TheraRadar
Data updated: May 26, 2026

TESTOSTERONE ENANTHATE

Endocrine Approved 1980-12-10

TESTOSTERONE ENANTHATE is indicated for the treatment of Primary Hypogonadism; Hypogonadotropic Hypogonadism; Delayed Puberty.

Source: FDA Label • WATSON LABS
5
Indications
--
Phase 3 Trials
45
Years on Market

Details

Status
Discontinued
First Approved
1980-12-10
Routes
INJECTION, Injection
Dosage Forms
INJECTABLE, Injectable

TESTOSTERONE ENANTHATE Approval History

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Original
New Indication
New Form
Label Update
35 FDA actions from 1980 to 2025
Jul 2025 SUPPL
Label · Labeling
Feb 2024 ORIGINAL
Update
Nov 2020 SUPPL
Label · Labeling

What TESTOSTERONE ENANTHATE Treats

3 indications

TESTOSTERONE ENANTHATE is approved for 3 conditions since its original approval in 1980. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Primary Hypogonadism
  • Hypogonadotropic Hypogonadism
  • Delayed Puberty
Source: FDA Label

TESTOSTERONE ENANTHATE Competitive Set

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Three rings of competition based on shared molecular targets and treated indications.

Indication competitors

3

Same indication, different mechanism — what else might this patient receive?

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Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

Drugs Similar to TESTOSTERONE ENANTHATE

3 of 4

FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.

NATESTO
TESTOSTERONE
1 shared
ACERUS
Shared indications:
Delayed Puberty
PREGNYL
GONADOTROPIN, CHORIONIC
1 shared
Merck
Shared indications:
Hypogonadotropic Hypogonadism
TESTOPEL
TESTOSTERONE
1 shared
ENDO OPERATIONS
Shared indications:
Delayed Puberty
📋

Clinical Trial Registry

14 trials
Trial Sponsor ID Phase Status Title
NCT06594926 WOMBAT ANZUP 2201 Ph 2 recruiting Working Out M0 Bipolar Androgen Therapy
NCT04363164 J2060sIRB IRB00312725 Ph 2 recruiting Sequential Testosterone and Enzalutamide Prevents Unfavorable Progression
NCT03516812 results posted 9984 NCI-2018-00542, 9984 Ph 2 completed Testosterone and Olaparib in Treating Patients With Castration-Resistant Prostate Cancer
NCT04460872 649726 Ph 2 recruiting Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
NCT02248701 results posted B1449-R 1I01RX001449-01A1 Ph 2 terminated Testosterone Plus Finasteride Treatment After Spinal Cord Injury
NCT03123913 STARFISH results posted 1R01NS095813-01 Ph 1 completed Study of Testosterone and rHGH in FSHD
NCT04026880 TPELVIC 2018P000248 Ph 3 withdrawn Testosterone Effects on Pelvic Floor Muscles
NCT02090114 Restore results posted J1416 NA_00093344, 1R01CA184012-01 Ph 2 completed RE-sensitizing With Supraphysiologic Testosterone to Overcome REsistance (The RESTORE Study)
NCT03674320 18-0202 Ph 2, Ph 3 withdrawn Cycled Testosterone Administration During Pulmonary Rehabilitation in Early Stage COPD
NCT01275365 OPTIMen results posted 2012P001321 7R01AG037547 Ph 3 completed Optimizing Protein Intake in Older Americans With Mobility Limitations
NCT02286921 Transformer results posted J14146 IRB00046414, W81XWH-14-2-0189 Ph 2 completed Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates Enzalutamide Resistance
NCT02734238 OPS results posted PBRC 2015-063 Ph 4 completed Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
NCT01962454 200030 Ph 1 completed A Study to Evaluate a Skeletal-muscle Microbiopsy Technique With Dynamic Proteomic Measurement in Healthy Male Volunteers
NCT01417364 11-132 Ph 4 withdrawn The Effects of Long Term Cyclic Testosterone Administration on Muscle Function and Bone in Older Men
🔬

Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

TESTOSTERONE ENANTHATE FDA Label Details

Indications & Usage

TESTOSTERONE ENANTHATE is indicated for the treatment of Primary Hypogonadism; Hypogonadotropic Hypogonadism; Delayed Puberty.

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.