Data updated: May 26, 2026
DIPRIVAN (propofol)
Trial Activity: Mature 50 active trials
Other
Approved 1989-10-02
Development Insights
Sichuan Haisco Pharmaceutical Group Co., Ltd conducting 10 trials (3%)
382 indications explored (Broad Platform)
→ anesthesia (45 trials)
→ sedation (22 trials)
→ general anesthesia (13 trials)
5
Indications
--
Phase 3 Trials
36
Years on Market
Details
- Status
- Discontinued
- First Approved
- 1989-10-02
- Routes
- INJECTION
- Dosage Forms
- INJECTABLE
DIPRIVAN Approval History
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
78 FDA actions from 1989 to 2025 · 3 indication expansions
Apr 2015 SUPPL
Mfg
May 2014 SUPPL
Mfg
Sep 2002 SUPPL
Mfg
Oct 2000 SUPPL
Mfg
Feb 2000 SUPPL
Mfg
Dec 1999 SUPPL
Mfg
Apr 1999 SUPPL
Mfg
Feb 1999 SUPPL
Mfg
Sep 1998 SUPPL
Mfg
Sep 1997 SUPPL
Mfg
Jun 1996 SUPPL
Mfg
Jul 1995 SUPPL
Mfg
Apr 1995 SUPPL
Label
Feb 1995 SUPPL
Mfg
Sep 1994 SUPPL
Label
May 1994 SUPPL
Label
May 1994 SUPPL
Mfg
Oct 1993 SUPPL
Label
Mar 1993 SUPPL
Mfg
Mar 1993 SUPPL
Efficacy
Dec 1992 SUPPL
Mfg
Feb 1992 SUPPL
Mfg
Dec 1991 SUPPL
Efficacy
Jan 1991 SUPPL
Mfg
Oct 1989 ORIGINAL
New Drug
What DIPRIVAN Treats
5 FDA approvalsOriginally approved for its first indication in 1989 . Covers 5 distinct patient populations.
- Other (5)
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Clinical Trial Registry
346 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT07479550 SPACE | 72097 | Ph 2 | not yet recruiting | Study of Psilocybin Under Anesthesia Controlled by EEG |
| NCT07556523 | IRB2025-0154 | Ph 4 | recruiting | Patient Quality of Recovery After TAVR With Different Sedation Regimens |
| NCT06674226 | Linyanshen[2024]201-002 | Ph 4 | recruiting | Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery |
| NCT05305313 | EC/01/22/1992 | Ph 4 | recruiting | Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System |
| NCT04680910 results posted | 202008037 U01MH128483 | Ph 1 | completed | Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I |
| NCT06330038 GASTIVA | SMC 2024-01-065 | Ph 4 | recruiting | Anesthesia and Non-small Cell Lung Cancer Recurrence |
| NCT05092152 PROMINE | PROMINE | Ph 2 | completed | Propofol Versus Ketamine for Rapid Sequence Intubation in Critically Ill Patients |
| NCT06690424 | CRCF-YXFN-202401029 | Ph 4 | completed | Clinical Studies of the Efficacy and Safety of Remimazolam for Anesthesia Induction and Maintenance in Elderly Patients |
| NCT07510945 | HSK3486-401 | Ph 3 | not yet recruiting | HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery |
| NCT05312385 INSPiRE-ICU1 results posted | SED003 | Ph 3 | completed | Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1) |
| NCT05327296 INSPiRE-ICU2 results posted | SED004 | Ph 3 | completed | Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2) |
| NCT07161518 | 79882 | Ph 4 | enrolling by invitation | Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation |
| NCT07456111 Bypro | LOC-100018379 | Ph 4 | recruiting | A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy |
| NCT07269808 SERENE | 2025P002893 | Ph 3 | recruiting | Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration |
| NCT06772727 | MD-265-2024 | Ph 4 | completed | Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy |
| NCT07000526 IS-CRITIC | HULP6844 2024-518521-14-00 | Ph 4 | recruiting | Inhaled Sedation in Critically Ill Patients |
| NCT06784479 | IRB2024-YX-607-01 82300120 | Ph 4 | active not recruiting | Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy |
| NCT07404306 | HSK3486-110 Dose Finding | Ph 1 | completed | Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users |
| NCT07028593 CP-MINS | TJ-IRB202502133 | Ph 4 | recruiting | Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery |
| NCT07347496 RAA-TS | HNMU-RAA-TS-2026-001 | Ph 4 | not yet recruiting | A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery |
| NCT07348614 | Pro00118605 | Ph 4 | not yet recruiting | Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia |
| NCT05881291 | 2023-0135 | Ph 4 | completed | Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement |
| NCT02527083 results posted | PRO00000878 | Ph 4 | completed | Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain |
| NCT06129188 | IRB-300011945 UAB | Ph 1 | completed | Comparison of Procedural Sedation in TEE |
| NCT05643066 | K2021-12-067 | Ph 4 | completed | Esketamine-propofol Versus Propofol for Flexible Bronchoscopy |
| NCT00577200 MACDrive | ABuv110507 | Ph 4 | active not recruiting | Safety of Driving After Minor Surgery With Monitored Anesthesia Care |
| NCT06741930 Ketamin stdy | 35-2024 | Ph 4 | completed | Pro-Epileptic Effects of IV Ketamine |
| NCT07268924 | EA-CHT-PvL-2025 | Ph 4 | not yet recruiting | The Effect of Propofol Versus Lidocaine on Emergence Agitation in Children Undergoing Tonsillectomy. |
| NCT06344949 | B2024-074 | Ph 4 | completed | Ciprofol Versus Propofol for Tracheal Intubation in ICU |
| NCT07118579 | RCTIVA | Ph 4 | recruiting | Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy |
| NCT07213544 | Pro00146765 | Ph 4 | recruiting | Remimazolam vs Propofol in Laser Burn Cases |
| NCT06867549 SWIPED II | 202411168 U01MH128483 | Ph 2 | recruiting | Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II |
| NCT05478174 results posted | HSK3486-305 | Ph 3 | completed | Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia |
| NCT05486416 results posted | HSK3486-309 | Ph 3 | completed | Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery |
| NCT04711837 results posted | HSK3486-304 | Ph 3 | completed | Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery |
| NCT05268562 | 21-004327 | Ph 4 | active not recruiting | Ketamine and Kidney Injury in Cardiac Surgery |
| NCT06312618 | FMASU MD292/2023 | Ph 4 | completed | Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation |
| NCT05728775 REPOSE-2 | NFEC-2022-286 | Ph 4 | recruiting | REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry |
| NCT07080528 | AITT 2023/8 2024-515545-41-00 | Ph 4 | enrolling by invitation | Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis |
| NCT07094945 | 2025S076 | Ph 4 | not yet recruiting | The Effect of Remimazolam on Postoperative Sleep Quality |
| NCT04532606 | 2020-212 | Ph 4 | recruiting | Impact of Remimazolam on Prognosis After Bladder Cancer Surgery |
| NCT02727296 VAPOR-2 | VAPOR-002 | Ph 4 | completed | Volatile Anesthetic Protection Of Renal Transplants 2 |
| NCT06763705 | 607/45/15284 | Ph 4 | recruiting | Comparison of Safety and Efficacy for Different Sedation Regimens During Colonoscopy |
| NCT07086911 | ZKL-KY20241015-78 | Ph 1, Ph 2 | not yet recruiting | The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy |
| NCT07076628 | J In 2021-1 | Ph 4 | completed | Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care |
| NCT06391931 | HSK3486-310 | Ph 3 | completed | A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery |
| NCT05822817 | K3501 | Ph 4 | completed | Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery |
| NCT03729011 DELICATE | 18 | Ph 4 | completed | Delirium Reduction by Volatile Anesthesia in Cardiac Surgery |
| NCT06777758 Remimazolam | KSVGH24-CT8-16 | Ph 4 | recruiting | Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments |
| NCT03034096 GA-CARES | 967670-3 | Ph 4 | completed | General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial |
Showing 50 of 346 trials
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Pro Active Pipeline
Ongoing clinical trials by development phase
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Pro Key Completed Trials
Completed studies with published results, ranked by significance
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Trial Timeline
Full development history with FDA approval milestones
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Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
DIPRIVAN FDA Label Details
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.
How We Calculate These Metrics
Trial Activity Stage
Measures the current development activity pattern based on trial phases, status, and trends. Important: This measures R&D activity, not commercial lifecycle.
Trial statuses: "Active" means recruiting or ongoing. "Completed" means reached planned endpoint. "Terminated" means stopped early—often due to safety, efficacy, or business reasons.
- Growth: High proportion of early-phase trials (Phase 1/2), active development
- Expansion: Significant Phase 3 activity, approaching or pursuing approvals
- Mature: Substantial Phase 4 post-marketing studies
- Stable: Mixed phase distribution, steady development
- Declining: Low active trial ratio, reduced R&D investment