Clinical-Stage Companies

Pre-revenue biotechs with active clinical programs. Spot acquisition targets before the bidding war.

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Clinical-Stage Companies

PRO Pre-Approval

Pre-revenue biotechs with active clinical programs — no FDA-approved drugs yet Updated: 5/3/2026

Spot Acquisition Targets Before the Bidding War

VCs & Investors: Early-stage bets with Phase 3 catalysts approaching

Pharma M&A: Pipeline acquisitions before approval de-risks the asset

Pipeline Scouting: Who's developing in your indication without an approved drug yet

200

Companies

Pre-approval stage

195

With Phase 3

Near potential approval

1789

Phase 3 Trials

Late-stage programs

263

Avg Score

Pipeline strength

How We Find These Companies

We analyze ClinicalTrials.gov for INDUSTRY sponsors without FDA-approved drugs. Score = Phase 3 × 15 + Phase 2 × 8 + Phase 1 × 3 + Recent Trials × 5. Higher scores indicate stronger pipeline activity.

Activity:

Company	Activity	Focus Area	P3	P2	P1	Recruiting	Score
Tanabe Pharma Corporation Lead: A Study of MT-0551 in Patients With Systemic Scler...	Active	Type 2 Diabetes Mellitus, Healthy	56	34	42	2	1243
Chong Kun Dang Lead: Phase 3 Trial to Evaluate the Efficacy and Safety ...	Active	Hypertension, Hypertension and Dyslipidemia	24	13	167	8	1025
Sichuan Baili Pharmaceutical Lead: A Study of BL-M07D1 Versus T-DM1 in the Adjuvant T...	Active	Solid Tumor, Non-small Cell Lung Cancer	24	47	52	95	1022
Hanmi Pharmaceutical Company Limited Lead: A Study to Evaluate Efficacy and Safety of HGP2102...	Active	Healthy, Hypertension	32	22	102	11	992
EMS Lead: Efficacy and Safety of Finlândia Hair Lotion Assoc...	Active	Allergic Rhinitis, Hypertension	56	7	—	6	911
Haisco Pharmaceutical Group Lead: A Clinical Trial Evaluating the Efficacy and Safet...	Active	Healthy, Chronic Obstructive Pulmonary Disease (COPD)	20	35	38	22	814
RemeGen Lead: A Study of Telitacicept in Patients With Ocular My...	Active	Urothelial Carcinoma, Solid Tumors	16	41	25	29	688
Boryung Pharmaceutical Lead: A Study to Evaluate the Efficacy and Safety of BR1...	Active	Essential Hypertension, Hypertension	21	7	75	7	656
Changchun GeneScience Pharmaceutical Lead: A Phase III Clinical Study of Cabergoline Tablets ...	Active	Pediatric Growth Hormone Deficiency (PGHD), Safety	12	17	41	22	589
Dong-A ST Lead: Efficacy and Safety of DA5221-T When Added to Ongo...	Active	Healthy, Type2 Diabetes	16	13	55	3	574
Catalysis SL Lead: Efficacy and Safety of Blue Cap for the Treatment ...	Active	Gastrointestinal Neoplasms, Digestive System Neoplasm	24	23	—	1	549
Boston Scientific Corporation Lead: MANDARIN (S6371)...	Slowing	Coronary Artery Disease, Varicose Veins	28	10	10	6	530
Keymed Biosciences Lead: Study of CM310 in Adolescent Subjects With Atopic ...	Active	Atopic Dermatitis, Healthy	9	31	22	19	524
Yuhan Corporation Lead: Clinical Trial to Evaluate the Safety and Efficacy...	Active	Hypertension, Healthy	11	20	55	8	520
ALK-Abelló Lead: A Research Study of House Dust Mite (HDM) SLIT-tab...	Active	Allergic Rhinoconjunctivitis, Allergic Rhinitis	23	20	2	2	516
Azidus Brasil Lead: Efficacy and Safety of Nitazoxanide 600 Mg in the ...	Slowing	Healthy, Cardiac Surgery	25	9	10	—	477
Green Cross Corporation Lead: A Study of GC1111 in Hunter Syndrom Patients...	Inactive	Influenza, Influenza, Human	20	14	15	1	457
Dompé Farmaceutici Lead: An Efficacy and Safety Study of DFL24498 in the Tr...	Active	Neurotrophic Keratitis, Dry Eye Disease	13	24	11	1	440
Medytox Lead: MT10109L in the Long-term, Open-label Treatment of...	Stale	Glabellar Frown Lines, Glabellar Lines	23	8	7	—	430
Fujian Shengdi Pharmaceutical Lead: A Multicenter, Randomized, Double-blind, Placebo-c...	Active	Type 2 Diabetes, Overweight or Obesity	10	16	22	19	424
Shanghai JMT-Bio Lead: A Phase III Study of KN026 in Combination With HB1...	Active	Non-Small Cell Lung Cancer, HER2-positive Gastric Cancer	15	13	10	15	419
Sinocelltech Lead: Efficacy and Safety Evaluation Study of SCT800 in ...	Active	COVID-19, Advanced Malignant Solid Tumor	11	20	18	13	419
HK inno.N Corporation Lead: Bridge Study to Evaluate the Efficacy and Safety o...	Active	Healthy, Erosive Esophagitis	16	2	46	1	419
Dexa Medica Group Lead: The Efficacy and Safety of Reconyl in Acute Cough ...	Active	Healthy, Acute Ischemic Stroke	19	14	5	—	417
Repros Lead: Phase III Study to Evaluated Morning Testosterone ...	Inactive	Uterine Fibroids, Secondary Hypogonadism	13	19	20	—	407
JW Lead: to Evaluate the Efficacy and Safety of KLH-2109 in...	Active	Healthy, Type 2 Diabetes Mellitus	16	7	27	7	402
Aldeyra US Lead: A Clinical Trial Evaluating Patients With Primary ...	Active	Dry Eye, Allergic Conjunctivitis	14	22	3	1	400
AB Science Lead: Efficacy and Safety of Masitinib Versus Placebo in...	Active	Alzheimer Disease, Amyotrophic Lateral Sclerosis (ALS)	22	6	1	3	391
Kyntra Bio US Lead: Evaluation of Efficacy and Safety of Neoadjuvant T...	Active	Anemia, Idiopathic Pulmonary Fibrosis	16	16	5	1	388
Bavarian Nordic Lead: A Safety and Immunogenicity Study of CHIKV VLP Vac...	Active	Smallpox, Chikungunya Virus	14	16	11	5	386
Grünenthal Lead: Comparison of a Single RTX-GRT7039 and Placebo Int...	Active	Chronic Pain, Pain	16	10	14	3	382
Addpharma Lead: A Study to Evaluate the Efficacy and Safety of AD-...	Active	Hypertension, Mixed Dyslipidemia	12	3	35	8	379
PT Bio Farma Lead: Immunogenicity and Safety Following In-House Recom...	Active	Safety Issues, Healthy	15	15	8	—	379
LG Life Sciences Lead: A Study Comparing LBAL to Humira® in Subjects With...	Inactive	Healthy, Type 2 Diabetes Mellitus	17	5	25	—	370
SK Chemicals Lead: Efficacy and Safety of SKCPT in Patients With Knee...	Stale	Influenza, Human, Pneumococcal Infections	18	7	14	—	368
Bial - Portela C Lead: Early ParkinSon wIth L-DOPA/DDCI and OpicapoNe (EP...	Stale	Parkinson Disease, Pulmonary Arterial Hypertension	9	9	53	—	366
Materia Medica Holding Lead: The Efficacy and Safety of Raphamin in the Treatme...	Active	Influenza, Acute Respiratory Viral Infection	24	—	—	4	365
Ache Laboratorios Farmaceuticos Lead: Efficacy/ Safety of Product DNN.65.21.005 in Patie...	Active	Migraine, Cough	23	1	2	—	364
Kissei Pharmaceutical Lead: Confirmatory Study 3 of KPS-0373 in Patients With ...	Active	Endometriosis, Parkinson Disease	17	10	2	3	351
Dr. Falk Pharma Lead: Once Daily Versus Twice Daily Budesonide Orodisper...	Slowing	Eosinophilic Esophagitis, Primary Sclerosing Cholangitis	17	11	—	3	343
Laboratoires Thea Lead: Study to Evaluate Sepofarsen in Subjects With Lebe...	Active	Glaucoma, Ocular Hypertension	13	14	5	6	342
Tasly Pharmaceutical Group Lead: A Study of Lianxiaxiaopi Granules in the Treatment...	Active	Depression, Cough	10	16	9	11	340
Daewon Pharmaceutical Lead: Study to Evaluate the Efficacy and Safety of DW180...	Active	Healthy, Rheumatoid Arthritis	16	2	18	2	340
Chipscreen Lead: A Study of Tucidinostat in Combination With Sintil...	Active	Small Cell Lung Cancer, Ovarian Cancer	10	13	19	9	336
Mabwell (Shanghai) Bioscience Lead: A Study to Evaluate 9MW2821 Versus Chemotherapy in...	Active	Urothelial Carcinoma, Solid Tumors	8	14	22	18	333
Lee's Pharmaceutical Limited Lead: Phase III Study of Socazolimab as First-Line Treat...	Active	Hypertension, Depression	15	7	15	4	331
CanSino Biologics Lead: A Study to Evaluate the Immunogenicity and Safety ...	Active	COVID-19, Tetanus	15	5	14	14	322
Taisho Pharmaceutical Lead: A Phase 3 Study of TS-172 in Hyperphosphatemia Pat...	Active	Hyperphosphatemia Patients on Hemodialysis, Healthy Volunteers	9	8	30	3	319
Gan & Lee Pharmaceuticals. Lead: Extension Study of the Phase 3 Clinical Study of G...	Active	Diabetes, Type 2 Diabetes Mellitus (T2DM)	13	2	9	16	318
Valneva Austria Lead: Antibody Persistence And Long Term Safety Of A Chi...	Active	Chikungunya Virus Infection, Japanese Encephalitis	15	8	8	1	318
Laboratorios Silanes S.A. de C.V. Lead: Confirmatory Study on the Efficacy and Safety of t...	Active	Healthy, Type 2 Diabetes	16	4	13	4	316
Ascentage Pharma Group Lead: A Pivotal Study of APG-2575 (Lisaftoclax) Combined...	Active	Chronic Lymphocytic Leukemia, Advanced Solid Tumor	7	13	32	25	315
Philogen Lead: Efficacy of Daromun Neoadjuvant Intratumoral Treat...	Active	Glioblastoma, Rheumatoid Arthritis	3	21	23	12	312
Alachua Government Services Lead: Immunogenicity and Safety Study of an Inactivated ...	Stale	Influenza, Pandemic Influenza	14	8	11	—	307
OPKO Health US Lead: Phase 3 Safety and Efficacy Study of CTAP101 Exten...	Active	Secondary Hyperparathyroidism, Vitamin D Insufficiency	7	18	11	—	292
Laboratorios Sophia S.A de C.V. Lead: PRO-232 in Patients Subjected to Cataract Surgery...	Active	Dry Eye, Myopia	10	6	21	2	286
Vyne US Lead: A Study to Compare the Efficacy and Safety of Topi...	Slowing	Pruritus, Acne Vulgaris	9	16	7	—	284
Celldex US Lead: Long-term Efficacy and Safety Extension (LTE) Stud...	Active	Chronic Spontaneous Urticaria, Non-small Cell Lung Cancer	5	15	23	8	279
Anhui Zhifei Longcom Biologic Pharmacy Lead: BCG for Therapeutic Use Phase Ⅲ Clinical Trial...	Active	Tuberculosis, Latent Tuberculosis Infection	10	10	14	5	277
Basilea Pharmaceutica Lead: A Phase 3 Efficacy and Safety Study of Fosmanogepi...	Active	Pharmacokinetics, Fungal Infection	6	10	30	4	270
Hanlim Pharm. Lead: Clinical Trial to Evaluate the Efficacy and Safety...	Active	Healthy Male Subjects, Acute Bronchitis	12	4	16	2	265
Xenon Canada Lead: A Randomized Study of Azetukalner Versus Placebo i...	Active	Major Depressive Disorder, Healthy Volunteers	11	7	8	6	260
PharmaMar Lead: Study of Lurbinectedin in Combination With Doxorub...	Stale	Advanced Solid Tumors, Advanced Solid Tumor	6	13	21	5	257
MediLink Therapeutics (Suzhou) Lead: A Phase III Study of YL201 in Relapsed Small Cell ...	Active	Advanced Solid Tumors, Advanced Solid Tumor	5	12	12	18	257
Betta Pharmaceuticals Lead: Ensartinib as Adjuvant Treatment in Anaplastic Lym...	Active	Non-Small Cell Lung Cancer, Non-small Cell Lung Cancer	6	12	18	9	255
Il-Yang Pharm. Lead: Study to Evaluate the Efficacy and Safety of Ilapr...	Active	Healthy, Pharmacokinetics	12	3	13	7	253
Maruho Lead: Phase III Study of ASP2151 in Herpes Simplex Patie...	Stale	Rosacea, Atopic Dermatitis	8	15	3	—	249
AO GENERIUM Lead: A Multi-cohort Study of Safety, Efficacy, PK and P...	Slowing	Healthy Volunteers, Mucopolysaccharidosis Type II	13	3	10	4	249
Mesoblast Lead: Efficacy and Safety of Rexlemestrocel-L Combined W...	Slowing	Degenerative Disc Disease, Degenerative Spondylolisthesis	8	14	5	1	247
Shanghai Pharmaceuticals Holding Lead: Safety and Efficacy of SPH4336 in Combination With...	Slowing	Advanced Solid Tumors, Hypertension	3	18	18	10	243
InventisBio Lead: A Study to Evaluate D-0502 in Subjects With ER+ He...	Active	NSCLC, Breast Cancer	3	13	17	11	240
Nihon Pharmaceutical Lead: Study of NPF-08 in Patients Who Receive Colonoscop...	Inactive	Bowel Disease, Bullous Pemphigoid	13	5	1	—	238
American Regent Lead: Double-blind Trial of Sodium Thiosulfate for the T...	Slowing	Iron Deficiency Anemia, Anemia	12	6	3	—	237
Abivax Lead: ABTECT - Maintenance...	Active	Ulcerative Colitis, Healthy Volunteers	6	15	7	5	236
Crucell Holland Lead: A Study to Evaluate the Immunogenicity, Safety and...	Inactive	Influenza, Healthy	10	6	12	—	234
Traws Pharma Lead: Controlled Study of Rigosertib Versus Physician's ...	Active	Myelodysplastic Syndrome, Myelodysplastic Syndromes	4	12	19	3	233
Menarini Group Lead: Delafloxacin IV and OS Administration Compared to ...	Slowing	Acute Pain, Irritable Bowel Syndrome With Diarrhea	7	13	8	1	233
Minghui Pharmaceutical Lead: MHB018A Treatment in Patients With Active Thyroid ...	Active	Advanced Malignant Solid Tumor, Thyroid Eye Disease (TED)	4	11	10	14	228
CytoDyn US Lead: Study of PRO 140 SC as Single Agent Maintenance Th...	Active	HIV, Coronavirus Disease 2019	5	18	1	1	227
Praxis Precision US Lead: Double-blind, Randomized Clinical Trial Evaluating...	Active	Essential Tremor, SCN2A Encephalopathy	8	10	2	7	226
Norgine Lead: A Study to Investigate Bowel Cleansing With PLENVU...	Active	Colorectal Cancer, Fecal Incontinence	9	5	15	1	225
Xiamen Amoytop Biotech Lead: The Efficacy and Safety of Inpegsomatropin Injecti...	Active	Chronic Hepatitis B, Preeclampsia	7	9	9	3	224
Tibotec Pharmaceuticals, Ireland Lead: TMC278-TiDP6-C215: A Clinical Trial in Treatment N...	Inactive	Hepatitis C, Hepatitis C Virus	2	8	43	—	223
Ardea Lead: Lesinurad and Febuxostat Combination Extension Stu...	Inactive	Gout, Healthy	7	7	20	—	221
Sumitomo Pharma Lead: A Clinical Trial to Evaluate the Long-term Safety ...	Slowing	Schizophrenia, Hepatocellular Carcinoma	10	4	12	—	218
Can-Fite Israel Lead: Namodenoson in the Treatment of Advanced Hepatocel...	Active	Plaque Psoriasis, Hepatocellular Carcinoma	6	14	2	3	218
Stealth BioTherapeutics Lead: ReNEW:Phase 3 Study of Efficacy, Safety & Pharmaco...	Active	Heart Failure, Healthy Volunteers	4	14	13	1	216
EyePoint Lead: CAPRI: A Phase 3 Randomized, Double-Masked Study C...	Active	Diabetic Macular Edema, Cataract	10	6	1	5	211
Esperion US Lead: Evaluation of Major Cardiovascular Events in Parti...	Stale	Hypercholesterolemia, Statin Adverse Reaction	7	12	3	—	210
International Partnership for Microbicides Lead: Phase 3 Safety and Effectiveness Trial of Dapiviri...	Stale	HIV Infections, Human Immunodeficiency Virus	5	7	26	—	209
Circassia Limited Lead: Phase III Cat-PAD Study...	Inactive	Cat Allergy, Rhinoconjunctivitis	3	19	4	—	209
Allist Lead: A Study Evaluating Furmonertinib Plus Platinum-bas...	Active	NSCLC, Solid Tumor	6	8	15	14	204
Taiho Pharmaceutical Lead: A Phase 3 Study of TAS-205 in Patients With Duchen...	Stale	Colorectal Cancer, Duchenne Muscular Dystrophy	5	12	11	5	204
CStone Lead: A Study of Nofazinlimab (CS1003) in Subjects With ...	Active	Advanced Solid Tumor, Advanced Solid Tumors	6	7	17	5	202
Ethicon Lead: The EVARREST® Pediatric Mild or Moderate Liver and...	Stale	Hemorrhage, Soft Tissue Bleeding	11	4	1	—	200
AVEO Lead: A Study of Ficlatuzumab in Combination With Cetuxi...	Stale	Cachexia, Renal Cell Carcinoma	5	9	17	3	198
Shenzhen Salubris Pharmaceuticals Lead: A Study of SAL003 in Participants With Hypercholes...	Active	Renal Anemia in Non-dialysis Chronic Kidney Disease, Anemia	9	2	7	4	197
Handok Lead: Clinical Efficacy and Safety Evaluation of Tenelig...	Active	Healthy Volunteers, Type 2 Diabetes Mellitus	8	3	16	—	197
Anthera Lead: SOLUTION: Study of Oral Liprotamase Unit-Matched T...	Inactive	Systemic Lupus Erythematosus, Exocrine Pancreatic Insufficiency	9	7	2	—	197
Enanta US Lead: A Phase 2 Study to Investigate the Efficacy and Sa...	Active	RSV Infection, NASH - Nonalcoholic Steatohepatitis	—	11	32	1	194
Tanabe Pharma America Lead: Extension Study to Evaluate Safety and Tolerabilit...	Slowing	Healthy Volunteer, ALS	7	7	11	3	194
Cinnagen Lead: Efficacy and Safety of YW17 (Laronidase-CinnaGen) ...	Stale	COVID-19, Covid19	12	1	2	—	194
Abbisko Therapeutics Lead: Study of Pimicotinib (ABSK021) for Tenosynovial Gi...	Active	Healthy Subjects, Non-Small Cell Lung Cancer	1	9	22	14	193
Astex Lead: Phase 3 Randomized, Open-Label Study of Guadecitab...	Stale	Acute Myeloid Leukemia, Myelodysplastic Syndromes	4	11	15	—	193
XOMA Lead: Safety and Efficacy Study of Gevokizumab to Treat ...	Inactive	Pyoderma Gangrenosum, Uveitis	7	11	—	—	193
Vir Biotechnology US Lead: A Study to Evaluate Tobevibart+Elebsiran in Partic...	Active	Covid19, Chronic Hepatitis B	4	10	12	8	191
Jiangsu vcare pharmaceutical technology Lead: Efficacy and Safety Phase III Clinical Study of VC...	Active	Atopic Dermatitis, Acute Coronary Syndrome	4	5	17	5	191
Chongqing Precision Biotech Lead: BCMA-Targeted CAR-T Cell Therapy for Relapsed/Refr...	Active	Lung Cancer, Gastric Cancer	—	6	31	30	191
Applied Biology Lead: Clinical Study of DA-001 as a Treatment for Hair S...	Active	Androgenetic Alopecia, Covid19	9	3	2	—	190
Alvotech Swiss Lead: Clinical Study to Compare Efficacy and Safety of A...	Active	Psoriasis, Healthy Volunteers	10	—	10	1	190
TBF Genie Tissulaire Lead: Use of a Freeze-dried Amniotic Membrane Post Cross...	Active	Osteoarthritis Hand, Corneal Ulcer	4	13	5	4	189
Laboratorios Leti, S.L. Lead: Subcutaneous Immunotherapy Treatment for Patients ...	Inactive	Rhinoconjunctivitis, Allergic Asthma	3	18	—	—	189
Jemincare Lead: Trial of JYB1904 Injection in Adult Patients With ...	Active	ADPKD (Autosomal Dominant Polycystic Kidney Disease), Healthy	2	8	14	11	186
BioDelivery Sciences Lead: Efficacy, Tolerability, and Safety Study of DFN-15...	Inactive	Low Back Pain, Pain	9	6	1	—	186
Inovio US Lead: REVEAL 2 Trial (Evaluation of VGX-3100 and Electro...	Stale	Coronavirus Infection, Healthy	3	10	20	1	185
Marinus Lead: Open-label Study of Adjunctive GNX Treatment in Ch...	Stale	Status Epilepticus, Tuberous Sclerosis Complex	7	10	—	—	185
Lykos Lead: A Multi-Site Phase 3 Study of MDMA-Assisted Psycho...	Active	Posttraumatic Stress Disorder, PTSD	3	14	6	—	185
Achieve Life Sciences US Lead: A Multinational, Randomized, Open-Label Study of C...	Active	Smoking Cessation, Vaping Cessation	8	4	9	—	184
Zeria Lead: A Phase III Trial of Z-338 in Paediatric Patients ...	Inactive	Iron Deficiency Anemia, Functional Dyspepsia	9	4	5	1	182
Inmunotek S.L. Lead: Efficacy and Safety of SLIT in Patients With Rhini...	Slowing	Rhinoconjunctivitis, Rhinitis, Allergic	10	4	—	4	182
Helixmith Lead: Extension of Phase 3 Gene Therapy for Painful Diab...	Stale	Diabetic Neuropathy, Painful, Amyotrophic Lateral Sclerosis	6	10	4	—	182
Genexine Lead: A Phase 3 Study of Efepoetin Alfa for Treatment of...	Slowing	Healthy, SARS-CoV-2	2	11	21	1	181
Gan and Lee Pharmaceuticals, U Lead: Gan & Lee Insulin Glargine Target Type (1) Evaluat...	Active	Type 2 Diabetes, Diabetes Mellitus, Type 1	3	8	20	5	179
POLYSAN Scientific & Technological Pharmaceutical Company Lead: REAMBERIN® 1.5% in Rehydration Therapy of Diabetic...	Slowing	Stroke, Diabetic Ketoacidosis	9	5	1	1	178
Ironwood US Lead: A Trial of IW-3718 for 8 Weeks in Patients With Pe...	Stale	Healthy Volunteers, Irritable Bowel Syndrome With Constipation	7	8	3	—	178
Mirror Biologics Lead: Immunotherapy for Advanced Liver Cancer...	Active	Hepatocellular Carcinoma, Metastatic Colorectal Cancer	2	15	7	—	176
Medigen Vaccine Biologics Lead: A Study to Evaluate the Immunogenicity and Safety ...	Active	Covid19 Vaccine, COVID-19 Vaccine	6	9	3	1	176
Atea US Lead: C-Forward: Efficacy and Safety of BEM/RZR vs SOF/V...	Active	Healthy Volunteer Study, Hepatitis C, Chronic	3	5	25	4	175
Foresee Pharmaceuticals Lead: Efficacy, Safety, and Pharmacokinetics of Leuproli...	Active	Healthy, Prostatic Neoplasms	7	5	5	2	175
NewAmsterdam Pharma Lead: A Study to Evaluate the Effect of Obicetrapib/Ezet...	Active	Dyslipidemias, Hypercholesterolemia	6	7	6	6	174
Vigonvita Life Sciences Lead: Long-term Safety of TPN171H Tablet in Erectile Dys...	Active	Erectile Dysfunction, Healthy Subjects	3	5	23	5	174
Humanis Saglık Anonim Sirketi Lead: Bioequivalence Study of Two Products of Apremilast...	Active	Type 2 Diabetes Mellitus (T2DM), Hypercholesterolaemia	1	2	34	—	173
Ascletis Pharmaceuticals Lead: Study to Evaluate the Safety and Efficacy of ASC40...	Stale	Healthy, Chronic Hepatitis C	5	7	14	1	173
Sol-Gel Technologies Israel Lead: Efficacy and Safety of Patidegib Gel 2% for Preven...	Stale	Papulopustular Rosacea, Acne Vulgaris	9	4	2	1	173
Trevi US Lead: PRISM Study-Pruritus Relief Through Itch Scratch M...	Active	Idiopathic Pulmonary Fibrosis, Prurigo Nodularis	5	8	6	2	172
LaNova Medicines Limited Lead: LM-108 in Combination With Toripalimab Versus Pacl...	Active	Advanced Solid Tumor, Malignant Tumors	1	12	12	8	172
Sichuan Haisco Pharmaceutical Group Lead: HSK7653 Treatment in Patients With Type 2 Diabetes...	Inactive	Sedation, Anesthesia	5	5	19	—	172
Revolution Medicines US Lead: Study of Daraxonrasib (RMC-6236) in Patients With ...	Active	Colorectal Cancer (CRC), PDAC	4	7	10	12	171
Kodiak Sciences US Lead: A Phase 3 Study to Evaluate the Efficacy and Safet...	Active	Wet Age-related Macular Degeneration, Diabetic Macular Edema	10	1	1	4	171
Biosplice Lead: 3-year, Open-Label Study Evaluating Safety, Tolera...	Stale	Knee Osteoarthritis, Androgenetic Alopecia	6	7	8	—	170
Biotest Lead: Efficacy and Safety of Trimodulin (BT588) in Subje...	Stale	Community-acquired Pneumonia, Rheumatoid Arthritis	8	6	—	1	168
SymBio Lead: A Phase 3 Trial to Compare IV BCV Versus IV CDV fo...	Active	Myelodysplastic Syndrome, Adenovirus Infections	3	10	11	2	168
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair Lead: Pharmacogenomics IND EXEMPT SNP Clinical Trial - A...	Active	Non-small Cell Lung Cancer, Breast Cancer	6	6	1	7	166
Ocuphire Pharma Lead: OPI-NXYDLD-303 Safety and Efficacy of Phentolamine...	Active	Mydriasis, Dilation	8	5	—	1	165
Bharat Biotech International Limited Lead: A Seamless Phase II/III, Observer-blind, to Evalua...	Active	Rotavirus Gastroenteritis, Tuberculosis (TB)	7	5	5	3	165
Talphera Lead: Study to Evaluate the Overall Performance of the Z...	Inactive	Post-Operative Pain, Moderate-to-severe Acute Pain	7	6	4	—	165
Sangamo US Lead: Safety and Tolerability Study of ST-503 for Refrac...	Active	Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2	—	15	13	2	164
Arcus US Lead: Study of Casdatifan and Cabozantinib Versus Placeb...	Active	Healthy Participants, Ovarian Cancer	3	5	23	9	164
Optinose Lead: OPN-375 Efficacy and Safety in Adolescents With Bi...	Active	Bilateral Nasal Polyposis, Chronic Rhinosinusitis	10	—	3	2	164
IlDong Pharmaceutical Lead: Study to Assess the Antiviral Activity and Safety ...	Slowing	Healthy, Healthy Adult Subjects	7	1	17	1	164
Newron Lead: Evenamide, a Glutamate Release Modulator, as Add-O...	Active	Idiopathic Parkinson's Disease, Schizophrenia	6	7	4	1	163
Shin Poong Pharmaceutical Lead: Efficacy and Safety of SP-8203 (Otaplimastat) in P...	Slowing	Ischemic Stroke, COVID-19	5	9	5	3	162
KGK Science Lead: A Study to Investigate the Effect of 7-Keto on Res...	Inactive	Healthy, Functional Constipation	—	18	6	—	162
Taiwan Liposome Company Lead: Extended and Controlled Release Liposomal Formulat...	Slowing	Osteoarthritis of the Knee, Postsurgical Pain Management	2	13	9	—	161
Scynexis US Lead: A Phase 3, Randomized, Double-blind Study for Pati...	Stale	Candidiasis, Invasive, Candidemia	7	5	5	—	160
PT. Prodia Stem Cell Indonesia Lead: Role of UC-MSC and CM to Inhibit Vision Loss in Re...	Active	Retinitis Pigmentosa, Acute Respiratory Distress Syndrome	1	12	11	6	159
Zhaoke (Guangzhou) Ophthalmology Lead: A Study of the Efficacy and Safety of Cyclosporin ...	Active	Corneal Epithelial Defect, Myopia	7	5	3	4	159
Intarcia Lead: Comparison of Efficacy, Safety, and Tolerability o...	Inactive	Type 2 Diabetes, Diabetes Mellitus, Type 2	9	1	5	—	158
Medipost Lead: Phase 3 Pivotal Trial Comparing CARTISTEM® and Sur...	Active	Bronchopulmonary Dysplasia, Knee Osteoarthritis	3	10	8	3	154
Iroko Lead: Study of Meloxicam Capsules in Subjects With Osteo...	Inactive	Osteoarthritis, Other Acute Postoperative Pain	7	6	—	—	153
Allakos Lead: An Extension Study of Lirentelimab in Eosinophilic...	Slowing	Eosinophilic Gastritis, Eosinophilic Duodenitis	5	7	7	—	152
Evopoint Lead: A Randomized, Double-blind, Multicenter Phase III ...	Active	Bacterial Infections, Advanced Solid Tumors	2	9	13	7	151
Zai Lab (Shanghai) Lead: A Study of ZL-1310 Versus Investigator's Choice of...	Active	Solid Tumors, Ovarian Cancer	3	6	11	6	151
RVL Lead: A Study to Investigate Arbaclofen ER Tablets for t...	Active	Multiple Sclerosis, Spasticity	9	1	1	—	151
medac Lead: Efficacy and Safety of Methotrexate Versus Placebo...	Stale	Steroid-refractory Acute Graft-versus-host Disease, Acute B-Cell Lymphoblastic Leukaemia	6	6	4	4	150
Shanghai Mabgeek Biotech. Lead: Phase III Clinical Study of MG-K10 Humanized Mab I...	Active	Atopic Dermatitis, Atopic Eczema	6	4	1	5	150
Chelsea Lead: Clinical Study of Droxidopa in Patients With Neuro...	Inactive	Dopamine Beta Hydroxylase Deficiency, Primary Autonomic Failure	6	6	4	—	150
InQpharm Group Lead: Safety and Efficacy of IQP- AK-102 in Reducing Bod...	Inactive	Overweight, Weight Loss	10	—	—	—	150
Polaris Group Lead: Study of ADI-PEG 20 Versus Placebo in Subjects Wit...	Stale	Hepatocellular Carcinoma, Acute Myeloid Leukemia	4	7	11	5	149
Kedrion Lead: A Study Investigating Intravenous Human Normal Imm...	Active	Primary Immunodeficiency Disease, Chronic Inflammatory Demyelinating Polyneuropathy	8	1	—	4	148
Onconic Lead: Study to Evaluate the Efficacy and Safety of JP-13...	Active	Healthy, Ovarian Cancer	4	5	9	4	147
JCR Pharmaceuticals Lead: A Phase III Study of JR-141 in Patients With Mucop...	Slowing	Mucopolysaccharidosis II, Mucopolysaccharidosis I	4	9	5	5	147
Genfit Lead: Phase 3 Study to Evaluate the Efficacy and Safety ...	Active	Abdominal Obesity, Renal Impairment	1	11	11	1	146
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Lead: FDA018-ADC vs Investigator's Choice Chemotherapy t...	Active	Port-Wine Stain, Papillomavirus Infections	3	7	13	7	145
Laboratorio Elea Phoenix Lead: Double-blind Study to Evaluate the PK, Efficacy, S...	Slowing	Neuroblastoma, COVID-19 Drug Treatment	5	8	2	3	145
Wave Life Sciences Singapore Lead: Efficacy and Safety Study of WVE-210201 (Suvodirse...	Active	Duchenne Muscular Dystrophy, Huntington Disease	1	11	12	3	144
Genfleet Therapeutics Lead: Phase III Study to Compare GFH375 and Chemotherapy...	Active	Metastatic Pancreatic Cancer, PDAC	1	10	8	5	144
Adamas Lead: Efficacy and Safety of Amantadine Hydrochloride (H...	Inactive	Parkinson's Disease, Dyskinesia	8	3	—	—	144
FORUM Lead: Study of the Safety and Effectiveness of Two Doses...	Inactive	Alzheimer's Disease, Schizophrenia	6	4	7	—	143
Xencor US Lead: Study of XmAb942 in Healthy Participants and Parti...	Active	Urothelial Carcinoma, Cervical Carcinoma	—	8	22	5	140
Hangzhou Sciwind Biosciences Lead: A Study of XW003 in Obese Participants With Obstru...	Active	Obesity, Weight Management	5	3	5	5	139
MoonLake Immunotherapeutics Switzerland Lead: Evaluation of Sonelokimab in Patients With Active ...	Active	Hidradenitis Suppurativa, Arthritis, Psoriatic	7	2	1	5	139
Sinotau Pharmaceutical Group Lead: Comparison of Diagnostic Accuracy Between XTR004 P...	Active	Coronary Artery Disease (CAD), Prostate Cancer	4	6	5	7	138
Stallergenes Greer Lead: Safety and Efficacy of STALORAL® Birch 300 IR in a...	Stale	House Dust Mite Allergy, Allergic Rhinitis Due to House Dust Mite	7	3	3	—	138
EyeBiotech Lead: A Clinical Trial of EYE201/MK-8748 in People With ...	Active	Diabetic Macular Edema (DME), Macular Degeneration	4	7	2	5	137
Repurposed Lead: Prevention and Treatment of Nausea Associated With...	Inactive	Motion Sickness, Motion Sickness, Space	7	4	—	2	137
Apnimed Lead: Parallel-Arm Study to Compare AD109 to Placebo Wit...	Slowing	Obstructive Sleep Apnea, OSA	3	11	1	1	136
Changchun BCHT Biotechnology Lead: Adsorption of Cell-free Diphtheria and Tetanus (Th...	Active	Influenza, Rabies Prevention	5	1	4	1	135
Veru US Lead: Efficacy & Safety Evaluation of Enobosarm in Combo...	Active	Metastatic Breast Cancer, Obesity & Overweight	4	8	2	1	135
Dynavax Technologies Corporation Lead: Comparing Safety and Immunogenicity of HEPLISAV-B®...	Active	Vaccine-Preventable Diseases, Healthy	4	5	10	2	135
Syntara Lead: A Safety and Efficacy Trial of Inhaled Mannitol in...	Stale	Cystic Fibrosis, Bronchiectasis	3	9	6	1	135
Anavex Life Sciences US Lead: OLE of Phase 2b/3 Study ANAVEX2-73-AD-004...	Stale	Rett Syndrome, Alzheimer Disease	4	9	1	1	135
Resverlogix Lead: A Study of Apabetalone in Subjects With Long -COVI...	Slowing	Coronary Artery Disease, Dyslipidemia	3	10	3	1	134
Hamad Medical Corporation Lead: Anakinra in the Management of COVID-19 Infection...	Stale	Bronchiolitis, Gastroenteritis	6	4	4	1	134
Shanghai Shengdi Pharmaceutical Lead: A Phase III Clinical Study of Adebrelimab Combined...	Active	Advanced Cervical Cancer, Locally Advanced Gastric or Gastroesophageal Junction Cancer	5	3	3	5	133
Apsen Farmaceutica Lead: Efficacy and Safety of APSMNF in the Treatment of ...	Active	Healthy Volunteers, Alopecia, Androgenetic	6	3	3	—	133
DualityBio Lead: A Study of DB-1303/BNT323 vs Investigator's Choice...	Active	Advanced Solid Tumor, Advanced/Metastatic Solid Tumors	2	8	8	10	133
Seikagaku Corporation Lead: A Study for Evaluation of the Efficacy and Safety ...	Inactive	Dry Eye Syndromes, Intervertebral Disc Disease	6	5	1	—	133
Anterogen Lead: Clinical Study to Evaluate Efficacy and Safety of ...	Slowing	Diabetic Foot Ulcer, Crohn's Fistula	3	8	8	3	133
RECORDATI GROUP Lead: Evaluation of the Efficacy and Safety of Two Metha...	Active	Cushing Syndrome, Pharmacokinetics	4	7	2	2	132

Why Track Clinical-Stage Companies?

Acquisition Targets: Big pharma acquires pipeline companies before approval to avoid bidding wars post-approval.

Catalyst Plays: Phase 3 readouts and FDA decisions create binary events for investors and competitors.

Showing top 200 companies by pipeline score. See also: Emerging Biotechs (1-10 approved drugs) | Acquisition Watch (at-risk companies)