TheraRadar
Landscape Oncology

Thyroid Cancer Clinical Trial Landscape

Data updated: May 20, 2026

223 clinical trials tracked since 2008

Thyroid Cancer is being studied across 223 clinical trials registered since 2008, with 98 programs currently active. The competitive pipeline includes 18 active Phase 3 trials, 61 active Phase 2 trials, and 29 active Phase 1 trials. Top industry sponsors include Exelixis, Eli Lilly, Chia Tai Tianqing Pharmaceutical Group Co., Ltd..

98 active
/
223 total (since 2008)
29
Phase 1 Active
74 total
61
Phase 2 Active
145 total
18
Phase 3 Active
33 total
5
Phase 4 Active
12 total

Top Industry Sponsors

Sorted by active Active Done Failed
Exelixis 3 2 0
Eli Lilly 3 0 0
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 2 2 0
Pfizer 2 0 0
Roche 1 1 2

+ 10 more sponsors — see full table below

Featured Phase 3 Trials

NCT01398085 ACTIVE NOT RECRUITING
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
University College, London n=504
NCT04211337 ACTIVE NOT RECRUITING
A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer
Loxo Oncology, Inc. n=291
NCT03570021 ACTIVE NOT RECRUITING
ESTIMation of the ABiLity of Prophylactic Central Compartment Neck Dissection to Modify Outcomes in Low-risk Differentiated Thyroid Cancer
Gustave Roussy, Cancer Campus, Grand Paris n=352
NCT06554652 RECRUITING
Selective Neck Dissection Versus Modified Neck Dissection in PTC
Fudan University n=250
NCT06558981 RECRUITING
Adjuvant Radiotherapy in High Risk Locally Advanced DTC
Fudan University n=124

+ 28 more Phase 3 trials — see full database below

Thyroid Cancer — Trials Started by Year (last 10 years)

2016
13
2017
17
2018
10
2019
10
2020
15
2021
16
2022
11
2023
17
2024
15
2025
17
2026
11

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Exelixis
5
Eli Lilly
3
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
4
Pfizer
2
Roche
4
Novartis
2
ModeX Therapeutics, An OPKO Health Company
1
Loxo Oncology, Inc.
1
Solve Therapeutics
1
Alpha Fusion Inc.
1

Active Trials by Phase

Phase 1
29
Phase 2
61
Phase 3
18
Phase 4
5

Enrollment Size Distribution

1-50
120
51-200
58
201-500
25
501-1k
10
1k+
2

All Industry Sponsors

Sorted by active Active Done Failed
Exelixis 3 2 0
Eli Lilly 3 0 0
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 2 2 0
Pfizer 2 0 0
Roche 1 1 2
Novartis 1 1 0
ModeX Therapeutics, An OPKO Health Company 1 0 0
Loxo Oncology, Inc. 1 0 0
Solve Therapeutics 1 0 0
Alpha Fusion Inc. 1 0 0
AccSalus Biosciences, Inc. 1 0 0
Merck 1 0 0
Beijing Scitech-Mq Pharmaceuticals Limited 1 0 0
Sensei Biotherapeutics, Inc. 1 0 0
Apollomics Inc. 1 0 0
NCT01398085 ACTIVE NOT RECRUITING
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
University College, London n=504
NCT04211337 ACTIVE NOT RECRUITING
A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer
Loxo Oncology, Inc. n=291
NCT03570021 ACTIVE NOT RECRUITING
ESTIMation of the ABiLity of Prophylactic Central Compartment Neck Dissection to Modify Outcomes in Low-risk Differentiated Thyroid Cancer
Gustave Roussy, Cancer Campus, Grand Paris n=352
NCT06554652 RECRUITING
Selective Neck Dissection Versus Modified Neck Dissection in PTC
Fudan University n=250
NCT07440290 NOT YET RECRUITING
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
Cancer Research UK n=30
NCT06558981 RECRUITING
Adjuvant Radiotherapy in High Risk Locally Advanced DTC
Fudan University n=124
NCT07383246 RECRUITING
CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC
Cancer Institute and Hospital, Chinese Academy of Medical Sciences n=150
NCT06860971 RECRUITING
A Study of AL2846 Capsule Versus Placebo in the Treatment of Advanced Radioiodine-Refractory Differentiated Thyroid Carcinoma
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. n=144
NCT06851663 RECRUITING
Trop2-targeted immunoPET Imaging of Solid Tumors
RenJi Hospital n=400
NCT04940052 ACTIVE NOT RECRUITING
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer
Novartis Pharmaceuticals n=153
NCT05768178 RECRUITING
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
Cancer Research UK n=30
NCT07239674 NOT YET RECRUITING
Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC
West China Hospital n=646
NCT05999630 RECRUITING
Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer
Vanderbilt University Medical Center n=100
NCT04290663 RECRUITING
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
Centre Francois Baclesse n=476
NCT03690388 ACTIVE NOT RECRUITING
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
Exelixis n=187
NCT06791005 RECRUITING
A Clinical Study on the Benefits of Carbon Nanoparticles Injection Time in Patients With Thyroid Cancer.
Second Affiliated Hospital of Xi'an Jiaotong University n=400
NCT06082180 RECRUITING
A Prospective, Open-label, Multicenter, Randomized Controlled Phase III Study of Prophylactic Central Neck Dissection in Low-risk Papillary Thyroid Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences n=1,199
NCT01837745 ACTIVE NOT RECRUITING
Differentiated Thyroid Cancer: is There a Need for Radioiodine Ablation in Low Risk Patients?
Gustave Roussy, Cancer Campus, Grand Paris n=776
NCT01298323 COMPLETED
Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment
Sanofi n=205
NCT01876784 COMPLETED
Evaluation of Efficacy, Safety of Vandetanib in Patients With Differentiated Thyroid Cancer
Genzyme, a Sanofi Company n=238
NCT04971473 COMPLETED
Comparison of the Efficacy and Safety of rhTSH as An Adjunctive Diagnostic Tool in Differentiated Thyroid Cancer Patients Who Had Been Thyroidectomized Vs. Patients Who After Thyroid Hormone Withdrawal
Suzhou Zelgen Biopharmaceuticals Co.,Ltd n=201
NCT04760288 WITHDRAWN
A Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MTC).
Hoffmann-La Roche
NCT01321554 COMPLETED
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Trial of Lenvatinib (E7080) in 131I-Refractory Differentiated Thyroid Cancer (DTC)
Eisai Inc. n=392
NCT02966093 COMPLETED
A Trial of Lenvatinib (E7080) in Radioiodine (131 I)-Refractory Differentiated Thyroid Cancer in China
Eisai Co., Ltd. n=151
NCT03602495 TERMINATED
A Phase 3 Study of Donafenib in Patients With Radioiodine-refractory Differentiated Thyroid Cancer
Suzhou Zelgen Biopharmaceuticals Co.,Ltd n=204
NCT00704730 COMPLETED
Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer
Exelixis n=330
NCT01843062 TERMINATED
Comparing Complete Remission After Treatment With Selumetinib/Placebo in Patient With Differentiated Thyroid Cancer
AstraZeneca n=233
NCT02586350 COMPLETED
Study of Anlotinib in Patients With Medullary Thyroid Carcinoma(ALTER01031)
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. n=91
NCT01083550 COMPLETED
Decision Making on Radioactive Iodine Treatment for Papillary Thyroid Cancer
University Health Network, Toronto n=74
NCT00795782 COMPLETED
Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Samsung Medical Center n=258
NCT01701349 WITHDRAWN
Fosbretabulin or Placebo in Combination With Carboplatin/Paclitaxel in Anaplastic Thyroid Cancer
Mateon Therapeutics
NCT01616316 COMPLETED
Efficacy of Subfascial Approach in Thyroidectomy to Quality of Life in Thyroid Disease Patients
Samsung Medical Center n=86
NCT01126060 COMPLETED
Efficacy of Fibrin Sealant to Reduce the Amount of Post-thyroidectomy Drain
Samsung Medical Center n=78

Full Thyroid Cancer Pipeline

Every sponsor, every trial across Phase 1–4. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only