DOXAPRAM HYDROCHLORIDE
DOXAPRAM HYDROCHLORIDE is indicated for the treatment of Postanesthesia Respiratory Depression; Apnea; Drug-Induced Central Nervous System Depression; Chronic Obstructive Pulmonary Disease; Acute Respiratory Insufficiency; Acute Hypercapnia.
How DOXAPRAM HYDROCHLORIDE Works
Doxapram hydrochloride produces respiratory stimulation by activating peripheral carotid chemoreceptors at lower doses and the central respiratory centers in the medulla at higher doses. This stimulation increases tidal volume and, to a lesser extent, the respiratory rate. As a non-specific CNS stimulant, higher doses may also affect the spinal cord and other brain regions. The drug's effect is rapid in onset but has a short duration of action.
Details
- Status
- Prescription
- First Approved
- 1992-01-30
- Routes
- INJECTION
- Dosage Forms
- INJECTABLE
DOXAPRAM HYDROCHLORIDE Approval History
What DOXAPRAM HYDROCHLORIDE Treats
6 indicationsDOXAPRAM HYDROCHLORIDE is approved for 6 conditions since its original approval in 1992. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Postanesthesia Respiratory Depression
- Apnea
- Drug-Induced Central Nervous System Depression
- Chronic Obstructive Pulmonary Disease
- Acute Respiratory Insufficiency
- Acute Hypercapnia
DOXAPRAM HYDROCHLORIDE Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
Drugs Similar to DOXAPRAM HYDROCHLORIDE
3 of 20FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Clinical Trial Registry
1 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT06585163 | QEV-817-101 5R44DA055336 | Ph 1 | not yet recruiting | Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension |
Active Pipeline
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Key Completed Trials
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Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
DOXAPRAM HYDROCHLORIDE FDA Label Details
Indications & Usage
DOXAPRAM HYDROCHLORIDE is indicated for the treatment of Postanesthesia Respiratory Depression; Apnea; Drug-Induced Central Nervous System Depression; Chronic Obstructive Pulmonary Disease; Acute Respiratory Insufficiency; Acute Hypercapnia.
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DOPRAM
Full clinical data, patents, trials, and competitive landscape for doxapram hydrochloride.
Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.