NCT07187531 RECRUITING SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
SAb Biotherapeutics, Inc.
NCT05791201 ACTIVE NOT RECRUITING A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
NCT07061574 RECRUITING A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
City of Hope Medical Center
NCT07224321 RECRUITING INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes
Mannkind Corporation
NCT06783309 RECRUITING CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company, Inc.
NCT05762107 RECRUITING A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
Zucara Therapeutics Inc.
NCT02064309 ACTIVE NOT RECRUITING An Open Label, Pilot Investigation, to Assess the Safety and Efficacy of Transplantation of Macro-encapsulated Human Islets Within the Bioartificial Pancreas Beta-Air in Patients With Type 1 Diabetes Mellitus
Uppsala University Hospital
NCT05594563 RECRUITING TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
Emily K. Sims
NCT05683990 ACTIVE NOT RECRUITING Study to Evaluate the Safety and Feasibility of Diamyd® in Individuals at Risk for Type 1 Diabetes
Diamyd Medical AB
NCT06474598 RECRUITING An Adaptive Design Study of MTX228
University of Alberta
NCT06791291 RECRUITING Efficacy and Safety of Teplizumab in Japanese Participants With Stage 2 Type 1 Diabetes
Sanofi
NCT06111586 RECRUITING FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
Sanofi
NCT06435156 RECRUITING Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
University of Dundee
NCT07142252 RECRUITING Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04335656 ACTIVE NOT RECRUITING Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin
NCT06812988 ACTIVE NOT RECRUITING Treatment of Type 1 Diabetes With Anti-OX40L Bispecific With Anti-TNF Activity In a Single Nanobody® Molecule
Sanofi
NCT06305286 RECRUITING Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
University of Chicago
NCT06575426 RECRUITING A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory, Inc.
NCT03513939 ACTIVE NOT RECRUITING A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation
Sernova Biotherapeutics Inc.
NCT07186660 RECRUITING Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes
University of Virginia
NCT07430332 NOT YET RECRUITING GLP-1 RA for Stage 1 Type 1 Diabetes
Children's Hospital Medical Center, Cincinnati
NCT03746769 RECRUITING Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
City of Hope Medical Center
NCT07216391 NOT YET RECRUITING Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATG
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05626712 RECRUITING Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings Inc
NCT03929601 ACTIVE NOT RECRUITING Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT07421518 NOT YET RECRUITING Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors
AdventHealth Translational Research Institute
NCT06227221 NOT YET RECRUITING Efficacy and Safety of Sorafenib in New-Onset Type 1 Diabetes Mellitus
Second Xiangya Hospital of Central South University
NCT07325201 NOT YET RECRUITING Reducing Risk of Diabetic Ketoacidosis in Type 1 Diabetes and Kidney Disease Using Continuous Ketone Monitoring
HealthPartners Institute
NCT05949281 ACTIVE NOT RECRUITING Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes
Asger Lund, MD
NCT06688331 RECRUITING Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody
PolTREG S.A.
NCT07247734 RECRUITING The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation
Asger Lund, MD
NCT05866536 RECRUITING Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years
Massachusetts General Hospital
NCT05180591 RECRUITING Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes
Massachusetts General Hospital
NCT01241864 RECRUITING Islet Transplantation in Type 1 Diabetic Kidney Allograft
University of Chicago
NCT06455319 RECRUITING Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
University of Florida
NCT01909245 ACTIVE NOT RECRUITING Islet Cell Transplant for Type 1 Diabetes
City of Hope Medical Center
NCT07225465 NOT YET RECRUITING Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin
St Vincent's Hospital Melbourne
NCT04141761 ACTIVE NOT RECRUITING Probiotics in Newly Diagnosed T1D
Medical College of Wisconsin
NCT06976619 RECRUITING The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
Mayo Clinic
NCT06820281 NOT YET RECRUITING Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes
Victor Chang Cardiac Research Institute
NCT06072326 NOT YET RECRUITING dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation
University Medical Center Groningen
NCT05743244 ACTIVE NOT RECRUITING Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT07199946 RECRUITING A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil
Johnny Ludvigsson
NCT05822609 RECRUITING Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
University of Washington
NCT07126873 RECRUITING A Safety, Tolerability, and Efficacy Study of E-islet 01 in Participants With Type 1 Diabetes
EndoCell Therapeutics, Inc.
NCT06238778 ACTIVE NOT RECRUITING Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec
Diasome Pharmaceuticlas, Inc.
NCT06180616 NOT YET RECRUITING Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity
Royal North Shore Hospital
NCT06524960 RECRUITING Denosumab for Type 1 Diabetes
City of Hope Medical Center
NCT05414409 RECRUITING The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Heba M. Ismail
NCT07083882 RECRUITING Faecal Autologous Capsule Transplantation for Type 1 Diabetes Mellitus
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT07041268 RECRUITING Immunotherapy of the Recent-onset Type 1 Diabetes in Adolescents With Repeated Courses of Rituximab
Pirogov Russian National Research Medical University
NCT04933851 RECRUITING ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes
Scripps Whittier Diabetes Institute
NCT05153070 RECRUITING Ciclosporin Followed by Low-dose IL-2 in Patients With Recently Diagnosed Type 1 Diabetes
Assistance Publique - Hôpitaux de Paris
NCT06981234 RECRUITING Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
University of California, San Diego
NCT06810726 RECRUITING Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
Estar Medical dba Medical Technologies, LTD
NCT04779645 ACTIVE NOT RECRUITING Effects of GRA in Patients With Type 1
University of California, San Diego
NCT06147232 NOT YET RECRUITING Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
Steno Diabetes Center Copenhagen
NCT05957055 RECRUITING Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes
Medical University of Lodz
NCT05696366 RECRUITING Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
University of California, San Diego
NCT07594145 NOT YET RECRUITING Precision T1D Platform - New Therapies for Cardio-Renal Complications
Oregon Health and Science University
NCT04291703 TERMINATED STOP-T1D Low-Dose (ATG)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03961854 COMPLETED Lactobacillus Johnsonii in Children and Adolescents With T1D
University of Florida
NCT05478707 SUSPENDED Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
University of Virginia
NCT05018416 COMPLETED Renal Autologous Cell Therapy (REACT) in Subjects With Type 1 or 2 Diabetes and Chronic Kidney Disease (REGEN-007)
Prokidney
NCT03961347 COMPLETED Lactobacillus Johnsonii Supplementation in Adults With T1D
University of Florida
NCT00690066 COMPLETED PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
Mesoblast, Inc.
NCT03977662 COMPLETED Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
Peter Stock
NCT05574335 TERMINATED Siplizumab in T1DM
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02586831 WITHDRAWN Diabetes Islet Preservation Immune Treatment
Camillo Ricordi and Jay Skyler
NCT05742243 COMPLETED Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes
Melbourne Health
NCT04247620 COMPLETED DiaBetter Together for Young Adults With Type 1 Diabetes
Baylor College of Medicine
NCT03406897 COMPLETED Pilot Study of OMEGA-3 and Vitamin D in High-Dose in Type I Diabetic Patients
Rodolfo Alejandro
NCT06152042 TERMINATED Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus
Biomea Fusion Inc.
NCT05537233 COMPLETED ADJUnct Semaglutide Treatment in Type 1 Diabetes
Viral N. Shah
NCT06025110 TERMINATED A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients
ITB-Med LLC
NCT02213003 COMPLETED Allogeneic Islet Cells Transplanted Onto the Omentum
Rodolfo Alejandro
NCT06062069 COMPLETED A Study of CT-868 in Type 1 Diabetes Mellitus
Carmot Therapeutics, Inc.
NCT06854861 SUSPENDED Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes
St. Olavs Hospital
NCT05960565 TERMINATED Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1
St. Olavs Hospital
NCT02218619 COMPLETED Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes
Robin Goland, MD
NCT03366337 COMPLETED A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX
Biogen
NCT05473364 COMPLETED Acetazolamide in Persons With Type 1 Diabetes - Dose Finding
University of California, San Diego
NCT04899271 TERMINATED A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at Baseline.
Dompé Farmaceutici S.p.A
NCT04129528 COMPLETED Study of Safety and Efficacy of CFZ533 in Type 1 Diabetes Pediatric and Young Adult Subjects
Novartis Pharmaceuticals
NCT03895996 COMPLETED Safety, Tolerability and Potential Efficacy of AVT001 in Patients With Type 1 Diabetes
Avotres Inc.
NCT04270942 COMPLETED At-Risk for Type 1 Diabetes Extension Study (TN-10 Extension)
Provention Bio, a Sanofi Company
NCT02846545 COMPLETED A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes
Janssen Research & Development, LLC
NCT05368402 TERMINATED Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes.
Dompé Farmaceutici S.p.A
NCT04509791 COMPLETED MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D)
Universitaire Ziekenhuizen KU Leuven
NCT04774224 COMPLETED Baricitinib in New-onset Type 1 Diabetes
St Vincent's Institute of Medical Research
NCT03163511 COMPLETED A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness
ViaCyte
NCT02529449 COMPLETED Pharmacodynamics, Pharmacokinetics, and Safety of ASP1941 in Patients With Type 1 Diabetes Mellitus
Astellas Pharma Inc
NCT04545151 COMPLETED Verapamil SR in Adults With Type 1 Diabetes
Medical University of Graz
NCT04432090 COMPLETED GPR119 Agonist for Hypoglycemia in Type 1 Diabetes
AdventHealth Translational Research Institute
NCT02620072 COMPLETED Fr1da Insulin Intervention
Technical University of Munich
NCT03364868 COMPLETED GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)
Technical University of Munich
NCT03182426 COMPLETED Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)
University of Alberta
NCT04524949 TERMINATED IMCY-0098 Proof of ACtion in Type 1 Diabetes (IMPACT Study)
Imcyse SA
NCT01773707 COMPLETED CTLA4-Ig (Abatacept)for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At -Risk for Type 1
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03243058 WITHDRAWN Low-dose IL-2 in Established T1D - The "PROREG" Study
Jay S. Skyler
NCT03867851 TERMINATED Study to Evaluate Safety and Efficacy of IBsolvMIR in Islet Transplantation
TikoMed AB
NCT03149770 COMPLETED Naloxone, Hypoglycemia and Exercise
University of Minnesota
NCT04074317 COMPLETED Phase 2, Randomized, Open-Label, Crossover, PD/PK Study of a Novel Pram-Insulin Co-Formulation in Adults With T1D
Xeris Pharmaceuticals
NCT01840189 TERMINATED Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 Diabetes
Haukeland University Hospital
NCT02505893 COMPLETED Minimal Islet Transplant at Diabetes Onset
Ospedale San Raffaele
NCT02354911 WITHDRAWN Autologous Immunoregulatory Dendritic Cells for Type 1 Diabetes Therapy
DiaVacs, Inc.
NCT05454709 WITHDRAWN A Stable Glucagon Analog Administered by a Bihormonal Closed Loop System
Inreda Diabetic B.V.
NCT02464878 COMPLETED Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant
Massachusetts General Hospital
NCT05351879 COMPLETED Evaluation of a Booster Administration of GAD-alum (Diamyd®) in Individuals With Type 1 Diabetes
Linkoeping University
NCT04678557 TERMINATED A Study to Evaluate Safety, Engraftment, and Efficacy of VC-01 in Subjects With T1 Diabetes Mellitus
ViaCyte
NCT02411253 COMPLETED Low-dose rhIL-2 in Patients With Recently-diagnosed Type 1 Diabetes
Assistance Publique - Hôpitaux de Paris
NCT03335371 COMPLETED Evaluation of TTP399 in Patients With Type 1 Diabetes
vTv Therapeutics
NCT02700048 TERMINATED Intra-nasal Naloxone for Treatment of Impaired Awareness of Hypoglycemia
University of Minnesota
NCT04545411 COMPLETED Combination GRA and SGLT-2i Treatment in Type 1 Diabetes
University of California, San Diego
NCT05480657 WITHDRAWN Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D
Eledon Pharmaceuticals
NCT03345004 COMPLETED Diamyd Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes
Diamyd Medical AB
NCT03635437 COMPLETED Evaluation of Safety and Diabetes Status Upon Oral Treatment With GABA in Patients With Longstanding Type-1 Diabetes
Per-Ola Carlsson
NCT04450407 COMPLETED A Study of LY3209590 in Participants With Type 1 Diabetes
Eli Lilly and Company
NCT04079881 TERMINATED Glucagon Response to Prandial Insulin Administration in Persons With Type 1 Diabetes
Washington University School of Medicine
NCT04764968 COMPLETED Pen-Administered Low-Dose Dasiglucagon for Prevention and Treatment of Hypoglycemia in People With Type 1 Diabetes
Steno Diabetes Center Copenhagen
NCT04711226 WITHDRAWN Safety, Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation
Anelixis Therapeutics, LLC
NCT04956263 COMPLETED A Comparison of Postprandial Glucose After a MMTT, and the Metabolic Effects of Insulin Withdrawal in a Crossover Study in Subjects With Type 1 Diabetes
Youngene Therapeutics Inc., Ltd.
NCT03919617 COMPLETED Metabolic Pathways of GRA in Patients With Type 1 Diabetes
University of California, San Diego
NCT04816890 COMPLETED A Trial to Assess the Efficacy and Safety of M1 Pram P037 Prandial Insulin in Subjects With Type 1 Diabetes (T1DM)
Adocia
NCT04585776 COMPLETED A Study of LY900014 and Insulin Degludec in Participants With Type 1 Diabetes
Eli Lilly and Company
NCT04150107 COMPLETED A Study to Compare ORMD-0801 Once Daily to ORMD-0801 Three Times Daily in Subjects With Type 1 Diabetes
Oramed, Ltd.
NCT02520076 COMPLETED Aralast NP in Islet Transplant
University of Alberta
NCT01079325 COMPLETED Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT03537131 TERMINATED Dapagliflozin During Exercise for the PrevenTion of Hypoglycaemia
University of Oxford
NCT02821026 COMPLETED Omental Islet Transplant
University of Alberta
NCT03618420 COMPLETED Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
University of Colorado, Denver
NCT02239354 TERMINATED A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus
ViaCyte
NCT02898506 COMPLETED Incretin-based Therapy in Late Preclinical Type 1 Diabetes
University of Oulu
NCT02908087 COMPLETED Incretin-based Therapy in Early Diagnosed Type 1 Diabetes
University of Oulu
NCT04729296 WITHDRAWN Anti-TNFα to Delay or Prevent Progression to Stage 3 T1D
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00807651 COMPLETED Autologous Hematopoietic Stem Cell Transplantation for Early Onset Type 1 Diabetes
Shanghai Jiao Tong University School of Medicine
NCT02544321 COMPLETED Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes
University of Colorado, Denver
NCT02293837 COMPLETED Tocilizumab (TCZ) in New-onset Type 1 Diabetes
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03182322 COMPLETED PINIT Study: Primary Intranasal Insulin Trial
Technical University of Munich
NCT03800875 COMPLETED Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting
McGill University
NCT02443155 COMPLETED A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function
Novo Nordisk A/S
NCT02527265 COMPLETED Afrezza Safety and Pharmacokinetics Study in Pediatric Patients
Mannkind Corporation
NCT02464033 COMPLETED EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes
Johnny Ludvigsson
NCT02971228 COMPLETED Feasibility Trial Testing the Bionic Pancreas With ZP4207
Zealand Pharma
NCT01220856 COMPLETED Reparixin in Pancreatic Islet Transplantation
Dompé Farmaceutici S.p.A
NCT03490942 TERMINATED Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses
Xeris Pharmaceuticals
NCT04449692 COMPLETED Low-dose Dasiglucagon for Prevention of Insulin-Induced Hypoglycemia in People With Type 1 Diabetes
Steno Diabetes Center Copenhagen
NCT03325114 TERMINATED Safety and Efficacy of Chlorthalidone in Type 1 Diabetes
University of Rochester
NCT03794960 WITHDRAWN Diabetes AutoimmunitY Withdrawn in Established Patients (DAY)
Tolerion, Inc.
NCT03794973 WITHDRAWN Diabetes Autoimmunity Withdrawn in New Onset Patients (DAWN)
Tolerion, Inc.
NCT03981627 COMPLETED A Trial to Assess Safety and Efficacy of ADO09 Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus
Adocia
NCT02387164 TERMINATED Prevention Trial: Immune-tolerance With Alum-GAD (Diamyd) and Vitamin D3 to Children With Multiple Islet Autoantibodies
Lund University
NCT01862120 COMPLETED Dose Finding Study of Il-2 at Ultra-low Dose in Children With Recently Diagnosed Type 1 Diabetes
Assistance Publique - Hôpitaux de Paris
NCT03895437 TERMINATED Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients
Tolerion, Inc.
NCT02057211 TERMINATED Mesenchymal Stem Cells to Intervene in the Development of Type 1 Diabetes: a Blinded Randomized Study
Uppsala University Hospital
NCT02617654 COMPLETED Liraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes
Per-Ola Carlsson
NCT02803892 COMPLETED Monotherapy With Rapamycin in Long-standing Type 1 Diabetes
Piemonti Lorenzo
NCT01722682 COMPLETED Bone Marrow vs Liver as Site for Islet Transplantation
Ospedale San Raffaele
NCT01222078 TERMINATED Investigating Re-Dosing With Otelixizumab in Adults With Newly-Diagnosed Type 1 Diabetes Mellitus
GlaxoSmithKline
NCT03161964 TERMINATED Propranolol in Treating Hypoglycemia Unawareness
Anu Sharma
NCT01030861 COMPLETED Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02580877 COMPLETED Immune Effects of Oral Insulin in Relatives at Risk for Type 1 Diabetes Mellitus (TN20)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02632747 COMPLETED Empagliflozin and ACEi- Effects on Hyperfiltration: BETWEEN Study
Boehringer Ingelheim
NCT02284009 COMPLETED Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus
GlaxoSmithKline
NCT03816761 COMPLETED Research Study to Look at Fast-acting Insulin Aspart With the Insulin Pump System 'iLet™' in Adults With Type 1 Diabetes
Novo Nordisk A/S
NCT02846831 COMPLETED Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT00529399 COMPLETED Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00505375 COMPLETED Intravenous CTLA4-lg Treatment in Recent Onset Type 1 Diabetes Mellitus
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00947427 COMPLETED Canakinumab Study in Individuals With Newly Diagnosed Type 1 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03938740 COMPLETED Comparison of Different Insulin Dosing Algorithms Using Hepatic Directed Vesicle-Insulin Lispro and Insulin Degludec
Diasome Pharmaceuticals
NCT03556033 COMPLETED Effect of Dapagliflozin on IAH in T1DM
Radboud University Medical Center
NCT02660242 COMPLETED The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes
Jaeb Center for Health Research
NCT02411578 COMPLETED Mini-Dose Glucagon to Treat Non-Severe Hypoglycemia
Jaeb Center for Health Research
NCT02215200 COMPLETED ATG-GCSF in New Onset Type 1 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02814123 COMPLETED Effect of Basal-Bolus Closed-Loop Co-Administration of Insulin and Pramlintide on Improving the Glycemic Control in Type 1 Diabetes
McGill University
NCT01742208 COMPLETED Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus
Lexicon Pharmaceuticals
NCT02383940 COMPLETED Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C
Lexicon Pharmaceuticals
NCT02459899 COMPLETED Dose-ranging Study in Patients With Type 1 Diabetes Mellitus
Lexicon Pharmaceuticals
NCT01781975 COMPLETED Imatinib Treatment in Recent Onset Type 1 Diabetes Mellitus
University of California, San Francisco
NCT01053078 COMPLETED Naltrexone and Hypoglycemia in Type 1 Diabetes
University of Minnesota
NCT02372253 COMPLETED Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes
University of Alabama at Birmingham
NCT02206152 COMPLETED A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes
University of Minnesota
NCT00645840 COMPLETED Anti-inflammatory Therapy With Anakinra in Newly Diagnosed Type 1 Diabetes
University of Texas Southwestern Medical Center
NCT01106157 COMPLETED Reversing Type 1 Diabetes After it is Established
University of Florida
NCT03017352 COMPLETED Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases
Filip Krag Knop
NCT02000817 COMPLETED Investigation of Otelixizumab in New-Onset, Autoimmune Type 1 Diabetes Mellitus Patients
GlaxoSmithKline
NCT01122446 COMPLETED Diabetes Prevention - Immune Tolerance
Lund University
NCT02535715 COMPLETED A Euglycemic Insulin Clamp Study in Type 1 Diabetic Patients With Oral Insulin (ORAMED)
The University of Texas Health Science Center at San Antonio
NCT01194245 COMPLETED Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Participants With Type 1 Diabetes Mellitus
Halozyme Therapeutics
NCT00774800 COMPLETED Phase II Pharmacokinetics Study of Humalog and Humulin-R With and Without rHuPH20 in Type 1 Diabetes Mellitus
Halozyme Therapeutics
NCT02855307 COMPLETED Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT02093221 TERMINATED Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus
Grifols Therapeutics LLC
NCT02265809 COMPLETED Adaptive Study of IL-2 Dose Frequency on Regulatory T Cells in Type 1 Diabetes
Cambridge University Hospitals NHS Foundation Trust
NCT01755416 COMPLETED Liraglutide Versus Insulin Mono-therapy in the Closed Loop Setting
Albert Einstein College of Medicine
NCT01159847 COMPLETED Protective Effects of Sitagliptin on β Cell Function in Patients With Adult-onset Latent Autoimmune Diabetes (LADA)
European Foundation for the Study of Diabetes
NCT02794155 COMPLETED Study of HDV Insulin Versus Insulin in Type 1 Diabetes Subjects (ISLE-1)
Diasome Pharmaceuticals
NCT03096392 COMPLETED Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control
Diasome Pharmaceuticals
NCT02509429 COMPLETED Comparison of an Artificial Pancreas Versus Threshold Low Glucose Suspend in Type 1 Diabetic Children
University Hospital, Montpellier
NCT03335501 WITHDRAWN Comparison of the Efficacy of Rapid-acting Aspart and Faster Acting Aspart Within the Context of Single-hormone Closed-loop Strategy at Regulating Postprandial Glucose Levels
Institut de Recherches Cliniques de Montreal
NCT01049412 COMPLETED A Study for Patients With Type 1 Diabetes
Eli Lilly and Company
NCT03111433 COMPLETED Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus
Ain Shams University
NCT02702011 COMPLETED Empa Add on to Insulin in Japanese Patient With Type 1 Diabetes Mellitus
Boehringer Ingelheim
NCT02547519 COMPLETED Pre-POINT-Early Study
Technical University of Munich
NCT02488616 WITHDRAWN Closed-loop Control of Glucose Levels (Artificial Pancreas) for 5 Days in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT02769884 COMPLETED MMPPC Outpatient Clinical Protocol 2016
Rensselaer Polytechnic Institute
NCT02774876 COMPLETED Closed-loop Control of Postprandial Glucose Levels After Meals With Different Macronutrients Content in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT02490098 WITHDRAWN Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT01739829 COMPLETED Open-label Investigation of the Safety and Effectiveness of DIABECELL® in Patients With Type 1 Diabetes Mellitus
Diatranz Otsuka Limited
NCT00940173 COMPLETED Open-label Investigation of the Safety and Effectiveness of DIABECELL(R) in Patients With Type I Diabetes Mellitus
Diatranz Otsuka Limited
NCT00575159 COMPLETED A Study to Assess the Safety of Single Doses of GSK189075 in Subjects With Type 1 Diabetes Mellitus
GlaxoSmithKline
NCT01155284 COMPLETED Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes
Sanford Health
NCT01785108 COMPLETED DIABGAD - Trial to Preserve Insulin Secretion in Type 1 Diabetes Using GAD-Alum (Diamyd) in Combination With Vitamin D and Ibuprofen
Johnny Ludvigsson
NCT00965458 TERMINATED Inducing Remission in Type 1 Diabetes With Alefacept
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02204397 COMPLETED Study of Tolerability and Safety of Adding Ustekinumab to INGAP Peptide for 12 Weeks in Adult Patients With TD1 Melitis
Jewish General Hospital
NCT02714972 COMPLETED Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents
Jaeb Center for Health Research
NCT02034266 COMPLETED The Effect of Omega-3 Supplementation on Nerve Structure and Function in Type 1 Diabetes
Eduardo Ng
NCT02798250 COMPLETED Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation - Part 2
Institut de Recherches Cliniques de Montreal
NCT01206101 TERMINATED Efficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation
Novo Nordisk A/S
NCT00841087 COMPLETED Comparison of NN1250 Versus Insulin Detemir, Both Combined With Insulin Aspart in Subjects With Type 1 Diabetes
Novo Nordisk A/S
NCT00612040 COMPLETED Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Insulin Aspart in Subjects With Type 1 Diabetes
Novo Nordisk A/S
NCT01778348 COMPLETED Closing the Loop in Children and Adolescents With Type 1 Diabetes in the Home Setting
University of Cambridge
NCT01498185 COMPLETED BMS - Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Dapagliflozin in Type 1 Diabetes
AstraZeneca
NCT02861157 COMPLETED Mobile Technology & Online Tools to Track Adherence in Chronic Illness Patients
3-C Institute for Social Development
NCT01661192 COMPLETED Long Term Treatment Effect of the Safety, Tolerability and Efficacy of AAT in Type 1 Diabetes
Rabin Medical Center
NCT01512680 COMPLETED Evaluation of Functional Insulin Therapy in Type 1 Diabetic Patients
University Hospital, Montpellier
NCT02627911 COMPLETED Diabeloop WP6.2 : Crossover Evaluation of Glycemic Control
Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
NCT02282254 COMPLETED Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Type 1 Diabètes Adults With Hypoglycemia Unawareness and Documented Nocturnal Hypoglycemia
Institut de Recherches Cliniques de Montreal
NCT01782261 COMPLETED Incretin Effect on the Immunological Phenotype
Medical University of Graz
NCT02408705 COMPLETED Investigating the Effect of Liraglutide on the Endogenous Glucose Production During in Tye 1 Diabetes Subjects
Medical University of Graz
NCT02028078 COMPLETED Pilot Study Investigating the Feasibility of Determining the Endogenous Glucose Production During a Hypoglycaemia
Medical University of Graz
NCT01823341 COMPLETED Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children
Jaeb Center for Health Research
NCT01736930 COMPLETED An Outpatient Pump Shutoff Pilot Feasibility and Safety Study
Jaeb Center for Health Research
NCT01591681 COMPLETED Outpatient Pump Shutoff Pilot Feasibility and Efficacy Study
Jaeb Center for Health Research
NCT02438189 COMPLETED Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms
Jaeb Center for Health Research
NCT02739906 COMPLETED A Trial to Investigate Post Prandial Blood Glucose Control With Fast-acting Human Insulin HinsBet® Compared to Insulin Lispro (Humalog®) and Regular Human Insulin (Huminsulin® Normal) After Ingestion of a Standardized Meal in Subjects With T1DM
Adocia
NCT01603121 TERMINATED Lisofylline as Continuous Subcutaneous and Intravenous Administration in Subjects With Type 1 Diabetes Mellitus
Eastern Virginia Medical School
NCT02139943 COMPLETED A Study of Effects of Canagliflozin as Add-on Therapy to Insulin in the Treatment of Participants With Type 1 Diabetes Mellitus (T1DM)
Janssen Research & Development, LLC
NCT02626936 COMPLETED Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation
Institut de Recherches Cliniques de Montreal
NCT01304537 COMPLETED Study of the Safety and Efficacy of Intravenous Alpha-1 Antitrypsin in Type 1 Diabetes Mellitus
Kamada, Ltd.
NCT01103817 COMPLETED Influence of Vitamin D on Vascular Function in Adolescents and Young Adults With Type 1 Diabetes
The Hospital for Sick Children
NCT00468403 COMPLETED LEA29Y (Belatacept) Emory Edmonton Protocol
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02713841 COMPLETED Pharmacologic Response and Safety of Inhaled Insulin in Type 1 Diabetes
Dance Biopharm Inc.
NCT02044848 TERMINATED Study of Secukinumab in Patients With Newly-diagnosed Type 1 Diabetes Mellitus
Novartis Pharmaceuticals
NCT00850161 WITHDRAWN Intranasal Insulin and Its Effect on Postprandial Metabolism in Comparison to Subcutaneous Insulin
CPEX Pharmaceuticals Inc.
NCT02416765 COMPLETED Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT02153190 COMPLETED Hybrid Artificial Pancreas in Home Setting
University Hospital, Montpellier
NCT01285934 WITHDRAWN Hematopoietic Stem Cell Support Versus Insulin in T1D
Northwestern University
NCT01469715 COMPLETED A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM)
University of Virginia
NCT01686620 COMPLETED A Study Evaluating Safety and Efficacy of BIOD-123 Compared to Insulin Lispro (Humalog®)
Biodel
NCT01536431 COMPLETED Safety Study to Assess Whether Proinsulin Peptide Injections Can Slow or Stop the Body Damaging Its Own Insulin-making Cells in the Pancreas in Patients Newly Diagnosed With Type 1 Diabetes
Cardiff University
NCT01827735 COMPLETED Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2
Cambridge University Hospitals NHS Foundation Trust
NCT00768651 COMPLETED Incretin Effect and Use After Clinical Islet Transplantation
University of Alberta
NCT02256293 WITHDRAWN Acceptability and Feasibility of an ACT-Based Group to Improve Diabetes Self-Management
Duke University
NCT01658579 COMPLETED Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus on Basal Plus Mealtime Insulin
Sanofi
NCT01871870 COMPLETED Artificial Pancreas Control System in an Outpatient Setting
Legacy Health System
NCT01966393 COMPLETED Closed-loop Control of Glucose Levels (Artificial Pancreas) for 60 Hours in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT01930110 COMPLETED Closed-loop Control of Glucose Levels (Artificial Pancreas) During Exercise in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT01480297 COMPLETED Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
University of Michigan
NCT01969747 COMPLETED Empagliflozin add-on to Insulin in Type 1 Diabetes Mellitus Over 28 Days
Boehringer Ingelheim
NCT01736228 COMPLETED Open-label Investigation of the Safety and Efficacy of DIABECELL in Patients With Type 1 Diabetes Mellitus
Living Cell Technologies
NCT02367534 COMPLETED Islet Transplantation Through an Indwelling Catheter in the Umbilical Vein
Fuzhou General Hospital
NCT01183455 WITHDRAWN A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part II
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01666028 COMPLETED Short Term Closed-loop Glucose Control in Adults With Type 1 Diabetes
University of Cambridge
NCT00747006 TERMINATED Safety and Efficacy of Technosphere® Insulin Inhalation Powder (TI Inhalation Powder)When an Optimal Dose is Taken With Varied Carbohydrate Intake
Mannkind Corporation
NCT01905020 COMPLETED Closed-loop Control of Overnight Glucose Levels in Adults and Adolescents With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT00784966 WITHDRAWN Islet After Kidney Transplant for Type 1 Diabetes
Virginia Commonwealth University
NCT00883558 COMPLETED Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus
Halozyme Therapeutics
NCT02189694 COMPLETED Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Children With Type 1 Diabetes in a Diabetes Camp
Institut de Recherches Cliniques de Montreal
NCT00896077 COMPLETED Subcutaneous Administration of Lisofylline to Healthy Normal Subjects and Subjects With Type 1 Diabetes
DiaKine Therapeutics, Inc.
NCT01754337 COMPLETED Closed-loop Control of Glucose Levels (Artificial Pancreas) for 24 Hours in Adults and Adolescents With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT01392560 COMPLETED Safety and Efficacy of Empagliflozin (BI 10773) in Type 1 Diabetes Mellitus Patients With or Without Renal Hyperfiltration
Boehringer Ingelheim
NCT00737763 WITHDRAWN Beta Cell Rescue in New Onset Type 1 Diabetes With Efalizumab
Emory University
NCT01930097 COMPLETED Closed-loop Control of Glucose Levels After Meal Intake in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT00998699 COMPLETED Study of the Effects of XOMA 052 on Insulin Production in Subjects With Well Controlled Type 1 Diabetes
XOMA (US) LLC
NCT00995540 TERMINATED Tolerability, Safety, and Efficacy Study of INGAP Peptide to Treat Type 1 Diabetes Mellitus in Adults
Exsulin Corporation
NCT01440140 COMPLETED Closing the Loop in Adults With Type 1 Diabetes in the Home Setting
University of Cambridge
NCT01828125 WITHDRAWN Efficacy of Small Subcutaneous Glucagon Dose to Treat Hypoglycemia in Adults With Type 1 Diabetes
Institut de Recherches Cliniques de Montreal
NCT01221467 COMPLETED Closing the Loop in Youth With Type 1 Diabetes in the Home Setting
University of Cambridge
NCT01452815 COMPLETED Affects of Once-daily Oral Administration of TZP-102 on the Treatment of Symptoms Associated With Diabetic Gastroparesis
Tranzyme, Inc.
NCT01293461 COMPLETED Safety and Pharmacokinetics of CBX129801 in Patients With Type 1 Diabetes
Cebix Incorporated
NCT01121029 COMPLETED Hematopoietic Stem Cell Transplantation in Type 1 Diabetes Mellitus
Dra. Olga Graciela Cantu Rodriguez
NCT01261052 COMPLETED Real-time Adaptation to Changes in Insulin Sensitivity
Legacy Health System
NCT00665145 COMPLETED Stem Cell Mobilization in Diabetic Neuropathy Subjects Receiving SB-509
Sangamo Therapeutics
NCT01629251 COMPLETED Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes: Evaluation of Reduced Meal Bolusing
University of Cambridge
NCT01629277 COMPLETED Closing the Loop in Adolescents During Non-compliance Behaviours
University of Cambridge
NCT01353833 COMPLETED Dose-effect Relationship of Low-dose IL-2 in Type 1 Diabetes
Assistance Publique - Hôpitaux de Paris
NCT01554566 COMPLETED Metabolic Effects of Honey in Type 1 Diabetes Mellitus
Ain Shams University
NCT01527981 COMPLETED Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 Diabetes
Massachusetts General Hospital
NCT00797823 COMPLETED Sensor-Augmented Insulin Delivery: Insulin Plus Glucagon Versus Insulin Alone
Legacy Health System
NCT00971503 WITHDRAWN Safety and Efficacy of Arterial Delivery of Autologous Bone Marrow Cells in the Treatment of Insulin-Dependent Diabetes
University of Moron
NCT01053728 COMPLETED Study of How Single Rising Doses of SAR161271 Are Absorbed and Act in Patients With Type 1 Diabetes Mellitus (T1DM)
Sanofi
NCT01074801 COMPLETED Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes
University of Cambridge
NCT00639600 TERMINATED Transplantation of Pancreatic Islets in Patients With Type 1 Diabetes Mellitus and Functional Kidney Graft
University Hospital, Grenoble
NCT01061216 COMPLETED Pharmacokinetics/Dynamics of Basal (Continuous) Insulin Infusion Administered Either Intradermally or Subcutaneously
Becton, Dickinson and Company