PD-1
11 drugsProgrammed Cell Death Protein 1
Predictive biomarker for patient selection in 31 indications
Understanding PD-1
What it means: PD-1 is an immune checkpoint receptor on T cells. When bound by PD-L1, it suppresses T cell activity, allowing cancer to evade immune attack.
Why it matters: Anti-PD-1 antibodies (pembrolizumab, nivolumab) block this interaction, reactivating T cells to attack tumors. Used across many cancer types.
Testing: PD-1 status is typically assessed via PD-L1 expression testing on tumor tissue (IHC). PD-L1 levels help predict response.
11
Approved Drugs
31
Indications
8
Companies
PD-1 is a precision-medicine biomarker linked to 11 FDA-approved targeted drugs from 8 companies, spanning 31 indications including Esophageal Cancer, Esophageal Squamous Cell Carcinoma, Gastric Cancer. Explore the targeted therapies, indications, testing methods, and companies developing PD-1 drugs below.
Search PD-1 Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting PD-1
| Drug | Company | Therapeutic Area |
|---|---|---|
| JEMPERLI | GSK | Oncology |
| KEYTRUDA | Merck | Oncology |
| KEYTRUDA QLEX | Merck | Oncology |
| LIBTAYO | Regeneron | Oncology |
| LOQTORZI | COHERUS BIOSCIENCES INC | Oncology |
| OPDIVO | Bristol-Myers Squibb | Oncology |
| OPDIVO QVANTIG | Bristol-Myers Squibb | Oncology |
| OPDUALAG | Bristol-Myers Squibb | Oncology |
| PENPULIMAB-KCQX | AKESO BIOPHARMA | Oncology |
| TEVIMBRA | BEIGENE | Oncology |
| ZYNYZ | INCYTE CORP | Oncology |
PD-1 Indications
Esophageal Cancer Esophageal Squamous Cell Carcinoma Gastric Cancer Gastroesophageal Junction Adenocarcinoma Melanoma Non-Small Cell Lung Cancer Endometrial Cancer Solid Tumors Nasopharyngeal Carcinoma Metastatic cutaneous squamous cell carcinoma Locally advanced cutaneous squamous cell carcinoma Adjuvant treatment of cutaneous squamous cell carcinoma at high risk of recurrence after surgery and radiation Locally advanced basal cell carcinoma Metastatic basal cell carcinoma First-line treatment of locally advanced or metastatic non-small cell lung cancer in combination with platinum-based chemotherapy First-line monotherapy for locally advanced or metastatic non-small cell lung cancer with high PD-L1 expression (TPS ≥50%) Renal Cell Carcinoma Head and Neck Cancer Classical Hodgkin Lymphoma Urothelial Carcinoma Cervical Cancer Hepatocellular Carcinoma Merkel Cell Carcinoma Cutaneous Squamous Cell Carcinoma Triple-Negative Breast Cancer Colorectal Cancer Biliary Tract Cancer Unresectable melanoma Metastatic melanoma Squamous Cell Carcinoma of the Anal Canal Mesothelioma