VEGF
17 drugsVascular Endothelial Growth Factor
Predictive biomarker for patient selection in 31 indications
Understanding VEGF
What it means: VEGF is a signaling protein that promotes angiogenesis (blood vessel formation). Tumors need blood supply to grow.
Why it matters: Anti-VEGF agents (bevacizumab) and VEGFR inhibitors (sorafenib, sunitinib) starve tumors by blocking angiogenesis.
Testing: VEGF is not routinely tested for patient selection. Anti-VEGF therapies are used based on tumor type, not biomarker.
17
Approved Drugs
31
Indications
11
Companies
Search VEGF Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting VEGF
| Drug | Company | Therapeutic Area |
|---|---|---|
| ALYMSYS | AMNEAL PHARMS LLC | Oncology |
| AVASTIN | Roche | Oncology |
| BEOVU | Novartis | Metabolic |
| BYOOVIZ | SAMSUNG BIOEPIS CO LTD | Ophthalmology |
| CIMERLI | Novartis | Metabolic |
| EYDENZELT | CELLTRION INC | Metabolic |
| EYLEA | Regeneron | Ophthalmology |
| EYLEA HD | Regeneron | Metabolic |
| JOBEVNE | BIOCON BIOLOGICS INC | Oncology |
| LUCENTIS | Roche | Ophthalmology |
| MVASI | Amgen | Oncology |
| PAVBLU | Amgen | Metabolic |
| SUSVIMO | Roche | Metabolic |
| VABYSMO | Roche | Metabolic |
| VEGZELMA | CELLTRION | Oncology |
| ZALTRAP | Sanofi | Oncology |
| ZIRABEV | Pfizer | Oncology |
Indications
Neovascular (Wet) Age-Related Macular Degeneration (AMD) Macular Edema Following Retinal Vein Occlusion (RVO) Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Myopic Choroidal Neovascularization (mCNV) Metastatic Colorectal Cancer Non-Small Cell Lung Cancer Glioblastoma Renal Cell Carcinoma Cervical Cancer Ovarian Cancer Fallopian Tube Cancer Peritoneal Cancer Neovascular Age-Related Macular Degeneration Diabetic Macular Edema Macular Edema Following Retinal Vein Occlusion Colorectal Cancer Diabetic Retinopathy Myopic Choroidal Neovascularization Metastatic Renal Cell Carcinoma Macular Edema Retinal Vein Occlusion Metastatic colorectal cancer Unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer Recurrent glioblastoma Metastatic renal cell carcinoma Persistent, recurrent, or metastatic cervical cancer Epithelial ovarian, fallopian tube, or primary peritoneal cancer Unresectable or metastatic hepatocellular carcinoma Neovascular Age-related Macular Degeneration Retinopathy of Prematurity (ROP)
Companies with VEGF Drugs
Roche Pfizer Sanofi Novartis BIOCON BIOLOGICS INC SAMSUNG BIOEPIS CO LTD Amgen AMNEAL PHARMS LLC CELLTRION CELLTRION INC Regeneron