Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Treatments by Mechanism

Top 12 mechanisms across 50 industry trials with a known mechanism of action.

See full pipeline →

Sodium Channel Blocker

8 trials 2 active 1 sponsor

Nonsteroidal Anti-inflammatory Drug

12 trials 8 sponsors

Opioid Agonist

5 trials 3 sponsors

Partial Opioid Agonist

5 trials 4 sponsors

Mu-opioid receptor

4 trials 4 sponsors

Prostaglandin E1 Analog

4 trials 3 sponsors

Amide Local Anesthetic

3 trials 1 sponsor

Mu-opioid receptor/Norepinephrine transporter/Serotonin transporter

2 trials 2 sponsors

MOR/NET

2 trials 2 sponsors

AXL/FLT-3/KIT/MER/MET/RET/ROS1/TIE-2/TRKB/TYRO3/VEGFR-1/VEGFR-2/VEGFR-3

2 trials 1 sponsor

opioid receptor

2 trials 2 sponsors

Anti-anginal

1 trials 1 sponsor

MoA derived from FDA pharmClassEpc when intervention matches an approved drug. Codenamed clinical-stage assets without an approved counterpart show "—" and aren't grouped here — they're still in the phase tables below.

Clinical Pipeline by Phase

462 industry-sponsored trials across 173 sponsors

Showing 50 of 50 trials

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	RECRUITING	2027-01-30	NCT07538570
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2025-10-27	NCT06887959
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2025-10-24	NCT06887972
HALEON	Voltaren Gel	—	COMPLETED	2024-10-29	NCT06379893
EMS	DEC103	—	COMPLETED	2023-12-01	NCT05800392
Bayer	Naproxen Sodium (Aleve, BAY117031)	—	COMPLETED	2020-10-02	NCT04307940
Purdue Pharma, Canada	Methoxyflurane 3mL	—	COMPLETED	2020-03-30	NCT03868436
VistaPharm, Inc.	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2019-08-21	NCT01959204
Cumberland Pharmaceuticals	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2019-07-02	NCT02583399
Taiwan Mundipharma Pharmaceuticals Ltd.	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2018-12-31	NCT03176199
Taiwan Mundipharma Pharmaceuticals Ltd.	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2018-12-31	NCT03176121
Mundipharma SAS	Methoxyflurane	—	COMPLETED	2018-12-20	NCT03798899
Menarini Group	Tramadol Hydrochloride/Dexketoprofen Trometamol	—	COMPLETED	2017-02-14	NCT02777970
Pacira Pharmaceuticals, Inc	EXPAREL	Amide Local Anesthetic [EPC]	COMPLETED	2017-02-08	NCT02713490
Mallinckrodt	IV Acetaminophen (Treatment A)	—	COMPLETED	2016-06-13	NCT02678416
Mallinckrodt	Oral Acetaminophen	—	COMPLETED	2016-03	NCT02848729
Depomed	diclofenac potassium oral solution	—	COMPLETED	2016-01	NCT02287350
GSK	IODEX® balm	—	COMPLETED	2015-05	NCT02424565
Pacira Pharmaceuticals, Inc	EXPAREL	Amide Local Anesthetic [EPC]	COMPLETED	2015-04	NCT02199574
Pacira Pharmaceuticals, Inc	Bupivacaine SNB	—	COMPLETED	2015-03	NCT02284386
Pacira Pharmaceuticals, Inc	Bupivacaine FNB	—	COMPLETED	2015-03	NCT02255500
Future Sciene Technology	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2015-02	NCT02327338
Mundipharma Korea Ltd	buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2014-11	NCT01983111
Cumberland Pharmaceuticals	IV ibuprofen	—	COMPLETED	2014-08	NCT01901393
Depomed	Zipsor®	—	COMPLETED	2014-05	NCT01982539
Cumberland Pharmaceuticals	Intravenous ibuprofen	—	COMPLETED	2012-12	NCT01334957
Cumberland Pharmaceuticals	Intravenous ibuprofen	—	COMPLETED	2012-09	NCT01334944
Roxane Laboratories	Morphine Sulfate	Mu-opioid receptor	COMPLETED	2012-04	NCT01322360
Takeda	Tinoridine HCl	—	COMPLETED	2011-10	NCT01224756
Nang Kuang Pharmaceutical Co., Ltd.	Carbatin	—	COMPLETED	2011-06	NCT02074267
Nang Kuang Pharmaceutical Co., Ltd.	Smilon®	—	COMPLETED	2010-08	NCT01119924
Boston Scientific Corporation	—	—	COMPLETED	2009-08	NCT00871819
Janssen Korea, Ltd., Korea	Hydromorphone HCl OROS	—	COMPLETED	2009-08	NCT01006356
Johnson & Johnson Taiwan Ltd	Tramadol hydrochloride	Mu-opioid receptor/Norepinephrine transporter/Serotonin transporter	COMPLETED	2009-03	NCT00766675
Pfizer	morphine sulfate extended release capsules	—	COMPLETED	2008-11	NCT00640042
Wyeth is now a wholly owned subsidiary of Pfizer	ibuprofen Formulation 1	—	COMPLETED	2008-11	NCT00740857
Mallinckrodt	XARTEMIS XR	—	TERMINATED	2017-04-26	NCT02508935
GSK	Paracetamol and caffeine	—	TERMINATED	2017-02-06	NCT02974114
Mallinckrodt	IV acetaminophen	—	TERMINATED	2016-05-05	NCT02746263
Pacira Pharmaceuticals, Inc	Intrathecal morphine injection	—	TERMINATED	2015-06	NCT02353754
Pacira Pharmaceuticals, Inc	EXPAREL	Amide Local Anesthetic [EPC]	TERMINATED	2013-12	NCT01919190
Boston Scientific Corporation	—	—	TERMINATED	2013-05	NCT01036529
Orexo AB	SL fentanyl	—	TERMINATED	2011-12-07	NCT01315886
Pfizer	morphine sulfate and naltrexone hydrochloride (EMBEDA)	—	TERMINATED	2011-04	NCT01179191
Janssen Pharmaceutica	Osmotic Release Oral System (OROS) hydromorphone	—	TERMINATED	2010-09	NCT01648699
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	Celecoxib	Nonsteroidal Anti-inflammatory Drug [EPC]	TERMINATED	2010-01	NCT00894790
Gilead	Ranolazine	Anti-anginal [EPC]	TERMINATED	2009-06	NCT00832572
Johnson & Johnson Taiwan Ltd	Tramadol /acetaminophen	—	TERMINATED	2009-02	NCT00766402
ZARS Pharma Inc.	lidocaine 70mg and tetracaine 70mg topical patch	—	SUSPENDED	2013-04	NCT00747669
Janssen Scientific Affairs, LLC	Nucynta ER	MOR/NET	WITHDRAWN	2012-08	NCT01631513

Showing 100 of 162 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Ensysce Biosciences	PF614 capsule	—	RECRUITING	2026-08	NCT06602271
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.	Experimental: YZJ-4729	—	NOT YET RECRUITING	2026-06	NCT06890533
AFT Pharmaceuticals, Ltd.	Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion)	—	NOT YET RECRUITING	2026-10	NCT07225634
AFT Pharmaceuticals, Ltd.	Combogesic® tablets	—	NOT YET RECRUITING	2026-10	NCT07225140
Cessatech A/S	CT001	—	COMPLETED	2025-05-09	NCT06364072
Pharmbio Korea Co., Ltd.	PBK_L1704 0.35mg	—	COMPLETED	2025-02-28	NCT05509868
Viatris Specialty LLC	MR-107A-02	—	COMPLETED	2025-01-31	NCT06215859
Tris Pharma, Inc.	Cebranopadol	—	COMPLETED	2025-01-31	NCT06423703
Tris Pharma, Inc.	Cebranopadol 400 ug	—	COMPLETED	2024-12-30	NCT06545097
Xgene Pharmaceutical Group	XG005 tablet	—	COMPLETED	2024-08-29	NCT06017999
Viatris Specialty LLC	MR-107A-02	—	COMPLETED	2024-08-24	NCT06215820
Eurofarma Laboratorios S.A.	FDC of oxycodone 5 mg/ibuprofen 400 mg	—	COMPLETED	2024-05-28	NCT05081102
Eurofarma Laboratorios S.A.	FDC of codeine 30 mg/dipyrone 500 mg	—	COMPLETED	2024-05-28	NCT04972292
Johnson & Johnson Consumer Inc. (J&JCI)	Acetaminophen/Naproxen Sodium Fixed Combination	—	COMPLETED	2024-05-25	NCT05868122
Johnson & Johnson Consumer Inc. (J&JCI)	Acetaminophen/Naproxen Sodium Fixed Combination	—	COMPLETED	2024-05-17	NCT05761574
Vertex Pharmaceuticals Incorporated	SUZ	—	COMPLETED	2023-12-15	NCT05553366
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2023-12-12	NCT05661734
Jiangsu HengRui Medicine Co., Ltd.	SHR8554 Injection	—	COMPLETED	2023-10-19	NCT05375305
Cessatech A/S	CT001	—	COMPLETED	2023-10-05	NCT05508594
Vertex Pharmaceuticals Incorporated	Suzetrigine (SUZ)	—	COMPLETED	2023-08-25	NCT05558410
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Meloxicam Nanocrystal Injection	—	COMPLETED	2023-07-11	NCT06379165
Nobelpharma	NPC-06	—	COMPLETED	2023-05-29	NCT05480553
Unither Pharmaceuticals, France	Paracetamol Uniflash 125mg	—	COMPLETED	2022-11-08	NCT04640376
Vivozon Pharmaceutical Inc.	VVZ-149 Injections	—	COMPLETED	2022-11-03	NCT05764525
Unither Pharmaceuticals, France	Paracetamol 500 Mg Oral Tablet X2	—	COMPLETED	2022-10-12	NCT04622735
Medical Developments International Limited	Methoxyflurane	—	COMPLETED	2022-06-15	NCT03215056
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2022-01-19	NCT05297669
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2021-12-29	NCT04526132
Neurana Pharmaceuticals, Inc.	Tolperisone Hydrochloride	—	COMPLETED	2021-12-13	NCT04671082
Jiangsu HengRui Medicine Co., Ltd.	SHR8554 Injection	—	COMPLETED	2021-10-19	NCT04766463
Jiangsu HengRui Medicine Co., Ltd.	SHR0410 Injection	—	COMPLETED	2021-06-26	NCT04852003
GSK	Diclofenac diethylamine 2.32% gel	—	COMPLETED	2020-11-12	NCT04052620
Reckitt Benckiser Healthcare (UK) Limited	Ibuprofen 300 mg Oral Tablet	—	COMPLETED	2020-02-20	NCT03785756
Grünenthal GmbH	Tapentadol oral solution 4 mg/mL	—	COMPLETED	2019-03-03	NCT02081391
Lee's Pharmaceutical Limited	Lidocaine (Zingo)	—	COMPLETED	2019-02-28	NCT03653260
Dompé Farmaceutici S.p.A	OKITASK®	—	COMPLETED	2018-07-04	NCT03836807
Mundipharma Research GmbH & Co KG	MR308	—	COMPLETED	2018-06-29	NCT03062644
Charleston Laboratories, Inc	CL-108 5 mg	—	COMPLETED	2018-04-16	NCT03657810
Pfizer	Ibuprofen/Caffeine	—	COMPLETED	2018-04-06	NCT02863575
Grünenthal GmbH	Tramadol/Diclofenac 50/50	—	COMPLETED	2018-03-09	NCT03714672
Mundipharma Pharmaceuticals S.L.	Methoxyflurane	—	COMPLETED	2018-03-06	NCT03256903
Mundipharma Research GmbH & Co KG	MR308	—	COMPLETED	2018-01-04	NCT02982161
Grünenthal GmbH	Tapentadol prolonged release	—	COMPLETED	2017-10-18	NCT02151682
Lachlan Pharma Holdings	Benzocaine Otic Solution	—	COMPLETED	2017-07-21	NCT03116737
Boehringer Ingelheim	Diclofenac	—	COMPLETED	2017-07-13	NCT02700815
Pacira Pharmaceuticals, Inc	bupivacaine liposome injectable suspension	—	COMPLETED	2017-07-07	NCT02713230
Pacira Pharmaceuticals, Inc	bupivacaine liposome injectable suspension	—	COMPLETED	2017-06-30	NCT02713178
Bausch & Lomb Incorporated	Loteprednol Etabonate Ophthalmic Gel dosed TID	—	COMPLETED	2017-06-13	NCT02786901
Trevena Inc.	TRV130	—	COMPLETED	2017-05	NCT02656875
Talphera, Inc	Zalviso™ 15 mcg	—	COMPLETED	2017-04-14	NCT02662764
Pfizer	FDC IBU/APAP 250 mg/500 mg	—	COMPLETED	2017-02-01	NCT02837952
Trevena Inc.	Oliceridine	—	COMPLETED	2016-12	NCT02820324
Trevena Inc.	Oliceridine	—	COMPLETED	2016-12	NCT02815709
Daiichi Sankyo Brasil Farmacêutica LTDA	Transdermal Patch	—	COMPLETED	2016-12	NCT02616068
Boehringer Ingelheim	Loxoprofen sodium	—	COMPLETED	2016-10-19	NCT02831569
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-10-10	NCT02289716
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-09-19	NCT02301234
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-09-16	NCT02336685
Johnson & Johnson	Fulranumab 1 mg	—	COMPLETED	2016-09-15	NCT02336698
INSYS Therapeutics Inc	Buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2016-06-24	NCT02634788
Talphera, Inc	sufentanil sublingual 30 mcg tablet	—	COMPLETED	2016-06	NCT02447848
Grünenthal GmbH	Lidocaine 5% medicated plaster	—	COMPLETED	2016-06	NCT01752322
Purdue Pharma LP	Buprenorphine transdermal system	—	COMPLETED	2016-05	NCT01324570
Tris Pharma, Inc.	Cebranopadol	—	COMPLETED	2016-04	NCT02031432
Teva Branded Pharmaceutical Products R&D, Inc.	TV-46763	—	COMPLETED	2016-03-30	NCT02487108
GSK	Paracetamol 1000 mg SR tablets	—	COMPLETED	2016-02	NCT02311881
Jazz Pharmaceuticals	Nabiximols	—	COMPLETED	2016-01-27	NCT01337089
Xigen SA	XG-102	—	COMPLETED	2016-01	NCT02508337
Xigen SA	XG-102	—	COMPLETED	2015-12	NCT02235272
Mundipharma (China) Pharmaceutical Co. Ltd	Oxycodone/Naloxone	—	COMPLETED	2015-08-30	NCT01885182
Mallinckrodt	IV Acetaminophen	—	COMPLETED	2015-08	NCT01635101
Jazz Pharmaceuticals	Nabiximols	—	COMPLETED	2015-07-10	NCT01424566
GW Pharmaceuticals Ltd	Nabiximols	—	COMPLETED	2015-07-02	NCT01262651
Joseph Hazelton	CL-108 (hydrocodone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)	—	COMPLETED	2015-07	NCT02462811
Elite Laboratories, Inc	Oxycodone Naltrexone (a)	—	COMPLETED	2015-07	NCT02401750
Egalet Ltd	SPRIX(intranasal ketorolac tromethamine)	—	COMPLETED	2015-06	NCT02102516
Lumosa Therapeutics Co., Ltd.	Sebacoyl Dinalbuphine Ester	—	COMPLETED	2015-04	NCT02468128
GSK	1% diclofenac sodium plus 3% menthol	—	COMPLETED	2015-03-01	NCT02100670
Bausch & Lomb Incorporated	Loteprednol Etabonate Gel (BID)	—	COMPLETED	2015-03	NCT02208297
Charleston Laboratories, Inc	CL-108	—	COMPLETED	2015-01	NCT02462850
Jazz Pharmaceuticals	Nabiximols	—	COMPLETED	2014-11-24	NCT01361607
Exelixis	cabozantinib	AXL/FLT-3/KIT/MER/MET/RET/ROS1/TIE-2/TRKB/TYRO3/VEGFR-1/VEGFR-2/VEGFR-3	COMPLETED	2014-09	NCT01605227
Purdue Pharma LP	Oxycodone HCl controlled-release tablets	—	COMPLETED	2014-07	NCT01192295
Bausch & Lomb Incorporated	Loteprednol Etabonate Gel (BID)	—	COMPLETED	2014-05	NCT01996839
Menarini Group	Dexketoprofen-single dose	—	COMPLETED	2014-05	NCT01904149
Pfizer	IBU BID	—	COMPLETED	2014-03-29	NCT01794923
American Regent, Inc.	SPRIX	COX-1/COX-2	COMPLETED	2014-03	NCT01819610
Mundipharma Research GmbH & Co KG	oxycodone/naloxone prolonged release (OXN PR) tablets	—	COMPLETED	2014-02	NCT01438567
Menarini Group	Tramadol-single dose	—	COMPLETED	2014-02	NCT01902134
Astellas Pharma Inc	Capsaicin 8%	—	COMPLETED	2014-02	NCT01533428
Purdue Pharma LP	Oxycodone hydrochloride controlled-release tablets	—	COMPLETED	2013-12	NCT01369615
Charleston Laboratories, Inc	CL-108 (hydrodocone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)	—	COMPLETED	2013-10	NCT01780428
Vivatech	—	—	COMPLETED	2013-06	NCT02318875
Wex Pharmaceuticals Inc.	Tetrodotoxin	—	COMPLETED	2012-11	NCT00725114
Orion Corporation, Orion Pharma	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2012-10	NCT01562717
BioDelivery Sciences International	BEMA Buprenorphine	—	COMPLETED	2012-08	NCT01298765
Johnson & Johnson	Oxycodone CR	—	COMPLETED	2012-08	NCT01165281
Orion Corporation, Orion Pharma	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2012-07	NCT01563289
Medical Developments International Limited	Methoxyflurane	—	COMPLETED	2012-07	NCT01420159
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	pregabalin	alpha 2 -delta site	COMPLETED	2012-03	NCT01202227

Showing 100 of 101 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Eli Lilly	LY4515100	—	RECRUITING	2026-11	NCT07511816
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.	YZJ-4729	—	ACTIVE NOT RECRUITING	2024-07-15	NCT06680466
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.	YZJ-4729	—	NOT YET RECRUITING	2025-10	NCT06901830
Latigo Biotherapeutics	Experimental: LTG-001 High Dose	—	COMPLETED	2026-01-07	NCT07102459
Latigo Biotherapeutics	LTG-001 High Dose	—	COMPLETED	2025-08-08	NCT06774625
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2025-05-27	NCT06619847
Levicept	LEVI-04	—	COMPLETED	2024-05-20	NCT05618782
Halia Therapeutics, Inc.	HT-6184	—	COMPLETED	2024-04-30	NCT06241742
Ensysce Biosciences	PF614	—	COMPLETED	2023-11-14	NCT06629402
Laboratorios Liomont	etoricoxib-tramadol	—	COMPLETED	2022-08-18	NCT05995912
Mylan Specialty, LP	MR-107A-02	—	COMPLETED	2022-06-15	NCT05317312
Cymra Life Sciences	Cybis™ 10:25 THC:CBD oil	—	COMPLETED	2022-06-15	NCT04976738
Jiangsu HengRui Medicine Co., Ltd.	HRS4800 tablets	—	COMPLETED	2022-02-28	NCT05318846
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2022-02-17	NCT04977336
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2021-12-05	NCT05034952
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division	Acetaminophen/naproxen sodium Dose A	—	COMPLETED	2021-04-09	NCT04447040
Jiangsu HengRui Medicine Co., Ltd.	HR18042	—	COMPLETED	2021-01-25	NCT04812860
Mylan Inc.	MR-107A-01	—	COMPLETED	2020-12-15	NCT04571515
Algenis SpA	GTX 2/3	—	COMPLETED	2020-03-19	NCT04799041
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division	440 mg naproxen sodium with 1000 mg acetaminophen	—	COMPLETED	2019-11-07	NCT03879408
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2019-09-30	NCT03872830
Charleston Laboratories, Inc	Arm 1: CL-H1T	—	COMPLETED	2019-08-27	NCT03877718
Concentric Analgesics	CA-008	—	COMPLETED	2019-07-02	NCT03885596
Panag Pharma Inc.	—	—	COMPLETED	2019-06-30	NCT03152578
Neurana Pharmaceuticals, Inc.	Tolperisone	—	COMPLETED	2019-06-28	NCT03802565
Aponia Laboratories, Inc.	S-Ibuprofen	—	COMPLETED	2019-04-04	NCT03852459
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2019-01-17	NCT03764072
Mati Therapeutics Inc.	—	—	COMPLETED	2018-12-17	NCT03496467
Propella Therapeutics	CGS-200-1	—	COMPLETED	2018-10-14	NCT03528369
Dr. Reddy's Laboratories Limited	DFN-15 (Celecoxib Oral Solution) 62.5 mg	—	COMPLETED	2018-08-20	NCT03554772
Baudax Bio	DEX-IN	—	COMPLETED	2018-01-18	NCT03348423
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2017-12-01	NCT03206749
INSYS Therapeutics Inc	Fentanyl	opioid receptor	COMPLETED	2017-02-10	NCT02915978
A.T. Resolve SARL	RX-10045	—	COMPLETED	2015-09	NCT02329743
Olatec Therapeutics LLC	OLT1177 Gel	—	COMPLETED	2015-08	NCT02104050
Trevena Inc.	TRV130	—	COMPLETED	2015-07	NCT02335294
Aponia Laboratories, Inc.	S-Ibuprofen Topical Gel 5%	—	COMPLETED	2015-07	NCT02324985
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.	JNJ-10450232 / Not yet marketed	—	COMPLETED	2015-04	NCT02209181
Adwin Life Care	—	—	COMPLETED	2014-11	NCT02380989
Trevena Inc.	TRV130	—	COMPLETED	2014-10	NCT02100748
BioDelivery Sciences International	Buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2014-07	NCT01871285
Astellas Pharma Europe B.V.	ASP3652	—	COMPLETED	2014-03-18	NCT01613586
gicare Pharma Inc.	GIC-1001	—	COMPLETED	2014-03	NCT01926444
Otic Therapy, LLC	Benzocaine	—	COMPLETED	2014-03	NCT02092454
Purdue Pharma LP	V116517 50-mg tablets	—	COMPLETED	2014-03	NCT01688947
Grünenthal GmbH	Tapentadol	—	COMPLETED	2014-02	NCT01729728
Eli Lilly	LY3023703	—	COMPLETED	2013-10	NCT01872910
Cara Therapeutics, Inc.	CR845	—	COMPLETED	2013-08	NCT01789476
Daiichi Sankyo Co., Ltd.	DS-5565	—	COMPLETED	2013-06	NCT01504412
Purdue Pharma LP	V116517 50-mg tablets	—	COMPLETED	2013-06	NCT01688934
IBSA Institut Biochimique SA	Diclofenac sodium	Prostaglandin E1 Analog [EPC]	COMPLETED	2013-05	NCT01706588
Mundipharma Research GmbH & Co KG	Oxycodone naloxone prolonged release tablets	—	COMPLETED	2013-03	NCT01197261
InSightec	—	—	COMPLETED	2013-03	NCT01085565
US Oncology Research	Synera (lidocaine 70mg/tetracaine 70mg)	—	COMPLETED	2013-02	NCT01744197
Talphera, Inc	Sufentanil NanoTab 20 mcg	—	COMPLETED	2013-02	NCT01710345
Pfizer	Ibuprofen/acetaminophen	—	COMPLETED	2012-09-13	NCT01559259
Arbor Pharmaceuticals, Inc.	benzocaine	—	COMPLETED	2012-08	NCT01588535
Grünenthal GmbH	Tapentadol	—	COMPLETED	2012-02	NCT01435577
Tris Pharma, Inc.	GRT6005	—	COMPLETED	2012-01	NCT01347671
Menarini Group	Dexketoprofen Trometamol	—	COMPLETED	2011-10	NCT01307020
NeurogesX	NGX-1998	—	COMPLETED	2011-09	NCT01228838
Hospira, now a wholly owned subsidiary of Pfizer	Dexmedetomidine	—	COMPLETED	2011-08	NCT01378988
Boehringer Ingelheim	Ambroxol Spray	—	COMPLETED	2011-08	NCT01361802
AbbVie (prior sponsor, Abbott)	Hydrocodone/Acetaminophen Extended Release	—	COMPLETED	2011-06	NCT01333722
PainReform LTD	PRF-108	—	COMPLETED	2011-04	NCT00883194
Janssen Pharmaceutical K.K.	Tapentadol	—	COMPLETED	2011-04	NCT01124617
Janssen Pharmaceutical K.K.	Tapentadol Hydrochloride	MOR/NET	COMPLETED	2010-12	NCT01124604
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	Celecoxib	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2010-08	NCT01062113
AbbVie (prior sponsor, Abbott)	Hydrocodone/Acetaminophen Extended Release	—	COMPLETED	2010-05	NCT01038609
Talphera, Inc	Sublingual sufentanil NanoTabs™ and placebo NanoTabs™	—	COMPLETED	2010-03	NCT00833040
Cara Therapeutics, Inc.	CR845	—	COMPLETED	2009-12	NCT00877799
Talphera, Inc	Sublingual Sufentanil/Triazolam NanoTab™ (ARX-F03)	—	COMPLETED	2009-09	NCT00894699
Pfizer	ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2009-08-01	NCT00913627
AbbVie (prior sponsor, Abbott)	ABT-712 Extended-release	—	COMPLETED	2009-08	NCT00935311
AstraZeneca	AZD2066	—	COMPLETED	2009-08	NCT00857623
Janssen Pharmaceutical K.K.	Tapentadol PR	—	COMPLETED	2009-07	NCT00805142
Sanofi	ataciguat (HMR1766)	—	COMPLETED	2009-06	NCT00799656
FORSIGHT Vision3	—	—	COMPLETED	2008-10	NCT00741624
AstraZeneca	AZD1386	—	COMPLETED	2008-06	NCT00672646
AstraZeneca	AZD1940	—	COMPLETED	2008-05	NCT00659490
GSK	GSK3858279	—	TERMINATED	2024-10-14	NCT05838755
GSK	GSK3858279	—	TERMINATED	2024-08-12	NCT05838742
Jiangsu HengRui Medicine Co., Ltd.	HR18042 tablets	—	TERMINATED	2022-12-16	NCT05470075
Kowa Research Institute, Inc.	K-285	—	TERMINATED	2021-03-19	NCT04484428
Nobelpharma	NPC-06	—	TERMINATED	2021-02-28	NCT04139330
Regeneron	REGN5069	—	TERMINATED	2020-05-01	NCT03956550
Ono Pharmaceutical Co., Ltd.	ONO-4474	—	TERMINATED	2018-01-09	NCT02997696
Trevena Inc.	TRV130	—	TERMINATED	2015-10-23	NCT02520297
Wex Pharmaceuticals Inc.	Tetrodotoxin	—	TERMINATED	2015-01	NCT01655823
Grünenthal GmbH	Lidocaine 5% medicated plaster	—	TERMINATED	2012-11	NCT01155986
Sanofi	SSR411298	—	TERMINATED	2012-02	NCT01439919
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Oxycodone CR (standard pain medication)	—	TERMINATED	2011-07-01	NCT01094262
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	JNJ-42160443	—	TERMINATED	2011-07	NCT00964990
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	JNJ-42160443	—	TERMINATED	2011-06-30	NCT00973141
AstraZeneca	AZD1386	—	TERMINATED	2009-07	NCT00878501
AstraZeneca	AZD1386	—	TERMINATED	—	NCT00976534
Sorrento Therapeutics, Inc.	Resiniferatoxin	—	SUSPENDED	2027-06	NCT05067257
EMS	Escócia association	—	WITHDRAWN	2025-02	NCT04666701
EMS	TIRADENTES ASSOCIATION	—	WITHDRAWN	2023-08	NCT04593329
Purdue Pharma LP	HYD tablets	—	WITHDRAWN	2019-07	NCT02542098

Showing 100 of 149 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Tafalgie Therapeutics	TT5	—	RECRUITING	2026-10-01	NCT06789861
Sparian Biosciences, Inc	SBS-147	—	RECRUITING	2027-01-31	NCT07335913
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	RECRUITING	2027-02-26	NCT07378865
Shanghai Hengrui Pharmaceutical Co., Ltd.	HRS-6257	—	RECRUITING	2026-05	NCT07301333
iN Therapeutics Co., Ltd.	iN1011-N17 HCl Suspension (Part 1)	—	RECRUITING	2024-07-29	NCT06218784
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	NOT YET RECRUITING	2026-07-11	NCT07570069
Nyree Penn	Diprivan (propofol), Astra-Zeneca	—	NOT YET RECRUITING	2026-05-01	NCT06644573
South Rampart Pharma, LLC	SRP-3D (diethylamide)	—	NOT YET RECRUITING	2025-12-31	NCT05484414
Jiangsu Aosaikang Pharmaceutical Co., Ltd.	5% ASKC200	—	NOT YET RECRUITING	2025-04	NCT06614608
Vertex Pharmaceuticals Incorporated	VX-973	—	COMPLETED	2025-07-21	NCT06615570
Joincare Pharmaceutical Group Industry Co., Ltd	JKN2306	—	COMPLETED	2025-07-02	NCT07412938
Shandong Suncadia Medicine Co., Ltd.	HRS-2129	—	COMPLETED	2025-07-02	NCT06742840
Vertex Pharmaceuticals Incorporated	14C-VX-993	—	COMPLETED	2025-05-17	NCT06886269
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2025-04-29	NCT06820307
Vertex Pharmaceuticals Incorporated	SUZ	—	COMPLETED	2025-04-24	NCT06834009
HALEON	Paracetamol ODT	—	COMPLETED	2025-04-17	NCT06855576
HALEON	ADA Liquid Filled Capsules (Test Product)	—	COMPLETED	2025-04-12	NCT06802185
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2025-03-22	NCT06420765
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2025-02-18	NCT06394167
Shandong Suncadia Medicine Co., Ltd.	HRS-2129	—	COMPLETED	2025-01-20	NCT06619392
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-12-31	NCT06523595
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-09-10	NCT06508762
Bayer	Naproxen (BAYH006689)	—	COMPLETED	2024-08-20	NCT06511973
Bayer	Naproxen (BAYH006689)	—	COMPLETED	2024-08-01	NCT06415019
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-07-02	NCT06392659
Vertex Pharmaceuticals Incorporated	Suzetrigine	Sodium Channel Blocker [EPC]	COMPLETED	2024-06-19	NCT06336096
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2024-06-12	NCT06226454
Merck	MK-4318	—	COMPLETED	2024-04-11	NCT06692647
Vertex Pharmaceuticals Incorporated	VX-973	—	COMPLETED	2024-04-04	NCT05866055
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2024-03-30	NCT05704556
Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd	Nabufine Hydrochloride Injection	—	COMPLETED	2023-12-26	NCT06902103
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-10-30	NCT05851157
iN Therapeutics Co., Ltd.	iN1011-N17	—	COMPLETED	2023-10-08	NCT05496205
Vertex Pharmaceuticals Incorporated	VX-993	—	COMPLETED	2023-09-12	NCT05653323
Sparian Biosciences, Inc	SBS-1000	—	COMPLETED	2023-08-15	NCT05721287
Yangtze River Pharmaceutical Group Co., Ltd.	Meloxicam Nanocrystal Injection(Yangtze River Pharmaceutical Group Co., Ltd.)	—	COMPLETED	2023-07-25	NCT06902090
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-07-24	NCT05560464
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-06-12	NCT05818852
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-06-08	NCT05635110
HALEON	Ibuprofen arginine granules 400 mg	—	COMPLETED	2023-05-15	NCT05737069
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2023-04-16	NCT05541471
Vertex Pharmaceuticals Incorporated	VX-708	—	COMPLETED	2023-04-14	NCT05347394
Tris Pharma, Inc.	Cebranopadol 600 µg	—	COMPLETED	2023-03-30	NCT05491785
HALEON	Advil PM Liqui-Gels Minis	—	COMPLETED	2023-03-21	NCT05674721
Vertex Pharmaceuticals Incorporated	VX-708	—	COMPLETED	2023-03-07	NCT05518734
GSK	GSK3858279	—	COMPLETED	2023-02-10	NCT05174013
Xgene Pharmaceutical Group	XG004	—	COMPLETED	2023-01-23	NCT05454020
Kures, Inc.	KUR-101	—	COMPLETED	2022-10-12	NCT05114265
Vertex Pharmaceuticals Incorporated	VX-548	—	COMPLETED	2022-09-17	NCT05455502
Vertex Pharmaceuticals Incorporated	VX-150	—	COMPLETED	2022-09-14	NCT05418712
Unither Pharmaceuticals, France	paracetamol Uniflash (125 mg/ 1.25 mL)	—	COMPLETED	2022-07-23	NCT05406752
Atridia Pty Ltd.	HRS4800 tablets	—	COMPLETED	2021-09-20	NCT04573036
HALEON	New Paracetamol Oral Suspension (24 mg/ml)	—	COMPLETED	2021-09-08	NCT05022810
AlzeCure Pharma	ACD440	—	COMPLETED	2021-03-10	NCT04704232
Nanoform Finland Plc	Nanoformed Piroxicam IR Tablet	—	COMPLETED	2021-02-01	NCT05104931
Xgene Pharmaceutical Group	XG005-03	—	COMPLETED	2021-01-28	NCT04283474
Syntrix Biosystems, Inc.	Desmetramadol	—	COMPLETED	2021-01-18	NCT04683926
Addpharma Inc.	AD-2111	—	COMPLETED	2020-07-16	NCT04375865
Xgene Pharmaceutical Group	XG005	—	COMPLETED	2019-12-03	NCT04067947
Centrexion Therapeutics	CNTX-6016	—	COMPLETED	2019-08-21	NCT04154501
GSK	Diclofenac Diethylamine (DDEA) gel	—	COMPLETED	2019-03-01	NCT03497039
Stragen France	STR-324 Dose Level 1	—	COMPLETED	2018-11-07	NCT03430232
Shijiazhuang Yiling Pharmaceutical Co. Ltd	Felbinac Trometamol Injection	—	COMPLETED	2018-11-05	NCT03617510
Atridia Pty Ltd.	0.5μg/kg SHR0410	—	COMPLETED	2018-06-29	NCT03493191
Bayer	Naproxen sodium and diphenhydramine hydrochloride soft capsules	—	COMPLETED	2018-03-26	NCT03396250
Abide Therapeutics	ABX-1431	—	COMPLETED	2018-03	NCT02929264
Xgene Pharmaceutical Group	XG005	—	COMPLETED	2018-01-18	NCT04499209
Syntrix Biosystems, Inc.	Omnitram	—	COMPLETED	2017-12-15	NCT03312777
AstraZeneca	EMLA test patch	—	COMPLETED	2017-11-09	NCT03313336
Liquidia Technologies, Inc.	LIQ865A bupivacaine formulation	—	COMPLETED	2017-03-23	NCT02982889
BDD Pharma Ltd	Radiolabelled Diclofenac Tablet A	—	COMPLETED	2016-05	NCT02714842
Charleston Laboratories, Inc	CL-108	—	COMPLETED	2015-09	NCT02712554
Mundipharma Research Limited	MRXXX	—	COMPLETED	2015-07	NCT02446561
Futura Medical Developments Ltd.	Ibuprofen	Nonsteroidal Anti-inflammatory Drug [EPC]	COMPLETED	2015-05	NCT02666846
Mundipharma Research Limited	BTDS	—	COMPLETED	2015-05	NCT02431624
Boston Scientific Corporation	—	—	COMPLETED	2015-04	NCT01461265
Lumosa Therapeutics Co., Ltd.	Bain®	—	COMPLETED	2015-04	NCT02446301
gicare Pharma Inc.	GIC-1001 375 mg TID	—	COMPLETED	2014-12	NCT02276768
Mundipharma Research Limited	Buprenorphine	Partial Opioid Agonist [EPC]	COMPLETED	2014-12	NCT02268422
GSK	Diclofenac sodium	Prostaglandin E1 Analog [EPC]	COMPLETED	2014-11-21	NCT02201238
Syntrix Biosystems, Inc.	Omnitram	—	COMPLETED	2014-10	NCT02205554
Mundipharma Research Limited	Second generation BTDS patch	—	COMPLETED	2014-08	NCT02160067
GSK	Diclofenac + Menthol Gel	—	COMPLETED	2014-07-15	NCT02192203
GSK	1% Diclofenac Sodium	—	COMPLETED	2014-07-01	NCT02169154
Mundipharma Research Limited	4 mg 12 hourly capsule - strong pain killer fasted	—	COMPLETED	2014-06	NCT02133820
Mundipharma Research Limited	Active comparator MR2XXX	—	COMPLETED	2014-05	NCT02089581
Menarini Group	Enantyum® oral solution	—	COMPLETED	2014-05	NCT02209454
Bayer	Acetylsalicylic acid (Aspirin, BAY1019036)	—	COMPLETED	2014-03	NCT03056703
BDD Pharma Ltd	Radiolabelled T4 Tablet	—	COMPLETED	2014-03	NCT02004301
Trevena Inc.	TRV130 1.5 mg	—	COMPLETED	2013-08	NCT02083315
Aros Pharma ApS	PPC-5650	—	COMPLETED	2013-05	NCT01449487
Pfizer	Ibuprofen 5% topical gel	—	COMPLETED	2013-02	NCT01771822
Pfizer	Topical gel vehicle	—	COMPLETED	2013-02	NCT01787448
Teva Branded Pharmaceutical Products R&D, Inc.	90 mg dose of the hydrocodone bitartrate extended-release tablet administered as either two 45-mg tablets (Treatment A) or one 90-mg tablet (Treatment B).	—	COMPLETED	2013-01	NCT01769677
Teva Branded Pharmaceutical Products R&D, Inc.	a 60 mg dose of the hydrocodone bitartrate extended-release tablet administered as either two 30-mg tablets (Treatment A) or one 60-mg tablet (Treatment B).	—	COMPLETED	2013-01	NCT01758978
Pfizer	PF-04427429	—	COMPLETED	2013-01	NCT01511497
Pfizer	PF-05089771	—	COMPLETED	2012-10	NCT01529671
Pain Therapeutics	Oxycodone	Opioid Agonist [EPC]	COMPLETED	2012-09	NCT01552863
Pfizer	PF-05089771	—	COMPLETED	2012-09	NCT01690351
Xian-Janssen Pharmaceutical Ltd.	Hydromorphone	—	COMPLETED	2012-08	NCT01824524

Novel Drugs by Company (New molecular entities)

IBSA 1 drug

HARROW EYE 1 drug

Reformulations (36 drugs) Click to expand

Reformulations are FDA-approved versions of existing molecules in new dosage forms (e.g., oral solution vs tablet, extended-release vs immediate-release). They require a new NDA but use an already-proven active ingredient.

XIFYRM

AZURITY

UNKNOWN 2025

PHENYLEPHRINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE