TheraRadar
Data updated: May 26, 2026

INTERMEZZO (zolpidem tartrate)

Trial Activity: Mature
Sleep Approved 2011-11-23

Development Insights

University of Pennsylvania conducting 1 trials (33%)
4 indications explored (Focused)
insomnia (2 trials)
insomnia chronic (1 trials)
sleep disturbance (1 trials)
1
Indication
--
Phase 3 Trials
14
Years on Market

Details

Status
Discontinued
First Approved
2011-11-23
Patent Cliff
2029

Pro Metrics

Patent cliff and revenue data

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Routes
SUBLINGUAL
Dosage Forms
TABLET

Companies

Active Ingredient: ZOLPIDEM TARTRATE

INTERMEZZO Approval History

2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
14 FDA actions from 2011 to 2019
Aug 2019 SUPPL
Label · Labeling
Feb 2019 SUPPL
Label · Labeling
Nov 2015 SUPPL
Mfg · Manufacturing (CMC)

What INTERMEZZO Treats

1 FDA approvals

Originally approved for its first indication in 2011 .

  • Other (1)
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Clinical Trial Registry

3 trials
Trial Sponsor ID Phase Status Title
NCT03774810 R01 results posted 831801 R01AG054521-01A1 Ph 4 completed Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia
NCT02783729 SUNRISE 1 results posted E2006-G000-304 2015-004347-39 Ph 3 completed Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)
NCT03307005 results posted IRB00142395 Ph 4 completed Improving Sleep Quality in Heart Failure
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Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

INTERMEZZO FDA Label Details

View full patent landscape →
2 OB patents · 2 families · 38 international docs across 12 countries

INTERMEZZO Patents & Exclusivity

Latest Patent: Aug 2029

Patents (2 active)

US8242131 Expires Aug 20, 2029
US7658945 Expires Apr 15, 2027
Source: FDA Orange Book

Pro Intelligence Preview

Deep insights for INTERMEZZO

Revenue Insights

  • Quarterly revenue tracking
  • Historical trend analysis

Patent Timeline

  • Cliff: 2029
  • 8 active patents

Trial Analysis

  • 3 total trials
  • Stage: Mature

Competitive Landscape

  • Competitor tracking
  • Same target/indication analysis
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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.

How We Calculate These Metrics

Trial Activity Stage

Measures the current development activity pattern based on trial phases, status, and trends. Important: This measures R&D activity, not commercial lifecycle.

Trial statuses: "Active" means recruiting or ongoing. "Completed" means reached planned endpoint. "Terminated" means stopped early—often due to safety, efficacy, or business reasons.

  • Growth: High proportion of early-phase trials (Phase 1/2), active development
  • Expansion: Significant Phase 3 activity, approaching or pursuing approvals
  • Mature: Substantial Phase 4 post-marketing studies
  • Stable: Mixed phase distribution, steady development
  • Declining: Low active trial ratio, reduced R&D investment