CHEMET (succimer)
Chemet treats lead poisoning in children aged one year and older who have blood lead levels exceeding 45 mcg/dL. This medication is used to manage high lead levels but is not intended to prevent poisoning in environments where lead is present. Because the drug cannot cross the blood-brain barrier, it is not used to address brain-related complications like encephalopathy that can occur with lead toxicity.
How CHEMET Works
This medication works by acting as a chelating agent that binds to lead within the body. Once bound, it forms water-soluble complexes that allow the lead to be filtered out and removed through the patient's urine.
Details
- Status
- Prescription
- First Approved
- 1991-01-30
- Routes
- ORAL
- Dosage Forms
- CAPSULE
CHEMET Approval History
What CHEMET Treats
2 indicationsCHEMET is approved for 2 conditions since its original approval in 1991. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Lead Poisoning
- Encephalopathy
CHEMET Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
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Clinical Trial Registry
1 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT03630991 | 2017-0752 NCI-2018-01610, 2017-0752 | Ph 1 | recruiting | Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy |
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
CHEMET FDA Label Details
Indications & Usage
FDA Label (PDF)CHEMET is indicated for the treatment of Lead Poisoning; Encephalopathy.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.