Data updated: Jul 17, 2026
READYPREP CHG (chlorhexidine gluconate) · MEDLINE INDUSTRIES
Infectious Disease
Approved 2018-11-20
READYPREP CHG is FDA-approved to treat 1 condition (same as PERIDEX).
1
Indication
--
Phase 3 Trials
7
Years on Market
Details
- Status
- Over-the-counter
- First Approved
- 2018-11-20
- Routes
- TOPICAL
- Dosage Forms
- CLOTH
READYPREP CHG Approval History
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
2 FDA actions from 2018 to 2023
What READYPREP CHG Treats
1 indicationsREADYPREP CHG is approved for 1 conditions since its original approval in 2018. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Gingivitis
Same approved indications as PERIDEX (same active ingredient).
Source: FDA Label
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Clinical Trial Registry
31 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT06587880 | 224000195 284/2023-2024 | Ph 4 | recruiting | The Effect of Different Types of Mouthwash on Extraction Sockets' Healing |
| NCT03489629 STAR-TER | 17-2144 | Ph 2 | completed | STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) |
| NCT05110001 REAGIR results posted | 18-26045-R UG1EY028518 | Ph 3 | completed | Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction |
| NCT03140254 results posted | MPS-16IPVAW01 | Ph 2 | completed | Evaluating Safety and Effectiveness of Octenidine Dihydrochloride |
| NCT06733506 | 2018-0488 | Ph 4 | completed | A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs |
| NCT06126614 PREVENT-iT | PiT-2023 | Ph 3 | recruiting | Infection Prophylaxis in Total Joint Replacement |
| NCT03331263 results posted | R17-023 | Ph 1 | completed | Single Dose CHG Pharmacokinetic Study |
| NCT06144983 | 417121 | Ph 4 | completed | Chlorhexidine Gel Versus Alvogyl Following Surgical Extraction of Impacted Mandibular Third Molar |
| NCT04021524 results posted | STUDY00005028 | Ph 4 | completed | BPO vs Hibiclens Soap for Surgical Preparation |
| NCT02326467 results posted | IRB-P00011128 | Ph 1 | completed | Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age |
| NCT02222896 results posted | R13-053 | Ph 3 | completed | Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects |
| NCT02291601 results posted | R13-052 | Ph 3 | completed | Preoperative CHG Cloth on Healthy Subjects |
| NCT04654182 | #2007591-102 | Ph 4 | completed | Evaluation of the Residual Antimicrobial Efficacy of One Test Material Based on a Modification of ASTM E1115-11 Test Method |
| NCT02589067 results posted | 30529 | Ph 2 | completed | Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization |
| NCT02526667 results posted | R15-029 | Ph 3 | completed | Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers |
| NCT02943759 | Chx_neemleaf | Ph 2, Ph 3 | completed | Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy |
| NCT03133312 | VAGPrep | Ph 4 | completed | Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery |
| NCT03372122 | #170104-150 | Ph 4 | completed | Removal of Bacterial Spores in Adults on Skin |
| NCT01537783 results posted | ED Staph Eradication | Ph 4 | completed | Evaluation of a Staphylococcus Eradication Protocol for Patients Who Present to the ED With Cutaneous Abscess |
| NCT01495117 CHG | NCCCTS-11-563 | Ph 3 | completed | Study of Chlorhexidine Gluconate as a Preoperative Antisepsis |
| NCT02639377 | UFRN-2 | Ph 2 | completed | Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis and Gingivitis |
| NCT02605382 | UFRN | Ph 2 | completed | Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis |
| NCT01613365 CHLORHEX | 2011-004536-63 2011-24 | Ph 3 | completed | Oropharyngeal and Nasopharyngeal Decontamination With Chlorhexidine Gluconate in the Reduction of the Postoperative Morbidity and Mortality After Major Pulmonary Resections |
| NCT02446158 | EDAHP99020 | Ph 4 | completed | Daily Chlorhexidine Care at the Exit Site in Peritoneal Dialysis Patients |
| NCT02433899 | CEP CMM/HUAP no 162/2010 | Ph 4 | completed | Microsurgical Versus Conventional Semilunar Coronally Advanced Flap |
| NCT02337192 | orto14 | Ph 1 | completed | Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients. |
| NCT01857804 | olivier1 | Ph 4 | completed | Surgical Treatment of Peri-implantitis |
| NCT02154594 | DHANASHREE289 | Ph 4 | completed | "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. |
| NCT01782573 | CCH - 110801 | Ph 4 | completed | The Efficacy of Chlorhexidine Gluconate Pre - Disinfection Scrubbing in Preventing Surgical Site Infections for Hepatectomy Patients |
| NCT00759187 results posted | CRO-0607-PLA-11-RR | Ph 3 | completed | Evaluate Clinical Research From Commerical Oral Care Products |
| NCT01024738 results posted | CRO-2008-PLA-05-RR | Ph 3 | completed | Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse |
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Pro Active Pipeline
Ongoing clinical trials by development phase
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Pro Key Completed Trials
Completed studies with published results, ranked by significance
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Trial Timeline
Full development history with FDA approval milestones
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Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
READYPREP CHG FDA Label Details
Indications & Usage
FDA Label (PDF)READYPREP CHG is FDA-approved to treat 1 condition — same approved indications as PERIDEX.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.