TheraRadar
Data updated: May 26, 2026

NITROGEN, NF (nitrogen)

Trial Activity: Stable 1 active trials
Other Approved 2013-06-23
Jump to: Indications Approvals Trials Competitors Safety Patents

Development Insights

Stanford University conducting 1 trials (25%)
4 indications explored (Focused)
→ obsessive-compulsive disorder (1 trials)
→ ptsd (1 trials)
→ heart arrest, out-of-hospital (1 trials)
14
Indications
--
Phase 3 Trials
12
Years on Market

Details

Status
Prescription
First Approved
2013-06-23
Routes
INHALATION
Dosage Forms
GAS

Companies

NORCO INC MATHESON TRI-GAS INC AIRGAS USA LLC PRAXAIR INC AIR PRODUCTS AND CHEMICALS INC AIR LIQUIDE LARGE INDUSTRIES US LP CRISTAL ASU LLC PRAXAIR CANADA INC LINDE GAS PUERTO RICO INC UNIVERSAL INDUSTRIAL GASES, INC ABSOLUTE AIR, LLC AIR LIQUIDE AMERICA LP LINDE NORTH AMERICA INC AIRGAS MERCHANTS GASES LLC ASPEN AIR AIR LIQUIDE CANADA INC
Active Ingredient: NITROGEN

NITROGEN, NF Approval History

2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
16 FDA actions from 2013 to 2022
Jun 2022 ORIGINAL
Update
FDA Letter
Jun 2020 ORIGINAL
Update
FDA Letter
Aug 2018 ORIGINAL
Update · Medical Gas
FDA Letter

What NITROGEN, NF Treats

14 FDA approvals

Originally approved for its first indication in 2013 . Covers 14 distinct patient populations.

  • Other (14)
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Clinical Trial Registry

4 trials
Trial Sponsor ID Phase Status Title
NCT03826693 48077 Ph 2 recruiting Efficacy of Nitrous Oxide in OCD: Pilot Study
NCT04378426 N2OP results posted MHBB-009-19S I01CX001789, 53017 Ph 2 terminated Nitrous Oxide for PTSD
NCT03079102 iNOOHCA results posted PRO16100408 Ph 2 terminated Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
NCT00771342 CTP 6 Ph 2 completed Efficacy Study to Evaluate the Effect of Nitric Oxide on the Treatment of Tinea Pedis (Athlete's Foot)
🔬

Active Pipeline

Pro

Ongoing clinical trials by development phase

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Key Completed Trials

Pro

Completed studies with published results, ranked by significance

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Trial Timeline

ClinicalTrials.gov ↗ Pro

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

NITROGEN, NF FDA Label Details

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Data Sources

FDA Approval: NDA205805 → Label: DailyMed → Trials: ClinicalTrials.gov →

Data sourced from official FDA and NIH databases. Click links to verify on original sources.

How We Calculate These Metrics

Trial Activity Stage

Measures the current development activity pattern based on trial phases, status, and trends. Important: This measures R&D activity, not commercial lifecycle.

Trial statuses: "Active" means recruiting or ongoing. "Completed" means reached planned endpoint. "Terminated" means stopped early—often due to safety, efficacy, or business reasons.

  • Growth: High proportion of early-phase trials (Phase 1/2), active development
  • Expansion: Significant Phase 3 activity, approaching or pursuing approvals
  • Mature: Substantial Phase 4 post-marketing studies
  • Stable: Mixed phase distribution, steady development
  • Declining: Low active trial ratio, reduced R&D investment