Data updated: Nov 8, 2026
PEMETREXED FOR INJECTION (pemetrexed) · Dr. Reddy's
Oncology
FDA label not available. This product's label is not in FDA's label database (openFDA, DailyMed). Search DailyMed → · Drugs@FDA approval documents →
Details
- Status
- Prescription
- First Approved
- N/A
- Routes
- INJECTION
- Dosage Forms
- INJECTABLE
PEMETREXED FOR INJECTION Approval History
No approval records found
PEMETREXED FOR INJECTION Competitive Set
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Clinical Trial Registry
508 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT06875310 | CA239-0004 2024-515698-85, U1111-1309-5596 | Ph 3 | recruiting | A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) |
| NCT07005102 | M25-287 2024-518586-10 | Ph 2, Ph 3 | recruiting | A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer |
| NCT06151574 | 1479-0008 2023-504308-27-00, U1111-1294-1407 | Ph 3 | active not recruiting | Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment |
| NCT03793179 | NCI-2018-03695 NCI-2018-03695, EA5163 | Ph 3 | active not recruiting | Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer |
| NCT06772623 | M24-536 2024-514465-18, 2024-514465-18-00 | Ph 1, Ph 2 | recruiting | Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations |
| NCT06694454 | 10001609 001609-C | Ph 1, Ph 2 | suspended | Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC) |
| NCT05775289 results posted | BO44178 | Ph 2 | completed | A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer |
| NCT06448754 eVOLVE-01 | D798KC00001 2023-509482-20-00, 2023 | Ph 2 | active not recruiting | Volrustomig Priming Regimens Exploratory Phase II Platform Study |
| NCT05198830 | NCI-2021-14403 NCI-2021-14403, CASE1522 | Ph 2 | active not recruiting | Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer |
| NCT03337698 Morpheus Lung results posted | BO39610 2017-001267-21 | Ph 1, Ph 2 | terminated | A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer) |
| NCT04245085 ABC-lung results posted | ETOP 15-19 MO40586 | Ph 2 | completed | ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma |
| NCT06119581 SUNRAY-01 | 18612 J3M-MC-JZQB, U1111-1288-0565 | Ph 3 | recruiting | A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer |
| NCT06074588 | 2870-004 2023-503539-16-00, jRCT2031240108 | Ph 3 | active not recruiting | Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004) |
| NCT07458347 | KST-6051-101 | Ph 1 | recruiting | A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation |
| NCT03819465 MAGELLAN | D933IC00001 2018-001748-74 | Ph 1 | active not recruiting | A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC |
| NCT03607539 results posted | CIBI308C302 | Ph 3 | completed | Efficacy and Safety Evaluation of Sintilimab in Patients With Advanced or Metastatic Non-squamous NSCLC |
| NCT06793215 Krascendo 2 | CO45042 | Ph 3 | recruiting | A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer |
| NCT06096844 | NCI-2023-08628 NCI-2023-08628, EA5221 | Ph 3 | recruiting | Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial |
| NCT07190248 | 1084-007 U1111-1307-9569, 2024-514500-14-00 | Ph 3 | recruiting | A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) |
| NCT04538664 PAPILLON results posted | CR108850 61186372NSC3001, 2023-506033-29-00 | Ph 3 | active not recruiting | A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions |
| NCT06632327 | CTIU2317-A082304-S2402 NCI-2024-06356 | Ph 3 | active not recruiting | Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer |
| NCT05870319 | SKB264-Ⅲ-09 | Ph 3 | active not recruiting | A Phase III Study of SKB264 for EGFR Mutant NSCLC Patients |
| NCT06431685 | LM-001 | Ph 1 | recruiting | Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer |
| NCT02609776 CHRYSALIS | CR108064 61186372EDI1001, 2018-003908-38 | Ph 1 | active not recruiting | Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer |
| NCT05498428 PALOMA-2 | CR109264 61186372NSC2002, 2022-000526-21 | Ph 2 | recruiting | A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer |
| NCT06459180 | 2870-020 MK-2870-020, TroFuse-020 | Ph 3 | active not recruiting | A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20) |
| NCT04988295 MARIPOSA-2 results posted | CR109061 61186372NSC3002, 2021-001825-33 | Ph 3 | active not recruiting | A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure |
| NCT04077463 Chrysalis-2 | CR108656 73841937NSC1001, 2020-000747-31 | Ph 1 | active not recruiting | A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer |
| NCT06312137 TroFuse-019 | 2870-019 2023-508012-35-00, MK-2870-019 | Ph 3 | recruiting | A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019) |
| NCT04083599 | GCT1042-01 2018-003716-47, IRAS ID: 263292 | Ph 1, Ph 2 | active not recruiting | GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors |
| NCT07335497 ASCEND | CR-001-101 2025-523590-42-00, 2025 | Ph 1, Ph 2 | recruiting | CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors |
| NCT07063745 MountainTAP-29 | CA240-0029 2025-521511-40, U1111-1319-8383 | Ph 2, Ph 3 | recruiting | A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion |
| NCT05012254 NIVIPI-Brain | GECP 21/02_NIVIPI-Brain 2021-000425-27 | Ph 2 | active not recruiting | Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases |
| NCT06305754 | 2870-009 2023-504910-31-00, U1111-1288-3804 | Ph 3 | active not recruiting | Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009) |
| NCT05083481 | 1570-CL-0101 jRCT2031220527, KEYNOTE-E59 | Ph 1 | terminated | A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab, Standard Therapies, or Both, in Adults With Solid Tumors |
| NCT03456076 results posted | BO40336 2017-004331-37, 2017 | Ph 3 | active not recruiting | A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer |
| NCT06623422 | V940-009 2023-506327-29-00, U1111-1293-5814 | Ph 3 | recruiting | A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009) |
| NCT05067283 KANDLELIT-001 | 1084-001 MK-1084-001, jRCT2041220034 | Ph 1 | recruiting | A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001) |
| NCT05456256 HARMONIC | LTRN300-2LC01-OR21 | Ph 2 | recruiting | A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma |
| NCT04585490 | IRB-54807 LUN0114, NCI-2021-09500 | Ph 3 | recruiting | Adaptive ctDNA-Based Personalization of Treatment During Consolidation Therapy in NSCLC |
| NCT05118854 | 2021-0649 NCI-2021-10907 | Ph 2 | active not recruiting | A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation |
| NCT05624996 | NRG-LU008 NCI-2022-08263, NRG-LU008 | Ph 3 | recruiting | Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer |
| NCT04736173 ARC-10 | ARC-10 2020-003562-39, PHRR210222-003371 | Ph 2 | completed | Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer |
| NCT06996782 ALTAIR | D702KC00001 2024-519786-22 | Ph 1, Ph 2 | recruiting | A Platform Study in Non-Small Cell Lung Cancer (NSCLC) |
| NCT06561386 RELATIVITY1093 | CA224-1093 2024-513682-40, U1111-1306-8896 | Ph 3 | recruiting | A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1% |
| NCT05358548 | 032201 Pro2022000346 | Ph 2 | recruiting | ATATcH Alternating Treatment Plans for Advanced Cancer |
| NCT02486718 results posted | GO29527 2014-003205-15, 2023-505981-26-00 | Ph 3 | completed | Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010] |
| NCT03768063 IMbrella B | BO40729 2023-506184-34-00, 2023 | Ph 3 | active not recruiting | A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study |
| NCT06630325 results posted | STUDY00026643 NCI-2024-07664, STUDY00026643 | Ph 2 | terminated | A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer |
| NCT06097728 eVOLVE-Meso | D7988C00001 2023-503231-17-00, 2023-000067-32 | Ph 3 | active not recruiting | MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma |
Showing 50 of 508 trials
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Trial Timeline
Full development history with FDA approval milestones
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Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
PEMETREXED FOR INJECTION FDA Label Details
FDA label not available. This product's label is not in FDA's label database (openFDA, DailyMed). Search DailyMed → · Drugs@FDA approval documents →
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.