PTSD Clinical Trial Landscape
Data updated: May 20, 2026
305 clinical trials tracked since 2008
PTSD is being studied across 305 clinical trials registered since 2008, with 80 programs currently active. The competitive pipeline includes 13 active Phase 3 trials, 49 active Phase 2 trials, and 15 active Phase 1 trials. Top industry sponsors include Oui Therapeutics, Inc., COMPASS Pathways, Senseye, Inc..
80 active
/
305 total (since 2008)
15
Phase 1 Active
69 total
49
Phase 2 Active
176 total
13
Phase 3 Active
61 total
9
Phase 4 Active
44 total
Top Industry Sponsors
Sorted by active Active Done Failed
Oui Therapeutics, Inc. 2 0 0
COMPASS Pathways 1 0 0
Senseye, Inc. 1 0 0
HB BioTech, LLC 1 0 0
Otsuka Medical Devices Co., Ltd. Japan 1 0 0
+ 4 more sponsors — see full table below
Featured Phase 3 Trials
NCT07280065 RECRUITING
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
Senseye, Inc. n=1,900
NCT04877093 RECRUITING
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences n=32
NCT03539614 ACTIVE NOT RECRUITING
Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
VA Office of Research and Development n=87
NCT06589505 RECRUITING
Software as a Medical Device for the Treatment of Patients With PTSD
Otsuka Medical Devices Co., Ltd. Japan n=52
+ 56 more Phase 3 trials — see full database below
PTSD — Trials Started by Year (last 10 years)
2016 18
2017 12
2018 8
2019 12
2020 11
2021 17
2022 15
2023 14
2024 19
2025 27
2026 24
TheraRadar.com
Full Trial Database
Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.
Top Sponsors (all-time)
Oui Therapeutics, Inc. 2
COMPASS Pathways 1
Senseye, Inc. 1
HB BioTech, LLC 1
Otsuka Medical Devices Co., Ltd. Japan 1
Reconnect Labs 1
Nyree Penn 1
Resilient Pharmaceuticals 14
Tonix Pharmaceuticals, Inc. 7
Bionomics Limited 2
Active Trials by Phase
Phase 1 15
Phase 2 49
Phase 3 13
Phase 4 9
Enrollment Size Distribution
1-50 145
51-200 111
201-500 20
501-1k 2
1k+ 3
All Industry Sponsors
Sorted by active Active Done Failed
Oui Therapeutics, Inc. 2 0 0
COMPASS Pathways 1 0 0
Senseye, Inc. 1 0 0
HB BioTech, LLC 1 0 0
Otsuka Medical Devices Co., Ltd. Japan 1 0 0
Reconnect Labs 1 0 0
Nyree Penn 1 0 0
Resilient Pharmaceuticals 0 10 4
Tonix Pharmaceuticals, Inc. 0 3 4
NCT07570654 NOT YET RECRUITING
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
COMPASS Pathways n=300
NCT07280065 RECRUITING
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
Senseye, Inc. n=1,900
NCT07537894 NOT YET RECRUITING
Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation
Stanford University n=100
NCT04877093 RECRUITING
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences n=32
NCT07167940 NOT YET RECRUITING
Rapid Acceleration Process for Intensive Treatment of PTSD in 5 Days
VA Office of Research and Development n=90
NCT07418554 NOT YET RECRUITING
Sleep Disturbances in Children and Adolescents With Post-traumatic Stress Disorder (PTSD): a Randomized Double-blind Placebo-controlled Trial to Investigate the Efficacy of Pediatric Prolonged-release Melatonin
University Hospital, Strasbourg, France n=120
NCT03539614 ACTIVE NOT RECRUITING
Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
VA Office of Research and Development n=87
NCT06589505 RECRUITING
Software as a Medical Device for the Treatment of Patients With PTSD
Otsuka Medical Devices Co., Ltd. Japan n=52
NCT05427500 ENROLLING BY INVITATION
Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder
The Royal's Institute of Mental Health Research n=54
NCT05637879 RECRUITING
Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder
White River Junction Veterans Affairs Medical Center n=92
NCT06394284 RECRUITING
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral Injury
Herzog Hospital n=60
NCT04985344 RECRUITING
Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol
University Hospital, Toulouse n=92
NCT06189027 COMPLETED
Epigenetics and MDMA-Assisted Psychotherapy for PTSD
University of Southern California n=45
NCT04192266 COMPLETED
Estrogen and Fear in PTSD
The University of Texas Health Science Center, Houston n=83
NCT05979844 COMPLETED
MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD
Dr. Leslie Morland n=16
NCT05243459 TERMINATED
Testing the Efficacy of an Eye-tracking-based Treatment in Reducing Stress-related Symptoms in Veterans With PTSD
Tel Aviv University n=121
NCT03827057 COMPLETED
RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD)
Uniformed Services University of the Health Sciences n=94
NCT04077437 COMPLETED
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)
Resilient Pharmaceuticals n=121
NCT04714359 COMPLETED
A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD
Resilient Pharmaceuticals n=87
NCT03537014 COMPLETED
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)
Resilient Pharmaceuticals n=100
NCT03110575 TERMINATED
12-Week Open-Label Extension Study of TNX-102 SL in PTSD Patients
Tonix Pharmaceuticals, Inc. n=190
NCT03841773 TERMINATED
A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Participants With PTSD
Tonix Pharmaceuticals, Inc. n=192
NCT03508700 COMPLETED
A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD
Tonix Pharmaceuticals, Inc. n=93
NCT05446857 COMPLETED
Glecaprevir/Pibrentasvir for the Treatment of PTSD
White River Junction Veterans Affairs Medical Center n=10
NCT03062540 TERMINATED
Safety and Efficacy Study of TNX-102 SL in Patients With Military-related PTSD
Tonix Pharmaceuticals, Inc. n=358
NCT02884908 COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
University of Maryland, Baltimore n=57
NCT02187224 COMPLETED
Progesterone Effect on Individuals Diagnoses With AD and PTSD.
Yale University n=13
NCT02789982 COMPLETED
Using Reconsolidation Blockade to Treat Trauma Related Disorders After Paris Attacks: an Effectiveness Study
Assistance Publique - Hôpitaux de Paris n=364
NCT03216356 WITHDRAWN
Effect of D-cycloserine on a Short Imagery Rescripting Intervention for Subclinical PTSD
Boston University Charles River Campus
NCT03151681 COMPLETED
The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol
Douglas Mental Health University Institute n=84
NCT04592159 WITHDRAWN
Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress Disorder
Jazz Pharmaceuticals
NCT01600456 COMPLETED
Optimizing Posttraumatic Stress Disorder Treatment: Prolonged Exposure (PE) Versus PE Plus Sertraline
Case Western Reserve University n=150
NCT02992899 COMPLETED
Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder
Emory University n=56
NCT02397889 COMPLETED
Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
Icahn School of Medicine at Mount Sinai n=30
NCT04322968 COMPLETED
Ketamine Infusion for Comorbid PTSD and Chronic Pain
VA Ann Arbor Healthcare System n=41
NCT04393818 COMPLETED
Mobile Phone Based Intervention to Protect Mental Health in Healthcare Workers at Frontline Against COVID19
Fundació d'investigació Sanitària de les Illes Balears n=560
NCT00622921 WITHDRAWN
Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence
Yale University
NCT03765138 TERMINATED
Combined Treatment of Prolonged Exposure and Pramipexole for Posttraumatic Stress Disorder and Depression
Research Foundation for Mental Hygiene, Inc. n=1
NCT02615197 COMPLETED
Effectiveness of PTSD Treatment For Suicidal and Multi-Diagnostic Clients
University of Washington n=35
NCT00475241 COMPLETED
Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms
VA Office of Research and Development n=36
NCT00532493 COMPLETED
Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD
VA Office of Research and Development n=304
NCT01987960 TERMINATED
Brexpiprazole as an Adjunctive Treatment to Paroxetine or Sertraline in Adult Patients Suffering From Post-traumatic Stress Disorder (PTSD)
H. Lundbeck A/S n=417
NCT02336971 COMPLETED
Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder
Toronto Metropolitan University n=64
NCT01955538 COMPLETED
The Effect of BAT Versus Mixed Physical Activity as add-on Treatment for Traumatised Refugees.
Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital n=338
NCT00639288 COMPLETED
Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence
Yale University n=9
NCT01998100 COMPLETED
Maximizing Treatment Outcome in Post-Traumatic Stress Disorder (PTSD)
University of Texas at Austin n=28
NCT00941629 COMPLETED
Comparison of Videoconference and Face-to-Face Delivery of Cognitive Processing Therapy for Posttraumatic Stress Disorder
University of Wisconsin, Madison n=90
NCT00640445 COMPLETED
Military to Civilian: Trial of an Intervention to Promote Postdeployment Reintegration
Minneapolis Veterans Affairs Medical Center n=1,292
NCT00879255 COMPLETED
Telemental Health and Cognitive Processing Therapy for Rural Combat Veterans With Posttraumatic Stress Disorder
US Department of Veterans Affairs n=125
NCT02398136 WITHDRAWN
To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSD
Adriana Feder
NCT02362477 COMPLETED
Telemental Health and Cognitive Processing Therapy for Female Veterans With Military-related PTSD
VA Pacific Islands Health Care System n=126
NCT01199107 COMPLETED
Maximizing Treatment Outcome and Examining Sleep in Post-traumatic Stress Disorder (PTSD)
Southern Methodist University n=9
NCT01362543 COMPLETED
Traumatized Refugees -Stress Management Versus Cognitive Re-structuring
Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital n=143
NCT00671099 COMPLETED
Tachikawa Project for Prevention of Posttraumatic Stress Disorder With Polyunsaturated Fatty Acid (TPOP): TPOP-02 Study
Japan Science and Technology Agency n=110
NCT00669981 COMPLETED
Effectiveness of Cognitive Behavioral Couples Therapy for Post-traumatic Stress Disorder
Toronto Metropolitan University n=80
NCT01239173 TERMINATED
Emotional Memory Reactivation in Posttraumatic Stress Disorder
Assistance Publique - Hôpitaux de Paris n=5
Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only