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Clinical-Stage Companies / 4D Molecular

4D Molecular

Pre-Approval PRO BETA
🟡

Slowing Activity

No new clinical trials started in 1-2 years. Monitor for changes in pipeline strategy. Last trial started: 7/22/2025

9
Total Trials
2
Phase 3
6
Phase 2
9
Recruiting
93
Score

Pipeline by Phase

Phase 3
2
Phase 2
6
Phase 1
5

Therapeutic Focus

Fabry Disease Neovascular Age-Related Macular Degeneration (nAMD) Macular Neovascularization Secondary to Age-Related Macular Degeneration Cystic Fibrosis Lung Neovascular (Wet) Age-Related Macular Degeneration

Clinical Trials (9)

NCT07064759 Phase 3 RECRUITING

Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Started: 7/22/2025

NCT06864988 Phase 3 ACTIVE NOT RECRUITING

4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Started: 3/3/2025

NCT05248230 Phase 2 RECRUITING

4D-710 in Adult Patients With Cystic Fibrosis

Started: 3/29/2022

NCT05930561 Phase 2 ACTIVE NOT RECRUITING

4D-150 in Patients With Diabetic Macular Edema

Started: 8/9/2023

NCT05197270 Phase 1 RECRUITING

4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

Started: 12/9/2021

NCT05629559 Phase 1 RECRUITING

4D-310 in Adults With Fabry Disease and Cardiac Involvement

Started: 10/16/2022

NCT04483440 Phase 1 ACTIVE NOT RECRUITING

Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia

Started: 6/2/2020

NCT04517149 Phase 1 ACTIVE NOT RECRUITING

4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)

Started: 6/9/2020

NCT04519749 Phase 1 ACTIVE NOT RECRUITING

An Open-label, Phase 1/2 Trial of Gene Therapy 4D-310 in Adults With Fabry Disease

Started: 9/1/2020

Drug Candidates

4D-150 IVT (3E10 vg/eye) 4D-710 4D-150 IVT Aflibercept IVT 4D-110 4D-125 IVT Injection 4D-310
Activity Status: Slowing
Last Trial Started: 7/22/2025
Last Trial Ended: N/A
Trials (12 months): 0
Completed Trials: 0
Data sourced from ClinicalTrials.gov. This company has no FDA-approved drugs.