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Data updated: May 26, 2026

EVOXAC (cevimeline hydrochloride)

Ophthalmology Approved 2000-01-11

EVOXAC is indicated for the treatment of Dry Mouth; Sjögren's Syndrome.

Source: FDA Label • COSETTE
1
Indication
--
Phase 3 Trials
26
Years on Market

Details

Status
Prescription
First Approved
2000-01-11
Routes
ORAL
Dosage Forms
CAPSULE

Companies

Active Ingredient: CEVIMELINE HYDROCHLORIDE

EVOXAC Approval History

2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
8 FDA actions from 2000 to 2013
Nov 2013 SUPPL
Mfg · Manufacturing (CMC)
Dec 2006 SUPPL
Label · Labeling
Dec 2005 SUPPL
Label · Labeling

What EVOXAC Treats

2 indications

EVOXAC is approved for 2 conditions since its original approval in 2000. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Dry Mouth
  • Sjögren's Syndrome
Source: FDA Label

EVOXAC Competitive Set

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Indication competitors

2

Same indication, different mechanism — what else might this patient receive?

Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

What's emerging in EVOXAC's indications

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Phase 3 candidates targeting molecules with no FDA-approved drug, in indications EVOXAC treats. First-in-class if their pivotal trials read out positive.

Drugs Similar to EVOXAC

FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.

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PILOCARPINE HYDROCHLORIDE
1 shared
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Shared indications:
Dry Mouth
PILOCARPINE HYDROCHLORIDE
PILOCARPINE HYDROCHLORIDE
1 shared
PADAGIS US
Shared indications:
Dry Mouth
SALAGEN
PILOCARPINE HYDROCHLORIDE
1 shared
ADVANZ PHARMA
Shared indications:
Dry Mouth
🔬

Active Pipeline

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

EVOXAC FDA Label Details

Indications & Usage

FDA Label (PDF)

EVOXAC is indicated for the treatment of Dry Mouth; Sjögren's Syndrome.

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.