Landscape → Musculoskeletal

Muscle Spasm Clinical Trial Landscape

Data updated: May 20, 2026

94 clinical trials tracked since 2008

Muscle Spasm is being studied across 94 clinical trials registered since 2008, with 11 programs currently active. The competitive pipeline includes 6 active Phase 3 trials, 5 active Phase 2 trials, and 3 active Phase 1 trials. Top industry sponsors include Chongqing Claruvis Pharmaceutical Co., Ltd., Ipsen, Merz Pharmaceuticals GmbH.

11 active

94 total (since 2008)

Phase 1 Active

16 total

Phase 2 Active

24 total

Phase 3 Active

45 total

Phase 4 Active

19 total

Top Industry Sponsors

Sorted by active Active Done Failed

Chongqing Claruvis Pharmaceutical Co., Ltd. 2 0 0

Ipsen 1 7 1

Merz Pharmaceuticals GmbH 1 6 0

RVL Pharmaceuticals, Inc. 1 4 0

Elpida Therapeutics SPC 1 0 0

+ 4 more sponsors — see full table below

Featured Phase 3 Trials

NCT03992404 ACTIVE NOT RECRUITING

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

Merz Pharmaceuticals GmbH n=603

NCT07478822 RECRUITING

A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity

Chongqing Claruvis Pharmaceutical Co., Ltd. n=300

NCT06783114 RECRUITING

A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults

Chongqing Claruvis Pharmaceutical Co., Ltd. n=254

NCT04815967 ACTIVE NOT RECRUITING

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

Supernus Pharmaceuticals, Inc. n=272

NCT06536751 COMPLETED

Therapeutic Photobiomodulation and Tretament of Spasticity

University of Nove de Julho n=12

+ 40 more Phase 3 trials — see full database below

Muscle Spasm — Trials Started by Year (last 10 years)

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Chongqing Claruvis Pharmaceutical Co., Ltd.

Ipsen

Merz Pharmaceuticals GmbH

RVL Pharmaceuticals, Inc.

Elpida Therapeutics SPC

Supernus Pharmaceuticals, Inc.

AbbVie

Medy-Tox

Sun Pharma Advanced Research Company Limited

Jazz Pharmaceuticals

Active Trials by Phase

Phase 1

Phase 2

Phase 3

Phase 4

Enrollment Size Distribution

1-50

51-200

201-500

501-1k

1k+

All Industry Sponsors

Sorted by active Active Done Failed

Chongqing Claruvis Pharmaceutical Co., Ltd. 2 0 0

Ipsen 1 7 1

Merz Pharmaceuticals GmbH 1 6 0

RVL Pharmaceuticals, Inc. 1 4 0

Elpida Therapeutics SPC 1 0 0

Supernus Pharmaceuticals, Inc. 1 0 0

AbbVie 0 5 3

Medy-Tox 0 6 0

Sun Pharma Advanced Research Company Limited 0 3 0

NCT03992404 ACTIVE NOT RECRUITING

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

Merz Pharmaceuticals GmbH n=603

NCT07478822 RECRUITING

A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity

Chongqing Claruvis Pharmaceutical Co., Ltd. n=300

NCT06783114 RECRUITING

A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults

Chongqing Claruvis Pharmaceutical Co., Ltd. n=254

NCT05179577 NOT YET RECRUITING

A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis

RVL Pharmaceuticals, Inc. n=442

NCT07242300 NOT YET RECRUITING

Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection in the Treatment of Adult Upper Limb Spasticity .

JHM BioPharma (Tonghua) Co. , Ltd. n=207

NCT04815967 ACTIVE NOT RECRUITING

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

Supernus Pharmaceuticals, Inc. n=272

NCT06536751 COMPLETED

Therapeutic Photobiomodulation and Tretament of Spasticity

University of Nove de Julho n=12

NCT06863662 COMPLETED

Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm

Laboratorios Silanes S.A. de C.V. n=136

NCT05289921 COMPLETED

To Evaluate HU-014 in the Treatment of Post Stroke Upper Limb

Huons Co., Ltd. n=198

NCT00681538 COMPLETED

A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)

Jazz Pharmaceuticals n=572

NCT01251367 COMPLETED

Dysport® Adult Lower Limb Spasticity Follow-on Study

Ipsen n=352

NCT01249417 COMPLETED

Dysport® Pediatric Lower Limb Spasticity Study

Ipsen n=241

NCT01251380 COMPLETED

Dysport® Pediatric Lower Limb Spasticity Follow-on Study

Ipsen n=216

NCT01249404 COMPLETED

Dysport® Adult Lower Limb Spasticity Study

Ipsen n=388

NCT02106351 COMPLETED

Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children

Ipsen n=212

NCT01682148 TERMINATED

Comparing Lower-concentration Dysport Treatment Targeted to the Neuromuscular Junction With Current Clinical Practice

Ipsen n=100

NCT03319732 COMPLETED

A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS

RVL Pharmaceuticals, Inc. n=323

NCT03290131 COMPLETED

A Study to Investigate the Safety and Effectiveness of Arbaclofen Extended-Release Tablets for Patients With MS

RVL Pharmaceuticals, Inc. n=536

NCT01844232 COMPLETED

One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity

RVL Pharmaceuticals, Inc. n=150

NCT01743651 COMPLETED

Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis

RVL Pharmaceuticals, Inc. n=353

NCT04671082 COMPLETED

Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm

Neurana Pharmaceuticals, Inc. n=1,004

NCT03289702 COMPLETED

CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase3)

Medy-Tox n=220

NCT01893411 COMPLETED

Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral Palsy

Merz Pharmaceuticals GmbH n=311

NCT02002884 COMPLETED

Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy

Merz Pharmaceuticals GmbH n=351

NCT03261167 COMPLETED

A Phase III Study to Evaluate the Efficacy and Safety of GSK1358820 in Subjects With Post-stroke Upper Limb Spasticity

GlaxoSmithKline n=124

NCT01603615 COMPLETED

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Allergan n=220

NCT01603641 COMPLETED

BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity

Allergan n=370

NCT01457352 COMPLETED

Efficacy and Safety of SPARC0921 in Subjects With Spasticity

Sun Pharma Advanced Research Company Limited n=392

NCT01520545 COMPLETED

Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump

Piramal Critical Care, Ltd. n=153

NCT01797185 COMPLETED

Safety Study of SPARC1104

Sun Pharma Advanced Research Company Limited n=375

NCT01313767 COMPLETED

MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity

Medy-Tox n=196

NCT01603628 COMPLETED

BOTOX® Treatment in Pediatric Lower Limb Spasticity

Allergan n=384

NCT01603602 COMPLETED

BOTOX® Treatment in Pediatric Upper Limb Spasticity

Allergan n=235

NCT01905683 COMPLETED

Long-term Open-label Study of Botulinumtoxin Type A to Treat Spasticity of Leg(s) or Leg(s) and Arm in Cerebral Palsy

Merz Pharmaceuticals GmbH n=370

NCT01603459 COMPLETED

Efficacy and Safety Dose Titration Study of Botulinum Toxin Type A to Treat Spasticity in the Leg and Arm

Merz Pharmaceuticals GmbH n=155

NCT02145676 TERMINATED

OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity

Allergan n=53

NCT01205451 COMPLETED

A Multicenter, Open-label, Single Dose Study of the Safety and Efficacy of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Focal Upper Limb Spasticity

GlaxoSmithKline n=109

NCT01392300 COMPLETED

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Arm After a Stroke

Merz Pharmaceuticals GmbH n=317

NCT01464307 COMPLETED

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke

Merz Pharmaceuticals GmbH n=290

NCT01575054 COMPLETED

BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity

Allergan n=468

NCT01945684 COMPLETED

A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity

Daewoong Pharmaceutical Co. LTD. n=197

NCT01915459 COMPLETED

Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity

Hugel n=186

NCT01051128 WITHDRAWN

Continuous Intrathecal Baclofen Infusion for Chronic Spasticity

Flowonix Medical

NCT02145689 WITHDRAWN

Long-Term Study of OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity

Allergan

NCT00819065 COMPLETED

Trial Comparing Two Commercial Formulations of Botulinum Toxin Type A in the Treatment of Spasticity

Hospital de Clinicas de Porto Alegre n=56

NCT04752774 RECRUITING

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

Ipsen

NCT03306615 ACTIVE NOT RECRUITING

Peripheral Modulation of Muscle Stiffness and Spasticity

Johns Hopkins University

NCT05518188 RECRUITING

Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)

Elpida Therapeutics SPC

NCT06584240 COMPLETED

A Clinical Study to Evaluate the Safety and Efficacy of JHM03 in Adult Patients With Upper Limb Spasticity

JHM BioPharma (Tonghua) Co. , Ltd.

NCT05974293 WITHDRAWN

A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders

Michael, Levy M.D.,Ph.D.

NCT04471714 WITHDRAWN

Effects of Baclofen on Presynaptic Inhibition in Humans

University of Alberta

NCT04502264 COMPLETED

Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox Injections

Cheng-Hsin General Hospital

NCT03821402 COMPLETED

Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity

Revance Therapeutics, Inc.

NCT03802565 COMPLETED

Tolperisone in Acute Muscle Spasm of the Back

Neurana Pharmaceuticals, Inc.

NCT03080454 COMPLETED

The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke

Northwell Health

NCT01839279 COMPLETED

A Study to Define the ECG Effects of Tizanidine Compared to Placebo and the Positive Control, Moxifloxacin, in Healthy Men and Women Using a Blinded ECG Evaluator: A Thorough ECG Trial

Acorda Therapeutics

NCT01553201 COMPLETED

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00914290 COMPLETED

A Study With IPX056 in Subjects With Spasticity Associated With Multiple Sclerosis

Impax Laboratories, LLC

NCT03008486 COMPLETED

Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness

Géraldine Martens

NCT02027025 COMPLETED

Study of SPARC1103 in Subjects With Spasticity

Sun Pharma Advanced Research Company Limited

NCT02934646 COMPLETED

Powered Exoskeleton for the Treatment of Elbow Spasticity

Auxilium Vitae Volterra

NCT02170779 COMPLETED

Developing and Testing a Comprehensive MS Spasticity Management Program

VA Office of Research and Development

NCT01222468 COMPLETED

Effect of Cannabinoids on Spasticity and Neuropathic Pain in Spinal Cord Injured Persons

University of Manitoba

NCT01882556 COMPLETED

Early Use of Botulinum Toxin in Spasticity Post Stroke.

Sandwell & West Birmingham Hospitals NHS Trust

NCT00607542 COMPLETED

Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00464958 TERMINATED

One Year Extension Study To Protocol C2/5/TZ:MS-05

Teva GTC

NCT07440173 NOT YET RECRUITING

Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity

Assiut University

NCT02462317 COMPLETED

Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment

University Hospital, Toulouse

NCT04936542 COMPLETED

A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.

Ipsen

NCT05887479 WITHDRAWN

The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Motion in Patients With Post-Stroke Upper Extremity Spasticity

Sisli Hamidiye Etfal Training and Research Hospital

NCT01964547 COMPLETED

A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients

Jazz Pharmaceuticals

NCT02321436 COMPLETED

Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression

Ipsen

NCT02903823 COMPLETED

Intrathecal (IT) Baclofen Drug Distribution

Vanderbilt University

NCT02546999 COMPLETED

Does Botulinum Toxin A Make Walking Easier in Children With Cerebral Palsy?

St. Olavs Hospital

NCT03367429 TERMINATED

The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination

Weill Medical College of Cornell University

NCT03302741 COMPLETED

Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings

The University of Texas Health Science Center, Houston

NCT03908580 COMPLETED

MEDITOXIN® Treatment in Subjects With Post-Stroke Upper Limb Spasticity

Medy-Tox

NCT02757404 COMPLETED

Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity

Medy-Tox

NCT01256021 COMPLETED

The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy

Medy-Tox

NCT03549975 COMPLETED

Hand Rehabilitation Using Botulinum Toxin and Functional Electrical Stimulation-pilot Study

National Rehabilitation Center, Seoul, Korea

NCT01032239 COMPLETED

SISTERS: Spasticity In Stroke Study - Randomized Study

MedtronicNeuro

NCT03044080 COMPLETED

Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot

Parc de Salut Mar

NCT01968902 COMPLETED

Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients

Multiple Sclerosis Center of Northeastern New York

NCT02052024 COMPLETED

Myobloc Atrophy Study

Georgetown University

NCT01278576 COMPLETED

Botulinum Toxin A Adult Gastrocnemius Muscle Study

The Catholic University of Korea

Full Muscle Spasm Pipeline

Every sponsor, every trial across Phase 1–4. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only