TheraRadar
Data updated: Jul 17, 2026

OXAYDO (oxycodone hydrochloride) · ZYLA

Pain Approved 2011-06-17

OXAYDO is FDA-approved to treat 1 condition (same as ROXYBOND).

1
Indication
--
Phase 3 Trials
1
Priority Reviews
15
Years on Market

Details

Status
Discontinued
First Approved
2011-06-17
Routes
ORAL
Dosage Forms
TABLET

Companies

Active Ingredient: OXYCODONE HYDROCHLORIDE

OXAYDO Approval History

2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
32 FDA actions from 2011 to 2026
Jun 2026 SUPPL
Update · REMS
Dec 2025 SUPPL
Label · Labeling
Oct 2024 SUPPL
Update · REMS

What OXAYDO Treats

1 indications

OXAYDO is approved for 1 conditions since its original approval in 2011. These indications span multiple therapeutic areas including oncology, immunology, and more.

Same approved indications as ROXYBOND (same active ingredient).

Source: FDA Label
📋

Clinical Trial Registry

12 trials
Trial Sponsor ID Phase Status Title
NCT02536209 MT-8554-E03 Ph 1 completed A Study to Investigate the Pharmacodynamic Effect of Single Doses of MT-8554 in Healthy Subjects
NCT04240626 1452523 Ph 4 active not recruiting Multimodal Analgesia Effect on Post Surgical Patient
NCT03685188 WCH2018086 Ph 4 enrolling by invitation Oxycodone and Sufentanil for Analgesia in Hip Surgery
NCT06444997 B2024-161R Ph 4 not yet recruiting Efficacy and Safety of Oxycodone Hydrochloride for Long-term Analgesia in ICU Patients
NCT02531906 I 262314 NCI-2015-01338, I 262314 Ph 1 completed Gabapentin, Methadone Hydrochloride, and Oxycodone Hydrochloride in Improving Quality of Life in Patients With Stage II-IV Head and Neck Cancer During Chemoradiation
NCT03586934 ORA 17071004 Ph 3 withdrawn Multimodal Analgesia in Shoulder Arthroplasty
NCT01643772 results posted OXYC09-CN-102 Ph 1 completed OxyNorm® Capsules (Immediate-Release) Pharmacokinetic (PK) Study
NCT02660229 SWITCH results posted OXI15-KR-401 Ph 4 completed An Interventional Study for Patient With Cancer Pain to Evaluate the Efficacy and Safety of OxyNorm® Compared to Morphine Sulfate Through the IV Continuous Infusion.
NCT03254459 results posted INS005-17-111 Ph 2 completed Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain
NCT00626600 OXI3001 2007-005101-21 Ph 3 terminated A Study to Assess the Safety and Tolerability of Oxycodone Hydrochloride 50mg/mL Administered as an Infusion
NCT00801788 OC-EG-001 Ph 1 completed Single Dose Pharmacokinetics of Egalet® Oxycodone
NCT01530542 K234-10-1001 B4501006 Ph 1 completed A Clinical Study To Characterize The Pharmacokinetics And The Effects Of Food On Oxycodone In Healthy Volunteers
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Active Pipeline

Pro

Ongoing clinical trials by development phase

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Key Completed Trials

Pro

Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

OXAYDO FDA Label Details

Indications & Usage

FDA Label (PDF)

OXAYDO is FDA-approved to treat 1 condition — same approved indications as ROXYBOND.

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.