KLOR-CON M20 (potassium chloride)
Klor-Con M20 is a potassium salt used to manage and prevent low potassium levels in the blood, a condition known as hypokalemia. It helps patients who cannot maintain healthy potassium levels through diet alone or by adjusting their diuretic medications. This medication is also used when low potassium occurs alongside metabolic alkalosis.
How KLOR-CON M20 Works
Potassium chloride works by providing potassium ions, the principal intracellular cations of most body tissues. These ions are essential for maintaining intracellular tonicity, transmitting nerve impulses, and ensuring the proper contraction of cardiac, skeletal, and smooth muscles. By replenishing these levels, the drug supports normal renal function and maintains the electrochemical gradient between intracellular and plasma potassium concentrations.
Details
- Status
- Prescription
- First Approved
- 1998-11-20
- Routes
- ORAL
- Dosage Forms
- TABLET, EXTENDED RELEASE
KLOR-CON M20 Approval History
What KLOR-CON M20 Treats
2 indicationsKLOR-CON M20 is approved for 2 conditions since its original approval in 1998. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Hypokalemia
- Metabolic Alkalosis
KLOR-CON M20 Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Indication competitors
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Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
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3 of 20FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Clinical Trial Registry
8 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT07238400 CARDAMOM | 2025P001799 R01HL181150 | Ph 2 | recruiting | Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia |
| NCT04316611 POTACREH | APHP180577 2019-002544-24 | Ph 2 | withdrawn | Potassium Chloride in Out-of-hospital Cardiac Arrest Due to Refractory Ventricular Fibrillation |
| NCT02450773 | 201501157 | Ph 2 | withdrawn | Prevention of Severe Postpartum Hypertension |
| NCT03627130 NITRATE-CIN | 18/1 | Ph 2 | completed | The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy |
| NCT03483051 PULSE-AS results posted | 828994 | Ph 2 | completed | Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) |
| NCT01074918 | 012007-080 | Ph 1, Ph 2 | withdrawn | Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients |
| NCT01818583 | AK-01 | Ph 4 | completed | Potassium Infusion for Conversion of Atrial Fibrillation/-Flutter |
| NCT01085071 GRIP-COMPASS | GRIP-COMPASS trial | Ph 4 | completed | Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients |
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
KLOR-CON M20 FDA Label Details
Indications & Usage
FDA Label (PDF)KLOR-CON M20 is indicated for the treatment of Hypokalemia; Metabolic Alkalosis.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.