TheraRadar
Data updated: May 26, 2026

EPIOXA HD/EPIOXA KIT (riboflavin 5'-phosphate sodium)

Other Approved 2025-10-17

EPIOXA HD/EPIOXA KIT is indicated for the treatment of Fever; Burns; Gastrointestinal Disorder; Alcoholism.

Source: FDA Label • GLAUKOS
1
Indication
--
Phase 3 Trials
0
Years on Market

Details

Status
Prescription
First Approved
2025-10-17
Patent Cliff
2028

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Routes
OPHTHALMIC
Dosage Forms
SOLUTION/DROPS

Companies

Active Ingredient: RIBOFLAVIN 5'-PHOSPHATE SODIUM

EPIOXA HD/EPIOXA KIT Approval History

2026
Original
New Indication
New Form
Label Update
1 FDA actions from 2025 to 2025
Oct 2025 ORIGINAL
Update · Type 5 - New Formulation or New Manufacturer

What EPIOXA HD/EPIOXA KIT Treats

4 indications

EPIOXA HD/EPIOXA KIT is approved for 4 conditions since its original approval in 2025. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Fever
  • Burns
  • Gastrointestinal Disorder
  • Alcoholism
Source: FDA Label

EPIOXA HD/EPIOXA KIT Competitive Set

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Three rings of competition based on shared molecular targets and treated indications.

Indication competitors

3

Same indication, different mechanism — what else might this patient receive?

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Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

Drugs Similar to EPIOXA HD/EPIOXA KIT

3 of 20

FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.

PHOTREXA VISCOUS IN DEXTRAN 20%/PHOTREXA
RIBOFLAVIN 5'-PHOSPHATE SODIUM
4 shared
GLAUKOS
Shared indications:
FeverBurnsGastrointestinal Disorder +1 more
ALLZITAL
ACETAMINOPHEN
1 shared
PHARMOBEDIENT
Shared indications:
ANAPROX DS
NAPROXEN SODIUM
1 shared
ATNAHS PHARMA US
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Active Pipeline

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Key Completed Trials

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

EPIOXA HD/EPIOXA KIT FDA Label Details

Indications & Usage

FDA Label (PDF)

EPIOXA HD/EPIOXA KIT is indicated for the treatment of Fever; Burns; Gastrointestinal Disorder; Alcoholism.

EPIOXA HD/EPIOXA KIT Patents & Exclusivity

Exclusivity: Oct 2028

Exclusivity

NP Until Oct 2028
Source: FDA Orange Book

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.