CALCIUM CHLORIDE 10% (calcium chloride)
Calcium Chloride 10% Injection is indicated for the treatment of hypocalcemia in conditions requiring a prompt increase in plasma calcium levels (such as hypocalcemic tetany). It is also used to treat magnesium intoxication due to overdosage of magnesium sulfate and is used as an aid in cardiac resuscitation when epinephrine fails to improve myocardial contractions, particularly in the presence of hyperkalemia.
How CALCIUM CHLORIDE 10% Works
Calcium is a vital cation essential for the functional integrity of the nervous, muscular, and skeletal systems. It plays a critical role in the transmission of nerve impulses, cardiac function, and the maintenance of capillary permeability. In the blood, calcium is essential for the coagulation process. The 10% injection provides a direct source of ionized calcium to rapidly increase extracellular calcium levels and antagonize the cardiotoxic effects of hyperkalemia or hypermagnesemia.
Details
- Status
- Prescription
- First Approved
- 2017-07-27
- Routes
- INJECTION
- Dosage Forms
- INJECTABLE
CALCIUM CHLORIDE 10% Approval History
What CALCIUM CHLORIDE 10% Treats
7 FDA approvalsOriginally approved for its first indication in 2017 . Covers 7 distinct patient populations.
- Other (7)
Other
(7 approvals)- • Approved indication (Jul 2017)Letter
- • Approved indication (May 2018)
- • Approved indication (May 2019)
- • Approved indication (Jul 2024)
- • Approved indication (Nov 2024)
- • Approved indication (Dec 2024)
- • Approved indication (Sep 2025) New
Clinical Trial Registry
7 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT07550413 | 20042026 | Ph 2 | not yet recruiting | Role of Intravenous Calcium to Decrease Blood Loss During Intrapartum Cesarean Section |
| NCT03772990 ICARUS | 21/2019 | Ph 4 | completed | Calcium Administration in Cardiac Surgery |
| NCT05027048 CALBLOC results posted | 62206 MRTG-02-15-2022-Ansari, YIG-2020 | Ph 3 | completed | Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery |
| NCT04153435 COCA results posted | 00002 2019-003387-46 | Ph 2 | completed | Calcium for Out-of-Hospital Cardiac Arrest |
| NCT03867383 results posted | 43076 | Ph 1, Ph 2 | completed | Calcium Chloride for Prevention of Uterine Atony During Cesarean |
| NCT01941914 | AA1310 | Ph 1 | completed | Calcium Electroporation for the Treatment of Keloids |
| NCT00955266 results posted | 2009-P-000052 | Ph 4 | terminated | A Trial of Intravenous Calcium and Myocardial Diastolic Dysfunction During Separation From Cardiopulmonary Bypass |
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
CALCIUM CHLORIDE 10% FDA Label Details
Indications & Usage
Ringer’s Injection is indicated for use as a source of water and electrolytes in adults and pediatric patients. Ringer’s Injection is indicated for use as a source of water and electrolytes in adults and pediatric patients.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.