CHIRHOSTIM (secretin synthetic human)
ChiRhoStim is a synthetic hormone used to help clinicians diagnose issues with the pancreas and certain digestive tumors. It helps patients with suspected pancreatic exocrine dysfunction by stimulating the release of bicarbonate-rich fluids for evaluation. Additionally, it is used to help identify gastrinomas and to assist physicians in locating anatomical structures like the ampulla of Vater during endoscopic procedures.
How CHIRHOSTIM Works
This drug works by binding to secretin receptors on pancreatic duct cells, which opens CFTR channels and triggers the release of large volumes of bicarbonate-rich fluid. It mimics the action of a natural hormone usually released by the small intestine in response to acid or nutrients. The drug may also stimulate these secretions through neural pathways involving the vagus nerve.
Details
- Status
- Prescription
- First Approved
- 2004-04-09
- Routes
- INTRAVENOUS
- Dosage Forms
- FOR SOLUTION
CHIRHOSTIM Approval History
What CHIRHOSTIM Treats
2 indicationsCHIRHOSTIM is approved for 2 conditions since its original approval in 2004. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Pancreatic Exocrine Dysfunction
- Gastrinoma
CHIRHOSTIM Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
MoA expansion candidates
Same target(s), different indications — where else is this mechanism being explored?
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
CHIRHOSTIM FDA Label Details
Indications & Usage
FDA Label (PDF)CHIRHOSTIM is indicated for the treatment of Pancreatic Exocrine Dysfunction; Gastrinoma.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.