the Treatment of Residual Insomnia in Major Depressive Disorder (MDD)

Unity Health Toronto

NCT07565974 NOT YET RECRUITING

THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia

Mayo Clinic

NCT05441280 RECRUITING

Pimavanserin for Insomnia in Veterans With PTSD

VA Office of Research and Development

NCT03255408 RECRUITING

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

University of Calgary

NCT07315516 RECRUITING

Sleep and Stress Study

RDC Clinical Pty Ltd

NCT06430333 RECRUITING

Sleep to Reduce Incident Depression Effectively in Peripartum

Henry Ford Health System

NCT07504536 NOT YET RECRUITING

Ning Shen Dan Xiang Gao Fang for Heart-Kidney Disharmony Insomnia

Shanghai 7th People's Hospital

NCT06972303 RECRUITING

Mindfulness Meditation for Insomnia

Brigham and Women's Hospital

NCT07420816 NOT YET RECRUITING

Efficacy and Safety of APSTZD in the Treatment of Insomnia Disorder

Apsen Farmaceutica S.A.

NCT07392177 NOT YET RECRUITING

Understanding the Role of the Locus Coeruleus in Insomnia

Woolcock Institute of Medical Research

NCT01628029 ACTIVE NOT RECRUITING

Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer

M.D. Anderson Cancer Center

NCT07316153 NOT YET RECRUITING

Deep Sleep in Older Adults

Proactive Life Inc

NCT07298941 RECRUITING

Resilience Enhancement Following Sleep Treatment

University of Virginia

NCT06983080 RECRUITING

Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study)

Centre hospitalier de l'Université de Montréal (CHUM)

NCT06434571 RECRUITING

Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

University of Kansas Medical Center

NCT06823752 RECRUITING

A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.

Woolcock Institute of Medical Research

NCT06685965 RECRUITING

A Study to Evaluate Effects on Sleep and Safety of RE03 in PTSD Patients With Sleep Disturbances

Reconnect Labs

NCT06679062 RECRUITING

Suvorexant for Treatment of AUD and PTSD

Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

NCT06428006 RECRUITING

Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis

University of Kansas Medical Center

NCT06981195 RECRUITING

Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects

Virginia Commonwealth University

NCT06609369 RECRUITING

Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse

Yale University

NCT06710431 NOT YET RECRUITING

A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder

Afasci Inc

NCT04875364 RECRUITING

Do Endotypes Predict Response and Sequelae in OSA Patients

University of California, San Diego

NCT06511011 NOT YET RECRUITING

Chinese Medicine in Treating Insomnia

Chinese University of Hong Kong

NCT05565833 RECRUITING

Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)

University of Virginia

NCT04396327 NOT YET RECRUITING

SM-1 vs. an Active Comparator in A Model of Transient Insomnia

Sequential Medicine Ltd

NCT07596342 NOT YET RECRUITING

Electrophysiological Analysis of Gamma-Hydroxybutyrate-induced Sleep in Intensive Care Patients

Assistance Publique - Hôpitaux de Paris

NCT06231641 TERMINATED

The Effects of Lemborexant on the Ability to Sleep During Daytime

Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

NCT07480096 COMPLETED

Efficacy and Safety of Lemborexant for Patients With Cirrhosis and Sleep Problems

Indonesia University

NCT04007796 COMPLETED

Apnea and Insomnia Relief Study

VA Office of Research and Development

NCT05423717 COMPLETED

Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder

Idorsia Pharmaceuticals Ltd.

NCT06278077 COMPLETED

Neurexan - a Clinical Trial in Short-Term Insomnia Patients

Biologische Heilmittel Heel GmbH

NCT05917379 COMPLETED

The Efficacy and Safty of FMT in Patients With CID

Peking University Sixth Hospital

NCT05041647 COMPLETED

Cannabinoids as a Treatment for Insomnia in Major Depression

St. Joseph's Healthcare Hamilton

NCT05908526 COMPLETED

Insomnia Treatment and EMA (Ecological Momentary Assessment) Outcomes

University of Maryland, Baltimore

NCT06956495 COMPLETED

Efficacy and Tolerability of Tasipimidine in Sleepless Patients

Orion Corporation, Orion Pharma

NCT04299490 COMPLETED

Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug

Johns Hopkins University

NCT05233761 COMPLETED

Evaluation of an Oral Cannabidiol (CBD)-Terpene Formulation on Sleep Physiology in Participants With Insomnia

Defined Research

NCT05700643 COMPLETED

Montmorency Cherry Supplementation, Sleep, and Inflammation

Michigan State University

NCT03375203 COMPLETED

A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder

Janssen Research & Development, LLC

NCT02464046 COMPLETED

Study to Evaluate Efficacy, Safety and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder Without Psychiatric Comorbidity

Janssen Research & Development, LLC

NCT05952297 COMPLETED

A Novel Wearable Device to Improve Sleep Quality

University of Utah

NCT04573725 COMPLETED

Early Phase 2 Clinical Study of TS-142 in Patients with Insomnia Disorder

Taisho Pharmaceutical Co., Ltd.

NCT04469023 COMPLETED

Late Phase II Study of TS-142 in Patients with Insomnia

Taisho Pharmaceutical Co., Ltd.

NCT04429347 COMPLETED

Gabapentin and Tizanidine for Insomnia in Chronic Pain

University of California, San Diego

NCT04846335 COMPLETED

Familiar Fatal Insomnia: Preventive Treatment With Doxycycline in Subject With Disease Risk

Mario Negri Institute for Pharmacological Research

NCT04928157 COMPLETED

Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids

University of California, San Diego

NCT06680505 COMPLETED

Safety and Efficacy Study of YZJ-1139 in Primary Chronic Insomnia Disorder

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT05344170 COMPLETED

Cannabinol Use in Patients With Insomnia Disorder

Woolcock Institute of Medical Research

NCT04035200 COMPLETED

Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation

Imbrium Therapeutics

NCT05253417 COMPLETED

The CANabidiol Use for RElief of Short Term Insomnia

Bod Australia

NCT03897062 TERMINATED

Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence

The Florey Institute of Neuroscience and Mental Health

NCT04766229 COMPLETED

The Menopause After Cancer Study

University College Dublin

NCT03814135 WITHDRAWN

Efficacy and Safety of Two Doses of Hipnos in the Treatment of Adults With Insomnia

EMS

NCT00664664 COMPLETED

Subjective Study to Assess the Efficacy of APD125 in Patients With Sleep Maintenance Insomnia

Arena Pharmaceuticals

NCT03984604 TERMINATED

Investigation of the Efficacy and Safety of CHI-921 in Insomnia.

Canopy Growth Corporation

NCT01745497 COMPLETED

Iron Treatment of Sleep Disorders in Children With Autism Spectrum Disorder

University of Colorado, Denver

NCT02841709 COMPLETED

Efficacy and Safety of ACT-541468 in Elderly Subjects With Insomnia Disorder

Idorsia Pharmaceuticals Ltd.

NCT02839200 COMPLETED

Efficacy and Safety of ACT-541468 in Adult Subjects With Insomnia Disorder

Idorsia Pharmaceuticals Ltd.

NCT01995838 COMPLETED

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Bayesian Adaptive Randomization Design, Dose Response Study of the Efficacy of E2006 in Adults and Elderly Subjects With Chronic Insomnia

Eisai Inc.

NCT02931474 WITHDRAWN

Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia

National Institute of Nursing Research (NINR)

NCT02831894 COMPLETED

The Role of Tapering Pace and Selected Traits on Hypnotic Discontinuation

National Jewish Health

NCT02818569 COMPLETED

Repurposing Dexmedetomidine as an Orally Administered Sleep Therapeutic

Massachusetts General Hospital

NCT03339583 COMPLETED

Effectiveness of BBT-I and Zopiclone for Chronic Insomnia

I.M. Sechenov First Moscow State Medical University

NCT03056053 COMPLETED

Study to Validate the Questionnaire Called IDSIQ™ in Patients With Insomnia Disorder

Idorsia Pharmaceuticals Ltd.

NCT01011218 COMPLETED

Management of Insomnia in Breast Cancer Patients

Stanford University

NCT01021852 COMPLETED

Polysomnography Study of MK-6096 in Participants With Primary Insomnia (MK-6096-011)

Merck Sharp & Dohme LLC

NCT00792298 COMPLETED

Phase IIB 2-Period Crossover Polysomnography Study in Participants With Primary Insomnia (MK-4305-006)

Merck Sharp & Dohme LLC

NCT01489969 COMPLETED

Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients

Neurim Pharmaceuticals Ltd.

NCT00940589 COMPLETED

Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor

Neurim Pharmaceuticals Ltd.

NCT02945254 COMPLETED

Effect of Background Noise on Sleep Quality

Brigham and Women's Hospital

NCT02671760 COMPLETED

Pilot Study of a Combination Drug Product for Treatment of Short-term Insomnia

Sequential Medicine Ltd

NCT01286324 COMPLETED

Chamomile for Chronic Primary Insomnia

University of Michigan

NCT01091974 COMPLETED

Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy

University of Rochester

NCT02409264 COMPLETED

The Effect of Individualised Homeopathic Treatment of Insomnia Disorder in Females

University of Johannesburg

NCT02319993 COMPLETED

Traditional Chinese Medicine Suan Tsao Jen Tang and Tian-Wang-Bu-Xin Dan in Patients With Primary Insomnia.

Chung Shan Medical University

NCT01558180 COMPLETED

Telephone Care Management to Address Sleep Problems in Young Children With Autism

Nationwide Children's Hospital

NCT01277107 COMPLETED

A Polysomnographic Study to Compare the Efficacy of Gastric Retentive Zaleplon Accordion Pill to Placebo in Subjects With Insomnia

Intec Pharma Ltd.

NCT02232204 COMPLETED

Sleep and Ventricular Arrhythmias Study

University of Florida

NCT00768781 COMPLETED

Mindfulness-Based Approaches to Insomnia

Rush University Medical Center

NCT00878553 COMPLETED

Study of Sleep-maintenance Activity of 3 Doses of SKP-1041

Somnus Therapeutics, Inc.

NCT01427192 COMPLETED

Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension

University of Zurich

NCT00949689 COMPLETED

Young Adult and Teen Sleep Study

Kaiser Permanente

NCT00784875 COMPLETED

An Efficacy Study of Compound LY2624803 in the Treatment of Patients With Chronic Insomnia

Eli Lilly and Company

NCT00935337 COMPLETED

Follow-up of a Study Examining Sleep Management in United States Veterans

University of Utah

NCT01196650 COMPLETED

Comparison of IN 10 003 to Placebo in Subjects With Insomnia Suffering From Difficulty in Falling Asleep and Staying Asleep

Intec Pharma Ltd.

NCT00832468 COMPLETED

The Complementary Effect of Ear Acupressure on Older Patients With Chronic Insomnia

National Yang Ming Chiao Tung University

NCT00933959 COMPLETED

Pilot Study on Sleep Management for US Veterans

University of Utah

NCT00748592 WITHDRAWN

A Dose-Ranging, Multicenter Polysomnography Trial of PD 0200390 in Elderly Subjects With Primary Insomnia

Pfizer

NCT00683436 TERMINATED

Efficacy and Safety Study of Adipiplon, Placebo and an Active Control in Primary Insomniacs

Neurogen Corporation

NCT07010718 NOT YET RECRUITING

Improving Sleep in a Psychiatric Hospital

The University of Texas Health Science Center, Houston

NCT06644573 NOT YET RECRUITING

Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

Nyree Penn

NCT06680531 ACTIVE NOT RECRUITING

A Clinical Study to Evaluate the Drug Interaction Between YZJ-1139 Tablets and Escitalopram Oxalate Tablets

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT06671470 ACTIVE NOT RECRUITING

A Drug-drug Interaction Study of YZJ-1139 Tablets and Ticagrelor Tablets in Healthy Subjects

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT06671444 ACTIVE NOT RECRUITING

Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Severe Renal Impairment and Normal Renal Impairment

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT04667429 COMPLETED

the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets

Sunshine Lake Pharma Co., Ltd.

NCT04596007 COMPLETED

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets in Chinses Healthy Subjects

Sunshine Lake Pharma Co., Ltd.

NCT06890715 COMPLETED

Comparative Pharmacokinetic Study of Ramelteon Modified-Release Tablets and Ramelteon Tablets in Healthy Subjects

Overseas Pharmaceuticals, Ltd.

NCT06673927 COMPLETED

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of YZJ-1139 in Healthy Participants

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT06512155 COMPLETED

Improving Perioperative Sleep Disorders

Mengchang Yang

NCT06685341 COMPLETED

PK/PD Study of YZJ-1139

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT06671509 COMPLETED

Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Mild, Moderate and Normal Hepatic Impairment

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

NCT05247697 COMPLETED

Mirtazapine for Chronic Insomnia in Older Adults

Centre hospitalier de l'Université de Montréal (CHUM)

NCT01421264 COMPLETED

Gabapentin's Effects on Insomnia in Patients With Recent Concussion

State University of New York at Buffalo

NCT03158025 COMPLETED

A Study to Determine the Abuse Potential of Single Oral Doses of Lemborexant Compared to Zolpidem, Suvorexant and Placebo in Healthy, Non-Dependent, Recreational Sedative Users

Eisai Inc.

NCT02350309 COMPLETED

Study to Evaluate the Effect of 2 Dosage Strengths of Lemborexant (E2006) on a Multiple Sleep Latency Test in Participants With Insomnia Disorder

Eisai Inc.

NCT01463098 COMPLETED

A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006

Eisai Inc.

NCT01209728 COMPLETED

Effects of Insomnia on Simulated Driving (MK-0000-183-00)

Merck Sharp & Dohme LLC

NCT01059851 COMPLETED

Pharmacokinetics of Suvorexant in Participants With Impaired Renal Function (MK-4305-023)(COMPLETED)

Merck Sharp & Dohme LLC

NCT01043926 COMPLETED

Pharmacokinetics of Suvorexant in Participants With Hepatic Insufficiency (MK-4305-017)

Merck Sharp & Dohme LLC

NCT01293006 COMPLETED

Effects of Suvorexant in Patients With Chronic Obstructive Pulmonary Disease (MK-4305-032)

Merck Sharp & Dohme LLC

NCT02043977 COMPLETED

Efficacy and Safety Study of Propofol Infusion for Refractory Chronic Primary Insomnia

Life Extension Foundation Inc.

NCT01311882 COMPLETED

A Study to Evaluate Next Day Effects of MK-4305 on Driving Performance (MK-4305-035 AM1)

Merck Sharp & Dohme LLC

NCT01655914 COMPLETED

Safety and Pharmacokinetic Study of Sublingual Flumazenil (CRLS035) in Healthy Adults

Coeruleus Ltd.

NCT01673880 COMPLETED

Open-Label Study of Bioavailability of E2006 Tablet Versus Capsule Formulations

Eisai Inc.

NCT01055834 COMPLETED

A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102)

Eisai Co., Ltd.

NCT01779830 COMPLETED

A Study of LY2624803 in Participants With Transient Insomnia

Eli Lilly and Company

NCT00927030 COMPLETED

Melatonin for Sleep in Children With Autism

Vanderbilt University

NCT00914862 COMPLETED

Pharmacokinetic and Safety of Ramelteon Between Adolescents With Insomnia and Healthy Adults

Takeda

NCT01106859 COMPLETED

Driving Performance After Middle of the Night Administration of 3.5 mg Zolpidem Tartrate Sublingual Tablet

Transcept Pharmaceuticals

NCT01236105 COMPLETED

Effect of Activated Charcoal and Time of Dose on the Pharmacokinetics of LY2624803 in Healthy Subject

Eli Lilly and Company

NCT00940550 COMPLETED

Study to Investigate the Effects of Melatonin, Temazepam & Zolpidem on Sleep EEG in Men and Women

University of Surrey

NCT01124851 COMPLETED

Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ABT-652 in Subjects With Excessive Daytime Sleepiness

Abbott

NCT01257178 TERMINATED

A Study to Evaluate the Pharmacokinetics of LY2624803 in Subjects With Hepatic Impairment

Eli Lilly and Company

NCT01114126 COMPLETED

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Neu-P11 in Subjects With Primary Insomnia

Neurim Pharmaceuticals Ltd.

NCT00722306 COMPLETED

A Study To Investigate The Absorption, Metabolism And Excretion Of [14C] PD 0200390 In Six Healthy Male Volunteers

Pfizer

NCT00786266 COMPLETED

Sleep Enhancement Training Study for Novice Shiftworkers

University of California, San Francisco

NCT00786357 COMPLETED

Sleep Enhancement Training Study for Experienced Shiftworkers

University of California, San Francisco

NCT07542756 NOT YET RECRUITING

A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia

University of Pennsylvania

NCT07555743 NOT YET RECRUITING

Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and Insomnia

Institut d'Investigació Biomèdica de Bellvitge

NCT05924425 RECRUITING

Daridorexant to Treat Insomnia in Patients With Mild Cognitive Impairment and Mild to Moderate Alzheimer Disease

University Hospital, Montpellier

NCT06788522 NOT YET RECRUITING

The Effects of Orexin Antagonism on Fear Extinction in PTSD

VA Office of Research and Development

NCT07384429 RECRUITING

Effects of Lemborexant on Motor-sleep Comorbidity in Parkinson's Disease

YangPan

NCT07136415 RECRUITING

Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

Brigham and Women's Hospital

NCT06435520 RECRUITING

Enhancing Hypnotic Medication Discontinuation in Primary Care

National Jewish Health

NCT06497894 RECRUITING

No More Sleepless Nights in Perimenopause

Insel Gruppe AG, University Hospital Bern

NCT07328594 NOT YET RECRUITING

Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking

Legacy Health System

NCT07306494 NOT YET RECRUITING

Compound Ciwujia Granules in the Treatment of Insomnia

Hui Zhu

NCT06306404 NOT YET RECRUITING

Sleeping Through Menopause

VU University of Amsterdam

NCT06787976 NOT YET RECRUITING

Effect of Dolutegravir Compared With Darunavir/Cobicistat on the Severity of Neuropsychiatric Effects al 12 Weeks in Antirretroviral Treatment-Naive Adults.

Instituto Mexicano del Seguro Social

NCT07018557 RECRUITING

Impact of Eszopiclone on Blood Pressure in Patients With Insomnia and Hypertension (PRYSMA-HTN)

University of Sao Paulo

NCT06093126 RECRUITING

Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial

Nova Scotia Health Authority

NCT04641819 ACTIVE NOT RECRUITING

Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients

ShuGuang Hospital

NCT05823844 RECRUITING

Efficacy of Suvorexant on Post-operative Sleep Disturbance

Columbia University

NCT04627480 ACTIVE NOT RECRUITING

Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial

ProofPilot

NCT05838430 COMPLETED

Solriamfetol and CBT-I in Patients With Insomnia Disorder

University of Pennsylvania

NCT05593653 COMPLETED

Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia

Brigham and Women's Hospital

NCT06162663 TERMINATED

Double-blind Randomized Controlled Trial Comparing Suvorexant 20 mg to Placebo for Treatment of Insomnia in Cancer Survivors

Medical University of South Carolina

NCT04693533 TERMINATED

Fremanezumab, Migraine and Sleep

Beth Israel Deaconess Medical Center

NCT04092894 COMPLETED

Suvorexant and Sleep/Delirium in ICU Patients

Beth Israel Deaconess Medical Center

NCT03937713 COMPLETED

Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD

VA Office of Research and Development

NCT05382494 COMPLETED

Intranasal Steroid as Medical Therapy For Sleep-Disordered Breathing in Children

Murdoch Childrens Research Institute

NCT03774810 COMPLETED

Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia

University of Pennsylvania

NCT06834386 WITHDRAWN

Suvorexant for Insomnia to Prevent Delirium in Hospitalized Cancer Patients

Mayo Clinic

NCT05597020 COMPLETED

A Study to Find Out if Daridorexant is Safe and Efficacious in Patients With Insomnia and Comorbid Nocturia

Idorsia Pharmaceuticals Ltd.

NCT04468776 COMPLETED

CBT-I or Zolpidem/Trazodone for Insomnia

California Pacific Medical Center Research Institute

NCT03110315 COMPLETED

A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia

Theodore R. Brown, MD MPH

NCT04528173 TERMINATED

Opioid-Free Anesthetic for Tonsillectomy

Children's Hospital of Philadelphia

NCT03461042 COMPLETED

The Study of Combination Use of Melatonin Receptor Agonist for Dose Reduction or Interruptions of Benzodiazepine (BZD) and Non-BZD Hypnotics on Chronic Insomnia

Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan

NCT06053840 COMPLETED

An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe Insomnia

Pharmanovia

NCT03818581 COMPLETED

Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

Massachusetts General Hospital

NCT02729714 COMPLETED

A Pilot Study of Suvorexant for Insomnia in Parkinson Disease

Burdick, Daniel, M.D.

NCT04610827 TERMINATED

Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder

Mayo Clinic

NCT02456532 COMPLETED

Safety and Efficacy of Chronic Hypnotic Use 2

Henry Ford Health System

NCT04706091 COMPLETED

Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia

Massachusetts General Hospital

NCT01033565 TERMINATED

Melatonin CR for the Treatment of Impaired Sleep Maintenance in 4-8 Year Old Children With Autism Spectrum Disorders

University of Nebraska

NCT04809116 WITHDRAWN

Pimavanserin for Insomnia in Veterans With Posttraumatic Stress Disorder: Proof of Concept

Baylor College of Medicine

NCT04742699 COMPLETED

An Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Transitioning to Lemborexant in Japanese Subjects With Insomnia

Kurume University

NCT02704754 COMPLETED

Suvorexant and Trauma Related Insomnia

Howard University

NCT05414864 TERMINATED

Insomnia Prevalence and Treatment Impact on Systemic Hypertension

University of Sao Paulo

NCT02527564 COMPLETED

Efficacy of Suvorexant to Treat Insomnia Related to Bipolar Disorder

Stanford University

NCT04188392 COMPLETED

Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder

Baylor College of Medicine

NCT03034018 COMPLETED

Efficacy of Suvorexant in the Treatment of Hot Flash-associated Insomnia

Brigham and Women's Hospital

NCT01689909 COMPLETED

Reducing Suicidal Ideation Through Insomnia Treatment

Augusta University

NCT02807922 COMPLETED

Pharmacological Treatment of Insomnia in Palliative Care

St. Olavs Hospital

NCT02684136 TERMINATED

Suvorexant in Insomnia Co-morbid With Fibromyalgia

Henry Ford Health System

NCT03265951 WITHDRAWN

Ramelteon for Complex Insomnia in Veterans With PTSD

State University of New York at Buffalo

NCT01896336 COMPLETED

Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia

EMS

NCT03764683 WITHDRAWN

Suvorexant (Belsomra) for the Treatment of Bipolar Depression With Insomnia

Massachusetts General Hospital

NCT03335904 COMPLETED

AT1R Blockade and Periodic Breathing During Sleep in Hypoxia

University of British Columbia

NCT02491788 COMPLETED

Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers

VA Palo Alto Health Care System

NCT03522207 TERMINATED

Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD Patient

Centre hospitalier de l'Université de Montréal (CHUM)

NCT03312517 COMPLETED

Study to Compare the Awakening Threshold Effects of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs

Henry Ford Health System

NCT00626210 TERMINATED

Modafinil Treatment for Sleep/Wake Disturbances in Older Adults

VA Palo Alto Health Care System

NCT02638168 TERMINATED

Effects of Evening Dose of Immediate Release Methylphenidate on Sleep in Children With ADHD

Milton S. Hershey Medical Center

NCT02849184 COMPLETED

To Compare the Effectiveness of Suvorexant vs Placebo on Sleep Pressure in Hypertensives With Insomnia

Jichi Medical University

NCT02669082 COMPLETED

The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy

Takeda

NCT01662297 TERMINATED

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

VA Connecticut Healthcare System

NCT02541747 COMPLETED

Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors

Taichung Veterans General Hospital

NCT00724282 COMPLETED

Treatment of Insomnia and Glucose Metabolism

University of Chicago

NCT01164592 COMPLETED

Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation

ResMed

NCT02153788 COMPLETED

Efficacy and Safety of Temazepam in HIV Seropositive Patients With Insomnia

Duke University

NCT01181232 COMPLETED

A Study to Compare Efficacy and Safety of Zolpidem Modified Release Formulation Versus Zolpidem in Insomnia Patients

Astellas Pharma Inc

NCT01156051 TERMINATED

Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia

Children's Specialized Hospital

NCT00869934 COMPLETED

Cognitive-Behavior Therapy for Insomnia

Laval University

NCT00622427 COMPLETED

Ramelteon for Treatment of Adult Patients With ADHD-Related Insomnia

University of Alabama at Birmingham

NCT01148186 TERMINATED

An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults

Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal

NCT00956319 COMPLETED

A Study to Evaluate Efficacy and Safety of Zolpidem Modified Release Formulation in Insomnia Patients

Astellas Pharma Inc

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only