TheraRadar
Data updated: May 26, 2026

RIZAFILM (rizatriptan benzoate)

CNS Approved 2023-04-14

RizaFilm is indicated for the acute treatment of migraine with or without aura in adults and in pediatric patients 6 to 17 years of age. Limitations of Use RizaFilm should only be used where a clear diagnosis of migraine has been established. If a patient has no response for the first migraine attack treated with RizaFilm, the diagnosis of migraine should be reconsidered before RizaFilm is administered to treat any subsequent attacks.

Source: FDA Label • GENSCO
2
Indications
--
Phase 3 Trials
3
Years on Market

Details

Status
Prescription
First Approved
2023-04-14
Patent Cliff
2034

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Routes
ORAL
Dosage Forms
FILM

Companies

Active Ingredient: RIZATRIPTAN BENZOATE

RIZAFILM Approval History

2024
2025
2026
Original
New Indication
New Form
Label Update
8 FDA actions from 2023 to 2026 · 1 indication expansions
Feb 2026 SUPPL
Efficacy
Jan 2026 SUPPL
Label · Labeling
Dec 2023 SUPPL
Label · Labeling

What RIZAFILM Treats

2 FDA approvals

Originally approved for its first indication in 2023 . Covers 2 distinct patient populations.

  • Other (2)
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Clinical Trial Registry

3 trials
Trial Sponsor ID Phase Status Title
NCT06473597 2023-12-20 Ph 4 recruiting A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
NCT00812006 results posted 0462-085 2008_597 Ph 3 completed A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis
NCT01004263 results posted 0462-086 2009_680 Ph 3 completed A Study to Evaluate the Safety and Tolerability of Rizatriptan for Long Term Treatment of Acute Migraine in Children and Adolescents (MK-0462-086 AM3)
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Active Pipeline

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

RIZAFILM FDA Label Details

Indications & Usage

FDA Label (PDF)

RizaFilm™ is indicated for the acute treatment of migraine with or without aura in adults and in pediatric patients 6 to 17 years of age. Limitations of Use RizaFilm should only be used where a clear diagnosis of migraine has been established. If a patient has no response for the first migraine attack treated with RizaFilm, the diagnosis of migraine should be reconsidered before RizaFilm is administered to treat any subsequent attacks. RizaFilm is not indicated for the preventive treatment of migraine. Safety and effectiveness of RizaFilm have not been established for cluster headache. RizaFil...

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1 OB patents · 1 families · 28 international docs across 18 countries

RIZAFILM Patents & Exclusivity

Latest Patent: Jul 2034

Patents (1 active)

US9301948 Expires Jul 30, 2034
Source: FDA Orange Book

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Revenue Insights

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Patent Timeline

  • Cliff: 2034
  • 2 active patents

Trial Analysis

  • Clinical trial tracking
  • Development stage analysis

Competitive Landscape

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  • Same target/indication analysis
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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.