TheraRadar
Data updated: May 26, 2026

THRIVE (nicotine polacrilex)

CNS Approved 2007-06-19
Jump to: Indications Approvals Trials Competitors Safety Patents
1
Indication
--
Phase 3 Trials
18
Years on Market

Details

Status
Discontinued
First Approved
2007-06-19
Routes
BUCCAL
Dosage Forms
GUM, CHEWING

Companies

GSK
Active Ingredient: NICOTINE POLACRILEX

THRIVE Approval History

2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
2 FDA actions from 2007 to 2007
Jun 2007 ORIGINAL
Update

What THRIVE Treats

1 FDA approvals

Originally approved for its first indication in 2007 .

  • Other (1)
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Clinical Trial Registry

4 trials
Trial Sponsor ID Phase Status Title
NCT02346539 2014P002495-01 5K01DA029645-04 Ph 1 completed Effect of Nicotine on Brain Reward Pathways
NCT01359709 ASCC-CM-NRT Ph 1 completed Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking
NCT01925781 results posted 13-16684 Ph 4 terminated e-Cigarettes Versus NRT Gum for Smoking Cessation
NCT01451814 results posted NCI-156241-1 Ph 2 completed Development of Positive Psychotherapy for Smoking Cessation
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Active Pipeline

Pro

Ongoing clinical trials by development phase

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Key Completed Trials

Pro

Completed studies with published results, ranked by significance

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📊

Trial Timeline

ClinicalTrials.gov ↗ Pro

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

THRIVE FDA Label Details

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Data Sources

FDA Approval: ANDA077658 → Trials: ClinicalTrials.gov →

Data sourced from official FDA and NIH databases. Click links to verify on original sources.