TheraRadar
Data updated: May 26, 2026

VIZZ (aceclidine hydrochloride)

Ophthalmology Approved 2025-07-31

VIZZ is a cholinergic agonist used to help adults who have presbyopia. This medication helps patients with age-related near vision loss by improving their visual focus. It is prescribed to enhance clarity by creating a specific physical change in the eye's pupil.

Source: FDA Label • LENZ THERAP

How VIZZ Works

This drug works by stimulating muscarinic receptors on the smooth muscles of the eye, specifically targeting the iris sphincter. When it binds, it causes the pupil to contract, creating a pinhole effect that extends the eye's depth of focus. This process improves vision with minimal impact on the ciliary muscle.

1
Indication
--
Phase 3 Trials
0
Years on Market

Details

Status
Prescription
First Approved
2025-07-31
Patent Cliff
2044

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Patent cliff and revenue data

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Routes
OPHTHALMIC
Dosage Forms
SOLUTION/DROPS

Companies

Active Ingredient: ACECLIDINE HYDROCHLORIDE

VIZZ Approval History

2026
Original
New Indication
New Form
Label Update
1 FDA actions from 2025 to 2025
Jul 2025 ORIGINAL
New Drug · Type 1 - New Molecular Entity

What VIZZ Treats

1 indications

VIZZ is approved for 1 conditions since its original approval in 2025. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Presbyopia
Source: FDA Label

VIZZ Competitive Set

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Three rings of competition based on shared molecular targets and treated indications.

Direct competitors

2

Same target(s) AND same indication — head-to-head.

MoA expansion candidates

3

Same target(s), different indications — where else is this mechanism being explored?

Indication competitors

1

Same indication, different mechanism — what else might this patient receive?

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Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

Drugs Similar to VIZZ

FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.

QLOSI
PILOCARPINE HYDROCHLORIDE
1 shared
ORASIS PHARMS
Shared indications:
Presbyopia
VUITY
PILOCARPINE HYDROCHLORIDE
1 shared
AbbVie
Shared indications:
Presbyopia
YUVEZZI
BRIMONIDINE TARTRATE
1 shared
VISUS
Shared indications:
Presbyopia
🔬

Active Pipeline

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

VIZZ FDA Label Details

Indications & Usage

FDA Label (PDF)

VIZZ is indicated for the treatment of Presbyopia.

View full patent landscape →
5 OB patents · 5 families · 29 international docs across 4 countries

VIZZ Patents & Exclusivity

Latest Patent: Mar 2044
Exclusivity: Jul 2030

Patents (6 active)

US12414942 Expires Mar 15, 2044
US12533347 Expires Oct 8, 2039
US12128036 Expires Oct 8, 2039
US10052313 Expires Mar 24, 2034
US9844537 Expires Mar 24, 2034
US11179328 Expires Mar 24, 2034

Exclusivity

NCE Until Jul 2030
Source: FDA Orange Book

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Deep insights for VIZZ

Revenue Insights

  • Quarterly revenue tracking
  • Historical trend analysis

Patent Timeline

  • Cliff: 2044
  • 6 active patents

Trial Analysis

  • Clinical trial tracking
  • Development stage analysis

Competitive Landscape

  • 3 similar drugs
  • Same target/indication analysis
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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.