5-HT Inhibitors
1 drugsAbout 5-HT
5-HT, or serotonin, is a key neurotransmitter in the central nervous system (CNS) that modulates neuronal activity and is implicated in various physiological processes.
5-HT receptors are attractive targets for therapeutic intervention in various CNS disorders, although there is currently no genetic evidence directly linking 5-HT to specific diseases in this dataset.
CELEXA is the only FDA-approved drug modulating 5-HT, developed by AbbVie as a small molecule for CNS indications, and was first approved in 1998.
Top 5-HT Drugs
AbbVie is the only company with an approved drug targeting 5-HT.
The market is highly concentrated, suggesting high barriers to entry or limited commercial opportunity.
5-HT Clinical Trials 48 trials
Phase 1-4 trials started in 2008 or later that test an FDA-approved drug acting on 5-HT. Source: ClinicalTrials.gov. How we count
Completion by Phase
| Phase | Total | Completed | Stopped | Active | Completion |
|---|---|---|---|---|---|
| Phase 1 | 11 | 10 | 1 | 0 | 91% |
| Phase 2 | 10 | 8 | 2 | 0 | 80% |
| Phase 3 | 5 | 4 | 1 | 0 | 80% |
| Phase 4 | 22 | 15 | 6 | 1 | 71% |
Top Sponsors
By Modality
Top Conditions
Top Drugs
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Competitive Landscape
- • 1 companies competing
- • Market share by company
Full Drug Portfolio
- • All 1 approved drugs
- • Approval dates & indications
Genetic Validation
- • Full genetic evidence table
- • Effect sizes & directions
Approval Timeline
- • Full 1-drug timeline
- • First-of-modality markers
Clinical Trials Analysis
- • Sponsors: 40 (11 companies)
- • Completion rates by condition
Full summary • All drugs • Genetic evidence • Trials • Timeline
How We Count Trials
- Trials: phase 1-4 interventional trials on ClinicalTrials.gov that started in 2008 or later and test an FDA-approved drug acting on 5-HT. A trial counts if an approved drug acting on 5-HT is in any arm, including as a comparator, and a trial that tests two such drugs counts once. Trials that test only unapproved drugs are not counted. A trial listed as phase 1/2 counts as phase 1, and phase 2/3 as phase 2.
- Active: recruiting, not yet recruiting, enrolling by invitation, or active and no longer recruiting.
- Completion rate: of the trials that have ended, the share marked Completed rather than Terminated or Withdrawn. Completed means the trial ended as planned; it does not mean the drug worked. Suspended trials are not counted as ended.
- Stopped: terminated or withdrawn. Trials stop for many reasons, including slow enrolment and business decisions, not only safety or efficacy.
- Sponsors: the lead sponsor of each trial. Companies are the sponsors ClinicalTrials.gov classes as industry; the rest are universities, hospitals, cooperative groups, government bodies and individuals.