Osteoporosis Clinical Trial Landscape
Data updated: May 20, 2026
368 clinical trials tracked since 2008
Osteoporosis is being studied across 368 clinical trials registered since 2008, with 69 programs currently active. The competitive pipeline includes 10 active Phase 3 trials, 17 active Phase 2 trials, and 9 active Phase 1 trials. Top industry sponsors include Amgen, Shenzhen Salubris Pharmaceuticals Co., Ltd., Qilu Pharmaceutical Co., Ltd..
69 active
/
368 total (since 2008)
9
Phase 1 Active
73 total
17
Phase 2 Active
103 total
10
Phase 3 Active
101 total
36
Phase 4 Active
115 total
Top Industry Sponsors
Sorted by active Active Done Failed
Amgen 2 23 1
Shenzhen Salubris Pharmaceuticals Co., Ltd. 2 2 0
Qilu Pharmaceutical Co., Ltd. 2 0 0
Mabwell (Shanghai) Bioscience Co., Ltd. 1 2 0
Angitia Biopharmaceuticals 1 1 0
+ 10 more sponsors — see full table below
Featured Phase 3 Trials
NCT04922333 RECRUITING
Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery
Wake Forest University Health Sciences n=200
NCT07062978 RECRUITING
A Comparative Study to Valuating the Efficacy and Safety of QL1206 and Prolia®
Qilu Pharmaceutical Co., Ltd. n=278
NCT07047131 ACTIVE NOT RECRUITING
Resorbable vs Non-resorbable Bone Substitute at Immediate Post-extractive Single Implants
Marco Esposito n=50
NCT05998863 RECRUITING
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
University of Texas Southwestern Medical Center n=56
NCT06804590 RECRUITING
A Study on Efficacy, Safety and Immunogenicity of 9MW0311 in Postmenopausal Women With Osteoporosis
Mabwell (Shanghai) Bioscience Co., Ltd. n=278
+ 96 more Phase 3 trials — see full database below
Osteoporosis — Trials Started by Year (last 10 years)
2016 8
2017 15
2018 16
2019 21
2020 15
2021 21
2022 15
2023 14
2024 16
2025 24
2026 7
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
Amgen 26
Shenzhen Salubris Pharmaceuticals Co., Ltd. 4
Qilu Pharmaceutical Co., Ltd. 2
Mabwell (Shanghai) Bioscience Co., Ltd. 3
Angitia Biopharmaceuticals 2
Insud Pharma 1
HELP Therapeutics Co., Ltd. 1
Xeolas Pharmaceuticals Limited 1
Eli Lilly 12
Novartis 9
Active Trials by Phase
Phase 1 9
Phase 2 17
Phase 3 10
Phase 4 36
Enrollment Size Distribution
1-50 145
51-200 130
201-500 50
501-1k 18
1k+ 12
All Industry Sponsors
Sorted by active Active Done Failed
Amgen 2 23 1
Shenzhen Salubris Pharmaceuticals Co., Ltd. 2 2 0
Qilu Pharmaceutical Co., Ltd. 2 0 0
Mabwell (Shanghai) Bioscience Co., Ltd. 1 2 0
Angitia Biopharmaceuticals 1 1 0
Insud Pharma 1 0 0
HELP Therapeutics Co., Ltd. 1 0 0
Xeolas Pharmaceuticals Limited 1 0 0
Eli Lilly 0 11 1
Novartis 0 8 1
Merck 0 5 4
Radius Health, Inc. 0 8 0
GSK 0 5 0
Organon and Co 0 4 0
Warner Chilcott 0 3 1
NCT04922333 RECRUITING
Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery
Wake Forest University Health Sciences n=200
NCT07062978 RECRUITING
A Comparative Study to Valuating the Efficacy and Safety of QL1206 and Prolia®
Qilu Pharmaceutical Co., Ltd. n=278
NCT07047131 ACTIVE NOT RECRUITING
Resorbable vs Non-resorbable Bone Substitute at Immediate Post-extractive Single Implants
Marco Esposito n=50
NCT05998863 RECRUITING
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
University of Texas Southwestern Medical Center n=56
NCT06898060 NOT YET RECRUITING
To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of Fracture
Qilu Pharmaceutical Co., Ltd. n=282
NCT06804590 RECRUITING
A Study on Efficacy, Safety and Immunogenicity of 9MW0311 in Postmenopausal Women With Osteoporosis
Mabwell (Shanghai) Bioscience Co., Ltd. n=278
NCT06773923 ENROLLING BY INVITATION
Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration
Universidad Austral de Chile n=10
NCT05918029 RECRUITING
Bone in CKD Alkali Response (BICARb Pilot Trial)
Albert Einstein College of Medicine n=103
NCT05602493 ACTIVE NOT RECRUITING
A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction
Xeolas Pharmaceuticals Limited n=60
NCT06242782 NOT YET RECRUITING
Vertical Ridge Augmentation Strategies
University College, London n=148
NCT03401060 COMPLETED
Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis
Assistance Publique - Hôpitaux de Paris n=24
NCT05405725 COMPLETED
A Phase 3 Study to Compare Biosimilar Denosumab With Prolia®
Enzene Biosciences Ltd. n=504
NCT04779216 COMPLETED
Effects of Romosozumab on Bone Density in Women With Anorexia Nervosa
Karen Klahr Miller, MD n=30
NCT03292146 COMPLETED
Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study
Massachusetts General Hospital n=30
NCT05345691 COMPLETED
Comparison of Efficacy, Pharmacodynamics, Safety, and Immunogenicity Between Bmab 1000 and Prolia® in Postmenopausal Women With Osteoporosis
Biocon Biologics UK Ltd n=479
NCT07028320 COMPLETED
To Evaluate the Efficacy and Safety of SAL056 for Postmenopausal Women With Osteoporosis at High Fracture Risk
Shenzhen Salubris Pharmaceuticals Co., Ltd. n=493
NCT05395091 COMPLETED
Multicenter Study in Postmenopausal Women With Osteoporosis, ALVOBOND
Alvotech Swiss AG n=532
NCT06504966 WITHDRAWN
Study to Compare the Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of MAB-22 Versus Prolia®
Xentria, Inc.
NCT05338086 COMPLETED
A Study to Compare Efficacy, PK, PD, Safety and IMM of MB09 to Prolia® [EU-sourced] in Postmenopausal Osteoporosis.
mAbxience Research S.L. n=558
NCT06853392 COMPLETED
Socket Preservation Using Dentin Graft Autogenous Dentin Graft With Collagen Sponge on Dental Implant Stability AUTOGENOUS TOOTH GRAFT WITH COLLAGEN SPONGE ON DENTAL IMPLANT STABILITY
Faculty of Dental Medicine for Girls n=16
NCT04934072 COMPLETED
A Study to Evaluate the Efficacy, Pharmacodynamics, Safety, and Immunogenicity of FKS518 in Postmenopausal Women With Osteoporosis
Fresenius Kabi SwissBioSim GmbH n=553
NCT01631214 COMPLETED
Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
Amgen n=4,093
NCT04591275 COMPLETED
Clinical Efficacy and Safety Comparative Study Between CMAB807 Injection and Prolia® .
Shanghai Biomabs Pharmaceutical Co., Ltd. n=278
NCT04664959 COMPLETED
A Study to Compare SB16 (Proposed Denosumab Biosimilar) to Prolia® in Postmenopausal Women With Osteoporosis
Samsung Bioepis Co., Ltd. n=457
NCT06780956 COMPLETED
Simplified vs Conventional Drilling Protocol for Implant Placment
Universidad Católica San Antonio de Murcia n=46
NCT06770894 COMPLETED
DPP4-Inhibitors and Bone Metabolism in Diabetes
Azienda Policlinico Umberto I n=132
NCT05067335 COMPLETED
A Study to Test the Efficacy, Safety and Tolerability of Romosozumab Treatment in Postmenopausal Chinese Women With Osteoporosis
UCB Biopharma SRL n=327
NCT05087030 COMPLETED
Comparative Efficacy and Safety Study of RGB-14-P and Prolia® in Women With Postmenopausal Osteoporosis
Gedeon Richter Plc. n=473
NCT01575834 COMPLETED
Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis
Amgen n=7,180
NCT03164928 COMPLETED
Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-induced Osteoporosis
Amgen n=24
NCT04757376 COMPLETED
A Phase 3 Study to Compare Between CT-P41 and US-licensed Prolia in Postmenopausal Women With Osteoporosis
Celltrion n=479
NCT00692913 COMPLETED
A Study to Test the Effect of MK0217A on Vitamin D Inadequacy in Postmenopausal Women With Osteoporosis (0217A-262)
Organon and Co n=515
NCT01437111 COMPLETED
Study of MK-217A/Alendronate Sodium 70-mg/Vitamin D3 5600 IU Combination Tablet (MK-0217A-329)
Organon and Co n=200
NCT04729621 COMPLETED
A Study to Test if TVB-009P is Effective in Relieving Postmenopausal Osteoporosis
Teva Pharmaceuticals USA n=332
NCT03930992 COMPLETED
Efficacy of Zoledronic Acid + Colaren vs Zoledronic Acid + Conventional Treatment for Osteoporosis in HIV+ and HIV- Men
University of Guadalajara n=30
NCT05215977 COMPLETED
Efficacy and Safety of MW031 in PMO Subjects
Mabwell (Shanghai) Bioscience Co., Ltd. n=448
NCT03512262 COMPLETED
Safety and Efficacy of Abaloparatide-SC in Men With Osteoporosis (ATOM)
Radius Health, Inc. n=228
NCT03974100 COMPLETED
Study Investigating PK, PD, Efficacy, Safety, and Immunogenicity of Biosimilar Denosumab (GP2411) in Patients With Postmenopausal Osteoporosis
Sandoz n=527
NCT04064411 COMPLETED
Efficacy & Safety of Abaloparatide-Solid Microstructured Transdermal System in Postmenopausal Women With Osteoporosis
Radius Health, Inc. n=511
NCT05631600 COMPLETED
Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
University of Zagreb n=12
NCT01796301 COMPLETED
An Open-label Study to Evaluate the Effect of Treatment With Romosozumab or Teriparatide in Postmenopausal Women
Amgen n=436
NCT03812380 TERMINATED
Averting Complications of Proton Pump Inhibitor Therapy by Effervescent Calcium Magnesium Citrate
University of Texas Southwestern Medical Center n=62
NCT02832648 COMPLETED
Selenium for Musculoskeletal Health
Sheffield Teaching Hospitals NHS Foundation Trust n=123
NCT04169698 COMPLETED
Alendronate Versus Denosumab in Kidney Transplant Patients
Ain Shams University n=90
NCT03710889 COMPLETED
Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption
Radius Health, Inc. n=23
NCT00757393 COMPLETED
Growth Hormone Therapy and Bone Quality in Pediatric Osteoporosis
The Hospital for Sick Children n=21
NCT01657162 COMPLETED
Twenty-Four Month Extension Study of BA058-05-003 (Abaloparatide) in Participants With Osteoporosis
Radius Health, Inc. n=1,139
NCT03432533 COMPLETED
A Comparison of Subject-administered Romosozumab With Healthcare Provider-administered Romosozumab for Osteoporosis
Amgen n=283
NCT00799266 COMPLETED
An Efficacy and Safety Trial of Intravenous Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
Novartis Pharmaceuticals n=34
NCT00919711 COMPLETED
Study to Evaluate the Safety and Efficacy of Denosumab and Actonel® in Post Menopausal Women Transitioned From Alendronate Therapy
Amgen n=870
NCT03331185 COMPLETED
Changes of Soft and Hard Tissues After Alveolar Ridge Preservation: Freeze-dried Bone Allograft vs. L-PRF Clot
University of Manitoba n=26
NCT03040765 TERMINATED
Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis
Hamad Medical Corporation n=17
NCT02791516 COMPLETED
A Safety and Efficacy Study to Evaluate Romosozumab (AMG 785) in South Korean Women With Osteoporosis
Amgen n=67
NCT01197300 COMPLETED
1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
Novartis Pharmaceuticals n=25
NCT01803607 TERMINATED
Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Oral Bisphosphonate (MK-0822-076)
Merck Sharp & Dohme LLC n=135
NCT03178526 COMPLETED
The Effect of Lovastatin Gel in the Treatment of Chronic Periodontitis
Islamic Azad University, Sanandaj n=15
NCT02186171 COMPLETED
A Study to Compare the Safety and Efficacy of Romosozumab (AMG 785) Versus Placebo in Men With Osteoporosis
Amgen n=245
NCT01512446 TERMINATED
Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy
Evangelisches Krankenhaus Lutherhaus gGmbH n=436
NCT02016716 COMPLETED
A Randomized Phase 3 Study to Evaluate Two Formulations of Romosozumab in Postmenopausal Women With Osteoporosis
Amgen n=294
NCT00980174 COMPLETED
Study to Compare the Efficacy and Safety of DenosumAb Versus Placebo in Males With Osteoporosis
Amgen n=242
NCT01120600 COMPLETED
A Study to Assess Safety and Efficacy of Odanacatib (MK-0822) in Men With Osteoporosis (MK-0822-053)
Merck Sharp & Dohme LLC n=294
NCT00729183 COMPLETED
Study to Evaluate Efficacy of Odanacatib (MK-0822) on Bone Mineral Density (BMD) and Bone Micro-architecture and Overall Safety in Postmenopausal Women (MK-0822-031)
Merck Sharp & Dohme LLC n=214
NCT00697463 COMPLETED
Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women
Columbia University n=22
NCT01656512 COMPLETED
Zometa Study in Pediatric Acute Lymphoblastic Leukemia
Children's Cancer Hospital Egypt 57357 n=95
NCT02157948 COMPLETED
A Double-blind Study to Assess the Efficacy and Safety of Denosumab Produced by Two Different Processes in Postmenopausal Women With Osteoporosis
Amgen n=394
NCT00925600 COMPLETED
Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss
Amgen n=769
NCT01348243 COMPLETED
Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal Osteoporosis
Chiesi Farmaceutici S.p.A. n=260
NCT00909961 COMPLETED
A Trial Evaluating the Effects of Zoledronic Acid 5 mg Infusion on Bone Mineral Density (BMD) in Postmenopausal Osteoporosis (PMO) Patients Between the Ages of 50 and 65 Years
Novartis Pharmaceuticals n=118
NCT01343004 COMPLETED
Study to Evaluate the Safety and Efficacy of BA058 (Abaloparatide) for Prevention of Fracture in Postmenopausal Women
Radius Health, Inc. n=2,463
NCT02063854 COMPLETED
A Phase II/III, Double-blind, Parallel Group Comparative Study of Oral Administration of NE-58095 Tablets
Takeda n=871
NCT01581320 COMPLETED
Phase III Clinical Trial of DP-R206 and Bonvia In Postmenopausal Women With Osteoporosis
Alvogen Korea n=201
NCT01377467 COMPLETED
Denosumab for Prevention of Osteoporosis in Renal Transplant Recipients
Rudolf Wuethrich n=90
NCT01426555 TERMINATED
FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI)
Antonio Lazzari n=70
NCT01315366 COMPLETED
Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism
American University of Beirut Medical Center n=257
NCT01522521 COMPLETED
Study of AK156 in Primary Osteoporosis Patients
Asahi Kasei Therapeutics Corporation n=600
NCT01552122 WITHDRAWN
Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Alendronate (MK-0822-050)
Merck Sharp & Dohme LLC
NCT01290094 COMPLETED
A Study of Bonviva/Boniva (Ibandronate) in Biphosphonate-Naïve Women With Post-Menopausal Osteoporosis
Hoffmann-La Roche n=41
NCT01387672 COMPLETED
Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
University of Toronto n=265
NCT00794443 COMPLETED
ONO-5920/YM529 Confirmatory Study in Involutional Osteoporosis Patients
Astellas Pharma Inc n=692
NCT00680953 COMPLETED
Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis
Daiichi Sankyo Co., Ltd. n=1,262
NCT01329666 WITHDRAWN
Primary Hyperparathyroidism (PHPT): Early Effect of Vitamin D
Columbia University
NCT01200277 COMPLETED
A Trial of Vertebroplasty for Painful Acute Osteoporotic Vertebral Fractures
Elisabeth-TweeSteden Ziekenhuis n=80
NCT00718861 COMPLETED
3 yr Efficacy & Safety Study of Zoledronic Acid in Post-menopausal Women With Osteoporosis Treated With Zol Acid for 6 Yrs
Novartis Pharmaceuticals n=190
NCT01457950 COMPLETED
A Study in Korean Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab
GlaxoSmithKline n=135
NCT00808132 COMPLETED
Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis
Pfizer n=1,886
NCT00890981 COMPLETED
A High-resolution Peripheral Quantitative Computed Tomography Study in Postmenopausal Women Previously Treated With Denosumab
Amgen n=79
NCT01495000 COMPLETED
A Study in Indian Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab
GlaxoSmithKline n=250
NCT00959764 COMPLETED
A Study Comparing Oral Calcitonin to Nasal Spray Calcitonin in Postmenopausal Osteoporotic Women
Tarsa Therapeutics, Inc. n=565
NCT00683163 COMPLETED
PTH & Ibandronate Combination Study (PICS)
University of California, San Francisco n=44
NCT00936897 COMPLETED
A Study to Evaluate the Safety and Efficacy of Denosumab and Ibandronate in Postmenopausal Women Sub-Optimally Treated With Daily or Weekly Bisphosphonates
Amgen n=833
NCT01057680 COMPLETED
Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
University of Saskatchewan n=90
NCT00734708 COMPLETED
Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin)
Kaken Pharmaceutical n=328
NCT00822029 TERMINATED
Use of Oral Bisphosphonates in the Treatment of Osteoporosis of Non-walking Children With Cerebral Palsy
Department of Clinical Research and Innovation n=2
NCT01463436 COMPLETED
The Effect of Soy Isoflavone Supplementation on Endothelial Function
Trisakti University n=200
NCT00577863 COMPLETED
Study of the Experience of Patients With Osteoporosis Using the Forteo B Pen to Self Administer Once Daily Teriparatide Therapy
Eli Lilly and Company n=200
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only