HICON (sodium iodide i-131)
HICON is a radioactive medication used for patients with hyperthyroidism or specific types of thyroid cancer. It helps patients with overactive thyroid glands or thyroid carcinoma by delivering targeted radiation directly to the affected tissue. This treatment is typically prescribed when a patient requires a radioactive approach to manage their thyroid condition.
How HICON Works
This drug works by entering thyroid follicular cells through the sodium-iodide symporter protein, where it reaches concentrations much higher than in the blood. Once inside, it is processed by thyroid peroxidase and incorporated into thyroglobulin. The therapeutic effect comes from beta emissions released by the I-131 isotope, which target the thyroid cells.
Details
- Status
- Prescription
- First Approved
- 2003-01-24
- Routes
- ORAL
- Dosage Forms
- SOLUTION
HICON Approval History
What HICON Treats
2 indicationsHICON is approved for 2 conditions since its original approval in 2003. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Hyperthyroidism
- Thyroid Carcinoma
HICON Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
What's emerging in HICON's indications
See all emerging drugs →Phase 3 candidates targeting molecules with no FDA-approved drug, in indications HICON treats. First-in-class if their pivotal trials read out positive.
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Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
HICON FDA Label Details
Indications & Usage
FDA Label (PDF)HICON is indicated for the treatment of Hyperthyroidism; Thyroid Carcinoma.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.