Data updated: May 26, 2026
CARBON DIOXIDE, USP (carbon dioxide)
X-Ray Contrast Activity
Respiratory
Approved 2013-07-05
18
Indications
--
Phase 3 Trials
12
Years on Market
Details
- Status
- Prescription
- First Approved
- 2013-07-05
- Routes
- INHALATION
- Dosage Forms
- GAS
Companies
MIDDLESEX GASES TECHNOLOGIES, INC. AIRGAS USA LLC CONTINENTAL CARBONIC PRODUCTS, INC. WELDERS SUPPLY COMPANY OF LOUISVILLE INC NEXAIR LLC HAUN SPECIALTY GASES INC DJB GAS SERVICES, INC ROBERTS OXYGEN CO INC LINDE NORTH AMERICA INC LINDE MERCHANT PRODUCTIONS INC RELIANT HOLDINGS LTD LISS AMERICA LLC A-OX WELDING SUPPLY CO, INC. LINDE GAS EQUIP MITCHELL WEDLING SUPPLY AIRGAS CARBONIC INC GENERAL DISTRIBUTING COMPANY PRAXAIR INC CENTRAL WELDING SUPPLY
Active Ingredient: CARBON DIOXIDE
Website: ↗
CARBON DIOXIDE, USP Approval History
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
19 FDA actions from 2013 to 2025
Aug 2017 ORIGINAL
Update
What CARBON DIOXIDE, USP Treats
18 FDA approvalsOriginally approved for its first indication in 2013 . Covers 18 distinct patient populations.
- Other (18)
Other
(18 approvals)- • Approved indication (Jul 2013)Letter
- • Approved indication (Jul 2013)Letter
- • Approved indication (Jul 2013)Letter
- • Approved indication (Sep 2013)Letter
- • Approved indication (May 2014)Letter
- • Approved indication (Aug 2017)
- • Approved indication (Jun 2019)Letter
- • Approved indication (Jul 2020)Letter
- • Approved indication (Oct 2021)Letter
- • Approved indication (Feb 2022)Letter
- • Approved indication (Apr 2022)Letter
- • Approved indication (Feb 2024)Letter
- • Approved indication (Aug 2024)Letter
- • Approved indication (Nov 2024)Letter
- • Approved indication (Feb 2025)Letter
- • Approved indication (Apr 2025)Letter
- • Approved indication (Jun 2025) NewLetter
- • Approved indication (Oct 2025) NewLetter
📋
Clinical Trial Registry
2 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT02473354 (OIRD) | Pro00060429 | Ph 1 | completed | Predictors of Opioid-Induced Respiratory Depression (OIRD) |
| NCT02113449 results posted | 202181 RH01910 | Ph 2 | completed | Market Potential of Carbon Dioxide Nasal Spray |
🔬
Pro Active Pipeline
Ongoing clinical trials by development phase
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Pro Key Completed Trials
Completed studies with published results, ranked by significance
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📊
Trial Timeline
Full development history with FDA approval milestones
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Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
CARBON DIOXIDE, USP FDA Label Details
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.