Landscape → Dermatology

Rosacea Clinical Trial Landscape

Data updated: May 20, 2026

124 clinical trials tracked since 2008

Rosacea is being studied across 124 clinical trials registered since 2008, with 4 programs currently active. The competitive pipeline includes 0 active Phase 3 trials, 3 active Phase 2 trials, and 0 active Phase 1 trials. Top industry sponsors include Tarsus Pharmaceuticals, Inc., Galderma R&D, LEO Pharma.

4 active

124 total (since 2008)

Phase 1 Active

23 total

Phase 2 Active

48 total

Phase 3 Active

39 total

Phase 4 Active

22 total

Top Industry Sponsors

Sorted by active Active Done Failed

Tarsus Pharmaceuticals, Inc. 1 1 0

Galderma R&D 0 20 0

LEO Pharma 0 5 0

Sol-Gel Technologies, Ltd. 0 4 1

Maruho Co., Ltd. 0 5 0

+ 7 more sponsors — see full table below

Featured Phase 3 Trials

NCT05296629 COMPLETED

A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.

Journey Medical Corporation n=323

NCT05343455 COMPLETED

A Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea (MVOR-2)

Journey Medical Corporation n=330

NCT01555463 COMPLETED

Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular Rosacea

LEO Pharma n=961

NCT01659853 COMPLETED

Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea

Galderma R&D n=70

NCT02576860 COMPLETED

Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle

Maruho Co., Ltd. n=263

+ 34 more Phase 3 trials — see full database below

Rosacea — Trials Started by Year (last 10 years)

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Tarsus Pharmaceuticals, Inc.

Galderma R&D

LEO Pharma

Sol-Gel Technologies, Ltd.

Maruho Co., Ltd.

Vyne Therapeutics Inc.

Actavis Inc.

AbbVie

Padagis LLC

CAGE Bio Inc.

Active Trials by Phase

Phase 2

Phase 4

Enrollment Size Distribution

1-50

51-200

201-500

501-1k

1k+

All Industry Sponsors

Sorted by active Active Done Failed

Tarsus Pharmaceuticals, Inc. 1 1 0

Galderma R&D 0 20 0

LEO Pharma 0 5 0

Sol-Gel Technologies, Ltd. 0 4 1

Maruho Co., Ltd. 0 5 0

Vyne Therapeutics Inc. 0 4 1

Actavis Inc. 0 5 0

AbbVie 0 5 0

Padagis LLC 0 4 0

CAGE Bio Inc. 0 3 0

Journey Medical Corporation 0 3 0

Sun Pharmaceutical Industries, Inc. 0 3 0

NCT05296629 COMPLETED

A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.

Journey Medical Corporation n=323

NCT05343455 COMPLETED

A Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea (MVOR-2)

Journey Medical Corporation n=330

NCT01555463 COMPLETED

Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular Rosacea

LEO Pharma n=961

NCT01659853 COMPLETED

Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea

Galderma R&D n=70

NCT02576860 COMPLETED

Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle

Maruho Co., Ltd. n=263

NCT02547441 COMPLETED

Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle

Maruho Co., Ltd. n=463

NCT02576847 COMPLETED

Study to Evaluate the Long-term Safety of a Once-Daily Omiganan Topical Gel

Maruho Co., Ltd. n=307

NCT03276936 COMPLETED

A Study to Evaluate the Long-Term Safety of Topical Administration of FMX103 in the Treatment of Moderate to Severe Papulopustular Rosacea

Vyne Therapeutics Inc. n=504

NCT03564119 COMPLETED

A Study of S5G4T-1 in the Treatment of Papularpustular Rosacea

Sol-Gel Technologies, Ltd. n=372

NCT03564145 TERMINATED

A Long-Term Safety Study of S5G4T-1 in the Treatment of Papulopustular Rosacea

Sol-Gel Technologies, Ltd. n=547

NCT03448939 COMPLETED

A Study of S5G4T-1 in the Treatment of Papulopustular Rosacea

Sol-Gel Technologies, Ltd. n=361

NCT02800148 COMPLETED

Bioequivalence Study of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea on the Face

Padagis LLC n=667

NCT03352323 COMPLETED

An Evaluation of the Reduction in Erythema in Adult Patients With Moderate to Severe Persistent Facial Erythema Associated With Rosacea

Padagis LLC n=50

NCT02795117 COMPLETED

Comparative Safety and Efficacy of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea

Padagis LLC n=486

NCT02385240 COMPLETED

Comparative Safety and Efficacy of Two Rosacea Products in the Treatment of Facial Erythema of Rosacea

Padagis LLC n=552

NCT01885000 COMPLETED

Patient-Reported Outcome Of Facial Erythema (PROOF)

Galderma R&D n=92

NCT03954444 COMPLETED

A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream"

Actavis Inc. n=1,105

NCT01494467 COMPLETED

Phase 3 Papulopustular Rosacea Study

Galderma R&D n=688

NCT01493687 COMPLETED

Phase 3 Papulopustular Rosacea Study

Galderma R&D n=683

NCT01318733 COMPLETED

Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Galderma R&D n=449

NCT01355471 COMPLETED

Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Galderma R&D n=293

NCT01355458 COMPLETED

Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Galderma R&D n=260

NCT03142451 COMPLETED

A Study (Study 1) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea

Vyne Therapeutics Inc. n=751

NCT04608500 COMPLETED

A Study (Study 2) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea

Vyne Therapeutics Inc. n=771

NCT04106726 COMPLETED

Bioequivalence Study of Ivermectin Cream 1% in Treatment of Moderate to Severe Facial Rosacea

Zydus Worldwide DMCC n=525

NCT02393937 COMPLETED

A Therapeutic Equivalence Study of Two Metronidazole Gel 1% Topical Treatments of Rosacea

bioRASI, LLC n=963

NCT02120924 COMPLETED

A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea

Actavis Inc. n=1,009

NCT02840461 COMPLETED

Clinical Endpoint Study of Ivermectin 1% Cream

Actavis Inc. n=630

NCT02289352 COMPLETED

Randomized, Double-blind, Multiple-site, Placebo-controlled, Parallel-design Study in Patients With Moderate to Severe Facial Erythema Associated With Rosacea

Actavis Inc. n=462

NCT02131636 COMPLETED

Efficacy and Safety of AGN-199201 in Patients With Persistent Erythema Associated With Rosacea

Allergan n=440

NCT02132117 COMPLETED

Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With Rosacea

Allergan n=445

NCT02095158 COMPLETED

A Long-Term Safety and Efficacy Study AGN-19920 in Patients With Persistent Erythema Associated With Rosacea

Allergan n=440

NCT03287791 COMPLETED

A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Participants With Rosacea

Actavis Inc. n=924

NCT03035955 COMPLETED

Azelaic Acid on Demodex Counts in Rosacea

Wake Forest University n=20

NCT01493947 COMPLETED

CD5024 1% [Ivermectin 1%] Cream Versus Metronidazole 0.75% Cream in Papulopustular Rosacea (PPR) Study

Galderma R&D n=962

NCT01789775 COMPLETED

Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema of Rosacea

Galderma R&D n=114

NCT01125930 TERMINATED

Atralin Gel for the Treatment of Rosacea

Lisa E. Maier n=68

NCT01016782 COMPLETED

Study of 0444 Gel in the Treatment of Inflammatory Lesions of Rosacea

Fougera Pharmaceuticals Inc. n=867

NCT00823901 COMPLETED

Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea

Massachusetts General Hospital n=83

NCT07443202 ENROLLING BY INVITATION

Study of Lotilaner Ophthalmic Gel in Patients With Ocular Rosacea (KORE)

Tarsus Pharmaceuticals, Inc.

NCT06312813 RECRUITING

Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Wright State University

NCT06952517 RECRUITING

Efficacy and Safety of Topical Clascoterone (WINLEVI) Cream 1% in Patients With Facial Acneiform Rosacea

Narrows Institute for Biomedical Research

NCT04886739 COMPLETED

CGB-400 Topical Gel for the Treatment of Inflammatory Lesions of Rosacea

CAGE Bio Inc.

NCT04275999 COMPLETED

Rosacea and Ivermectin

Wake Forest University Health Sciences

NCT04731259 WITHDRAWN

Study to Evaluate the Safety of ATR-04

Azitra Inc.

NCT06013371 TERMINATED

PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea

Icahn School of Medicine at Mount Sinai

NCT05045469 COMPLETED

Therapeutic Effects of Topical Herbal Medicine -Rhubarb Ointment on Rosacea

Chang Gung Memorial Hospital

NCT06532136 WITHDRAWN

Deucravacitinib Rosacea

Icahn School of Medicine at Mount Sinai

NCT03883945 WITHDRAWN

A Safety and Efficacy Study to Evaluate Rosacea

AiViva BioPharma, Inc.

NCT06033352 COMPLETED

Potassium-titanyl Phosphate (KTP) Laser vs KTP Laser and Ivermectin Cream for Facial Rosacea

Insel Gruppe AG, University Hospital Bern

NCT05150587 COMPLETED

Safety, Efficacy and Pharmacokinetics of Rifaximin in Patients With Moderate-to-severe Papulopustular Rosacea

Alfasigma S.p.A.

NCT05838170 COMPLETED

Study of TP-04 in Participants With Papulopustular Rosacea

Tarsus Pharmaceuticals, Inc.

NCT05278624 COMPLETED

Evaluation of the Safety and Efficacy of Topical Roflumilast Cream in the Treatment of Facial Papulopustular Rosacea

Dermatology Consulting Services, PLLC

NCT03756389 SUSPENDED

Evaluation of Topical Application of BMX-010 in Subjects With Rosacea

BioMimetix JV, LLC

NCT03590366 COMPLETED

A Study to Determine Safety and Efficacy of B244 in Subjects With Mild to Moderate Rosacea

AOBiome LLC

NCT02806414 COMPLETED

Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.

University of California, San Diego

NCT03064438 COMPLETED

Safety and Efficacy of ACU-D1 in the Treatment of Acne Rosacea

Accuitis, Inc.

NCT01993446 COMPLETED

A Safety and Efficacy Study of DRM02 in Subjects With Rosacea

Dermira, Inc.

NCT03340961 COMPLETED

A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules

Dr. Reddy's Laboratories Limited

NCT01174030 COMPLETED

Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Galderma R&D

NCT01449591 COMPLETED

Safety, Tolerability and Efficacy of BFH772 in Rosacea Patients

Novartis Pharmaceuticals

NCT00989014 COMPLETED

Dose-Finding Study of CD07805/47 Topical Gel in Subjects With Erythematotelangiectatic Rosacea

Galderma R&D

NCT00697541 COMPLETED

Systemic Bioavailability Study Of Col-118 Administered Topically as a 0.18 % Facial Gel And Brimonidine Ophthalmic Solution 0.2%

Galderma R&D

NCT01614743 COMPLETED

A Double-Blinded, Randomized Placebo Controlled Pilot Study Comparing the Efficacy and Safety of IncobotulinumtoxinA Versus Saline Injections to the Cheek Region in Patients With Rosacea

DeNova Research

NCT00617903 COMPLETED

Exploration of Safety and Efficacy of AzA 15% Foam Twice a Day in Rosacea

LEO Pharma

NCT01025635 COMPLETED

Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular Rosacea

LEO Pharma

NCT03079531 COMPLETED

Open Label Study to Assess the Effect of Secukinumab in Moderate to Severe Papulopustular Rosacea

Anne Chang

NCT01735201 COMPLETED

AGN-199201 for the Treatment of Erythema With Rosacea

Allergan

NCT03263273 COMPLETED

Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea

Hovione Scientia Limited

NCT01933464 COMPLETED

An Analysis of the Effect of Topical Cromolyn Sodium on Rosacea-associated Erythema

University of California, San Diego

NCT03050086 COMPLETED

Open Label Phase 2 Feasibility Study of BPX-04 Topical Minocycline Gel in Rosacea

BioPharmX, Inc.

NCT02828241 COMPLETED

A Study to Assess the Efficacy, Safety and Tolerability of DFD-04

Dr. Reddy's Laboratories Limited

NCT03003104 COMPLETED

DMT210 Topical Gel in the Treatment of Acne Rosacea

Dermata Therapeutics

NCT02601963 COMPLETED

Safety and Efficacy Study of a Topical Minocycline Foam in Patients With Papulopustular Rosacea

Vyne Therapeutics Inc.

NCT01045551 COMPLETED

Open Label Pilot Study of Apremilast in Treatment of Rosacea

Julian M. Mackay-Wiggan

NCT02300129 COMPLETED

Effect of CD07805/47 Gel in Rosacea Flushing

Galderma R&D

NCT02583009 COMPLETED

A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Rosacea

Amorepacific Corporation

NCT01134991 TERMINATED

Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Rosacea Patients

Vyne Therapeutics Inc.

NCT01784133 COMPLETED

A Twelve Week Safety and Efficacy Study in Rosacea

Maruho Co., Ltd.

NCT00940992 COMPLETED

A Study of DER 45-EV Gel to Treat Rosacea

Sol-Gel Technologies, Ltd.

NCT01359228 WITHDRAWN

Rifaximin Treatment of Papulopustular Rosacea

University of California, San Francisco

NCT02052999 COMPLETED

Study to Evaluate the Efficacy and Safety of PAC-14028 Cream in Rosacea Patients

Amorepacific Corporation

NCT00991198 COMPLETED

The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage

Aria Aesthetics Inc.

NCT01186068 COMPLETED

Dose Response Study of Patients With Erythematous Rosacea

Vicept Therapeutics, Inc.

NCT00621218 COMPLETED

A Study to Determine the Safety and Efficacy of Atralin (Tretinoin 0.05%) Gel for the Treatment of Rosacea

Coria Laboratories, Ltd.

NCT06776445 COMPLETED

Efficacy and Safety of Different Dose Regimens of Gabapentin for Treating Erythema/Flushing in Rosacea: A Randomized Controlled Trial

First Affiliated Hospital of Chongqing Medical University

NCT06557603 COMPLETED

Bioequivalence Study of Ivermectin 1% Cream and Soolantra (Ivermectin) 10 mg/g Cream

Humanis Saglık Anonim Sirketi

NCT03094403 COMPLETED

To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel

Sun Pharmaceutical Industries, Inc.

NCT05597462 COMPLETED

Impact of DFD-29 on Microbial Flora of Healthy, Adult Human Subjects When Administered Over 16 Weeks

Journey Medical Corporation

NCT01257919 COMPLETED

Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular Rosacea

LEO Pharma

NCT05616923 COMPLETED

Topical Mitogenic-Activated Protein Kinase (MAPK) Inhibition in Rosacea

Albany Research Institute, Inc.

NCT05675501 COMPLETED

Evaluation of Topical Encapsulated Benzoyl Peroxide on the Skin Microbiome and Skin Biophysical Properties

Sol-Gel Technologies, Ltd.

NCT02774590 COMPLETED

Timolol for the Treatment of Acne and Rosacea

Johns Hopkins University

NCT04508205 COMPLETED

CGB-400 for the Reduction of Facial Redness and Bumps and Blemishes

CAGE Bio Inc.

NCT04508660 COMPLETED

CGB-400 for the Reduction of Facial Redness

CAGE Bio Inc.

NCT01579084 COMPLETED

Safety and Tolerability of AGN-199201 in Patients With Erythema Associated With Rosacea

Allergan

NCT00945373 COMPLETED

Combination Therapy for the Treatment of Rosacea

Ellen Marmur

NCT03689010 COMPLETED

To Evaluate the Therapeutic Equivalence and Safety in Treatment of Moderate Facial Rosacea

Sun Pharmaceutical Industries, Inc.

NCT03478436 COMPLETED

Pharmacokinetics of Doxycycline in Skin of Healthy Volunteers

Medical University of Vienna

NCT01451619 COMPLETED

A Study of Laropiprant (MK-0524) in Participants With Moderate to Severe Erythematotelangiectatic Rosacea (MK-0524-155)

Merck Sharp & Dohme LLC

NCT02028286 COMPLETED

A 21 Day Pharmacokinetics Study in Papulopustular Rosacea

Maruho Co., Ltd.

NCT01513863 COMPLETED

A Therapeutic Equivalence Study of Two Metronidazole 1%Topical Gel Treatments for Patients With Rosacea

Sun Pharmaceutical Industries, Inc.

NCT05296837 ACTIVE NOT RECRUITING

Ocular Rosacea Biome Study

University of California, San Francisco

NCT07431476 COMPLETED

Brimonidine 0.33% for Rosacea-Related Facial Erythema

Istanbul Training and Research Hospital

NCT06873087 COMPLETED

Changes in PACAP, CGRP, and VIP Levels in Rosacea Patients on Systemic Isotretinoin and Their Association with Erythema

SB Istanbul Education and Research Hospital

NCT06331533 COMPLETED

Intradermal BoNT-A Treatment in Erythematotelangiectatic Rosacea

Istanbul Training and Research Hospital

NCT04839549 WITHDRAWN

Efficacy and Safety of Dextenza Compared to Topical Fluorometholone in Patients With Ocular Rosacea

Eye Associates of Central Texas

NCT02075671 COMPLETED

Photodynamic Therapy for Papulopustular Rosacea

George Washington University

NCT03053700 WITHDRAWN

Intense Pulsed Light as an Adjunctive to Bromonidine for the Treatment of Rosacea

Rabin Medical Center

NCT00892281 COMPLETED

ORCA - Oracea® for Rosacea: A Community-based Assessment

Galderma R&D

NCT01872715 COMPLETED

Patient Centered Outcomes in Rosacea: An Exploratory Multi-media Analysis of the Patient Experience on Oracea

Galderma R&D

NCT01426269 COMPLETED

Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo

Galderma R&D

NCT02249065 COMPLETED

Mirvaso in Use Study

Galderma R&D

NCT01308619 COMPLETED

Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo

Galderma R&D

NCT04153188 COMPLETED

Pulsed Dye Laser Treatment and Oxymetazoline Hydrochloride (HCL) 1% Cream for Erythematotelangiectatic Rosacea

Candela Corporation

NCT05014906 COMPLETED

Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea

Dermatology Specialists Research

NCT03075891 COMPLETED

Oracea Soolantra Association in Participants With Severe Rosacea

Galderma R&D

NCT02616250 COMPLETED

MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea.

Galderma R&D

NCT04555525 COMPLETED

A Pilot Study on the Use of Seysara for Rosacea

Derm Research, PLLC

NCT00855595 COMPLETED

Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea

LEO Pharma

NCT03380390 COMPLETED

Safety and Tolerability of Oxymetazoline and Energy-Based Therapy in Participants With Rosacea

Aclaris Therapeutics, Inc.

NCT03418610 COMPLETED

Azelaic Acid Foam 15% in the Treatment of Papulopustular Rosacea

Clinical Research Center of the Carolinas

NCT03048058 COMPLETED

Internet Surveys and Their Impact on Adherence for Rosacea

Wake Forest University Health Sciences

NCT02147691 COMPLETED

Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study

Derm Research, PLLC

Full Rosacea Pipeline

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only