TheraRadar
Data updated: May 26, 2026

BLUJEPA (gepotidacin mesylate)

First-in-Class Priority Review
Infectious Disease Approved 2025-03-25

BLUJEPA is an antibacterial medication that treats uncomplicated urinary tract infections in adult women and adolescent girls. It also helps patients with uncomplicated urogenital gonorrhea, specifically those who have few or no other treatment options available. To help prevent the development of drug-resistant bacteria, this medication is used only when an infection is proven or strongly suspected to be bacterial in nature.

How BLUJEPA Works

This medication works by inhibiting bacterial type II topoisomerase, an enzyme essential for bacterial function. By targeting this specific protein, the drug interferes with the bacteria's ability to thrive, which helps clear the infection from the body.

2
Indications
--
Phase 3 Trials
2
Priority Reviews
1
Years on Market

Details

Status
Prescription
First Approved
2025-03-25
Patent Cliff
2042

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Routes
ORAL
Dosage Forms
TABLET

Companies

Active Ingredient: GEPOTIDACIN MESYLATE

BLUJEPA Approval History

2026
Original
New Indication
New Form
Label Update
2 FDA actions from 2025 to 2025 · 1 indication expansions
Dec 2025 SUPPL Priority
Efficacy
Mar 2025 ORIGINAL Priority
New Drug · Type 1 - New Molecular Entity

What BLUJEPA Treats

2 indications

BLUJEPA is approved for 2 conditions since its original approval in 2025. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Urinary Tract Infection
  • Urogenital Gonorrhea
Source: FDA Label

BLUJEPA Competitive Set

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Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

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Active Pipeline

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Key Completed Trials

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Trial Timeline

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

BLUJEPA FDA Label Details

Indications & Usage

FDA Label (PDF)

BLUJEPA is indicated for the treatment of Urinary Tract Infection; Urogenital Gonorrhea.

View full patent landscape →
3 OB patents · 2 families · 80 international docs across 35 countries

BLUJEPA Patents & Exclusivity

Latest Patent: Dec 2042
Exclusivity: Mar 2035

Patents (4 active)

US12528809 Expires Dec 13, 2042
US10702521 Expires Aug 20, 2035
US11229646 Expires Aug 20, 2035
US8389524 Expires Feb 12, 2029

Exclusivity

I-978 Until Dec 2028
NCE Until Mar 2030
GAIN Until Mar 2035
Source: FDA Orange Book

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Patent Timeline

  • Cliff: 2042
  • 5 active patents

Trial Analysis

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  • Development stage analysis

Competitive Landscape

  • 20 similar drugs
  • Same target/indication analysis
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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.