TheraRadar
Data updated: May 26, 2026

KALEXATE (sodium polystyrene sulfonate)

Potassium Ion Exchange Activity
Renal Approved 2009-03-30

KALEXATE is indicated for the treatment of Hyperkalemia.

Source: FDA Label • KVK TECH
1
Indication
--
Phase 3 Trials
17
Years on Market

Details

Status
Prescription
First Approved
2009-03-30
Routes
ORAL, RECTAL
Dosage Forms
POWDER

Companies

Active Ingredient: SODIUM POLYSTYRENE SULFONATE

KALEXATE Approval History

2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
6 FDA actions from 2009 to 2020
Feb 2020 SUPPL
Label · Labeling
Nov 2011 SUPPL
Label · Labeling
Mar 2009 ORIGINAL
Update

What KALEXATE Treats

1 indications

KALEXATE is approved for 1 conditions since its original approval in 2009. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Hyperkalemia
Source: FDA Label

KALEXATE Competitive Set

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Three rings of competition based on shared molecular targets and treated indications.

Indication competitors

1

Same indication, different mechanism — what else might this patient receive?

Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

Drugs Similar to KALEXATE

3 of 4

FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.

KIONEX
SODIUM POLYSTYRENE SULFONATE
1 shared
ANI PHARMS
Shared indications:
Hyperkalemia
LOKELMA
SODIUM ZIRCONIUM CYCLOSILICATE
1 shared
AstraZeneca
Shared indications:
Hyperkalemia
SODIUM POLYSTYRENE SULFONATE
SODIUM POLYSTYRENE SULFONATE
1 shared
ROXANE
Shared indications:
Hyperkalemia
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Clinical Trial Registry

2 trials
Trial Sponsor ID Phase Status Title
NCT02065076 SKIP 13089 Ph 4 completed Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients
NCT01866709 results posted SPS-001 Ph 4 terminated Safety and Efficacy of Sodium Polystyrene Sulfonate in Hyperkalemia
🔬

Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

KALEXATE FDA Label Details

Indications & Usage

KALEXATE is indicated for the treatment of Hyperkalemia.

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.