TheraRadar
Landscape → Pain

Postoperative Pain Clinical Trial Landscape

Data updated: May 20, 2026

1,086 clinical trials tracked since 2008

Postoperative pain is pain experienced after a surgical procedure, affecting a large proportion of patients and impacting recovery. Clinical trial activity in this space includes 1,078 registered trials since 2008, with 167 trials currently active, meaning they are recruiting, enrolling, or active but not recruiting. The majority of active trials are in Phase 4, with 100 trials, while Phase 2 and Phase 3 have 33 and 31 active trials, respectively. Phase 1 trials account for 12 active trials. Industry sponsorship is led by Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. with 2 active trials. Pacira Pharmaceuticals, Inc, Haisco Pharmaceutical Group Co., Ltd., Yung Shin Pharm. Ind. Co., Ltd., and Luye Pharma Group Ltd. each have 1 active trial. The high number of Phase 4 trials suggests a focus on post-market studies and real-world evidence generation for existing treatments in postoperative pain management.

170 active
/
1086 total (since 2008)
12
Phase 1 Active
67 total
33
Phase 2 Active
214 total
33
Phase 3 Active
235 total
102
Phase 4 Active
626 total

Top Industry Sponsors

Sorted by active Active Done Failed
Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. 2 0 0
Pacira Pharmaceuticals, Inc 1 9 5
Haisco Pharmaceutical Group Co., Ltd. 1 2 0
Cali Pharmaceuticals LLC 1 1 0
Yung Shin Pharm. Ind. Co., Ltd. 1 1 0

+ 10 more sponsors — see full table below

Featured Phase 3 Trials

NCT04659317 RECRUITING
Opioid-Free Orthopaedics
Emory University n=80
NCT05058287 RECRUITING
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Hospital for Special Surgery, New York n=150
NCT07548385 RECRUITING
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
Icahn School of Medicine at Mount Sinai n=235
NCT07060495 RECRUITING
RADA16 for Adult Tonsillectomy
Rutgers, The State University of New Jersey n=134
NCT07539623 RECRUITING
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
Icahn School of Medicine at Mount Sinai n=235

+ 230 more Phase 3 trials — see full database below

Postoperative Pain — Trials Started by Year (last 10 years)

2016
60
2017
81
2018
73
2019
91
2020
58
2021
75
2022
51
2023
53
2024
63
2025
59
2026
39

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
2
Pacira Pharmaceuticals, Inc
15
Haisco Pharmaceutical Group Co., Ltd.
3
Cali Pharmaceuticals LLC
2
Yung Shin Pharm. Ind. Co., Ltd.
2
Luye Pharma Group Ltd.
2
CSPC Ouyi Pharmaceutical Co., Ltd.
1
Bausch & Lomb Incorporated
1
Ensysce Biosciences
1
Chengdu Kanghong Pharmaceutical Group Co., Ltd.
1

Active Trials by Phase

Phase 1
12
Phase 2
33
Phase 3
33
Phase 4
102

Enrollment Size Distribution

1-50
268
51-200
635
201-500
104
501-1k
13
1k+
6

All Industry Sponsors

Sorted by active Active Done Failed
Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. 2 0 0
Pacira Pharmaceuticals, Inc 1 9 5
Haisco Pharmaceutical Group Co., Ltd. 1 2 0
Cali Pharmaceuticals LLC 1 1 0
Yung Shin Pharm. Ind. Co., Ltd. 1 1 0
Luye Pharma Group Ltd. 1 1 0
CSPC Ouyi Pharmaceutical Co., Ltd. 1 0 0
Bausch & Lomb Incorporated 1 0 0
Ensysce Biosciences 1 0 0
Chengdu Kanghong Pharmaceutical Group Co., Ltd. 1 0 0
TLC Biopharmaceuticals, Inc. 1 0 0
Shandong Suncadia Medicine Co., Ltd. 1 0 0
Yangtze River Pharmaceutical Group Co., Ltd. 1 0 0
Heron Therapeutics 0 11 0
Innocoll 0 8 1
NCT07565870 NOT YET RECRUITING
Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)
Alexandre P. Joosten n=400
NCT04659317 RECRUITING
Opioid-Free Orthopaedics
Emory University n=80
NCT05058287 RECRUITING
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Hospital for Special Surgery, New York n=150
NCT07548385 RECRUITING
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
Icahn School of Medicine at Mount Sinai n=235
NCT07060495 RECRUITING
RADA16 for Adult Tonsillectomy
Rutgers, The State University of New Jersey n=134
NCT07539623 RECRUITING
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
Icahn School of Medicine at Mount Sinai n=235
NCT06996561 RECRUITING
Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
Dr. Asma Abdus Salam n=263
NCT07413055 RECRUITING
Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial
Oman Ministry of Health n=138
NCT07490496 NOT YET RECRUITING
Phase 3 Bunionectomy Study
Cali Pharmaceuticals LLC n=112
NCT06077422 ENROLLING BY INVITATION
Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain
Rutgers, The State University of New Jersey n=150
NCT07186426 RECRUITING
A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery
Haisco Pharmaceutical Group Co., Ltd. n=405
NCT07357376 NOT YET RECRUITING
Evaluating Suzetrigine for Pain Control Following TKA
AdventHealth n=210
NCT06602271 RECRUITING
PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301)
Ensysce Biosciences n=320
NCT07330375 NOT YET RECRUITING
Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia
Zagazig University n=50
NCT07222748 RECRUITING
A Study of TLC590 for Postsurgical Pain Following Bunionectomy
TLC Biopharmaceuticals, Inc. n=300
NCT06740214 RECRUITING
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty
The University of Hong Kong n=177
NCT04874038 RECRUITING
Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)
University Health Network, Toronto n=1,602
NCT04724252 RECRUITING
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
University of California, Davis n=60
NCT05625360 RECRUITING
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Wake Forest University Health Sciences n=160
NCT06989866 ENROLLING BY INVITATION
RCT to Test Regional Anesthesia Effect on Decreased Opiate Use
United States Naval Medical Center, Portsmouth n=50
NCT07113483 RECRUITING
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
Romanian Society for Enteral and Parenteral Nutrition n=120
NCT07108582 NOT YET RECRUITING
Reducing Chronic Pain After Lung Surgery: A Trial of Limiting NSAIDs During Recovery
University Hospital, Strasbourg, France n=270
NCT07047040 NOT YET RECRUITING
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Assiut University n=86
NCT06381063 RECRUITING
Non-steroidal Anti-inflammatory in Cardiac Surgery
Centre Hospitalier Universitaire, Amiens n=238
NCT07062497 RECRUITING
Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty
Universidade Federal do Rio de Janeiro n=62
NCT04084548 ACTIVE NOT RECRUITING
Perioperative Lidocaine and Ketamine in Abdominal Surgery
The Cleveland Clinic n=420
NCT05010148 RECRUITING
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
University of California, San Francisco n=278
NCT05913284 ACTIVE NOT RECRUITING
Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients
Chinese University of Hong Kong n=86
NCT06728371 RECRUITING
Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery
Chinese University of Hong Kong n=86
NCT06618820 ENROLLING BY INVITATION
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
Campbell Clinic n=120
NCT05283980 ACTIVE NOT RECRUITING
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center n=62
NCT06271174 RECRUITING
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children
Nantes University Hospital n=208
NCT07590752 RECRUITING
"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia
Sahiwal medical college sahiwal n=96
NCT03768440 TERMINATED
Continuous Erector Spinae Block Versus Continuous Paravertebral Block
Boston Children's Hospital n=34
NCT04641338 COMPLETED
Fixed Combination of Dipyrone and Codeine for Controlling Pain After Pelvic-abdominal Surgery
Brazilian Clinical Research Institute n=491
NCT05831449 COMPLETED
CPL-01 in the Management of Postoperative Pain After Bunionectomy
Cali Pharmaceuticals LLC n=616
NCT05324358 SUSPENDED
Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy
Neumentum, Inc. n=341
NCT03237481 COMPLETED
Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)
Heron Therapeutics n=418
NCT03295721 COMPLETED
Bunionectomy Study for Postoperative Analgesia (EPOCH 1)
Heron Therapeutics n=412
NCT07350668 COMPLETED
Opioid-Free vs Opioid-Based Anesthesia for Nasal Surgeries
Benha University n=60
NCT07194694 COMPLETED
Dexmedetomidine vs Ketamine as Adjuvants to Bupivacaine in Transversus Abdominus Plane Block in Inguinal Hernioplasty
Ain Shams University n=60
NCT05153785 COMPLETED
Perioperative Intravenous Lidocaine in Liver Surgery
Lund University Hospital n=124
NCT03238430 COMPLETED
Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .
University Hospital, Lille n=186
NCT01082744 COMPLETED
Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.
Hospices Civils de Lyon n=90
NCT07098962 COMPLETED
KinesioTaping for Thoracic Drain Support
Kastamonu University n=100
NCT06319859 COMPLETED
Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries
Cairo University n=50
NCT04122196 COMPLETED
Perioperative Pregabalin in Ureteroscopy
University of Missouri-Columbia n=118
NCT03216187 TERMINATED
Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery
Benno Rehberg-Klug n=126
NCT04222010 COMPLETED
Serratus Plain Block Versus Paravertebral Block Versus Serratus Plain Block and Paravertebral Block for Postoperative Pain Following Thoracoscopic Surgery
Centre Hospitalier Universitaire, Amiens n=155
NCT06561438 COMPLETED
Postoperative Pain Management Following Laparoscopic Cholecystectomy
Future University in Egypt n=86
NCT06313632 TERMINATED
Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy
Icahn School of Medicine at Mount Sinai n=33
NCT05345639 COMPLETED
Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)
University Hospital, Angers n=254
NCT06871033 COMPLETED
Ketamine Versus Neostigmine in Ultrasound-Guided Transversus Abdominis Plane Block in Caesarean Section
Alexandria University n=80
NCT03859635 COMPLETED
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Indiana University n=120
NCT05764525 COMPLETED
Efficacy and Safety of VVZ-149 Injections in Patients Undergoing Laparoscopic Colectomy
Vivozon Pharmaceutical Inc. n=285
NCT06026527 COMPLETED
Intra-operative Magnesium Sulphate for Post-operative Pain in Patients Undergoing Total Abdominal Hysterectomy Under General Anesthesia
Tribhuvan University Teaching Hospital, Institute Of Medicine. n=42
NCT06128369 TERMINATED
Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery
Oculis n=117
NCT06717672 COMPLETED
Effect of Lidocaine in Reducing Opioids Requirement in Day Care Surgery
Liaquat National Hospital & Medical College n=80
NCT05958589 COMPLETED
Caudal Block for Inguinal Hernioplasty in Children
University of Novi Sad n=70
NCT04176419 TERMINATED
Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery
Case Comprehensive Cancer Center n=30
NCT04443569 COMPLETED
Lidocaine Patches After Cesarean Section
Yale University n=93
NCT06629285 COMPLETED
Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery
University Medical Center Ho Chi Minh City (UMC) n=72
NCT03929640 TERMINATED
Management Of Pain After Cesarean Trial
Milton S. Hershey Medical Center n=49
NCT04724772 WITHDRAWN
Use of Tranexamic Acid in Blepharoplasties
Northwestern University
NCT04551196 COMPLETED
Management of Post-Tonsillectomy Pain in Pediatric Patients
Washington University School of Medicine n=50
NCT02712151 WITHDRAWN
Efficacy of Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy
Boston Children's Hospital
NCT04646694 COMPLETED
The Ketamine for Acute Postoperative Analgesia (KAPA) Trial
University Health Network, Toronto n=40
NCT03261193 TERMINATED
ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain
Nicholas Schott n=21
NCT03874936 COMPLETED
The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy.
Odense University Hospital n=90
NCT05172570 TERMINATED
Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy
Indiana University n=20
NCT06288685 COMPLETED
Percutaneous Trigger Finger Release Concomitant Steroid Injection Versus Percutaneous Trigger Finger Release Alone
Police General Hospital, Thailand n=38
NCT04426500 COMPLETED
Use of Perioperative Pain Blocks In Urological Surgery
Icahn School of Medicine at Mount Sinai n=148
NCT04680286 TERMINATED
Intraoperative Methadone in Children Undergoing Surgery
University of Aarhus n=60
NCT05998317 COMPLETED
Dexamethasone at Night vs at Induction on PONV After Laparoscopic Cholecystectomy
Mansoura University n=60
NCT05752305 COMPLETED
Use of Corticosteroids in Third Molar Surgery
Universidad de Granada n=84
NCT05346588 COMPLETED
THRIVE Feasibility Trial
Washington University School of Medicine n=300
NCT04610398 COMPLETED
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Hip Arthroscopy
Balgrist University Hospital n=60
NCT06040060 COMPLETED
Ketamine Effects as Preemptive Analgesia
Universitas Padjadjaran n=40
NCT05974748 COMPLETED
Role of Propolis Endodontic Irrigant on Post-Operative Pain
Dow University of Health Sciences n=44
NCT04825704 COMPLETED
Bupivacaine in Tonsillectomy
Nordlandssykehuset HF n=84
NCT04429022 COMPLETED
Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy
State University of New York at Buffalo n=68
NCT05096468 COMPLETED
Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.
Beijing Tiantan Hospital n=90
NCT03323385 COMPLETED
Evaluation of Preoperative N1539 in Colorectal Surgery
Baudax Bio n=57
NCT05904184 COMPLETED
Comparison of Calcium Silicate-based Sealer and Epoxy Resin-based Sealer
University of Medicine and Pharmacy at Ho Chi Minh City n=42
NCT03434275 COMPLETED
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
Baudax Bio n=194
NCT04622813 COMPLETED
Nonopioid Analgesics and Cholecystectomy
American University of Beirut Medical Center n=90
NCT04189107 COMPLETED
Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS
Rigshospitalet, Denmark n=18
NCT04672252 COMPLETED
The Use of Cannabidiol (CBD) in Pain Reduction and Opioid Use After Shoulder Arthroscopy
NYU Langone Health n=100
NCT04785638 COMPLETED
An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries
Innocoll n=100
NCT04785625 COMPLETED
Efficacy and Safety Study of Postsurgical Analgesia With INL-001 in Abdominoplasty
Innocoll n=366
NCT03005899 TERMINATED
Study of SyB P-1501 (Fentanyl HCI) for Treatment of Postoperative Pain
SymBio Pharmaceuticals n=49
NCT02410317 COMPLETED
Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section
University Hospital, Grenoble n=101
NCT03158376 COMPLETED
Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).
University Hospital, Lille n=201
NCT03677817 COMPLETED
Perioperative Lidocaine Administration in Thoracoscopic Surgery for Improved Postoperative Pain Control
University Hospital, Basel, Switzerland n=113
NCT03678675 COMPLETED
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
Tufts Medical Center n=148
NCT03639389 COMPLETED
Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy
Karolinska Institutet n=211
NCT04910165 COMPLETED
Exparel Use in Adductor Canal Block After Total Knee Arthroplasty
St. Luke's Hospital, Pennsylvania n=100
NCT03967847 COMPLETED
Oral Ketorolac for Arthroscopic Rotator Cuff Repair
University Hospitals Cleveland Medical Center n=44
NCT04808544 COMPLETED
Naldebain for Pain Management of Laparoscopic Cholecystectomy
E-DA Hospital n=80
NCT03404518 COMPLETED
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Loma Linda University n=185
NCT04246541 COMPLETED
Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery
University Hospitals Cleveland Medical Center n=48
NCT04688814 COMPLETED
SEQ Block for Perioperative Analgesia in Acetabular Surgery
Alexandria University n=52
NCT00820027 COMPLETED
Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)
Organon and Co n=776
NCT04246554 COMPLETED
Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery
University Hospitals Cleveland Medical Center n=49
NCT02687451 TERMINATED
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
Endo Pharmaceuticals n=28
NCT00726388 COMPLETED
An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain
Pfizer n=1,050
NCT02678117 COMPLETED
Analgesic Potentials of Preoperative Pregabalin,Magnesium Sulphate and Their Combination in Acute Post-thoracotomy Pain
National Cancer Institute, Egypt n=120
NCT04005755 COMPLETED
Maxigesic® IV Phase 3 Exposure Study
AFT Pharmaceuticals, Ltd. n=232
NCT03667001 COMPLETED
Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery
Miodrag Filipovic, Prof. Dr. med. n=140
NCT01802411 COMPLETED
Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy
Pacira Pharmaceuticals, Inc n=191
NCT03508830 COMPLETED
Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial
University of California, San Francisco n=91
NCT01052012 COMPLETED
Bupivacaine Effectiveness and Safety in SABER® Trial
Durect n=331
NCT02156154 COMPLETED
Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
The Cleveland Clinic n=580
NCT03927781 COMPLETED
Perioperative Pregabalin in Ureteroscopy: a Pilot
University of Missouri-Columbia n=10
NCT04697537 COMPLETED
Ultrasound-guided Regional Anesthesia vs Local Infiltration Anesthesia With Dexmedetomidine and Ropivacaine
Medical University of Graz n=50
NCT03936387 COMPLETED
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management: A Pilot Study
Boston Children's Hospital n=10
NCT03093454 COMPLETED
Effects of Lavender Oil on Postoperative Pain, Sleep Quality and Mood
Scott Hollenbeck, MD n=58
NCT03867240 WITHDRAWN
Gabapentin and Chronic Post Surgical Pain
Emory University
NCT03151434 COMPLETED
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
Indiana University n=147
NCT00551135 COMPLETED
Surgical Pain After Inguinal Hernia Repair (SPAIHR)
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=425
NCT02988700 COMPLETED
Spinal Versus Caudal Analgesia After Pediatric Infra-umbilical Surgery
Assiut University n=120
NCT02364167 COMPLETED
Acupuncture for Pain Control After Elective Caesarean Section
University Medicine Greifswald n=180
NCT02523599 COMPLETED
Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty
Innocoll n=305
NCT02525133 COMPLETED
Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty
Innocoll n=319
NCT03682302 COMPLETED
Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL
Pacira Pharmaceuticals, Inc n=98
NCT01683071 COMPLETED
Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty
Pacira Pharmaceuticals, Inc n=297
NCT02021240 COMPLETED
Ketamine in Post-operative Dental Pain and Recovery
The University of Hong Kong n=150
NCT03328299 COMPLETED
Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block
Assiut University n=24
NCT03011905 COMPLETED
Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block
Oslo University Hospital n=53
NCT03997838 COMPLETED
Evaluate the Efficacy and Safety of VVZ-149 Injections for the Treatment of Post-Operative Pain Following Abdominoplasty
Vivozon, Inc. n=307
NCT02698995 COMPLETED
Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia
Foisor Orthopedics Clinical Hospital n=180
NCT03730714 COMPLETED
Surgicel and Analgesic Reservoir
Assiut University n=90
NCT03485625 COMPLETED
Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol
Assiut University n=60
NCT02161705 TERMINATED
Pre-op Paravertebral Blocks to Decrease Post-op Pain Following Mastectomy With Immediate Tissue Expander (TE) Reconstruction
Johns Hopkins University n=18
NCT04342065 COMPLETED
Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Spine Fixation Surgery
South Egypt Cancer Institute n=200
NCT03765827 COMPLETED
Vitamin E on Staple Line and Anastomoses of Roux-en-Y Gastric Bypass
Hospital General Universitario Elche n=140
NCT03944291 COMPLETED
Pudendal Nerve Block for Post-Episiotomy Pain Relief
Ain Shams University n=102
NCT02950233 TERMINATED
Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial
Population Health Research Institute n=27
NCT03640390 COMPLETED
Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia
Cairo University n=60
NCT01591746 COMPLETED
Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction
Mayo Clinic n=131
NCT03429400 COMPLETED
Study of Oral Morphine Sulfate Administration in Pediatric Subjects
West-Ward Pharmaceutical n=51
NCT02720406 COMPLETED
Topical Ketamine Analgesia in Children Undergoing Tonsillectomy: a Clinical and Serum Level Assays Study.
Assiut University n=100
NCT03723980 COMPLETED
Role of Propolis Paste in Preventing Pain After Root Canal Treatment.
Juzer Shabbir Saifee n=80
NCT02783144 COMPLETED
Dexamethasone Added in Ultrasound-guided Transversus Abdominis Plain Block for Postoperative Analgesia
San Salvatore Hospital of L'Aquila n=120
NCT02438852 WITHDRAWN
Continuous Infusion of Ropivacaine Hydrochloride in Reducing Pain After Surgery in Patients With Bladder Cancer
University of Southern California
NCT00801398 COMPLETED
Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.
Endo Pharmaceuticals n=58
NCT02806713 COMPLETED
The Effect of Oral PhenazopyrIdine on Perioperative Voiding After Mid-urethral sliNg (EPIPhANy Study)
University of Massachusetts, Worcester n=92
NCT03248648 COMPLETED
Efficacy of Intra-articular Neostigmine Versus Ketamine for Postoperative Analgesia in Arthroscopic Knee Surgery
Assiut University n=100
NCT02976597 COMPLETED
Ultrasound Guided TAP Block for Postoperative Analgesia After Abdominal Surgery.
Assiut University n=90
NCT02949674 COMPLETED
Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients
Instituto Mexicano del Seguro Social n=93
NCT03587025 COMPLETED
Preemptive Analgesia With Amitryptyline for Prevention of Pain in Women After Hysterectomy
University of Campinas, Brazil n=150
NCT03027661 COMPLETED
Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.
University of Tennessee n=41
NCT02652156 TERMINATED
TAP Block for Postoperative Pain Control
Joshua Herskovic n=14
NCT01229449 COMPLETED
Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study
Reckitt Benckiser LLC n=678
NCT02959996 COMPLETED
Liposomal Bupivacaine at Cesarean Delivery to Decrease Post-operative Pain
Massachusetts General Hospital n=80
NCT03626753 COMPLETED
Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section
Centre de Maternité de Monastir n=200
NCT02959476 COMPLETED
Ropivacaine 0.2% Pre-Filled Dispenser for the Treatment of Postsurgical Pain in Patients Undergoing Cesarean Delivery
BioQ Pharma, Inc. n=132
NCT02525900 TERMINATED
ssTAP vs TAP Catheters in TAH
University of Arkansas n=15
NCT02920905 COMPLETED
Atracurium Mixed With Magnesium Sulfate Versus Atracurium Alone as Adjuvant to Lidocaine in IVRA
Assiut University n=75
NCT03183596 WITHDRAWN
Optimal Injection Site for Serratus Anterior Plane Block in Reconstructive Breast Surgery
University of Alabama at Birmingham
NCT03187899 WITHDRAWN
Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia
University of Alabama at Birmingham
NCT03458078 COMPLETED
Analgesic Efficacy of Two Adjuvants During Spinal Anaesthesia.
Centre de Maternité de Monastir n=150
NCT01675635 COMPLETED
OxyNorm Capsules in Post-Operative Pain Study
Mundipharma (China) Pharmaceutical Co. Ltd n=240
NCT02862327 COMPLETED
Intravenous Dexamethasone for Ropivacaine Axillary Block
Centre Hospitalier Universitaire de Besancon n=99
NCT02395653 COMPLETED
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The Medicines Company n=71
NCT02954484 COMPLETED
Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty
National University Hospital, Singapore n=116
NCT02969733 COMPLETED
The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy
University Hospital, Lille n=135
NCT03043027 WITHDRAWN
Efficacy of Liposomal Bupivacaine for Pain Control After Percutaneous Nephrostolithotomy
Northwell Health
NCT02310581 TERMINATED
Buprenorphine Sublingual Spray for the Treatment of Moderate to Severe Pain
INSYS Therapeutics Inc n=40
NCT02749162 COMPLETED
Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction
Foisor Orthopedics Clinical Hospital n=90
NCT00678379 COMPLETED
Pediatric Tonsillectomy Pain Reduction Study
Vanderbilt University Medical Center n=120
NCT01983020 COMPLETED
Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery
Beth Israel Medical Center n=46
NCT02109640 COMPLETED
A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
University of Edinburgh n=50
NCT02356588 COMPLETED
A Trial Evaluating the Efficacy and Safety of the Sublingual Sufentanil Tablet 30 mcg for Post-Operative Pain After Abdominal Surgery
Talphera, Inc n=161
NCT02514980 COMPLETED
Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery.
Assiut University n=30
NCT02726828 COMPLETED
intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain
Assiut University n=90
NCT02642497 COMPLETED
Local Ketamine Instillation for Postoperative Analgesia
Assiut University n=90
NCT01929031 COMPLETED
Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
Boehringer Ingelheim n=562
NCT01903551 COMPLETED
Loco-regional Analgesia for Post-operative Pain Management in Cardiac Surgery
University of Turin, Italy n=56
NCT01484652 COMPLETED
Safety and Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain With an Open-label Extension
Mallinckrodt n=329
NCT01743625 COMPLETED
Safety and Efficacy Study of COV155 for Post-operative Bunionectomy Pain
Mallinckrodt n=406
NCT02568995 COMPLETED
Pain Management Following Total Hip Arthroplasty
Örebro University, Sweden n=55
NCT01701921 COMPLETED
The Effects of Pregabalin on Postoperative Pain After Cardiac Surgery
Larissa University Hospital n=94
NCT02541552 COMPLETED
Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's n=26
NCT01752322 COMPLETED
Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain
Grünenthal GmbH n=444
NCT02466022 COMPLETED
Dexmedetomidine for Sedation in Total Knee Replacements
University of Saskatchewan n=54
NCT02506855 WITHDRAWN
Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP)
University of Mississippi Medical Center
NCT02752971 COMPLETED
Wound Infiltration With Sodium Diclofenac vs Bupivacaine for Postoperative Pain Following Appendectomy
Hospital Central Dr. Luis Ortega n=43
NCT02750917 COMPLETED
Lornoxicam Versus Etoricoxib in Postoperative Pain After Total Knee Arthroplasty
Foisor Orthopedics Clinical Hospital n=120
NCT01394718 COMPLETED
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
Children's Hospital of Philadelphia n=67
NCT00737048 COMPLETED
A Comparative Study of JNS013 in Participants With Post-Tooth-Extraction Pain
Janssen Pharmaceutical K.K. n=328
NCT02724293 COMPLETED
Efficacy and Safety of Peri-operative Pregabalin After Radical Cystectomy
Assiut University n=60
NCT02619799 COMPLETED
A Comparative Study of Intrathecal Magnesium Sulphate & Midazolam With Epidural Ropivacaine for Caesarean Patients
Rangaraya Medical College n=50
NCT01324544 WITHDRAWN
Pharmacokinetics, Safety, and Efficacy of Intravenous Dosing of Buprenorphine in Pediatric Patients Who Require Opioid Analgesia for Acute Moderate to Severe Pain
Purdue Pharma LP
NCT02662660 COMPLETED
Analgesia iv vs Epidural Analgesia vs Port-sites Infiltration After Laparoscopic Sleeve Gastrectomy
Hospital General Universitario Elche n=147
NCT01539642 COMPLETED
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™) for the Treatment of Post-Operative Pain in Patients After Open Abdominal Surgery
Talphera, Inc n=172
NCT02462174 COMPLETED
Topical Ketamine Versus Caudal Ketamine for Postoperative Analgesia in Children Undergoing Inguinal Herniotomy
Assiut University n=80
NCT01539538 COMPLETED
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
Talphera, Inc n=357
NCT01389284 COMPLETED
Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium
Bayer n=300
NCT01304134 COMPLETED
Oxycodone Hydrochloride Injection in the Postoperative Pain Relieving Treatment
Mundipharma (China) Pharmaceutical Co. Ltd n=240
NCT01280591 COMPLETED
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
Bayer n=712
NCT01495858 COMPLETED
Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
Bayer n=267
NCT02435537 COMPLETED
Combined Intrathecal Morphine and Dexmedetomidine Analgesia
Assiut University n=90
NCT01437644 COMPLETED
The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Guy's and St Thomas' NHS Foundation Trust n=54
NCT02385435 COMPLETED
Caudal Bupivacaine vs Bupivacaine Plus Two Doses of Dexmedetomidine for Postoperative Analgesia in Children
University of Jordan n=91
NCT01458431 COMPLETED
Levobupivacaine to the Surgical Wound Following Cesarean
Manuel Ángel Gómez-Ríos n=70
NCT02254525 TERMINATED
A Multicenter Trial of the Efficacy and Safety of a New Formulation of Ibuprofen 800 mg Every 6 Hours in the Management of Postoperative Pain
Biomendi S.A.U. n=231
NCT01116583 COMPLETED
The Effect of Gabapentin on Thoracic Epidural Analgesia Following Thoracotomy
University of Aarhus n=104
NCT02145975 COMPLETED
Efficacy of Fentanyl to Reduce the Time of Severe Postoperative Pain Relief Compared to Morphine
Universidad de Antioquia n=60
NCT01626118 COMPLETED
Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Iroko Pharmaceuticals, LLC n=373
NCT00666393 WITHDRAWN
An Evaluation of Safety of the Fentanyl Transdermal System for Management of Acute Post-Operative Pain in Pediatric Patients
Alza Corporation, DE, USA
NCT01543685 COMPLETED
Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Iroko Pharmaceuticals, LLC n=462
NCT01462435 COMPLETED
Study of Diclofenac Capsules to Treat Pain Following Bunionectomy
Iroko Pharmaceuticals, LLC n=428
NCT01077752 COMPLETED
Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia
Assistance Publique - Hôpitaux de Paris n=95
NCT00745290 COMPLETED
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
Pacira Pharmaceuticals, Inc n=245
NCT01008553 COMPLETED
A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome
Janssen Pharmaceutical K.K. n=258
NCT01249872 COMPLETED
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
University of Patras n=96
NCT01814878 COMPLETED
A Study Comparing the Effectiveness and Safety of Extended Release (ER) Tramadol Hydrochloride (HCl)/Acetaminophen With Immediate Release (IR) Tramadol HCl/Acetaminophen in Participants With Moderate to Severe Postoperative Pain
Janssen Korea, Ltd., Korea n=320
NCT01492660 COMPLETED
Echogenic Versus Stimulating Needle and Catheter for Sciatic Blocks
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's n=70
NCT01353456 COMPLETED
Multimodal Analgesic Using Morphine and COX-2 With or Without Dexmedetomidine for Colorectal Surgery
The University of Hong Kong n=100
NCT01025102 COMPLETED
The Addition of Sufentanil Interscalene Block in Shoulder Surgery
Bent Gymoese Jorgensen n=26
NCT01432496 TERMINATED
Peritoneal Nebulization of Ropivacaine for Pain Control After Laparoscopic Colectomy
San Gerardo Hospital n=130
NCT00814580 COMPLETED
Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone IR for Treatment of Acute Post-op Pain Following Elective Arthroscopic (Surgery Using a Thin Flexible Scope) Shoulder Surgery
Ortho-McNeil Janssen Scientific Affairs, LLC n=382
NCT01629992 COMPLETED
Preoperative Counseling in Cholecystectomy
Federal University of Mato Grosso n=119
NCT01016808 COMPLETED
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
QRxPharma Inc. n=522
NCT01280331 COMPLETED
Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients
QRxPharma Inc. n=375
NCT01055015 COMPLETED
Double Blind Efficacy and Safety Study of Flexible-Dose vs Low-Dose Q8003 After Undergoing Primary Unilateral Total Knee Arthroplasty
QRxPharma Inc. n=141
NCT01418807 COMPLETED
Transumbilical Versus Transvaginal Specimen Retrieval at Minilaparoscopy
Università degli Studi dell'Insubria n=56
NCT01394445 COMPLETED
Pilot Study of Physostigmine-Enhanced Opioid Analgesia
Medical University of Graz n=20
NCT00709436 COMPLETED
Safety and Efficacy of Repeated Doses of PMI-150 (Intranasal Ketamine) in Acute Post-operative Pain Following Orthopedic Surgery
Hospira, now a wholly owned subsidiary of Pfizer n=250
NCT01378819 COMPLETED
3-midline-ports Cholecystectomy
Universidad Miguel Hernandez de Elche n=100
NCT00957177 COMPLETED
Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy
Medical University of Graz n=20
NCT00707057 COMPLETED
Ibuprofen Extended-Release Dental Pain Study
SCOLR Pharma, Inc. n=256
NCT00307892 SUSPENDED
Traumeel S for Reduction of Post Operative Pain Following Arthroscopy
Shaare Zedek Medical Center n=98
NCT01116713 COMPLETED
Effect of Dexamethasone in Postoperative Symptoms After Mastectomy for Breast Cancer
Instituto Mexicano del Seguro Social n=70

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only