TheraRadar
Landscape Oncology

Hodgkin Lymphoma Clinical Trial Landscape

Data updated: May 20, 2026

475 clinical trials tracked since 2008

Hodgkin Lymphoma is being studied across 475 clinical trials registered since 2008, with 159 programs currently active. The competitive pipeline includes 13 active Phase 3 trials, 115 active Phase 2 trials, and 54 active Phase 1 trials. Top industry sponsors include Merck, Takeda, Tessa Therapeutics.

159 active
/
475 total (since 2008)
54
Phase 1 Active
210 total
115
Phase 2 Active
303 total
13
Phase 3 Active
36 total
3
Phase 4 Active
4 total

Top Industry Sponsors

Sorted by active Active Done Failed
Merck 3 8 0
Takeda 2 2 0
Tessa Therapeutics 2 0 0
AstraZeneca 1 1 0
Akeso 1 1 0

+ 10 more sponsors — see full table below

Featured Phase 3 Trials

NCT05675410 RECRUITING
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
National Cancer Institute (NCI) n=1,875
NCT02166463 ACTIVE NOT RECRUITING
Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB, Stage IIIB, IVA, or IVB Hodgkin Lymphoma
National Cancer Institute (NCI) n=600
NCT03907488 ACTIVE NOT RECRUITING
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
National Cancer Institute (NCI) n=994
NCT04685616 RECRUITING
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
University College, London n=1,042
NCT06563245 RECRUITING
Brentuximab Vedotin for Newly Diagnosed cHL in Chinese CAYA Based on PET/CT Assessment
Children's Cancer Group, China n=96

+ 31 more Phase 3 trials — see full database below

Hodgkin Lymphoma — Trials Started by Year (last 10 years)

2016
30
2017
35
2018
29
2019
24
2020
18
2021
19
2022
27
2023
18
2024
29
2025
18
2026
14

TheraRadar.com

Full Trial Database

Complete sponsor table, every trial across all phases, plus competitive analytics. Sortable, filterable, exportable for Pro users.

Top Sponsors (all-time)

Merck
11
Takeda
4
Tessa Therapeutics
2
AstraZeneca
2
Akeso
2
Compass Therapeutics
1
FBD Biologics Limited
1
VIVUS LLC
1
MacroGenics
1
GSK
1

Active Trials by Phase

Phase 1
54
Phase 2
115
Phase 3
13
Phase 4
3

Enrollment Size Distribution

1-50
267
51-200
155
201-500
23
501-1k
5
1k+
7

All Industry Sponsors

Sorted by active Active Done Failed
Merck 3 8 0
Takeda 2 2 0
Tessa Therapeutics 2 0 0
AstraZeneca 1 1 0
Akeso 1 1 0
Compass Therapeutics 1 0 0
FBD Biologics Limited 1 0 0
VIVUS LLC 1 0 0
MacroGenics 1 0 0
GSK 1 0 0
Immunitas Therapeutics 1 0 0
Marker Therapeutics, Inc. 1 0 0
Bio-Path Holdings, Inc. 1 0 0
Checkpoint Therapeutics, Inc. 1 0 0
Innolake Biopharm 1 0 0
NCT07572123 NOT YET RECRUITING
Evaluating the Addition of Maintenance Immunotherapy Compared to the Usual Treatment of Chemotherapy and Autologous Stem Cell Transplant Alone for High-risk Patients With Relapsed or Refractory Hodgkin Lymphoma
National Cancer Institute (NCI) n=374
NCT05675410 RECRUITING
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
National Cancer Institute (NCI) n=1,875
NCT02166463 ACTIVE NOT RECRUITING
Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB, Stage IIIB, IVA, or IVB Hodgkin Lymphoma
National Cancer Institute (NCI) n=600
NCT03907488 ACTIVE NOT RECRUITING
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
National Cancer Institute (NCI) n=994
NCT04685616 RECRUITING
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
University College, London n=1,042
NCT06563245 RECRUITING
Brentuximab Vedotin for Newly Diagnosed cHL in Chinese CAYA Based on PET/CT Assessment
Children's Cancer Group, China n=96
NCT07256158 NOT YET RECRUITING
PET Guided Dose Reduction for InvOlved Site Radiotherapy In Early sTage Unfavourable Hodgkin Lymphoma
Fondazione Italiana Linfomi - ETS n=518
NCT04459416 ACTIVE NOT RECRUITING
Managing Pain and Symptom Burden Caused by Chemotherapy in People With Myeloma or Lymphoma
Memorial Sloan Kettering Cancer Center n=299
NCT05595447 RECRUITING
Treatment Strategy for Relapsed/Refractory Hodgkin Lymphoma
Hospital Regional de Alta Especialidad del Bajio n=20
NCT06170489 RECRUITING
A Phase III Clinical Study Comparing JS004 Plus Toripalimab With Investigator-Selected Chemotherapy in Patients With PD-(L)1monoclonal Antibody Refractory Classic Hodgkin Lymphoma (cHL)
Shanghai Junshi Bioscience Co., Ltd. n=185
NCT04638790 RECRUITING
First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia (HL-Russia-1)
State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia n=300
NCT06465446 NOT YET RECRUITING
A Study of IMM01 Plus Tiselizumab Versus Physician's Choice Chemotherapy in PD(L)1-refractory Classical Hodgkin Lymphoma
ImmuneOnco Biopharmaceuticals (Shanghai) Inc. n=202
NCT02661503 ACTIVE NOT RECRUITING
HD21 for Advanced Stages
University of Cologne n=1,500
NCT01231412 COMPLETED
Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant
Fred Hutchinson Cancer Center n=174
NCT02684708 COMPLETED
Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents
University of Giessen n=2,921
NCT07450508 COMPLETED
Study of Bendamustine, Gemcitabine and Vinorelbine Regimen in Relapsed/Refractory Classical Hodgkin Lymphoma
Cairo University n=88
NCT04486391 TERMINATED
Tislelizumab Monotherapy Versus Salvage Chemotherapy for Relapsed/Refractory Classical Hodgkin Lymphoma
BeiGene n=3
NCT01712490 COMPLETED
A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma
Takeda n=1,334
NCT02684292 COMPLETED
Study of Pembrolizumab (MK-3475) vs. Brentuximab Vedotin in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (MK-3475-204/KEYNOTE-204)
Merck Sharp & Dohme LLC n=304
NCT01358747 COMPLETED
Study of a Treatment Driven by Early PET Response to a Treatment Not Monitored by Early PET in Patients With AA Stage 3-4 or 2B HL
Centre Hospitalier Universitaire Dijon
NCT03159897 COMPLETED
FIL Study on ABVD DD-DI as Upfront Therapy in HL.
Fondazione Italiana Linfomi - ETS n=500
NCT05181540 TERMINATED
A Study of the Effects of AB-205 in Patients With Lymphoma Undergoing Autologous Hematopoietic Cell Transplantation
Angiocrine Bioscience n=130
NCT05711628 WITHDRAWN
A Trial Comparing Chemotherapy Versus Novel Immune Checkpoint Inhibitor (Pembrolizumab) Plus Chemotherapy in Treating Relapsed/Refractory Classical Hodgkin Lymphoma
National Cancer Institute (NCI)
NCT01026220 COMPLETED
Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma
Children's Oncology Group n=166
NCT02566395 COMPLETED
Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies
Northwell Health n=10
NCT01597778 COMPLETED
Double Cord Versus Haploidentical (BMT CTN 1101)
Medical College of Wisconsin n=368
NCT00992030 TERMINATED
R-ABVD vs ABVD-RT in Early Stage Hodgkin's Lymphoma
Fondazione Michelangelo n=112
NCT01652261 WITHDRAWN
Very Early FDG-PET/CT-response Adapted Therapy for Advanced Hodgkin Lymphoma (H11)
European Organisation for Research and Treatment of Cancer - EORTC
NCT01987596 TERMINATED
Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer
Barbara Ann Karmanos Cancer Institute n=23
NCT03242902 COMPLETED
To Decrease Fatigue With Light Therapy
The Netherlands Cancer Institute n=166
NCT01356680 COMPLETED
HD17 for Intermediate Stage Hodgkin Lymphoma
University of Cologne n=1,100
NCT01305200 COMPLETED
Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant
Children's Oncology Group n=226
NCT00928018 COMPLETED
Tacrolimus/Sirolimus/Methotrexate vs Tacrolimus/Methotrexate or Cyclosporine/Mycophenolate Mofetil for GVHD Prophylaxis After Reduced Intensity Allogeneic Stem Cell Transplantation for Patients With Lymphoma
Dana-Farber Cancer Institute n=139
NCT00784537 COMPLETED
High-dose Chemotherapy and Stem Cell Transplantation, in Patients PET-2 Positive, After 2 Courses of ABVD and Comparison of RT Versus no RT in PET-2 Negative Patients
Fondazione Italiana Linfomi - ETS n=520
NCT01034163 COMPLETED
A Phase III Randomized, Double Blind, Placebo Controlled Multi-center Study of Panobinostat for Maintenance of Response in Patients With Hodgkin's Lymphoma (HL)
Novartis Pharmaceuticals n=41
NCT00799461 COMPLETED
Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium n=1,337

Full Hodgkin Lymphoma Pipeline

Every sponsor, every trial across Phase 1–4. Sortable, filterable, exportable.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards · Industry sponsors only