VEGF
17 drugsVascular Endothelial Growth Factor
Predictive biomarker for patient selection in 31 indications
Understanding VEGF
What it means: VEGF is a signaling protein that promotes angiogenesis (blood vessel formation). Tumors need blood supply to grow.
Why it matters: Anti-VEGF agents (bevacizumab) and VEGFR inhibitors (sorafenib, sunitinib) starve tumors by blocking angiogenesis.
Testing: VEGF is not routinely tested for patient selection. Anti-VEGF therapies are used based on tumor type, not biomarker.
17
Approved Drugs
31
Indications
10
Companies
VEGF is a precision-medicine biomarker linked to 17 FDA-approved targeted drugs from 10 companies, spanning 31 indications including Neovascular Age-Related Macular Degeneration, Diabetic Macular Edema, Metastatic Colorectal Cancer. Explore the targeted therapies, indications, testing methods, and companies developing VEGF drugs below.
Search VEGF Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting VEGF
| Drug | Company | Therapeutic Area |
|---|---|---|
| ALYMSYS | AMNEAL PHARMS | Oncology |
| AVASTIN | Roche | Oncology |
| BEOVU | Novartis | Metabolic |
| BYOOVIZ | SAMSUNG BIOEPIS CO LTD | Ophthalmology |
| CIMERLI | Novartis | Metabolic |
| EYDENZELT | CELLTRION | Metabolic |
| EYLEA | Regeneron | Ophthalmology |
| EYLEA HD | Regeneron | Metabolic |
| JOBEVNE | BIOCON BIOLOGICS INC | Oncology |
| LUCENTIS | Roche | Ophthalmology |
| MVASI | Amgen | Oncology |
| PAVBLU | Amgen | Metabolic |
| SUSVIMO | Roche | Metabolic |
| VABYSMO | Roche | Metabolic |
| VEGZELMA | CELLTRION | Oncology |
| ZALTRAP | Sanofi | Oncology |
| ZIRABEV | Pfizer | Oncology |
VEGF Indications
Neovascular Age-Related Macular Degeneration Diabetic Macular Edema Metastatic Colorectal Cancer Non-Small Cell Lung Cancer Glioblastoma Metastatic Renal Cell Carcinoma Cervical Cancer Fallopian Tube Cancer Peritoneal Cancer Diabetic Retinopathy Macular Edema Following Retinal Vein Occlusion Neovascular (Wet) Age-Related Macular Degeneration (AMD) Macular Edema Following Retinal Vein Occlusion (RVO) Diabetic Macular Edema (DME) Diabetic Retinopathy (DR) Retinopathy of Prematurity (ROP) Colorectal Cancer Renal Cell Carcinoma Ovarian Cancer Neovascular Age-related Macular Degeneration Myopic Choroidal Neovascularization Macular Edema Retinal Vein Occlusion Myopic Choroidal Neovascularization (mCNV) Metastatic colorectal cancer Unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer Recurrent glioblastoma Metastatic renal cell carcinoma Persistent, recurrent, or metastatic cervical cancer Epithelial ovarian, fallopian tube, or primary peritoneal cancer Unresectable or metastatic hepatocellular carcinoma