Landscape → Ophthalmology

Glaucoma Clinical Trial Landscape

Data updated: May 20, 2026

515 clinical trials tracked since 2008

Glaucoma is being studied across 515 clinical trials registered since 2008, with 63 programs currently active. The competitive pipeline includes 18 active Phase 3 trials, 18 active Phase 2 trials, and 16 active Phase 1 trials. Top industry sponsors include Glaukos Corporation, AbbVie, SpyGlass Pharma, Inc..

63 active

515 total (since 2008)

Phase 1 Active

82 total

Phase 2 Active

160 total

Phase 3 Active

146 total

Phase 4 Active

173 total

Top Industry Sponsors

Sorted by active Active Done Failed

Glaukos Corporation 5 15 0

AbbVie 4 41 3

SpyGlass Pharma, Inc. 3 0 0

Qlaris Bio, Inc. 2 7 0

PolyActiva Pty Ltd 2 3 0

+ 10 more sponsors — see full table below

Featured Phase 3 Trials

NCT06822738 RECRUITING

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

AbbVie n=130

NCT07354516 RECRUITING

Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension

Qlaris Bio, Inc. n=60

NCT07495852 RECRUITING

Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Glaukos Corporation n=510

NCT07075718 RECRUITING

Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Glaukos Corporation n=610

NCT06066645 RECRUITING

Travoprost Intraocular Implant + iStent Infinite vs. iStent Infinite Alone

Glaukos Corporation n=230

+ 141 more Phase 3 trials — see full database below

Glaucoma — Trials Started by Year (last 10 years)

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Glaukos Corporation

AbbVie

SpyGlass Pharma, Inc.

Qlaris Bio, Inc.

PolyActiva Pty Ltd

Amneal Pharmaceuticals, LLC

Santen Pharmaceutical Co., Ltd.

Laboratoires Thea

Bausch & Lomb Incorporated

EyeD Pharma

Active Trials by Phase

Phase 1

Phase 2

Phase 3

Phase 4

Enrollment Size Distribution

1-50

179

51-200

204

201-500

501-1k

1k+

All Industry Sponsors

Sorted by active Active Done Failed

Glaukos Corporation 5 15 0

AbbVie 4 41 3

SpyGlass Pharma, Inc. 3 0 0

Qlaris Bio, Inc. 2 7 0

PolyActiva Pty Ltd 2 3 0

Amneal Pharmaceuticals, LLC 2 0 0

Santen Pharmaceutical Co., Ltd. 1 9 0

Laboratoires Thea 1 8 0

Bausch & Lomb Incorporated 1 7 0

EyeD Pharma 1 0 1

IVIEW Therapeutics Inc. 1 0 0

Life Biosciences Inc. 1 0 0

Rheon Medical SA 1 0 0

Huons Co., Ltd. 1 0 0

Perfuse Therapeutics, Inc. 1 0 0

NCT06822738 RECRUITING

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

AbbVie n=130

NCT07354516 RECRUITING

Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension

Qlaris Bio, Inc. n=60

NCT07495852 RECRUITING

Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Glaukos Corporation n=510

NCT07075718 RECRUITING

Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Glaukos Corporation n=610

NCT06066645 RECRUITING

Travoprost Intraocular Implant + iStent Infinite vs. iStent Infinite Alone

Glaukos Corporation n=230

NCT07335211 RECRUITING

Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Huons Co., Ltd. n=206

NCT05695027 ACTIVE NOT RECRUITING

Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study

Columbia University n=250

NCT03933631 RECRUITING

Pilocarpine Use After Kahook Goniotomy

Montefiore Medical Center n=142

NCT07218796 RECRUITING

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)

SpyGlass Pharma, Inc. n=400

NCT07218783 RECRUITING

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)

SpyGlass Pharma, Inc. n=400

NCT03891446 ACTIVE NOT RECRUITING

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

AbbVie n=455

NCT06666855 ACTIVE NOT RECRUITING

A Phase III Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension in China

Santen Pharmaceutical Co., Ltd. n=345

NCT06731582 ENROLLING BY INVITATION

Nicotinamide Supplementation in Glaucoma

Singapore Eye Research Institute n=520

NCT06680245 NOT YET RECRUITING

Effect of Mitomycin-C on the Outcomes of Patients Receiving Ahmed Glaucoma Valve Implantation Surgery

St. Joseph's Healthcare Hamilton n=144

NCT06061718 ACTIVE NOT RECRUITING

Travoprost Intraocular Implant in Conjunction With Cataract Surgery

Glaukos Corporation n=60

NCT05405868 RECRUITING

Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial

University College, London n=496

NCT05710198 RECRUITING

Efficacy of Citicoline Eye Drops 2% on Visual Field Preservation in Patients With Open Angle Glaucoma

Omikron Italia S.r.l. n=1,000

NCT05401357 RECRUITING

Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.

Amneal Pharmaceuticals, LLC n=168

NCT07082816 COMPLETED

Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction

Alcon Research n=489

NCT05411198 COMPLETED

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

AbbVie n=74

NCT04630808 COMPLETED

MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Nicox Ophthalmics, Inc. n=696

NCT05938699 COMPLETED

Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution

Nicox Ophthalmics, Inc. n=18

NCT02390284 TERMINATED

Stop Retinal Ganglion Cell Dysfunction Study

University of Miami n=28

NCT03850782 COMPLETED

Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension

AbbVie n=515

NCT04445519 COMPLETED

Phase 3 Trial of NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Nicox Ophthalmics, Inc. n=691

NCT06431113 COMPLETED

Effect of Fixed Combination Citicoline Homotaurine and Pyrroloquinoline Quinone on Pattern-electroretinogram in Glaucoma

Fondazione IRCCS Policlinico San Matteo di Pavia n=40

NCT04944290 COMPLETED

To Compare the Efficacy and Safety of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes

Padagis LLC n=447

NCT05583474 COMPLETED

OPC-1085EL in the Treatment of Primary Open Angle Glaucoma or Ocular Hypertension in Chinese Subjects

Otsuka Beijing Research Institute n=204

NCT03193333 TERMINATED

PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)

Laboratorios Sophia S.A de C.V. n=51

NCT03868124 COMPLETED

Clinical Study Comparing Two Models of a Travoprost Intraocular Implant

Glaukos Corporation n=560

NCT03519386 COMPLETED

Randomized Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, 0.5%

Glaukos Corporation n=590

NCT05397600 COMPLETED

Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients

Laboratoires Thea n=684

NCT05503901 COMPLETED

A Long Term Study of STN1012600 in Subjects With Open Angle Glaucoma or Ocular Hypertension

Santen Pharmaceutical Co., Ltd. n=131

NCT02801617 TERMINATED

Non-inferiority of PRO-067 Ophthalmic Solution vs GAAP Ofteno® in Glaucoma or Ocular Hypertension

Laboratorios Sophia S.A de C.V. n=116

NCT02507687 COMPLETED

Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension

AbbVie n=240

NCT02981446 COMPLETED

A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT

Santen Pharmaceutical Co., Ltd. n=370

NCT03235232 COMPLETED

BREMEN Eye Drops Versus Combigan for Open-angle Glaucoma or Intraocular Hypertension

EMS n=406

NCT05022004 COMPLETED

A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Sun Pharmaceutical Industries Limited n=599

NCT05495061 COMPLETED

A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Santen Pharmaceutical Co., Ltd. n=325

NCT03825380 COMPLETED

Efficacy and Safety Assessment of T4032 Versus Lumigan® in Ocular Hypertensive or Glaucomatous Patients

Laboratoires Thea n=485

NCT05042609 COMPLETED

A Study of TRS01 in Subjects With Active Non-infectious Anterior Uveitis Including Subjects With Uveitic Glaucoma

Tarsier Pharma n=142

NCT05973305 COMPLETED

Comparative Study of Dorzol Eye Drops, 20 mg/ml Versus Trusopt® Eye Drops, 20 mg/ml

Jadran Galenski laboratorij d.d. n=118

NCT05973318 COMPLETED

Comparative Study of Dorzotimol Eye Drops, 20 mg/mL + 5 mg/mL Versus Cosopt® Eye Drops, 20 mg/mL + 5 mg/mL

Jadran Galenski laboratorij d.d. n=110

NCT04061044 COMPLETED

A Study to Evaluate the Long Term Safety of OTX-TP (Sustained Release Travoprost) Intracanalicular Insert

Ocular Therapeutix, Inc. n=40

NCT04285580 COMPLETED

A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension

AbbVie n=37

NCT03362931 COMPLETED

Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma

Allergan n=65

NCT02617459 COMPLETED

Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension

Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. n=366

NCT01722604 COMPLETED

Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

Bausch & Lomb Incorporated n=258

NCT04024072 COMPLETED

To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes

Padagis LLC n=495

NCT04620135 COMPLETED

Efficacy and Safety Study of Netarsudil 0.02% Ophthalmic Solution Compared to Ripasudil Hydrochloride Hydrate 0.4% Ophthalmic Solution in Japanese Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=245

NCT04890106 COMPLETED

Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% to LUMIGAN® In The Treatment of Chronic Open-Angle Glaucoma

Mankind Pharma Limited n=310

NCT05127525 TERMINATED

EffiCacy, Safety and ToLErability of a Novel Ocular ANtiseptic for Ocular Use (CLEAN)

iRenix Medical, Inc. n=5

NCT04005079 WITHDRAWN

Pilocarpine After Combined Cataract/Trabectome Surgery

Montefiore Medical Center

NCT02636946 COMPLETED

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Allergan n=144

NCT03450629 COMPLETED

Evaluation of Safety and Efficacy of PDP-716

Sun Pharma Advanced Research Company Limited n=682

NCT03284853 COMPLETED

Safety and Efficacy Study of PG324 (Netarsudil/Latanoprost 0.02% / 0.005%) Ophthalmic Solution Compared to GANFORT® Ophthalmic Solution in Open Angle Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=436

NCT03927443 WITHDRAWN

A Comparative Study of SPARC's SDP-133 Once Daily and Lumigan in Subjects With Open Angle Glaucoma or Ocular Hypertension

Sun Pharmaceutical Industries Limited

NCT04563559 WITHDRAWN

PREFERENTIAL Study

Duke University

NCT02914509 COMPLETED

Phase 3 Study Evaluating Safety and Efficacy of OTX-TP in Subjects With OAG or OHT

Ocular Therapeutix, Inc. n=565

NCT02767219 COMPLETED

The Use of Bevacizumab as a Modulator of Wound Healing Following Trabeculectomy Surgery

Moorfields Eye Hospital NHS Foundation Trust n=6

NCT02250651 COMPLETED

Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension

Allergan n=528

NCT02731118 TERMINATED

Antisecretory Factor (AF) Effects on Intraocular-pressure

St. Erik Eye Hospital n=50

NCT00945958 COMPLETED

Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension

Sun Pharma Advanced Research Company Limited n=161

NCT00947661 COMPLETED

Efficacy and Safety of SPARC0912 and Reference0912 in Open Angle Glaucoma or Ocular Hypertension

Sun Pharma Advanced Research Company Limited n=578

NCT00716859 COMPLETED

A Phase 3 Prospective, Randomized, Double-Masked, 12-Week, Parallel Group Study In Pediatric Subjects With Glaucoma.

Pfizer's Upjohn has merged with Mylan to form Viatris Inc. n=139

NCT04052269 SUSPENDED

Phosphodiesterase Inhibitors in Glaucoma Study (PhiGS)

Imperial College London n=30

NCT04455126 COMPLETED

Preservative-free Tafluprost Eye Drops in Newly Diagnosed Patients With Glaucoma

Alexandria University n=30

NCT02247804 COMPLETED

Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension

Allergan n=594

NCT03639675 COMPLETED

Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied

Bayer n=16

NCT02512042 COMPLETED

Bioequivalence Study With Clinical Endpoint Comparing Brinzolamide 1% Ophthalmic Suspension to Azopt® 1% Ophthalmic Suspension In the Treatment of Chronic Open Angle Glaucoma or Ocular Hypertension in Both Eyes

Actavis Inc. n=973

NCT03257813 COMPLETED

Non-inferiority of PRO-122 Ophthalmic Solution vs KRYTANTEK Ofteno® in Glaucoma or Ocular Hypertension (CONFORTK)

Laboratorios Sophia S.A de C.V. n=60

NCT03419975 COMPLETED

A Multi-center, Randomized, Blinded Evaluator, Active Control, Parallel, Phase III Study to Evaluate the Efficacy and Safety of TJO-002 in POAG or Ocular Hypertension Patients

Taejoon Pharmaceutical Co., Ltd. n=146

NCT01908816 COMPLETED

An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.

Novartis Pharmaceuticals n=270

NCT02558400 COMPLETED

Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=718

NCT02674854 COMPLETED

Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=750

NCT01099774 COMPLETED

Safety and Efficacy of Different Formulations of Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Allergan n=597

NCT01749930 COMPLETED

Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Bausch & Lomb Incorporated n=420

NCT01749904 COMPLETED

Comparing Safety and Efficacy of BOL-303259-X With Timolol Maleate in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Bausch & Lomb Incorporated n=420

NCT01254604 COMPLETED

Preservative-Free Tafluprost (MK-2452) for the Treatment of Open-Angle Glaucoma or Ocular Hypertension (MK-2452-002)

Merck Sharp & Dohme LLC n=190

NCT02059278 COMPLETED

Safety and Efficacy of T-2345 Compared to Xalatan in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Nephron Pharmaceuticals Corporation n=335

NCT01895972 COMPLETED

Long-Term Safety of Latanoprostene Bunod Ophthalmic Solution 0.024% in Japanese Subjects With OAG or OHT

Bausch & Lomb Incorporated n=130

NCT00853905 COMPLETED

Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?

Wills Eye n=77

NCT00853073 COMPLETED

Does Adding Bevacizumab Therapy in Glaucoma Surgery Improve the Success of Needle Bleb Revisions?

Wills Eye n=63

NCT02339584 COMPLETED

Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Alcon Research n=493

NCT02207491 COMPLETED

Double-masked Study of AR-13324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=411

NCT02246764 COMPLETED

Study of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=93

NCT02207621 COMPLETED

Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension

Aerie Pharmaceuticals n=756

NCT02558374 COMPLETED

Double-masked Study of Netarsudil (AR-13324) Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals n=708

NCT00626782 COMPLETED

Lucentis Versus Mitomycin C During Glaucoma Surgery

Wills Eye n=24

NCT02822729 COMPLETED

A Long-term Study of DE-117 Ophthalmic Solution Monotherapy and Concomitant Use of DE-117 Ophthalmic Solution With Timolol Ophthalmic Solution in Patients With OAG or OH: RENGE Study

Santen Pharmaceutical Co., Ltd. n=125

NCT02822742 COMPLETED

A Study Assessing the Safety and Efficacy of DE-117 in Subjects With POAG or OH Who Are Non-/Low-responders to Latanoprost: FUJI Study

Santen Pharmaceutical Co., Ltd. n=26

NCT02623738 COMPLETED

A Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension -AYAME Study-

Santen Pharmaceutical Co., Ltd. n=253

NCT02396316 COMPLETED

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

Bayer n=54

NCT01026831 COMPLETED

Preservative-Free MK2452 (Tafluprost) for Open-Angle Glaucoma/Ocular Hypertension (MK2452-001)(COMPLETED)

Merck Sharp & Dohme LLC n=643

NCT02278614 COMPLETED

Efficacy and Safety Assessment of T2347 Versus Xalacom® in Ocular Hypertensive or Glaucomatous Patients

Laboratoires Thea n=242

NCT01217606 COMPLETED

Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

Allergan n=185

NCT02565173 COMPLETED

Study of Trabodenoson in Adults With Ocular Hypertension or Primary Open-angle Glaucoma

Inotek Pharmaceuticals Corporation n=303

NCT02901236 COMPLETED

Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma

Athens Vision Eye Institute n=40

NCT00901108 TERMINATED

Trabectome Versus Trabeculectomy With Mitomycin C in Patients With Open Angle Glaucoma

University of Alberta n=19

NCT01640756 COMPLETED

AqueSys Microfistula Implant in Refractory Glaucoma

AqueSys, Inc. n=60

NCT02641457 COMPLETED

Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis

Instituto de Olhos de Goiania n=2

NCT02105285 COMPLETED

Efficacy and Safety Study of OPC-1085EL Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Otsuka Pharmaceutical Co., Ltd. n=193

NCT02105272 COMPLETED

Efficacy and Safety Study of OPC-1085EL Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Otsuka Pharmaceutical Co., Ltd. n=237

NCT01426113 TERMINATED

A Study of the Safety and Efficacy of Bimatoprost Ophthalmic Solution in Paediatric Patients With Glaucoma

Allergan n=6

NCT01652664 COMPLETED

Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients

Alcon Research n=184

NCT01342094 COMPLETED

DE-111 Against Timolol Ophthalmic Solution 0.5%

Santen Pharmaceutical Co., Ltd. n=166

NCT01343082 COMPLETED

DE-111 Ophthalmic Solution in Patients With Open Angle Glaucoma or Ocular Hypertension

Santen Pharmaceutical Co., Ltd. n=148

NCT01342081 COMPLETED

DE-111 Against Tafluprost Ophthalmic Solution 0.0015% Alone and Concomitant Use of Tafluprost Ophthalmic Solution 0.0015% Plus Timolol Ophthalmic Solution 0.5%

Santen Pharmaceutical Co., Ltd. n=489

NCT01052558 COMPLETED

GTS400 Stent Implantation in Conjunction With Cataract Surgery in Subjects With Open-angle Glaucoma

Glaukos Corporation n=164

NCT01830140 COMPLETED

A Safety Study of Bimatoprost in Patients With Glaucoma or Ocular Hypertension

Allergan n=466

NCT01156012 COMPLETED

Efficacy and Safety Assessment of T2345 in Ocular Hypertensive or Glaucomatous Patients

Laboratoires Thea n=404

NCT01721707 WITHDRAWN

Latanoprost/Brinzolamide BID Versus Latanoprost BID in Patients With OAG or OH

Adapt Produtos Oftalmológicos Ltda.

NCT01241240 COMPLETED

Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

Allergan n=192

NCT00928590 COMPLETED

Safety Study of DuoTrav APS in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research n=155

NCT00760539 COMPLETED

Safety and Efficacy of Travoprost/Timolol BAC-free

Alcon Research n=87

NCT00672997 COMPLETED

A Phase III Study of Travoprost/Timolol Combination in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research n=301

NCT00892762 COMPLETED

Travoprost APS Versus Xalatan® in Patient Reported Outcomes and Ocular Surface Health

Alcon Research n=434

NCT01357616 COMPLETED

Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension

Alcon Research n=328

NCT01309204 COMPLETED

Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID Plus Brimonidine BID in Patients With Open Angle Glaucoma or Ocular Hypertension

Alcon Research n=1,184

NCT01310777 COMPLETED

Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID and Brimonidine BID in Patients With Open Angle Glaucoma or Ocular Hypertension

Alcon Research n=771

NCT01263834 COMPLETED

Results of Adjunctive Intraoperative Bevacizumab Injection on Trabeculectomy Outcome

Prince of Songkla University n=39

NCT01453855 COMPLETED

Travoprost 3-Month Safety and Efficacy Study

Alcon Research n=1,099

NCT01216943 COMPLETED

Safety and Efficacy of Triple Combination Therapy in Patients With Glaucoma or Ocular Hypertension

Allergan n=126

NCT01284166 WITHDRAWN

Safety and Efficacy of Triple Combination Therapy With Dorzolamide Hydrochloride / Brimonidine Tartrate / Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Allergan

NCT01297920 COMPLETED

Three Month Efficacy/Safety Study With a 3-Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2%

Alcon Research n=1,062

NCT01087671 COMPLETED

Ocular Signs and Symptoms in Glaucoma Patients Switched From Latanoprost to Preservative Free Tafluprost Eye Drops

Santen Oy n=185

NCT01297517 COMPLETED

Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2%

Alcon Research n=1,001

NCT01177098 COMPLETED

Safety and Efficacy of a New Formulation of Bimatoprost/Timolol Ophthalmic Solution Compared With Bimatoprost/Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Allergan n=561

NCT00872651 COMPLETED

Travoprost 0.004%/Timolol 0.5% Versus Latanoprost 0.005%/Timolol in Chinese Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research n=242

NCT01292460 COMPLETED

Tafluprost-Timolol Preservative-free Fixed Dose Combination (FDC) Superiority Study Against Monotherapies

Santen Oy n=600

NCT00691717 COMPLETED

Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research n=201

NCT00767494 TERMINATED

Travoprost/Brinzolamide Fixed Combination Versus Travatan and Versus AZOPT

Alcon Research n=17

NCT00690794 COMPLETED

Travatan Z in Ocular Surface Health in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research n=726

NCT00912054 TERMINATED

DuoTrav APS Versus XALACOM® in Ocular Surface Health

Alcon Research n=240

NCT00767481 TERMINATED

1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT

Alcon Research n=6

NCT01306461 COMPLETED

Tafluprost-Timolol Fixed Dose Combination Non-Inferiority Study Against Concomitant Administrations

Santen Oy n=401

NCT00705770 WITHDRAWN

A Multi-Dose Study With a Treatment for Open-Angle Glaucoma

Alcon Research

NCT00761319 COMPLETED

Phase III Clinical Trial of TRAVATAN Z in Ocular Surface Health

Alcon Research n=705

NCT00848536 COMPLETED

Efficacy Study of Travoprost APS Versus TRAVATAN

Alcon Research n=371

NCT01544192 COMPLETED

Impact of Oral Versatile Antioxidants on Glaucoma Progression

Bagcilar Training and Research Hospital n=60

NCT01452009 WITHDRAWN

Three Month Safety and Efficacy Study of TRAVATAN® Versus Travoprost Ophthalmic Solution, 0.004%

Alcon Research

NCT00862472 WITHDRAWN

Safety and Efficacy Study of DuoTrav APS Versus DuoTrav

Alcon Research

NCT01168414 COMPLETED

A Study of Ganfort Versus Duotrav in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Ministry of Health, Malaysia n=42

NCT00878917 COMPLETED

Equivalence Study of Dorzolamide 2% Eye Drops Solution

Alfred E. Tiefenbacher (GmbH & Co. KG) n=32

NCT00709449 COMPLETED

An Open Study Comparing the Effects of Moxaverine on Ocular Blood Flow in Patients With Age- Related Macular Degeneration, Primary Open Angle Glaucoma and Healthy Control Subjects

Medical University of Vienna n=60

NCT00596791 COMPLETED

Ocular Signs and Symptoms in Glaucoma Patients Switched From Latanoprost 0.005% to Preservative Free Tafluprost Eye Drops

Santen Oy n=150

NCT07168902 ACTIVE NOT RECRUITING

Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension

Bausch & Lomb Incorporated

NCT06921317 RECRUITING

GVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle Glaucoma

IVIEW Therapeutics Inc.

NCT05180994 RECRUITING

Topical Infliximab in Eyes With Penetrating Keratoplasty

Centre hospitalier de l'Université de Montréal (CHUM)

NCT04499248 RECRUITING

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

AbbVie

NCT07354477 RECRUITING

Single-site Pilot Study Evaluating the Effect of QLS-111 Ophthalmic Solution on Posterior Perfusion and Vessel Dilation

Qlaris Bio, Inc.

NCT05426044 RECRUITING

Metformin as a Neuroprotective Therapy for Glaucoma

Christopher Kai Shun Leung

NCT04577300 ACTIVE NOT RECRUITING

Dual Intravitreal Implantation of NT-501 Encapsulated Cell Therapy for Glaucoma

Stanford University

NCT02862938 ACTIVE NOT RECRUITING

Study of NT-501 Encapsulated Cell Therapy for Glaucoma Neuroprotection and Vision Restoration

Stanford University

NCT06120842 ACTIVE NOT RECRUITING

Evaluation of the Bimatoprost Implant System Used in Combination With the SpyGlass Intraocular Lens Compared to Timolol Ophthalmic Solution

SpyGlass Pharma, Inc.

NCT05694858 RECRUITING

Transdermal Microneedle Lignocaine Delivery Versus EMLA Patch for Topical Analgesia Before Venepuncture Procedure To Adults in Clinical Setting

Universiti Kebangsaan Malaysia Medical Centre

NCT06991712 RECRUITING

Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients

Christopher Kai Shun Leung

NCT06964191 RECRUITING

Evaluate Efficacy and Safety of PA5108 Ocular Implants in Primary Open Angle Glaucoma or Ocular Hypertension

PolyActiva Pty Ltd

NCT05822245 ACTIVE NOT RECRUITING

A Study of PER-001 in Participants With Open-Angle Glaucoma

Perfuse Therapeutics, Inc.

NCT06223048 RECRUITING

A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma

Amydis Inc.

NCT05389267 ACTIVE NOT RECRUITING

Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.

Laboratoires Thea

NCT06030193 COMPLETED

Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG)

Qlaris Bio, Inc.

NCT06144918 COMPLETED

Ph2 Placebo-Controlled Study for Safety & Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Pts w/ Elevated Eye Pressure

Skye Bioscience, Inc.

NCT06394973 COMPLETED

Efficacy and Safety Assessment of T4090 Ophthalmic Solution Versus Rhopressa® Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension

Laboratoires Thea

NCT06903156 COMPLETED

Efficacy and Safety of Different Dosages of Mexidol® in Patients With Primary Open-angle Glaucoma (POAG)

Pharmasoft

NCT06441643 COMPLETED

Next Generation Rocklatan

Alcon Research

NCT05913232 COMPLETED

Study of Safety and Efficacy of H-1337 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

D. Western Therapeutics Institute, Inc.

NCT04149899 COMPLETED

Safety and IOP-Lowering Effects of WB007

Bausch & Lomb Incorporated

NCT05335122 COMPLETED

A Study to Evaluate the Efficacy and Safety of OTX-TIC (Travoprost) Intracameral Implant for Patients With Open-angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Ocular Therapeutix, Inc.

NCT04857827 COMPLETED

A Study to Evaluate Safety and Tolerability of QLS-101 in NTG

Qlaris Bio, Inc.

NCT04947124 COMPLETED

A Study to Determine the Safety and Tolerability of 2 Concentrations of QLS-101

Qlaris Bio, Inc.

NCT06249152 COMPLETED

Qlaris Study of QLS-111 in Combination With a PGA for OAG and/or OHT Patients

Qlaris Bio, Inc.

NCT06016972 COMPLETED

Qlaris Phase 2 Study of QLS-111 in POAG And/or OHT Patients

Qlaris Bio, Inc.

NCT05495269 COMPLETED

Safety and Tolerability Study of QLS-101 in Adolescents With Sturge-Weber Syndrome (SWS)-Related Glaucoma Due to Elevated Episcleral Venous Pressure (EVP)

Qlaris Bio, Inc.

NCT04830397 COMPLETED

Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension).

Qlaris Bio, Inc.

NCT06582732 COMPLETED

Performance of the Travoprost Intraocular Implant

Glaukos Corporation

NCT04761705 SUSPENDED

Safety and Efficacy Study of JV-GL1 in Patients With Open-Angle Glaucoma or Ocular Hypertension

JeniVision, Inc.

NCT04910100 COMPLETED

Nebivolol 0.5, 1.0, or Timolol 0.5 Suspension Compared to Timolol 0.5 Solution to Treat Glaucoma/Ocular Hypertension

Betaliq, Inc.

NCT01494753 COMPLETED

Pharmacokinetics, Efficacy and Safety Assessment of T2345 Compared With Active Comparator in Newly Diagnosed Patients With Open-angle Glaucoma or Ocular Hypertension

Laboratoires Thea

NCT05451329 COMPLETED

A Phase 2 Double-masked Study of VVN539 in Subjects With Elevated Intraocular Pressure

VivaVision Biotech, Inc

NCT02754596 COMPLETED

Study Comparing Travoprost Intraocular Implants to Timolol Ophthalmic Solution

Glaukos Corporation

NCT04615403 COMPLETED

Study of Exchange of Travoprost Intraocular Implant

Glaukos Corporation

NCT03960866 COMPLETED

Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucoma

Ocuphire Pharma, Inc.

NCT01699464 COMPLETED

A Study Assessing the Safety and Ocular Hypotensive Efficacy of AR-12286 in Patients With Elevated Intraocular Pressure for 3 Months

Aerie Pharmaceuticals

NCT04742283 COMPLETED

Multicenter Study Assessing the Efficacy and Safety of DE-126 Ophthalmic Solution 0.002% Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Santen Inc.

NCT03657797 COMPLETED

Phase 2 Dose-Response Study Evaluating the Safety and Efficacy of NCX 470 vs Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Nicox Ophthalmics, Inc.

NCT04405245 COMPLETED

Study to Assess the Efficacy, Safety and Tolerability of AKB-9778 Ophthalmic Solution as and Adjunct to Latanoprost in Patients With Ocular Hypertension or Open Angle Glaucoma

EyePoint Pharmaceuticals, Inc.

NCT03896633 COMPLETED

Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

Bausch & Lomb Incorporated

NCT03959592 TERMINATED

Macular Pigment and Visual Performance in Glaucoma Patients

Felipe Medeiros, MD

NCT03452033 COMPLETED

H-1337 Ophthalmic Solution Phase 1/2

Allysta Pharmaceutical

NCT04747808 COMPLETED

Study of LL-BMT1 in Patients With Elevated Intraocular Pressure

MediPrint Ophthalmics, Inc.

NCT02805257 COMPLETED

Ahmed Glaucoma Valve Surgery With Mitomycin-C

University of California, San Francisco

NCT01033422 COMPLETED

Safety and Efficacy of Daily CF101 Administered Orally in Subjects With Elevated Intraocular Pressure

Can-Fite BioPharma

NCT01064817 COMPLETED

PRM-151 in the Prevention of Scarring Following Trabeculectomy

Hoffmann-La Roche

NCT00934089 COMPLETED

A Phase 2 Study Of The 24-Hour Intraocular Pressure Lowering And Systemic Exposure Of PF-04217329

Pfizer

NCT02990143 TERMINATED

The Effectiveness of Ologen® Collagen Matrix in Preventing Intraocular Pressure (IOP) Spikes After Ahmed Glaucoma Valve Surgery (AGV-FP7)

The New York Eye & Ear Infirmary

NCT02250612 COMPLETED

SYL040012, Treatment for Open Angle Glaucoma

Sylentis, S.A.

NCT00846989 COMPLETED

Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension

Novartis Pharmaceuticals

NCT02466399 COMPLETED

POLAT-001 Compared to Latanoprost Ophthalmic Solution in Patients With Ocular Hypertension and Open-angle Glaucoma

Peregrine Ophthalmic

NCT03844945 COMPLETED

Efficacy and Systemic Safety of Netarsudil 0.01%, 0.02%, 0.04% Relative to Placebo in Subjects With Open-angle Glaucoma or Ocular Hypertension in Japan

Aerie Pharmaceuticals

NCT03292796 COMPLETED

RCT to Investigate if Prostaglandin Analogue Drops Increase the Risk of Cystoid Macular Oedema After Cataract Surgery.

Julie Dawson

NCT02358369 COMPLETED

Dose-Ranging Study of the Bimatoprost Ocular Insert

ForSight Vision5, Inc.

NCT01157364 COMPLETED

Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular Hypertension

Allergan

NCT04317573 COMPLETED

Effect on the Adherence to Glaucoma Eye Drops by Improving Patient Understanding and Using a Tele-reminder System

National University Health System, Singapore

NCT00727038 WITHDRAWN

Lucentis for New Onset Neovascular Glaucoma

University of Illinois at Chicago

NCT04205201 COMPLETED

The Effectiveness of Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma

Chittagong Medical College

NCT03310580 COMPLETED

Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals

NCT01527682 COMPLETED

Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

NCT04088084 COMPLETED

Effects of Palmitoylethanolamide on Inner Retinal Function in Glaucoma Patients by Pattern Electroretinogram

Fondazione IRCCS Policlinico San Matteo di Pavia

NCT01864317 TERMINATED

Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging

Medical University of Vienna

NCT03233308 COMPLETED

Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)

Aerie Pharmaceuticals

NCT02057575 COMPLETED

Study Assessing Safety and Efficacy of PG324 Ophthalmic Solution in Patients With Elevated Intraocular Pressure

Aerie Pharmaceuticals

NCT02537015 COMPLETED

An Open-label Extension Study to Evaluate the Safety of the 13 mg Bimatoprost Ocular Insert

ForSight Vision5, Inc.

NCT01564108 COMPLETED

The LIMO Study, Lucentis for Treatment of Uveitic Patients With Refractory Cystoid Macular Oedema

Moorfields Eye Hospital NHS Foundation Trust

NCT02143843 COMPLETED

An Open-Label Extension Study to Evaluate the Safety of the ForSight VISION5 Product

ForSight Vision5, Inc.

NCT02742649 COMPLETED

A Study to Evaluate Efficacy and Safety of a Fixed Combination Ocular Insert in Participants With Open-angle Glaucoma or Ocular Hypertension

ForSight Vision5, Inc.

NCT03065036 COMPLETED

Safety and Efficacy Study of the Hydrus Aqueous Implant in Subjects With POAG

Ivantis, Inc.

NCT01936389 COMPLETED

A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma

Robert Ritch, MD, LLC.

NCT03106532 COMPLETED

Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma

pH Pharma

NCT01707381 COMPLETED

BOL-303259-X With Timolol 0.5% in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Bausch & Lomb Incorporated

NCT02743780 COMPLETED

A Three Part Study of MGV354 in Ocular Hypertension or Glaucoma

Alcon Research

NCT03506542 COMPLETED

Phacotrabeculectomy With Collagen Matrix Implant (Ologen®) Versus Mitomycin C

Medical University of Lublin

NCT01915940 COMPLETED

Bimatoprost Ocular Insert Compared to Topical Timolol Solution in Patients With Glaucoma or Ocular Hypertension

ForSight Vision5, Inc.

NCT01528787 COMPLETED

Study of AR-13324 in Patients With Elevated Intraocular Pressure

Aerie Pharmaceuticals

NCT02179008 COMPLETED

Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension

Santen Inc.

NCT01731002 COMPLETED

Study Comparing the Safety and Efficacy of AR-13324 to Latanoprost in Patients With Elevated Intraocular Pressure

Aerie Pharmaceuticals

NCT02874846 COMPLETED

Nocturnal/Diurnal Intraocular Pressure-Lowering Effect of Netarsudil Ophthalmic Solution

Aerie Pharmaceuticals

NCT02129673 COMPLETED

A Phase 1/2 Multicenter, Randomized, Study to Evaluate the Safety and Efficacy of VS101 Subconjunctival Latanoprost Insert in Subjects With Open-Angle Glaucoma or Ocular Hypertension

ViSci Ltd.

NCT02829996 COMPLETED

Study of Fixed-Dose Combinations of Trabodenoson and Latanoprost in Adults With OHT or POAG

Inotek Pharmaceuticals Corporation

NCT02016898 COMPLETED

The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device

Duke University

NCT01917383 COMPLETED

A Phase II Study to Evaluate the Additivity of Trabodenoson to Latanoprost in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma

Inotek Pharmaceuticals Corporation

NCT00832377 COMPLETED

COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED)

Merck Sharp & Dohme LLC

NCT01298687 COMPLETED

Divided Dose of TRAVATAN®

Alcon Research

NCT01965106 COMPLETED

Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG)

Quark Pharmaceuticals

NCT02226094 TERMINATED

Safety and Efficacy of Deep Wave Trabeculoplasty (DWT) in Primary Open Angle Glaucoma and Ocular Hypertension

OcuTherix, Inc.

NCT02051946 COMPLETED

Novel Drug Delivery Technique Via Retroject Device

Molly Walsh

NCT02014142 COMPLETED

A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.

NCT02312544 COMPLETED

Phase 2b Study Evaluating Safety and Efficacy of OTX-TP Compared to Timolol Drops in the Treatment of Subjects With Open Angle Glaucoma or Ocular Hypertension

Ocular Therapeutix, Inc.

NCT00661583 COMPLETED

Use of Ranibizumab With Mitomycin C During Trabeculectomy

University of Colorado, Denver

NCT01474135 COMPLETED

AR-12286 Fixed Dose Combination to Lower Elevated Intraocular Pressure

Aerie Pharmaceuticals

NCT01912638 COMPLETED

Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma

National Centre of Ophthalmology named after academician Zarifa Aliyeva

NCT01254370 COMPLETED

Safety and Efficacy Study of Catioprost® (Unpreserved Latanoprost 0.005% Emulsion) Compared to Travatan Z® to Treat Glaucoma and Ocular Surface Disease

Santen SAS

NCT02083289 COMPLETED

A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)

Ono Pharmaceutical Co., Ltd.

NCT02140060 COMPLETED

6-Week Proof-of-Concept Study of Travoprost/Brinzolamide Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT01528111 COMPLETED

Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension

Lexicon Pharmaceuticals

NCT02114073 COMPLETED

Comparison of Effect of Postoperative Cyclosporine A 2% Ophthalmic Emulsion and Betamethasone Eye Drop on Surgical Success of Trabeculectomy Procedure

Mashhad University of Medical Sciences

NCT00824720 COMPLETED

Safety and Efficacy of a Glaucoma Drug Delivery System

Vistakon Pharmaceuticals

NCT01016691 COMPLETED

Safety and Efficacy of a Drug Delivery System in Glaucoma

Vistakon Pharmaceuticals

NCT02376114 COMPLETED

Ginkgo Biloba and Ocular Blood Flow in Primary Open-angle Glaucoma

Maisonneuve-Rosemont Hospital

NCT01863953 COMPLETED

A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension

Allergan

NCT02136940 COMPLETED

Multiple Dose-parallel-group Study of AMA0076 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

Amakem, NV

NCT01896180 COMPLETED

Study to Compare the Safety and Efficacy of ALZ-1101 to Latanoprost in Patients With Intraocular Pressure Inadequately Controlled by Latanoprost

Alleanza Pharmaceuticals, Inc.

NCT01110499 COMPLETED

Safety and Efficacy of AGN-210961 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Allergan

NCT01318252 COMPLETED

AL-54478 Proof of Concept Study

Alcon Research

NCT00761709 COMPLETED

Safety and Intraocular Pressure (IOP)-Lowering Efficacy of AL-39256 in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT00670033 COMPLETED

Travoprost New Formulations in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT01060579 COMPLETED

Study of AR-12286 Versus Latanoprost in Patients With Elevated Intraocular Pressure

Aerie Pharmaceuticals

NCT01302249 COMPLETED

AR-12286 in Combination With Latanoprost

Aerie Pharmaceuticals

NCT01330979 COMPLETED

24-hour Efficacy of AR-12286

Aerie Pharmaceuticals

NCT01789736 COMPLETED

A Study Assessing PG286 Ophthalmic Solution, 0.5% Compared to Its Individual Components for 28 Days

Aerie Pharmaceuticals

NCT01410188 COMPLETED

Safety/Efficacy Study: OPA-6566 Ophthalmic Solution in Subjects With Primary Open-Angle Glaucoma or Ocular Hypertension

Kubota Vision Inc.

NCT01037036 COMPLETED

A Study of the L-PPDS With Adjunctive Xalatan® Eye Drops in Subjects With OH or OAG

Mati Therapeutics Inc.

NCT01291108 COMPLETED

Safety and Efficacy of AGN-210669 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Open-Angle Glaucoma or Ocular Hypertension

Allergan

NCT01312454 TERMINATED

Safety and Intraocular Pressure (IOP) Lowering Effect of AL-59412C

Alcon Research

NCT01001195 COMPLETED

Safety and Efficacy of Three Formulations of AGN-210669 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution

Allergan

NCT00809848 COMPLETED

Safety and Efficacy of AGN 210669 Ophthalmic Solution in Patients With Ocular Hypertension or Primary Open-Angle Glaucoma

Allergan

NCT01481077 COMPLETED

A Dose Evaluation Study of the Effect of Plug Placement on the Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.

NCT01481051 COMPLETED

A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.

NCT00967811 COMPLETED

A Study of Different Formulations of the L-PPDS in Subjects With OH or OAG

Mati Therapeutics Inc.

NCT00845299 COMPLETED

Study of the Effects of Artificial Tears on the Response to the Latanoprost Punctal Plug Delivery System in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.

NCT00820300 COMPLETED

A Safety Study of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open Angle Glaucoma

Mati Therapeutics Inc.

NCT01229982 COMPLETED

A Study Evaluating the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.

NCT00650702 COMPLETED

Safety and Efficacy of Punctum Plug Delivery System in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Mati Therapeutics Inc.

NCT00821002 COMPLETED

A Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug Delivery System (L-PPDS)

Mati Therapeutics Inc.

NCT00855517 WITHDRAWN

A Phase 2 Study of the Latanoprost Punctal Plug Delivery System in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.

NCT01693315 COMPLETED

Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma

Amakem, NV

NCT01426867 COMPLETED

A Comfort Study of Brinzolamide 1% / Brimonidine 0.2% Fixed Combination, Brinzolamide 1% and Brimonidine 0.2%

Alcon Research

NCT00961649 TERMINATED

Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination

Alcon Research

NCT01887223 COMPLETED

Transconjunctival Needling Revision Versus Medical Treatment

University of Sao Paulo General Hospital

NCT01739244 COMPLETED

Dose Finding Clinical Trial With SYL040012 to Evaluate the Tolerability and Effect on Intraocular Pressure in Subjects With Ocular Hypertension or Open Angle Glaucoma

Sylentis, S.A.

NCT00693485 COMPLETED

Safety and Effects of Brimonidine Intravitreal Implant in Patients With Glaucomatous Optic Neuropathy

Allergan

NCT01279083 COMPLETED

Safety and Efficacy Trial to Treat Open-Angle Glaucoma or Ocular Hypertension

Santen Inc.

NCT00788541 TERMINATED

A Dose-Volume Study of a Treatment for Elevated IOP Due to Open-Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT00643669 COMPLETED

24 Hour IOP Lowering Efficacy of AL-3789

Alcon Research

NCT01123785 COMPLETED

A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma

Inotek Pharmaceuticals Corporation

NCT01227291 COMPLETED

SYL040012. Tolerance and Effect on Intraocular Pressure in Subjects With Intraocular Pressure (IOP) >= 21 mm Hg

Sylentis, S.A.

NCT01668524 COMPLETED

ATS907 Ph2a Open-Label Dose-ranging Safety and Tolerability in Primary Open Angle Glaucoma (POAG) and Ocular Hypertension (OHT) Subjects

Altheos, Inc.

NCT00650338 COMPLETED

Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension

Santen Inc.

NCT00868894 COMPLETED

Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension

Santen Inc.

NCT01114893 COMPLETED

Travoprost Five Day Posology Study

Alcon Research

NCT00753168 COMPLETED

Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma

Othera Pharmaceuticals

NCT07290244 RECRUITING

Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)

Life Biosciences Inc.

NCT06964061 ACTIVE NOT RECRUITING

Evaluate Efficacy, Safety, Tolerability and Biodegradation of PA5346 Ocular Implant in Patients With Open-Angle Glaucoma or Ocular Hypertension

PolyActiva Pty Ltd

NCT07480603 ACTIVE NOT RECRUITING

Pilot Study on a New Self Adjustable Glaucoma Drainage Device

Rheon Medical SA

NCT05206877 RECRUITING

Topical Insulin for Glaucoma

Stanford University

NCT07036510 RECRUITING

Safety of TimoD Sustained-Release Implant in Participants With Glaucoma or Ocular Hypertension Undergoing Cataract Surgery

EyeD Pharma

NCT04844619 ACTIVE NOT RECRUITING

KDR2-2 Suspension Eyedrop in the Treatment of Neovascular Glaucoma (KDR-NVG) Trial

Sun Yat-sen University

NCT04118920 ACTIVE NOT RECRUITING

Safety of Topical Insulin Drops for Open-angle Glaucoma

Centre hospitalier de l'Université de Montréal (CHUM)

NCT06267274 RECRUITING

A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes

Amneal Pharmaceuticals, LLC

NCT06506305 NOT YET RECRUITING

Clinical Study of FB1001 in Patients

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

NCT04060758 COMPLETED

Open Label, Sequential-dose Study of PA5108 Latanoprost FA SR Ocular Implant for Mild-moderate Glaucoma

PolyActiva Pty Ltd

NCT04500574 TERMINATED

Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension

Massachusetts Eye and Ear Infirmary

NCT06321562 TERMINATED

Safety and Tolerability of a Timolol Releasing Intraocular Implant in Subjects With Primary Open-angle Glaucoma

EyeD Pharma

NCT06572397 COMPLETED

Open-Label Study of Safety of H1337 in Healthy Volunteers

D. Western Therapeutics Institute, Inc.

NCT05160805 COMPLETED

A Phase 1b Study of ONL1204 Ophthalmic Solution in Patients with Progressing Open Angle Glaucoma

ONL Therapeutics

NCT04360174 COMPLETED

CLN-0045: Safety, and Efficacy of OTX-TIC in Participants With Open Angle Glaucoma or Ocular Hypertension

Ocular Therapeutix, Inc.

NCT05333419 COMPLETED

Study of a Latanoprost Ocular Implant for Treatment of Open Angle Glaucoma or Ocular Hypertension.

PolyActiva Pty Ltd

NCT05207761 COMPLETED

Study to Evaluate Drug-drug Interaction, Safety and Tolerability in Case of the Co-administration of D565 and D930

Chong Kun Dang Pharmaceutical

NCT04035239 COMPLETED

Retinal Effects of Balance Goggles System in Glaucoma Balance Goggles System (BGS) in Patients With Glaucoma

Stanford University

NCT02852057 COMPLETED

Effectiveness and Safety of Timolol and Dorzolamide Loaded Contact Lenses

University of Florida

NCT03131167 COMPLETED

Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma

Shire

NCT02984813 TERMINATED

Safety and Efficacy of Anti-Oxidants and Anti-inflammatory Agents in Glaucoma and Diabetic Retinopathy

The New York Eye & Ear Infirmary

NCT00638742 COMPLETED

A Phase 1, Open-Label Study of Latanoprost Acid Plasma Concentrations in Pediatric and Adult Glaucoma Patients Treated With Latanoprost.

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

NCT02855450 COMPLETED

Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma

Dompé Farmaceutici S.p.A

NCT03604328 COMPLETED

Safety and Tolerability of a Prostaglandin Ocular Implant for Treatment of Open Angle Glaucoma

PolyActiva Pty Ltd

NCT04188015 COMPLETED

Study of ANX007 in Participants With Primary Open-angle Glaucoma

Annexon, Inc.

NCT03488550 COMPLETED

Single-dose Study of ANX007 in Participants With Primary Open-angle Glaucoma

Annexon, Inc.

NCT03293992 COMPLETED

A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Hoffmann-La Roche

NCT04284514 COMPLETED

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AKB-9778 Ophthalmic Solution

Aerpio Therapeutics

NCT03966365 COMPLETED

Safety and Tolerability of the Preservative-free Ophthalmic Solution PRO-122 Compared With Krytantek Ofteno®

Laboratorios Sophia S.A de C.V.

NCT03965052 COMPLETED

Safety and Tolerability of the Ophthalmic Solution PRO-179 Compared With Travatan®

Laboratorios Sophia S.A de C.V.

NCT02330978 COMPLETED

Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma.

University of Sao Paulo

NCT02639975 COMPLETED

"First-in-human" Study To Assess the Safety and Tolerability of PBF-677 in Healthy Volunteers

Palobiofarma SL

NCT02967614 COMPLETED

KJ-TFC-004 Drug-drug Interaction Study

Kukje Pharma

NCT02622334 COMPLETED

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).

Hoffmann-La Roche

NCT02406833 COMPLETED

Phase I Dose Escalation Study to Investigate the Safety of ISTH0036 in Subjects With Glaucoma Undergoing Trabeculectomy

Isarna Therapeutics GmbH

NCT02102750 COMPLETED

A Study to Evaluate Pharmacokinetics of Tafluprost Ophthalmic Solution (0.0015%) in Pediatric Patients With Glaucoma or Ocular Hypertension

Santen Oy

NCT01845038 COMPLETED

Multi-Arm Feasibility Study Evaluating OTX-TP Compared to Timolol in Treatment of Subjects With Open Angle Glaucoma

Ocular Therapeutix, Inc.

NCT01408472 COMPLETED

NT-501 CNTF Implant for Glaucoma: Safety, Neuroprotection and Neuroenhancement

Jeffrey L Goldberg

NCT02531152 COMPLETED

28-Day Repeated Topical Study to Evaluate the Safety and Activity of 5 Escalating Dose Levels of SAR366234 and One Dose of Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension

Sanofi

NCT01658839 COMPLETED

Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients

Alcon Research

NCT01887873 COMPLETED

Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy

Croma-Pharma GmbH

NCT02031380 WITHDRAWN

iDropper Usability in Glaucoma

Care Team Solutions

NCT00767793 COMPLETED

A Placebo-Controlled Study of INS117548 Ophthalmic Solution in Subjects With Glaucoma (P08650)

Merck Sharp & Dohme LLC

NCT01215786 COMPLETED

Safety and Pharmacodynamics Study of AGN-207281 Ophthalmic Solutions Compared With Timolol Ophthalmic Solution or Placebo in Patients With Ocular Hypertension or Primary Open-Angle Glaucoma

Allergan

NCT02108288 COMPLETED

Pharmacokinetic Study of OPC-1085EL Ophthalmic Solution in Healthy Male Adult Volunteers

Otsuka Pharmaceutical Co., Ltd.

NCT01943721 COMPLETED

A Study of the VISION5 Product in Patients With Glaucoma or Ocular Hypertension

ForSight Vision5, Inc.

NCT01180062 TERMINATED

Safety Study of Latanoprost Slow Release Insert

Daniel Moore

NCT01384149 COMPLETED

EXTERNAL SLT Treatment in Patients With Uncontrolled OPEN ANGLE GLAUCOMA

Meir Medical Center

NCT02003547 COMPLETED

A Single Centre Study to Evaluate 3 Ophthalmic Formulations in Healthy Subjects

Amakem, NV

NCT01670266 COMPLETED

Single and Multiple Dose Escalation and Two-sequence Crossover Study of ONO-9054 in Patients With Ocular Hypertension or Mild Open-angle Glaucoma

Ono Pharma USA Inc

NCT00990743 COMPLETED

Tolerance and Effect on Intraocular Pressure After Administration of SYL040012

Sylentis, S.A.

NCT07325240 RECRUITING

24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

Mayo Clinic

NCT05821855 ACTIVE NOT RECRUITING

A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China

AbbVie

NCT07465913 NOT YET RECRUITING

Rocklatan vs Latanoprost Post-DSLT

Eye Centers of Southeast Texas

NCT07217678 RECRUITING

Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use

University of Miami

NCT07396441 RECRUITING

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

Universiti Sains Malaysia

NCT06848946 RECRUITING

Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone

Glaukos Corporation

NCT07174401 NOT YET RECRUITING

Rocklatan Retinal Perfusion OCT Study

Oregon Health and Science University

NCT05344274 RECRUITING

Retinal Blood Flow and Autoregulation

University of Maryland, Baltimore

NCT07209410 RECRUITING

Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma

Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,

NCT07228221 RECRUITING

Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma

Jonathon Myers

NCT04007276 NOT YET RECRUITING

The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients

Tulane University

NCT07048886 NOT YET RECRUITING

Rocklatan Adds Pressure Reduction After MIGS (Minimally Invasive Glaucoma Surgery)

Center for Sight Las Vegas

NCT06865144 RECRUITING

Effect of Rhopressa on Intraocular Pressure (IOP) in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Post-SLT

East Coast Institute for Research

NCT06883123 RECRUITING

Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

Prairie Eye Center

NCT06792422 RECRUITING

A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma

Glostrup University Hospital, Copenhagen

NCT06761313 ACTIVE NOT RECRUITING

Triplenex (triple Fixed Combination) Use Evaluation in Patients with Glaucoma

Federal University of São Paulo

NCT06017362 RECRUITING

Clinical Trial to Determine the Efficacy and Safety of Insulin Eye Drops in Dry Eye in Patients with Topical Hypotensors

Barbara Burgos Blasco

NCT06498440 NOT YET RECRUITING

Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT

St. Joseph's Healthcare Hamilton

NCT05498103 ACTIVE NOT RECRUITING

Use of Methazolamide to Lower Intraocular Pressure

University of Colorado, Denver

NCT04957329 RECRUITING

Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells

Rigshospitalet, Denmark

NCT07588152 NOT YET RECRUITING

Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension

Indiana University

NCT04702789 TERMINATED

Comparative Study of the Efficacy of Either Krytantek Ofteno PF® or Eliptic Ofteno PF® Plus Gaap Ofteno PF® for POAG or Ocular Hypertension.

Laboratorios Sophia S.A de C.V.

NCT06539715 COMPLETED

Comparison of Visual Field Assessments Between Three Perimeters

Gainesville Eye Associates

NCT04412096 COMPLETED

Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance

Ohio State University

NCT06437639 COMPLETED

MEXIDOL® Sequential Therapy of Patients With Primary Open-angle Glaucoma (POAG)

Pharmasoft

NCT06449352 COMPLETED

Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost

Westlake Eye Specialists

NCT06078592 COMPLETED

Comparison of Efficacy and Ocular Surface Assessment Between BRIDIN-plus and Combigan in Glaucoma or Ocular Hypertensive

CHA University

NCT06407973 TERMINATED

A Clinical Trial Comparing the OMNI Surgical System to Standard Medical Treatment in Patients With Primary Open Angle Glaucoma

Sight Sciences, Inc.

NCT05857267 COMPLETED

Dorzolamide+Timolol Multidose Preservative-free vs Dorzolamida+Timolol BAK Preserved Efficacy and Safety

Laboratorios Poen

NCT06369077 TERMINATED

How Much Does Reduced Dosing of Latanoprost and Dorzolamide-timolol Affect Pressure?

CT Glaucoma Associates

NCT01229202 WITHDRAWN

Use of Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery

Nova Scotia Health Authority

NCT01704989 WITHDRAWN

The Laser in Pseudoexfoliation (LIP) Study

Nova Scotia Health Authority

NCT04846179 COMPLETED

To Evaluate the Effect of Ginkgo Biloba Extract on Optic Nerve Head Perfusion Examined Using OCTA

Nova Scotia Health Authority

NCT02053298 COMPLETED

Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients

Universitaire Ziekenhuizen KU Leuven

NCT05283395 COMPLETED

Rocklatan® Evaluation

Aerie Pharmaceuticals

NCT04200651 TERMINATED

Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery

The New York Eye Surgery Center

NCT03875911 TERMINATED

Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy

University of California, Los Angeles

NCT01166594 COMPLETED

Use of Bevacizumab in Trabeculectomy Surgery

Sunnybrook Health Sciences Centre

NCT00666237 COMPLETED

Primary Tube Versus Trabeculectomy Study

University of Miami

NCT04676126 WITHDRAWN

Augmented Macular Pigment-containing Nutraceutical and Central Visual Function

University of the Incarnate Word

NCT02868190 COMPLETED

Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication

Glaukos Corporation

NCT01444040 COMPLETED

Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost

Glaukos Corporation

NCT01252914 COMPLETED

A Prospective Evaluation of Open-Angle Glaucoma Subjects on Two Topical Hypotensive Medications Treated With One Suprachoroidal Stent

Glaukos Corporation

NCT01252888 COMPLETED

Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents

Glaukos Corporation

NCT02873806 COMPLETED

Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents

Glaukos Corporation

NCT04465864 COMPLETED

Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert

Wolstan and Goldberg Eye Associates

NCT05474716 COMPLETED

The Effect of Topical Brimonidine on the Ocular Hemodynamics in Patients of POAG Using OCTA

Fayoum University

NCT03654885 COMPLETED

XEN-45 Gel Stent Versus Trabeculectomy in Glaucoma: Gold-Standard Pathway Study (GPS)

Allergan

NCT03949244 COMPLETED

Nailfold Capillary Blood Flow With Latanoprost Bunod

Icahn School of Medicine at Mount Sinai

NCT01922154 COMPLETED

Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma

Siriraj Hospital

NCT03648229 WITHDRAWN

African Glaucoma Laser Trial

West Virginia University

NCT02388360 COMPLETED

The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma

Maisonneuve-Rosemont Hospital

NCT04743622 COMPLETED

Comparison of Efficacy and Ocular Surface Disease Assessment Between Monoprost and BAK-preserved Latanoprost

CHA University

NCT03323164 COMPLETED

Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study

Wills Eye

NCT03612817 COMPLETED

Preservative-free Tafluprost/Timolol Fixed Combination: Morning vs Evening Dosing

Aristotle University Of Thessaloniki

NCT02802137 COMPLETED

24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy

Aristotle University Of Thessaloniki

NCT00757835 COMPLETED

24-hr IOP With Travoprost/Timolol Compared With Latanoprost/Timolol in XFG

Aristotle University Of Thessaloniki

NCT00981786 COMPLETED

24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol

Aristotle University Of Thessaloniki

NCT04654611 COMPLETED

Tafluprost Preservative Free Switch Study

Tun Hussein Onn National Eye Hospital

NCT02796560 COMPLETED

Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Université de Sherbrooke

NCT03808688 COMPLETED

Study of Rhopressa® for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting

Aerie Pharmaceuticals

NCT04352660 COMPLETED

Subconjunctival Versus Direct Mitomycin C in Trabeculectomy

University of California, San Diego

NCT02017327 COMPLETED

Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose

Laboratoires Thea

NCT04075227 COMPLETED

Topical 0.2% Loteprednol Etabonate vs. Topical 0.1% Dexamethasone in Impending Recurrent Pterygium

Wannisa Suphachearabhan

NCT00981435 COMPLETED

Steroids After Laser Trabeculoplasty for Glaucoma

Stanford University

NCT02730871 TERMINATED

Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®

Alcon Research

NCT03966560 COMPLETED

Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma

Afyon Kocatepe University Hospital

NCT02338362 COMPLETED

Inhaled Corticosteroids: Effect on Intraocular Pressure in Patients With Controlled Glaucoma

University Health Network, Toronto

NCT00811850 COMPLETED

Comparing Effects of Two Fixed Combinations Ophthalmic Solutions on Ocular Blood Flow

Allergan

NCT01170884 COMPLETED

Comparing Safety and Efficacy of Combigan® and Lumigan® With Lumigan® Alone in Glaucoma or Ocular Hypertension Subjects Treated With Xalatan®

Allergan

NCT00735449 COMPLETED

Comparing Efficacy and Safety of Combigan With Timolol Adjunctive to Xalatan in Glaucoma or Ocular Hypertension Subjects

Allergan

NCT02006693 COMPLETED

Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants

AqueSys, Inc.

NCT02061683 COMPLETED

A Study of Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension

Allergan

NCT01243567 COMPLETED

Safety and Efficacy of Bimatoprost/Timolol Fixed Combination Versus Latanoprost in Patients With Open-Angle Glaucoma Who Have Never Been Treated

Allergan

NCT03150160 COMPLETED

Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma

Novartis Pharmaceuticals

NCT02419508 COMPLETED

SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA)

Alcon Research

NCT02167035 COMPLETED

Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)

Cornerstone Health Care, PA

NCT03690622 COMPLETED

Effect of Topical Dexmedetomidine on Intraocular Pressure

Beirut Eye Specialist Hospital

NCT01298700 COMPLETED

Long-Term Safety of Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Allergan

NCT02863705 COMPLETED

Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG)

Allergan

NCT00798694 COMPLETED

How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?

Wills Eye

NCT02571712 COMPLETED

Safety of GANFORT® Ophthalmic Solution in Chinese Patients With Open-angle Glaucoma or Ocular Hypertension

Allergan

NCT02770248 COMPLETED

24-hr Intraocular Pressure Control With SIMBRINZA ®

Alcon Research

NCT01927406 WITHDRAWN

The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients.

Stanford University

NCT02681419 TERMINATED

Evaluating the Efficacy of Fenestrations in Tube Shunt Implants During the Early Postoperative Period

The University of Texas Health Science Center, Houston

NCT03395535 COMPLETED

Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension

Moorfields Eye Hospital NHS Foundation Trust

NCT01443988 COMPLETED

Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost

Glaukos Corporation

NCT01252862 COMPLETED

Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents

Glaukos Corporation

NCT03331770 COMPLETED

Efficacy and Tolerability of an Innovative Formulation of BAK-free Latanoprost

Laboratorios Poen

NCT01440751 COMPLETED

Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery

Aeon Astron Europe B.V.

NCT01677507 COMPLETED

Glaucoma Biomarkers

University of Michigan

NCT03204487 COMPLETED

A Study on the Effect of Changing From Preserved Prostaglandin Formulations to Preservative Free Tafluprost on Tear Film Thickness

Ordination Dr. Hommer

NCT01228149 COMPLETED

COSOPT-S® Treatment Versus Acetazolamide Before Trabeculectomy

Katrin Lorenz

NCT02047630 TERMINATED

Efficacy of the Brand-name Latanoprost and One of Its Generic Version in Primary Open Angle Glaucoma and Ocular Hypertension

CHU de Quebec-Universite Laval

NCT01682460 COMPLETED

Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients

University of Waterloo

NCT00906087 COMPLETED

Effect of Myocilin Genetic Variants on Intraocular Pressure and Pressure Variation in Sitting and Supine Positions

University of Michigan

NCT03104621 COMPLETED

Efficacy and Tolerability of Preservative-free 0.0015% Tafluprost in Glaucoma Patients

Gangnam Severance Hospital

NCT01155219 COMPLETED

Safety, Efficacy Assessment of Geltim LP® 1 mg/g in Ocular Hypertensive or Glaucomatous Patients.

Laboratoires Thea

NCT01315574 TERMINATED

Effects of Anti-Glaucoma Medications on the Ocular Surface

Massachusetts Eye and Ear Infirmary

NCT02325518 COMPLETED

Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution

Alcon, a Novartis Company

NCT00759239 COMPLETED

Phase IV Randomised Double-masked Clinical Trial: Assessing Morning Versus Evening Dosing of a Fixed Dose Combination of Travoprost 0.004% / Timolol Maleate 0.5% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension

Alcon Research

NCT01471158 COMPLETED

Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Glaucoma

Alcon Research

NCT01230736 COMPLETED

Safety and Efficacy of Changing to DuoTrav From Prior Therapy

Alcon Research

NCT00966576 COMPLETED

Efficacy and Safety of Adding Azarga to Prostaglandin Monotherapy

Alcon Research

NCT02003391 COMPLETED

Efficacy of Travoprost/Timolol for Uncontrolled Intraocular Pressure

Alcon Research

NCT00705757 COMPLETED

The Effects of Xalatan, Travatan and Lumigan on Skin Pigmentation Near the Eye

Summa Health System

NCT02097719 COMPLETED

Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension

Allergan

NCT02647515 COMPLETED

Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma

Ruijin Hospital

NCT00869141 COMPLETED

Earlier Intraocular Pressure Control After Ahmed Glaucoma Valve Implantation for Glaucoma

University of California, Los Angeles

NCT01881126 COMPLETED

An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension

Allergan

NCT01938287 COMPLETED

SENSIMED Triggerfish in Closed Eyes

Sensimed AG

NCT01983579 TERMINATED

TF (SENSIMED Triggerfish) in Intraocular Anti-VEGF (Vascular Endothelial Growth Factor) Injection

Sensimed AG

NCT01975714 COMPLETED

Intraocular Pressure and Tolerability Study of Preservative-free Prostaglandins (Bimatoprost and Latanoprost) on Glaucoma and Ocular Hypertension: European, Multicentric, Investigator-led, Single Masked Study

Association for Innovation and Biomedical Research on Light and Image

NCT01995136 COMPLETED

Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma

Alcon Research

NCT01518244 COMPLETED

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Latin America

Alcon Research

NCT01664039 COMPLETED

An Efficacy and Tolerability Study of TRAVATAN® Versus LUMIGAN®

Alcon Research

NCT01111890 COMPLETED

Comparison of the Efficacy of AZARGA® Versus COSOPT® in Patients With Open-Angled Glaucoma or Ocular Hypertension

Alcon Research

NCT01937312 COMPLETED

Effect of SIMBRINZA® Suspension as an Added Therapy to a Prostaglandin Analogue

Alcon Research

NCT00941525 COMPLETED

Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure

Aristotle University Of Thessaloniki

NCT01592955 COMPLETED

Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU)

EyeTechCare

NCT00913029 COMPLETED

Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG)

Glaukos Corporation

NCT00911924 COMPLETED

A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma

Glaukos Corporation

NCT01937299 COMPLETED

Effect of SIMBRINZA® Suspension as an Added Therapy to TRAVATAN Z®

Alcon Research

NCT01979913 COMPLETED

An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More

Dr. Anton Hommer

NCT00887029 COMPLETED

A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma

Ophthalmic Consultants Centres, Canada

NCT01978600 COMPLETED

Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT00804648 COMPLETED

Patient Satisfaction With Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Vistakon Pharmaceuticals

NCT01514721 TERMINATED

Efficacy of Changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5% BAK-Free Fixed Combination) From Prior Therapy

Alcon Research

NCT00913562 WITHDRAWN

Effect of Rosuvastatin on Endothelial Function in Patients With Diabetes and Glaucoma

Medical University of Vienna

NCT01369771 COMPLETED

The Effects of Preservative-free Prostaglandin Eye Drops in Sign and Symptoms on the Eyes of Patients With Glaucoma

FinnMedi Oy

NCT00967694 COMPLETED

Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers

Oregon Health and Science University

NCT01547598 COMPLETED

Safety and Efficacy of LUMIGAN® RC Versus DuoTrav® in Patients Who Require Further Intraocular Pressure (IOP) Reduction

Allergan

NCT02003534 COMPLETED

A Study of 0.15% Brimonidine Tartrate in Patients With Primary Open Angle Glaucoma and Ocular Hypertension

Allergan

NCT02020512 COMPLETED

A Study of 0.03% Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension

Allergan

NCT01415401 COMPLETED

Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada

Alcon Research

NCT01271686 COMPLETED

24-hour IOP-lowering Effect of 0.01% Bimatoprost

University of California, San Diego

NCT01510145 COMPLETED

Efficacy of Changing to TRAVATAN® From Prior Therapy

Alcon Research

NCT01263444 COMPLETED

Safety and Efficacy of Adding AZARGA® Adjunctive to Prostaglandin Therapy

Alcon Research

NCT01493427 COMPLETED

Efficacy of Changing to TRAVATAN® From Prior Therapy

Alcon Research

NCT00972257 COMPLETED

24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination

Aristotle University Of Thessaloniki

NCT01779284 COMPLETED

Travoprost/Timolol vs Latanoprost/Timolol Fixed Combination Therapy

Aristotle University Of Thessaloniki

NCT01448837 COMPLETED

24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice

Aristotle University Of Thessaloniki

NCT01327599 COMPLETED

Efficacy of Changing to DUOTRAV® From Prior Therapy

Alcon Research

NCT01340014 COMPLETED

Patient Preference Comparison of AZARGA Versus COSOPT

Alcon Research

NCT01594970 COMPLETED

A Safety and Efficacy Study of Bimatoprost 0.01% in Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OH)

Allergan

NCT01525173 COMPLETED

A Safety and Efficacy Study of ALPHAGAN® P and LUMIGAN® in Subjects Previously Treated With Latanoprost for Glaucoma and Ocular Hypertension

Allergan

NCT01514734 TERMINATED

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brimonidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Brazil

Alcon Research

NCT01833741 COMPLETED

A Study of LUMIGAN® RC in the Clinical Setting

Allergan

NCT01464424 COMPLETED

Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®)

Alcon Research

NCT01336569 COMPLETED

Safety and Efficacy of Changing to DuoTrav in Patients Uncontrolled on Timolol

Alcon Research

NCT01162603 COMPLETED

Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP)

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

NCT01484951 COMPLETED

AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure

Alcon Research

NCT00800540 COMPLETED

Circadian Ocular Perfusion Pressure and Ocular Blood Flow

Alcon Research

NCT01696383 WITHDRAWN

Assessing the Efficacy of DuoTrav as a Replacement Therapy in Glaucoma Patients in Russia

Alcon Research

NCT01151904 TERMINATED

Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients

Allergan

NCT01055366 COMPLETED

ELAZOP Switching Study in Korea

Alcon Research

NCT01253902 COMPLETED

Ocular Surface Tolerability Study of Prostaglandin Analogues in Patients With Open-Angle Glaucoma or Ocular Hypertension

Allergan

NCT01510132 WITHDRAWN

Travacom Post Marketing Surveillance Study

Alcon Research

NCT00828906 COMPLETED

DuoTrav® Eye Drops As Replacement Therapy Program

Alcon Research

NCT01263535 TERMINATED

Use of an Ocular Telemetry Sensor in Tafluprost Treated Patients

Sensimed AG

NCT00761995 COMPLETED

Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Reducing Intraocular Pressure in Patients With Open Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT00966940 COMPLETED

Efficacy and Safety of Travoprost 0.004% Versus Tafluprost 0.0015% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension

Alcon Research

NCT00798759 COMPLETED

Examination of Ocular Surface Effects With Administration of Travatan Z and XALATAN

Alcon Research

NCT00708422 COMPLETED

Effects of Travatan Z and Xalatan on Ocular Surface Health

Alcon Research

NCT01540331 COMPLETED

Efficacy And Safety of Pneumatic Trabeculoplasty

University of Catanzaro

NCT00811564 COMPLETED

An Evaluation of the Fixed Combination Brimonidine Tartrate 0.2%/ Timolol Maleate 0.5% to Latanoprost 0.005% in Glaucoma or Ocular Hypertension Subjects

Allergan

NCT00972426 COMPLETED

A Study to Evaluate Efficacy and Safety Effects Using Mikelan® LA Ophthalmic Solution (OS) 2% Versus Timoptol® XE Ophthalmic Solution (OS) 0.5% in Ocular Hypertension Patients

Taiwan Otsuka Pharm. Co., Ltd

NCT01273285 TERMINATED

Reproducibility of Nerve Fiber Layer Thickness Measurements in Patients With Glaucoma and Healthy Controls Using Spectral-Domain and Time-Domain OCT

University of Zurich

NCT00941096 COMPLETED

Intraocular Pressure Reduction With the Bimatoprost/Timolol Fixed Combination

Larissa University Hospital

NCT01228721 TERMINATED

Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and Retest Function of Spectralis® SD-OCT in Glaucomatous Eyes and Healthy Controls

University of Zurich

NCT00607685 COMPLETED

5FU vs 5FU With Viscoelastic Formulation for the Prevention of Scarring Post-trabeculectomy

Singapore National Eye Centre

NCT00698945 COMPLETED

Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG)

Bp Consulting, Inc

NCT00801658 COMPLETED

Efficacy of SLT in Patients With Insufficient IOP Control Under Maximum Tolerated Drug Therapy (Eye Drops)

University of Zurich

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only